JVS-vascular science最新文献

{"title":"Retrograde aortic endograft side-branch design is associated with delayed cervical branch filling: A fluid mechanics scaling analysis","authors":"Sanjeev Dhara MD ,&nbsp;Kameel Khabaz BS ,&nbsp;Mason McIntyre BS ,&nbsp;Noor Malo ,&nbsp;Miroslav Peev MD ,&nbsp;Luka Pocivavsek MD, PhD","doi":"10.1016/j.jvssci.2026.100419","DOIUrl":"10.1016/j.jvssci.2026.100419","url":null,"abstract":"<div><div>Although perioperative stroke is a recognized risk in thoracic endovascular aortic arch repair, the long-term impact of altered cervical flow resulting from different device configurations is underappreciated. We compared angiographic data from two aortic stents, with anatomical (in-line) and nonanatomical (retrograde inner branch) configurations, and demonstrated a persistent filling delay in the retrograde inner branch device. Using computational fluid dynamic modeling, we demonstrated that parameters such as turbulence, vorticity, and Q-criterion are elevated in an idealized retrograde inner branch geometry. By way of a fluid mechanic scaling analysis, we show that the retrograde inner branch configuration results in a larger Dean number, thereby explaining our observed angiographic and computational modeling results. Our work should prompt further investigation regarding the long-term impact of branch configuration and altered cervical blood flow.</div></div><div><h3>Clinical Relevance</h3><div>Thoracic endovascular aortic arch repair is growing in prevalence. Perioperative stroke risk remains a major risk factor. A less studied phenomenon is the impact of differing branch configurations on long-term hemodynamics. This work compared angiographic data from two devices with differing branch flow configurations: antegrade vs retrograde. A persistent cervical branch filling was noted in the retrograde branch device. We applied fluid mechanic scaling analysis and validated with computational modeling to show that the retrograde branch configuration is promoting of disturbed flow. This work should promote further clinical investigation regarding long-term impact of branch configuration.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100419"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro characterization and angiogenic potential of quality-and-quantity mononuclear cell-derived extracellular vesicles","authors":"Suttipong Tianwattanatada MD ,&nbsp;Nuttapol Chruewkamlow PhD ,&nbsp;Narinee Srimark MSc ,&nbsp;Ladawan Khowawisetsut PhD ,&nbsp;Kovit Pattanapanyasat PhD ,&nbsp;Chutipon Sathan-ard MSc ,&nbsp;Pisol Senawongse DDS, PhD ,&nbsp;Nuttawut Sermsathanasawadi MD, PhD","doi":"10.1016/j.jvssci.2026.100410","DOIUrl":"10.1016/j.jvssci.2026.100410","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the presence, production rate, and in vitro angiogenic properties of quality-and-quantity culture mononuclear cells-derived extracellular vesicles (QQMNC-EVs).</div></div><div><h3>Methods</h3><div>Peripheral blood from three healthy volunteers was processed into five groups: QQMNC-EVs, QQMNCs, peripheral blood mononuclear cell-derived EVs (PBMNC-EVs), CD34⁺-EVs, and late endothelial progenitor cell-derived EVs (late EPC-EVs). EVs were identified and characterized using nanoparticle tracking analysis, flow cytometry, western blot analysis, and electron microscopy. EV production rates were quantified, and angiogenesis was evaluated via tube length formation assay.</div></div><div><h3>Results</h3><div>QQMNC-EVs were identified and met established EVs criteria. QQMNCs produced the highest EVs yield. This was significantly higher than CD34⁺ cells (<em>P</em> = .044), late EPCs (<em>P</em> = .004), and PBMNCs (<em>P</em> = .046). At low concentration, QQMNC-EVs showed angiogenic effects comparable with CD34⁺-EVs and late EPC-EVs, significantly greater than PBMNC-EVs (<em>P</em> = .018). At high concentration, QQMNC-EVs produced the highest tube length formation, demonstrating a dose-dependent effect. This was significantly higher than CD34⁺-EVs (<em>P</em> = .018), late EPC-EVs (<em>P</em> = .011), and PBMNC-EVs (<em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>QQMNC-EVs were successfully identified and showed in vitro angiogenic efficacy, highlighting their potential as a novel therapeutic strategy for patients with no-option chronic limb-threatening ischemia.