JVS-vascular science最新文献

{"title":"Vascular Loss of Type VIII Collagen Improves Venous Remodeling After Arteriovenous Fistula Creation In Mice","authors":"Xochilt Labissiere, Miguel Gabriel Rojas, Laisel Martinez, Roberto Vazquez-Padron","doi":"10.1016/j.jvssci.2024.100220","DOIUrl":"10.1016/j.jvssci.2024.100220","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair","authors":"Kenneth Tran MD ,&nbsp;Celine Deslarzes-Dubuis MD ,&nbsp;Sebastien DeGlise MD ,&nbsp;Adrien Kaladji MD ,&nbsp;Weiguang Yang PhD ,&nbsp;Alison L. Marsden PhD ,&nbsp;Jason T. Lee MD","doi":"10.1016/j.jvssci.2023.100183","DOIUrl":"10.1016/j.jvssci.2023.100183","url":null,"abstract":"<div><h3>Background</h3><p>Endovascular aneurysm repair with four-vessel fenestrated endovascular aneurysm repair (fEVAR) or branched endovascular aneurysm repair (bEVAR) currently represent the forefront of minimally invasive complex aortic aneurysm repair. This study sought to use patient-specific computational flow simulation (CFS) to assess differences in postoperative hemodynamic effects associated with fEVAR vs bEVAR.</p></div><div><h3>Methods</h3><p>Patients from two institutions who underwent four-vessel fEVAR with the Cook Zenith Fenestrated platform and bEVAR with the Jotec E-xtra Design platform were retrospectively selected. Patients in both cohorts were treated for paravisceral and extent II, II, and V thoracoabdominal aortic aneurysms. Three-dimensional finite element volume meshes were created from preoperative and postoperative computed tomography scans. Boundary conditions were adjusted for body surface area, heart rate, and blood pressure. Pulsatile flow simulations were performed with equivalent boundary conditions between preoperative and postoperative states. Postoperative changes in hemodynamic parameters were compared between the fEVAR and bEVAR groups.</p></div><div><h3>Results</h3><p>Patient-specific CFS was performed on 20 patients (10 bEVAR, 10 fEVAR) with a total of 80 target vessels (40 renal, 20 celiac, 20 superior mesenteric artery stents). bEVAR was associated with a decrease in renal artery peak flow rate (−5.2% vs +2.0%; <em>P</em> &lt; .0001) and peak pressure (−3.4 vs +0.1%; <em>P</em> &lt; .0001) compared with fEVAR. Almost all renal arteries treated with bEVAR had a reduction in renal artery perfusion (n = 19 [95%]), compared with 35% (n = 7) treated with fEVAR. There were no significant differences in celiac or superior mesenteric artery perfusion metrics (<em>P</em> = .10-.27) between groups. Time-averaged wall shear stress in the paravisceral aorta and branches also varied significantly depending on endograft configuration, with bEVAR associated with large postoperative increases in renal artery (+47.5 vs +13.5%; <em>P</em> = .002) and aortic time-averaged wall shear stress (+200.1% vs −31.3%; <em>P</em> = .001) compared with fEVAR. Streamline analysis revealed areas of hemodynamic abnormalities associated with branched renal grafts which adopt a U-shaped geometry, which may explain the observed differences in postoperative changes in renal perfusion between bEVAR and fEVAR.</p></div><div><h3>Conclusions</h3><p>bEVAR may be associated with subtle decreases in renal perfusion and a large increase in aortic wall shear stress compared with fEVAR. CFS is a novel tool for quantifying and visualizing the unique patient-specific hemodynamic effect of different complex EVAR strategies.