JVS-vascular science最新文献

{"title":"Supramolecularly Fabricated Non-thrombogenic Small Diameter Vascular Graft","authors":"Nitisha Mehrotra, Aparna Adumbumkulath, Paul Kim, Suran Somawardana, Kirti Mhatre, Aladdein Mattar, Abdelmotagaly Elgalad, Nilson Salas, Ramyar Gilani, Crystal Shin, Ghanashyam Acharya, Pulickel M. Ajayan","doi":"10.1016/j.jvssci.2024.100267","DOIUrl":"10.1016/j.jvssci.2024.100267","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100267"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camouflaging endovascular stents with an endothelial coat using CD31 domain 1 and 2 mimetic peptides","authors":"Jean Sénémaud MD, PhD ,&nbsp;Charles Skarbek PhD ,&nbsp;Belen Hernandez PhD ,&nbsp;Ran Song PhD ,&nbsp;Isabelle Lefevre PhD ,&nbsp;Elisabetta Bianchi PhD ,&nbsp;Yves Castier MD, PhD ,&nbsp;Antonino Nicoletti PhD ,&nbsp;Christophe Bureau PhD ,&nbsp;Giuseppina Caligiuri MD, PhD","doi":"10.1016/j.jvssci.2024.100213","DOIUrl":"10.1016/j.jvssci.2024.100213","url":null,"abstract":"<div><h3>Objective</h3><p>Implantation of an endovascular device disrupts the homeostatic CD31:CD31 interactions among quiescent endothelial cells (ECs), platelets, and circulating leukocytes. The aim of this study was to design an endothelial-mimetic coating of nitinol and cobalt-chromium (CoCr) surfaces and stents using synthetic CD31 peptides, to promote device endothelialization and pacific integration within the arterial wall.</p></div><div><h3>Methods</h3><p>Peptides mimicking the domains 1 (D1) and 2 (D2) of CD31 were synthetized and immobilized onto experimental nitinol and CoCr surfaces using a three-step, dip-coating, mussel-inspired protocol using copper-free click chemistry. Human aortic EC phenotype and endothelialization assessment using parallel scratch tests were carried out using five synthetic CD31 peptides coated on 4.8-mm nitinol and CoCr flat disks and were compared with control disks. The CD31 peptide exhibiting the best results in vitro was then immobilized on clinical-grade 3 × 40-mm self-expanding nitinol and 2.5 × 20.0-mm balloon-expandable CoCr stents. Such devices were implanted in native arteries of White New Zealand rabbits, and compared with control uncoated bare metal stents (BMS) and drug-eluting stents 7 and 30 days after implantation using resin cross-sections and scanning electron microscopy (n = 2-3 per group at each time point).</p></div><div><h3>Results</h3><p>Membrane-distal CD31 D1 and D2 peptides exhibited a distinct capability to foster a healthy endothelial phenotype and to promote endothelialization in vitro. By day 7 after implantation, CD31 nitinol and CoCr stents were evenly covered by wholesome ECs, devoid of thromboinflammatory signs, in contrast with both BMS and drug-eluting stents. Such results were consistent until day 30.</p></div><div><h3>Conclusions</h3><p>Membrane-distal CD31 biomimetic peptides seem to camouflage the device surface effectively, preventing local reactions and promoting rapid and seamless endovascular integration.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000245/pdfft?md5=586568decde158b644a6988f3b5e2f40&pid=1-s2.0-S2666350324000245-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study","authors":"Rania Shahbaz PhD ,&nbsp;Etienne Charpentier MD ,&nbsp;Maharajah Ponnaiah PhD ,&nbsp;Frédérique Deshours PhD ,&nbsp;Hamid Kokabi PhD ,&nbsp;Isabelle Brochériou MD, PhD ,&nbsp;Gilles Le Naour PhD ,&nbsp;Alban Redheuil MD, PhD ,&nbsp;Fabien Koskas MD, PhD ,&nbsp;Jean-Michel Davaine MD, PhD","doi":"10.1016/j.jvssci.2023.100182","DOIUrl":"10.1016/j.jvssci.2023.100182","url":null,"abstract":"<div><h3>Objective</h3><p>Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and MW technology has emerged as a promising field of research for distinguishing abnormal tissues from healthy ones. We here evaluated the ability of a dedicated MW sensor developed in our laboratory to identify vulnerable carotid lesions.</p></div><div><h3>Methods</h3><p>We included 50 carotid lesions in this study. The plaques were analyzed and classified preoperatively by ultrasound (US) examination, computed tomography angiography and tested postoperatively using a MW sensor. Histopathological analysis was used as a gold standard to separate vulnerable plaques (VPs) from nonvulnerable plaques (NVPs).