</div></div><div><h3>Clinical Relevance</h3><div>Extracellular vesicles (EVs) were successfully identified and characterized from QQMNCs and had the highest production rate among the four cell groups: QQMNCs, standard peripheral blood mononuclear cells, CD34⁺ cells, and late endothelial progenitor cells. Moreover, QQMNC-EVs produced markedly higher tube length formation than standard mononuclear cell-derived EVs. These findings in angiogenic efficacy in vitro highlight their potential as a novel optional therapeutic strategy. Further investigation may advance treatment options for patients with no-option chronic limb-threatening ischemia.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100410"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147449014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VRIC Abstracts 2025","authors":"","doi":"10.1016/j.jvssci.2026.100415","DOIUrl":"10.1016/j.jvssci.2026.100415","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100415"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using patient-specific computational fluid dynamics to assess intraprosthetic thrombus formation risk and guide relining after endovascular aneurysm repair","authors":"Lysette V. Scheepmaker BSc,&nbsp;Paul van Schaik PhD,&nbsp;Lennart van de Velde PhD,&nbsp;Michel M.P.J. Reijnen PhD","doi":"10.1016/j.jvssci.2026.100437","DOIUrl":"10.1016/j.jvssci.2026.100437","url":null,"abstract":"<div><div>A patient-specific computational fluid dynamics (CFD) analysis was performed to explore hemodynamic contributors of recurrent intraprosthetic thrombus and limb thrombosis in a patient after endovascular aneurysm repair (EVAR) and to investigate the potential of CFD to guide revision strategies. Key hemodynamic parameters, Time-averaged wall shear stress (TAWSS) and residence time (RT), were assessed showing a region with depressed TAWSS (below 0.1 Pa) at the site of intraprosthetic thrombus and a quasi-infinite RT of entrapped particles in that area. Next, CFD simulations tested a virtual limb-relining configuration, with geometric modifications resulting in improved TAWSS and RT. After mimicking the CFD-based relining with the implantation of an endograft a postprocedural analysis was performed. The postoperative results were in line with the prediction model and showed a 544% reduction in low area of TAWSS (&lt;0.1 Pa) and a normalization of RT to 5 seconds. A contrast-enhanced computed tomography 1 year after stent placement showed a patent endograft without any signs of recurrent mural thrombus. Therefore, CFD may provide valuable insights into the hemodynamic mechanisms underlying endograft thrombosis and may support personalized planning of relining strategies to reduce recurrent thromboembolic risk.</div></div><div><h3>Clinical relevance</h3><div>The second most common complication after endovascular aneurysm repair is thrombosis in one of the iliac stent graft limbs or distal thromboembolic events, which can cause acute limb ischemia. In some patients, these events persist even after a successful relining of the iliac stent graft with normal flow profiles on ultrasound. This report describes how computational fluid dynamics can identify flow pattern abnormalities and high residence time in a patient with recurring thromboembolic events after endovascular aneurysm repair placement, coinciding with the location of thrombus formation. Moreover, relining strategies can be virtually assessed in the patient's computer model to select a strategy that is expected to normalize the increased residence time.