</p></div><div><h3>Clinical Relevance</h3><p>This study used patient-specific CFS to compare postoperative hemodynamic effects of four-vessel fenestrated endovascular aneurysm repair (fEVAR) and branched endovascular aneurysm repair ","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000871/pdfft?md5=a80815d2199cb6cf5b972868ccdb2934&pid=1-s2.0-S2666350323000871-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum detection of blood brain barrier injury in subjects with a history of stroke and transient ischemic attack","authors":"Scott French ,&nbsp;Juan Arias MD ,&nbsp;Ikeoluwapo Bolakale-Rufai MD ,&nbsp;Summan Zahra MD ,&nbsp;Kaneez Zahra Rubab Khakwani MD ,&nbsp;Edward J. Bedrick PhD ,&nbsp;Geidy E. Serrano PhD ,&nbsp;Thomas G. Beach MD, PhD ,&nbsp;Eric Reiman MD ,&nbsp;Craig Weinkauf MD, PhD","doi":"10.1016/j.jvssci.2024.100206","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100206","url":null,"abstract":"<div><h3>Objective</h3><p>Stroke and transient ischemic attack may have long-term negative effects on the blood-brain barrier (BBB) and promote endothelial inflammation, both of which could increase neurodegeneration and dementia risk beyond the cell death associated with the index event.</p></div><div><h3>Methods</h3><p>Serum from 88 postmortem subjects in the Arizona Study of Aging and Neurodegenerative Disorders were analyzed by sandwich ELISA for specific biomarkers to investigate the effects of cerebrovascular accidents (CVAs) on BBB integrity and endothelial activation. Statistical analyses were performed using the Mann-Whitney <em>U</em> Test, Spearman rank correlation, and linear/logistic regressions adjusted for potential confounders; a <em>P</em>-value &lt; .05 was considered significant for all analyses.</p></div><div><h3>Results</h3><p>Serum PDGFRẞ, a putative biomarker of BBB injury, was significantly increased in subjects with vs without a history of CVA who had similar cardiovascular risk factors (<em>P</em> &lt; .01). This difference was stable after adjusting for age, hypertension, and other potential confounders in regression analysis (odds ratio, 27.02; 95% confidence interval, 2.61-411.7; <em>P</em> &lt; .01). In addition, PDGFRẞ was positively associated with VCAM-1, a biomarker of endothelial inflammation (ρ = 0.42; <em>P</em> &lt; .01).</p></div><div><h3>Conclusions</h3><p>Our data suggest that patients with stroke or transient ischemic attack have lasting changes in the BBB. Still more, this demonstrates the utility of PDGFRẞ as a serum-based biomarker of BBB physiology, a potentially powerful tool in studying the role of the BBB in various neurodegenerative diseases and COVID infection sequelae.</p></div><div><h3>Clinical Relevance</h3><p>Our data demonstrate the utility of serum PDGFRẞ, a putative biomarker of BBB integrity in the setting of stroke and TIA (CVA). A serum biomarker of BBB integrity could be a useful tool to detect early BBB damage and allow prospective work to study how such damage affects long-term neurodegenerative risk. Since BBB disruption occurs early in ADRD development, it could be monitored to help better understand disease progression and involvement of vascular pathways in ADRD.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000178/pdfft?md5=2882cf384347395014f8173be3bf2f3e&pid=1-s2.0-S2666350324000178-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Endothelial Cell-Mediated Efferocytosis Promotes Abdominal Aortic Aneurysm Formation","authors":"Jeff Arni C. Valisno,&nbsp;Gang Su,&nbsp;Paolo Bellotti,&nbsp;Jonathan Krebs,&nbsp;Guoshuai Cai,&nbsp;Guanyi Lu,&nbsp;Ashish K. Sharma,&nbsp;Gilbert R. Upchurch Jr.","doi":"10.1016/j.jvssci.2024.100244","DOIUrl":"10.1016/j.jvssci.2024.100244","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Varicose Vein Using Induced Pluripotent Stem Cells","authors":"Chikage Noishiki,&nbsp;Shaunak S. Adkar,&nbsp;David Wu,&nbsp;Lu Liu,&nbsp;Naima C. Turbes,&nbsp;Dipti Tripathi,&nbsp;Amit Manhas,&nbsp;Dilip Thomas,&nbsp;Karim Sallam,&nbsp;Jason T. Lee,&nbsp;Nick J. Leeper,&nbsp;Derek Klarin,&nbsp;Eri Fukaya,&nbsp;Nazish Sayed","doi":"10.1016/j.jvssci.2024.100265","DOIUrl":"10.1016/j.jvssci.2024.100265","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100265"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological PERK/ATF4 Activation in Vascular Smooth Muscle Cells Drives Abdominal Aortic Aneurysm Development","authors":"Brennan Callow,&nbsp;Kevin Dale Mangum,&nbsp;Tyler