</p></div><div><h3>Results</h3><p>VPs were more frequently types 2 or 3 plaques (on US examination), had a greater proportion of low (&lt;60 Hounsfield unit) and moderate (60-130 Hounsfield unit) attenuation components (computed tomography angiography) and displayed higher dielectric constant values (MW) than NVPs, which had an opposite profile. NVPs were more frequently asymptomatic plaques compared with VPs (<em>P</em> = .035). Multivariate analysis showed that US examination and MW identified VPs with a sensitivity of 77% and a specificity of 76% (cutoff value, –0.045; area under the curve, 0.848; <em>P</em> &lt; .0001).</p></div><div><h3>Conclusions</h3><p>We found that the presence of types 2 to 3 (on US examination) and high dielectric constant plaques in vitro was highly indicative of a VP based on histological analysis. Further studies are needed to determine the potential of MW to identify the most dangerous asymptomatic carotid lesions.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635032300086X/pdfft?md5=afffd8fbb14ab1c4a89531bcf8ce250b&pid=1-s2.0-S266635032300086X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence: The magic 8 ball for vascular surgery","authors":"Sharon C. Kiang MD, FACS","doi":"10.1016/j.jvssci.2024.100197","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100197","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100197"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000087/pdfft?md5=506c99565c872936917c1c97d9bd2319&pid=1-s2.0-S2666350324000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Events of Interest","authors":"","doi":"10.1016/S2666-3503(24)00087-7","DOIUrl":"10.1016/S2666-3503(24)00087-7","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100276"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Loss of Type VIII Collagen Improves Venous Remodeling After Arteriovenous Fistula Creation In Mice","authors":"Xochilt Labissiere,&nbsp;Miguel Gabriel Rojas,&nbsp;Laisel Martinez,&nbsp;Roberto Vazquez-Padron","doi":"10.1016/j.jvssci.2024.100220","DOIUrl":"10.1016/j.jvssci.2024.100220","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Sex-Based Differences in Plaque Histology in Patients With End-Stage Peripheral Arterial Disease","authors":"Madeline Drake,&nbsp;Fouzul Kansul,&nbsp;Judit Csore,&nbsp;Deborah Vela,&nbsp;Trisha Roy","doi":"10.1016/j.jvssci.2024.100225","DOIUrl":"10.1016/j.jvssci.2024.100225","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair","authors":"Kenneth Tran MD ,&nbsp;Celine Deslarzes-Dubuis MD ,&nbsp;Sebastien DeGlise MD ,&nbsp;Adrien Kaladji MD ,&nbsp;Weiguang Yang PhD ,&nbsp;Alison L. Marsden PhD ,&nbsp;Jason T. Lee MD","doi":"10.1016/j.jvssci.2023.100183","DOIUrl":"10.1016/j.jvssci.2023.100183","url":null,"abstract":"<div><h3>Background</h3><p>Endovascular aneurysm repair with four-vessel fenestrated endovascular aneurysm repair (fEVAR) or branched endovascular aneurysm repair (bEVAR) currently represent the forefront of minimally invasive complex aortic aneurysm repair. This study sought to use patient-specific computational flow simulation (CFS) to assess differences in postoperative hemodynamic effects associated with fEVAR vs bEVAR.</p></div><div><h3>Methods</h3><p>Patients from two institutions who underwent four-vessel fEVAR with the Cook Zenith Fenestrated platform and bEVAR with the Jotec E-xtra Design platform were retrospectively selected. Patients in both cohorts were treated for paravisceral and extent II, II, and V thoracoabdominal aortic aneurysms. Three-dimensional finite element volume meshes were created from preoperative and postoperative computed tomography scans. Boundary conditions were adjusted for body surface area, heart rate, and blood pressure. Pulsatile flow simulations were performed with equivalent boundary conditions between preoperative and postoperative states. Postoperative changes in hemodynamic parameters were compared between the fEVAR and bEVAR groups.</p></div><div><h3>Results</h3><p>Patient-specific CFS was performed on 20 patients (10 bEVAR, 10 fEVAR) with a total of 80 target vessels (40 renal, 20 celiac, 20 superior mesenteric artery stents). bEVAR was associated with a decrease in renal artery peak flow rate (−5.2% vs +2.0%; <em>P</em> &lt; .0001) and peak pressure (−3.4 vs +0.1%; <em>P</em> &lt; .0001) compared with fEVAR. Almost all renal arteries treated with bEVAR had a reduction in renal artery perfusion (n = 19 [95%]), compared with 35% (n = 7) treated with fEVAR. There were no significant differences in celiac or superior mesenteric artery perfusion metrics (<em>P</em> = .10-.27) between groups. Time-averaged wall shear stress in the paravisceral aorta and branches also varied significantly depending on endograft configuration, with bEVAR associated with large postoperative increases in renal artery (+47.5 vs +13.5%; <em>P</em> = .002) and aortic time-averaged wall shear stress (+200.1% vs −31.3%; <em>P</em> = .001) compared with fEVAR. Streamline analysis revealed areas of hemodynamic abnormalities associated with branched renal grafts which adopt a U-shaped geometry, which may explain the observed differences in postoperative changes in renal perfusion between bEVAR and fEVAR.