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100437"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduit type is associated with distinct fibrin-mediated coagulation trajectories following lower extremity bypass","authors":"Shezan Fouzdar MBBS, MS,&nbsp;Radha Bansal MBBS,&nbsp;Swechha Bhatt MBBS,&nbsp;Shiv Patel BA,&nbsp;Aseman Bagheri Sheshdeh BS,&nbsp;Prajakta Lokhande MBBS, MPH,&nbsp;Shaidah Deghan Manshadi MD,&nbsp;Anahita Dua MD, MS, MBA","doi":"10.1016/j.jvssci.2026.100451","DOIUrl":"10.1016/j.jvssci.2026.100451","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Prosthetic and autogenous vein conduits used in lower extremity bypass differ in biologic composition and thrombogenic potential, but their influence on postoperative coagulation remains poorly understood. Postoperative antithrombotic strategies following bypass remain largely empiric. We aimed to determine whether the choice of conduit is associated with distinct longitudinal postoperative coagulation trajectories that may inform conduit-specific antithrombotic strategies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This single-center prospective observational study evaluated patients undergoing lower extremity bypass with serial perioperative thromboelastography with platelet mapping assessment and stratified according to conduit type: prosthetic or autogenous vein conduit. Longitudinal coagulation trajectories were analyzed using linear mixed-effects models with random intercepts for patients. Fixed effects included postoperative time point, conduit type, antiplatelet therapy, anticoagulation regimen, and time-by-conduit interaction terms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 338 longitudinal thromboelastography with platelet mapping measurements were obtained from 81 patients undergoing lower extremity bypass, including 59 (72.8%) receiving prosthetic conduit and 22 (27.2%) receiving autogenous vein conduit. Adjusted mixed-effects modeling demonstrated a significant time-by-conduit interaction for citrated functional fibrinogen maximum amplitude (&lt;em&gt;P&lt;/em&gt; = .048), indicating differing postoperative fibrin-mediated clot strength trajectories according to conduit type. Prosthetic conduit recipients demonstrated an earlier postoperative rise in citrated functional fibrinogen maximum amplitude, peaking around postoperative day 4, whereas vein conduit recipients demonstrated a later peak around postoperative day 5.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Conduit type was associated with distinct postoperative coagulation trajectories following lower extremity bypass, with the principal conduit-associated differences observed in fibrin-mediated clot-strength trajectories. These findings should be considered hypothesis generating and suggest that postoperative coagulation physiology may differ according to conduit type and support further investigation into whether conduit-specific coagulation phenotypes can inform individualized antithrombotic strategies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Clinical relevance&lt;/h3&gt;&lt;div&gt;Postoperative antithrombotic management following lower extremity bypass remains largely empirical despite well-recognized differences in thrombogenicity between prosthetic and autogenous vein conduits. In this prospective longitudinal study, conduit type was associated with distinct fibrin-mediated coagulation trajectories during early postoperative recovery, with prosthetic conduit recipients demonstrating an earlier rise in citrated functional fibrinogen maximum amplitude than autogenous vein conduit recipients. ","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100451"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149211367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galectin-3 is dispensable for thoracic aortic aneurysmal formation and rupture in mice","authors":"Nithya Ramesh PhD ,&nbsp;Edward Downey BS ,&nbsp;Sudheer Kumar Kanumuri MD ,&nbsp;Zhenguo Liu MD ,&nbsp;Venkateswaran Subramanian PhD","doi":"10.1016/j.jvssci.2025.100396","DOIUrl":"10.1016/j.jvssci.2025.100396","url":null,"abstract":"<div><div>Thoracic aortic aneurysm (TAA) development involves disruption of extracellular matrix structural proteins such as collagen and elastin. An increased level of Galectin-3 (Gal-3), a β-galactoside-binding lectin, was reported in ascending aortic aneurysmal