Bauer,&nbsp;Xianying Xing,&nbsp;Mary O'Riordan,&nbsp;Johann Gudjonsson,&nbsp;Andrea T. Obi,&nbsp;Katherine A. Gallagher,&nbsp;Frank M. Davis","doi":"10.1016/j.jvssci.2024.100249","DOIUrl":"10.1016/j.jvssci.2024.100249","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Characterization of Sex Differences in Abdominal Aortic Aneurysm Progression Via Vascular Deformation Mapping","authors":"Drew Braet,&nbsp;Luciano Delbono,&nbsp;Greg Spahlinger,&nbsp;Nathan Graham,&nbsp;Akul Arora,&nbsp;C. Alberto Figueroa,&nbsp;Jonathan Eliason,&nbsp;Nicholas S. Burris","doi":"10.1016/j.jvssci.2024.100251","DOIUrl":"10.1016/j.jvssci.2024.100251","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia","authors":"Amy L. Lu ,&nbsp;Li Yin PhD ,&nbsp;Yitao Huang BS ,&nbsp;Zain Husain Islam ,&nbsp;Rohan Kanchetty ,&nbsp;Campbell Johnston ,&nbsp;Kaijie Zhang MD ,&nbsp;Xiujie Xie PhD ,&nbsp;Ki Ho Park PhD ,&nbsp;Charles E. Chalfant PhD ,&nbsp;Bowen Wang PhD","doi":"10.1016/j.jvssci.2024.100214","DOIUrl":"10.1016/j.jvssci.2024.100214","url":null,"abstract":"<div><h3>Background</h3><p>Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosis is intimal hyperplasia (IH), in which the hyperproliferative and migratory vascular smooth muscle cell (VSMC) accumulate excessively in the tunica intima. 6-Phosphogluconate dehydrogenase (6PGD), sometimes referred to as PGD, is one of the critical enzymes in pentose phosphate pathway (PPP). In this study, we sought to probe whether 6PGD is aberrantly regulated in IH and contributes to VSMC phenotypic switching.</p></div><div><h3>Methods</h3><p>We used clinical specimens of diseased human coronary arteries with IH lesions and observed robust upregulation of 6PGD at protein level in both the medial and intimal layers in comparison with healthy arterial segments.</p></div><div><h3>Results</h3><p>6PGD activity and protein expression were profoundly stimulated upon platelet-derived growth factor-induced VSMC phenotypic switching. Using gain-of-function (dCas9-mediated transcriptional activation) and loss-of-function (small interfering RNA-mediated) silencing, we were able to demonstrate the pathogenic role of 6PGD in driving VSMC hyperproliferation, migration, dedifferentiation, and inflammation. Finally, we conducted a rat model of balloon angioplasty in the common carotid artery, with Pluronic hydrogel-assisted perivascular delivery of <em>Physcion</em>, a selective 6PGD inhibitor with poor systemic bioavailability, and observed effective mitigation of IH.</p></div><div><h3>Conclusions</h3><p>We contend that aberrant 6PGD expression and activity—indicative of a metabolic shift toward pentose phosphate pathway—could serve as a new disease-driving mechanism and, hence, an actionable target for the development of effective new therapies for IH and restenosis after endovascular interventions.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000257/pdfft?md5=015a2d171ee9d906e05a42573e145c34&pid=1-s2.0-S2666350324000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Neointimal hyperplasia after carotid transection and anastomosis surgery is associated with degradation of decorin and platelet-derived growth factor signaling” [JVS–Vascular Science 2 (2021) 2 - 12]","authors":"Roshan J. D'Cruz MD ,&nbsp;Valerie B. Sampson PhD ,&nbsp;Carly A. Askinas MD ,&nbsp;Rebecca A. Scott PhD ,&nbsp;Karyn G. Robinson MS ,&nbsp;Claude A. Beaty MD ,&nbsp;Anne M. Hesek AS ,&nbsp;Robert E. Akins PhD, FAHA","doi":"10.1016/j.jvssci.2024.100216","DOIUrl":"10.1016/j.jvssci.2024.100216","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surgeon-scientist's approach to improving arteriovenous fistula patency","authors":"Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100207","DOIUrl":"10.1016/j.jvssci.2024.100207","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635032400018X/pdfft?md5=2180a3dc765c68551038549c6179d79f&pid=1-s2.0-S266635032400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}