</p></div><div><h3>Conclusions</h3><p>bEVAR may be associated with subtle decreases in renal perfusion and a large increase in aortic wall shear stress compared with fEVAR. CFS is a novel tool for quantifying and visualizing the unique patient-specific hemodynamic effect of different complex EVAR strategies.</p></div><div><h3>Clinical Relevance</h3><p>This study used patient-specific CFS to compare postoperative hemodynamic effects of four-vessel fenestrated endovascular aneurysm repair (fEVAR) and branched endovascular aneurysm repair ","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000871/pdfft?md5=a80815d2199cb6cf5b972868ccdb2934&pid=1-s2.0-S2666350323000871-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum detection of blood brain barrier injury in subjects with a history of stroke and transient ischemic attack","authors":"Scott French ,&nbsp;Juan Arias MD ,&nbsp;Ikeoluwapo Bolakale-Rufai MD ,&nbsp;Summan Zahra MD ,&nbsp;Kaneez Zahra Rubab Khakwani MD ,&nbsp;Edward J. Bedrick PhD ,&nbsp;Geidy E. Serrano PhD ,&nbsp;Thomas G. Beach MD, PhD ,&nbsp;Eric Reiman MD ,&nbsp;Craig Weinkauf MD, PhD","doi":"10.1016/j.jvssci.2024.100206","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100206","url":null,"abstract":"<div><h3>Objective</h3><p>Stroke and transient ischemic attack may have long-term negative effects on the blood-brain barrier (BBB) and promote endothelial inflammation, both of which could increase neurodegeneration and dementia risk beyond the cell death associated with the index event.</p></div><div><h3>Methods</h3><p>Serum from 88 postmortem subjects in the Arizona Study of Aging and Neurodegenerative Disorders were analyzed by sandwich ELISA for specific biomarkers to investigate the effects of cerebrovascular accidents (CVAs) on BBB integrity and endothelial activation. Statistical analyses were performed using the Mann-Whitney <em>U</em> Test, Spearman rank correlation, and linear/logistic regressions adjusted for potential confounders; a <em>P</em>-value &lt; .05 was considered significant for all analyses.</p></div><div><h3>Results</h3><p>Serum PDGFRẞ, a putative biomarker of BBB injury, was significantly increased in subjects with vs without a history of CVA who had similar cardiovascular risk factors (<em>P</em> &lt; .01). This difference was stable after adjusting for age, hypertension, and other potential confounders in regression analysis (odds ratio, 27.02; 95% confidence interval, 2.61-411.7; <em>P</em> &lt; .01). In addition, PDGFRẞ was positively associated with VCAM-1, a biomarker of endothelial inflammation (ρ = 0.42; <em>P</em> &lt; .01).</p></div><div><h3>Conclusions</h3><p>Our data suggest that patients with stroke or transient ischemic attack have lasting changes in the BBB. Still more, this demonstrates the utility of PDGFRẞ as a serum-based biomarker of BBB physiology, a potentially powerful tool in studying the role of the BBB in various neurodegenerative diseases and COVID infection sequelae.</p></div><div><h3>Clinical Relevance</h3><p>Our data demonstrate the utility of serum PDGFRẞ, a putative biomarker of BBB integrity in the setting of stroke and TIA (CVA). A serum biomarker of BBB integrity could be a useful tool to detect early BBB damage and allow prospective work to study how such damage affects long-term neurodegenerative risk. Since BBB disruption occurs early in ADRD development, it could be monitored to help better understand disease progression and involvement of vascular pathways in ADRD.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000178/pdfft?md5=2882cf384347395014f8173be3bf2f3e&pid=1-s2.0-S2666350324000178-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Characterization of Sex Differences in Abdominal Aortic Aneurysm Progression Via Vascular Deformation Mapping","authors":"Drew Braet,&nbsp;Luciano Delbono,&nbsp;Greg Spahlinger,&nbsp;Nathan Graham,&nbsp;Akul Arora,&nbsp;C. Alberto Figueroa,&nbsp;Jonathan Eliason,&nbsp;Nicholas S. Burris","doi":"10.1016/j.jvssci.2024.100251","DOIUrl":"10.1016/j.jvssci.2024.100251","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}