patients. To examine the role of Gal-3 on TAA formation in mice, two models were used: administration of lysyl oxidase inhibitor, β-aminopropionitrile (BAPN 0.5%, 0.3%, and 0.1% wt/vol) to 3- to 4 -week-old male and female Gal-3 wild-type (WT) or deficient knockout (KO) mice for 4 weeks in drinking water; and 8- to 10-week-old Gal-3 WT or KO mice were infused with either saline or angiotensin II (AngII) via osmotic mini-pumps for 28 days. High or low doses of BAPN administration promoted TAA rupture-induced death equivalently in both WT and KO male (WT = 64%; KO = 73%) and female (WT = 41%; KO = 54%) mice compared with controls. Similarly, AngII infusion caused a significantly increased, but equivalent, dilation of thoracic aortas in both male and female Gal-3 and Gal-3 KO mice compared with controls. Histological analysis revealed increased elastin fragmentation and collagen accumulation in both BAPN- and AngII-infused male and female WT and KO mice compared with controls. These findings suggest that Gal-3 deficiency did not influence either BAPN- or AngII-induced TAA formation or rupture in mice.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100396"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145765721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated system combining cerebral protection and active steering directional puncture for thoracic aortic in situ fenestration","authors":"Xiangxiang Ru MSc,&nbsp;Xinxi Li MSc,&nbsp;Lei Zhang MSc,&nbsp;Jingdong Tang PhD,&nbsp;Shuai Jiang PhD,&nbsp;Yerbao Zaiying MSc,&nbsp;Gulitenken Aihemaitijiang MSc,&nbsp;Donglin Li MSc,&nbsp;Dilinerkezi Ablimit MSc,&nbsp;Li Chen MSc,&nbsp;Yuxin Deng MSc,&nbsp;Halizati Halimulati MSc,&nbsp;Ye Tian MD","doi":"10.1016/j.jvssci.2026.100433","DOIUrl":"10.1016/j.jvssci.2026.100433","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to introduce and systematically evaluate the preclinical performance and safety of a novel integrated interventional device that simultaneously addresses the cerebral embolism risk and the difficulty of puncture and fenestration during thoracic aortic in situ fenestration.</div></div><div><h3>Methods</h3><div>A study design combining in vitro experiments with anatomically accurate human aortic arch models and in vivo large animal experiments was adopted. (1) In in vitro experiments, a closed-loop pulsatile flow system was used to test the device's capture efficiency for 100 , 120 , and 150 μm embolic microspheres, and to verify its puncture accuracy for the three supra-aortic branch vessels under types Ⅰ to Ⅲ aortic arch configurations. (2) In in vivo experiments, six healthy Ukrainian White pigs were used as the animal model to assess the surgical technical success rate, procedural efficiency, operator usability feedback, and immediate safety of the device.</div></div><div><h3>Results</h3><div>In in vitro experiments, the device achieved capture rates of (98.1 ± 0.9)% and (87.1 ± 2.7)% for the stroke-causing critical particle sizes of 150 and 120 μm, respectively, capture efficiency exhibited a size-dependent trend (<em>F</em> = 174,771; <em>P</em> &lt; .001). Across all types Ⅰ to Ⅲ aortic arch scenarios, the puncture coverage ratio ranged from 41.9% to 68.8%, with no out-of-bounds puncture events. In in vivo experiments, the surgical technical success rate was 100%, with a mean fenestration time of only 9 seconds (range, 5-11 seconds) and a total procedural time of 38.92 ± 4.36 minutes. The overall operator usability score was 7.47 ± 0.89, among which the directional accuracy dimension received the highest score (7.83 ± 0.75). After the procedure, the device was retrieved with intact structural integrity, only mild vascular intimal injury was observed, and successful capture of thrombus debris by the embolic protection filter was confirmed.</div></div><div><h3>Conclusions</h3><div>This integrated system offers a potential approach to the inherent challenge of incompatible access for cerebral protection and puncture during in situ fenestration procedures. Preclinical results indicate it may facilitate improved puncture success and holds potential for clinical translation.</div></div><div><h3>Clinical Relevance</h3><div>This study addresses two core clinical challenges of thoracic endovascular aortic repair: the high risk of perioperative stroke and the technical difficulty of in situ fenestration (ISF) in complex aortic arch anatomies. The integrated device provides a novel, single-access solution that synchronizes cerebral protection and precision puncture, with the potential to improve procedural safety and efficiency, and expand the application of ISF for complex aortic pathologies.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100433"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148735521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms","authors":"Yasir AlSiraj PhD ,&nbsp;Kelly Putnam PhD ,&nbsp;Seth I. Brunner BS ,&nbsp;Victoria L. English PhD ,&nbsp;Charles M. Ensor PhD ,&nbsp;Lisa A. Cassis PhD","doi":"10.1016/j.jvssci.2025.100397","DOIUrl":"10.1016/j.jvssci.2025.100397","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;Adipocytes express renin–angiotensin system (RAS) components, including angiotensinogen (&lt;em&gt;Agt&lt;/em&gt;), the precursor to angiotensin II (AngII), and the angiotensin type 1a receptor (&lt;em&gt;AT1aR&lt;/em&gt;). The RAS contributes to atherosclerosis, and AngII infusion causes abdominal aortic aneurysm (AAA) formation. We studied effects of adipocyte &lt;em&gt;Agt&lt;/em&gt; or &lt;em&gt;AT1aR&lt;/em&gt; deficiency on diet-induced atherosclerosis and AngII-induced AAAs in male low-density lipoprotein receptor (&lt;em&gt;Ldlr&lt;/em&gt;)-deficient mice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;For atherosclerosis, adipocyte &lt;em&gt;Agt-&lt;/em&gt; or &lt;em&gt;AT1aR&lt;/em&gt;-deficient &lt;em&gt;Ldlr&lt;/em&gt;-deficient mice and littermate controls were fed a Western diet for 3 months. For AAAs, adipocyte &lt;em&gt;Agt-&lt;/em&gt; or &lt;em&gt;AT1aR&lt;/em&gt;-deficient &lt;em&gt;Ldlr&lt;/em&gt;&lt;sup&gt;&lt;em&gt;−/−&lt;/em&gt;&lt;/sup&gt; mice and littermate controls were fed a Western diet and infused with AngII (1000 ng/kg/min) for 28 days. Atherosclerosis was quantified en face in the aortic arch by the percent of intimal surface area covered by an atherosclerotic lesion. Serum (cholesterol, triglyceride) and plasma renin activity were quantified at study end point. AAAs were quantified in vivo by ultrasound quantification of abdominal aortic lumen diameters in anesthetized mice or at study end point by quantifying maximal external abdominal aortic diameter and AAA incidence (percent). Systolic blood pressure was quantified in AngII-infused mice by tail cuff plethysmography. Adipocyte size was quantified in tissue sections of white adipose tissue. Male &lt;em&gt;Ldlr&lt;/em&gt;&lt;sup&gt;&lt;em&gt;−/−&lt;/em&gt;&lt;/sup&gt; mice were fed a standard diet or a Western diet (1 or 3 months) and &lt;em&gt;Agt&lt;/em&gt; or &lt;em&gt;AT1aR&lt;/em&gt; messenger RNA (mRNA) abundance quantified in periaortic fat (PAF) by reverse transcriptase polymerase chain reaction.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;There was no effect of adipocyte &lt;em&gt;Agt&lt;/em&gt; deficiency on body weight, serum cholesterol concentrations, or atherosclerotic lesions of Western diet-fed &lt;em&gt;Ldlr&lt;/em&gt;&lt;sup&gt;&lt;em&gt;−/−&lt;/em&gt;&lt;/sup&gt; mice. Adipocyte &lt;em&gt;Agt&lt;/em&gt; deficiency had no effect on body weight, serum cholesterol concentrations, abdominal aortic lumen diameter, AAA incidence, or atherosclerosis of AngII-infused &lt;em&gt;Ldlr&lt;/em&gt;&lt;sup&gt;&lt;em&gt;−/−&lt;/em&gt;&lt;/sup&gt; mice. There was no effect of adipocyte AT1aR deficiency on body weight, serum cholesterol concentrations, or atherosclerotic lesions of Western diet-fed &lt;em&gt;Ldlr&lt;/em&gt;&lt;sup&gt;&lt;em&gt;−/−&lt;/em&gt;&lt;/sup&gt; mice. Control, but not adipocyte &lt;em&gt;AT1aR&lt;/em&gt;-deficient mice lost weight during AngII infusion. The size of adipocytes in white adipose tissue was increased in adipocyte &lt;em&gt;AT1aR&lt;/em&gt;-deficient mice with no significant influences on abdominal aortic lumen diameter, AAA incidence, or atherosclerosis of AngII-infused mice. In mice fed a Western diet for 1 or 3 months, &lt;em&gt;Agt&lt;/em&gt; mRNA abundance in abdominal PAF increased over time in both diet groups, with modest diet-induced decreases in thoracic PAF &lt;em&gt;Agt&lt;/em&gt; mRNA abunda","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100397"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future is bright","authors":"Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2025.100407","DOIUrl":"10.1016/j.jvssci.2025.100407","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100407"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cutting ballon versus plain balloon dilatation after electrified wire in situ fenestration","authors":"Marcello Silvano MD ,&nbsp;Teodora Ormandzhieva MD ,&nbsp;Eberhard Grambow MD ,&nbsp;Florian Elger MD","doi":"10.1016/j.jvssci.2026.100417","DOIUrl":"10.1016/j.jvssci.2026.100417","url":null,"abstract":"<div><h3>Objective</h3><div>Electrified wire in situ fenestration (EW-ISF) has been recently described both in vivo and in vitro as a feasible alternative to laser ISF to address complex aortic pathologies in emergency situations. However, no data are currently available regarding the preferred dilatation method after puncture. The aim of this paper was to compare two established schemes of fenestration dilation after an EW-ISF setting.</div></div><div><h3>Methods</h3><div>A total of 72 EW-ISFs were performed in 4 commercially available endografts: Zenith Alpha (n = 20), RelayPro (n = 20), Endurant IIs (n = 20), and Valiant Captivia (n = 12). In group A, fenestrations were sequentially dilatated with a 2-mm and a 6-mm plain balloon dilatation (PBD). In group B, fenestrations were dilatated with a 2-mm PBD, a 4-mm cutting balloon, and a 6-mm PBD. Postdilatation fenestration morphological features were analyzed, and diameters and surface were measured after dilatation and after 24 hours to assess the relative fabric elastic recoil. For each graft, in both group one bridging stent (BS) was implanted and its caliber measured with intravascular ultrasound.</div></div><div><h3>Results</h3><div>In both the Zenith and the Endurant, group B showed more tearing (<em>P</em> = .302 and <em>P</em> &lt; .001 respectively), less bulging (<em>P</em> = .039 and <em>P</em> &lt; .001), and more frequent slit-like fenestration morphology (<em>P</em> = .015 and <em>P</em> = .001). The Valiant graft displayed major (&gt;0.5 cm long) tearing in group B. Fenestration dimensions and recoil momentum were comparable between the two groups in all grafts, but the Endurant, where group B fenestrations had significantly higher fenestration area (6.5 mm² vs 2.3 mm²; <em>P</em> &lt; .001). BS caliber was comparable in both groups in the RelayPro and Zenith Alpha, but a significant stenosis was assessed in group A in the Endurant IIs.</div></div><div><h3>Conclusions</h3><div>Both cutting balloon dilatation and PBD are feasible and comparable after EW-ISF in the in the RelayPro and the Zenith grafts. Cutting balloon provides more ideal fenestration dimensions in the Endurant IIs and might be preferred. It determines excessive damages in the monofilament graft and should, therefore, be avoided.</div></div><div><h3>Clinical Relevance</h3><div>Electrified wire in situ fenestration is an emerging, low-cost alternative for urgent aortic branch revascularization, but optimal postfenestration dilation remains undefined. This study provides practical guidance on balloon selection according to graft fabric. Cutting balloons may improve fenestration enlargement and reduce the risk of bridging stent stenosis in multifilament grafts such as Endurant IIs, while causing excessive damage in monofilament devices. Tailoring dilation strategy to graft type may enhance safety, durability, and procedural success in emergency endovascular aortic repair.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100417"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147650118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}