JVS-vascular science最新文献

{"title":"Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms","authors":"Yasir AlSiraj PhD , Kelly Putnam PhD , Seth I. Brunner BS , Victoria L. English PhD , Charles M. Ensor PhD , Lisa A. Cassis PhD","doi":"10.1016/j.jvssci.2025.100397","DOIUrl":"10.1016/j.jvssci.2025.100397","url":null,"abstract":"<div><h3>Objective</h3><div>Adipocytes express renin–angiotensin system (RAS) components, including angiotensinogen (<em>Agt</em>), the precursor to angiotensin II (AngII), and the angiotensin type 1a receptor (<em>AT1aR</em>). The RAS contributes to atherosclerosis, and AngII infusion causes abdominal aortic aneurysm (AAA) formation. We studied effects of adipocyte <em>Agt</em> or <em>AT1aR</em> deficiency on diet-induced atherosclerosis and AngII-induced AAAs in male low-density lipoprotein receptor (<em>Ldlr</em>)-deficient mice.</div></div><div><h3>Methods</h3><div>For atherosclerosis, adipocyte <em>Agt-</em> or <em>AT1aR</em>-deficient <em>Ldlr</em>-deficient mice and littermate controls were fed a Western diet for 3 months. For AAAs, adipocyte <em>Agt-</em> or <em>AT1aR</em>-deficient <em>Ldlr</em><sup><em>−/−</em></sup> mice and littermate controls were fed a Western diet and infused with AngII (1000 ng/kg/min) for 28 days. Atherosclerosis was quantified en face in the aortic arch by the percent of intimal surface area covered by an atherosclerotic lesion. Serum (cholesterol, triglyceride) and plasma renin activity were quantified at study end point. AAAs were quantified in vivo by ultrasound quantification of abdominal aortic lumen diameters in anesthetized mice or at study end point by quantifying maximal external abdominal aortic diameter and AAA incidence (percent). Systolic blood pressure was quantified in AngII-infused mice by tail cuff plethysmography. Adipocyte size was quantified in tissue sections of white adipose tissue. Male <em>Ldlr</em><sup><em>−/−</em></sup> mice were fed a standard diet or a Western diet (1 or 3 months) and <em>Agt</em> or <em>AT1aR</em> messenger RNA (mRNA) abundance quantified in periaortic fat (PAF) by reverse transcriptase polymerase chain reaction.</div></div><div><h3>Results</h3><div>There was no effect of adipocyte <em>Agt</em> deficiency on body weight, serum cholesterol concentrations, or atherosclerotic lesions of Western diet-fed <em>Ldlr</em><sup><em>−/−</em></sup> mice. Adipocyte <em>Agt</em> deficiency had no effect on body weight, serum cholesterol concentrations, abdominal aortic lumen diameter, AAA incidence, or atherosclerosis of AngII-infused <em>Ldlr</em><sup><em>−/−</em></sup> mice. There was no effect of adipocyte AT1aR deficiency on body weight, serum cholesterol concentrations, or atherosclerotic lesions of Western diet-fed <em>Ldlr</em><sup><em>−/−</em></sup> mice. Control, but not adipocyte <em>AT1aR</em>-deficient mice lost weight during AngII infusion. The size of adipocytes in white adipose tissue was increased in adipocyte <em>AT1aR</em>-deficient mice with no significant influences on abdominal aortic lumen diameter, AAA incidence, or atherosclerosis of AngII-infused mice. In mice fed a Western diet for 1 or 3 months, <em>Agt</em> mRNA abundance in abdominal PAF increased over time in both diet groups, with modest diet-induced decreases in thoracic PAF <em>Agt</em> mRNA abunda","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100397"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future is bright","authors":"Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2025.100407","DOIUrl":"10.1016/j.jvssci.2025.100407","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100407"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cutting ballon versus plain balloon dilatation after electrified wire in situ fenestration","authors":"Marcello Silvano MD ,&nbsp;Teodora Ormandzhieva MD ,&nbsp;Eberhard Grambow MD ,&nbsp;Florian Elger MD","doi":"10.1016/j.jvssci.2026.100417","DOIUrl":"10.1016/j.jvssci.2026.100417","url":null,"abstract":"<div><h3>Objective</h3><div>Electrified wire in situ fenestration (EW-ISF) has been recently described both in vivo and in vitro as a feasible alternative to laser ISF to address complex aortic pathologies in emergency situations. However, no data are currently available regarding the preferred dilatation method after puncture. The aim of this paper was to compare two established schemes of fenestration dilation after an EW-ISF setting.</div></div><div><h3>Methods</h3><div>A total of 72 EW-ISFs were performed in 4 commercially available endografts: Zenith Alpha (n = 20), RelayPro (n = 20), Endurant IIs (n = 20), and Valiant Captivia (n = 12). In group A, fenestrations were sequentially dilatated with a 2-mm and a 6-mm plain balloon dilatation (PBD). In group B, fenestrations were dilatated with a 2-mm PBD, a 4-mm cutting balloon, and a 6-mm PBD. Postdilatation fenestration morphological features were analyzed, and diameters and surface were measured after dilatation and after 24 hours to assess the relative fabric elastic recoil. For each graft, in both group one bridging stent (BS) was implanted and its caliber measured with intravascular ultrasound.</div></div><div><h3>Results</h3><div>In both the Zenith and the Endurant, group B showed more tearing (<em>P</em> = .302 and <em>P</em> &lt; .001 respectively), less bulging (<em>P</em> = .039 and <em>P</em> &lt; .001), and more frequent slit-like fenestration morphology (<em>P</em> = .015 and <em>P</em> = .001). The Valiant graft displayed major (&gt;0.5 cm long) tearing in group B. Fenestration dimensions and recoil momentum were comparable between the two groups in all grafts, but the Endurant, where group B fenestrations had significantly higher fenestration area (6.5 mm² vs 2.3 mm²; <em>P</em> &lt; .001). BS caliber was comparable in both groups in the RelayPro and Zenith Alpha, but a significant stenosis was assessed in group A in the Endurant IIs.</div></div><div><h3>Conclusions</h3><div>Both cutting balloon dilatation and PBD are feasible and comparable after EW-ISF in the in the RelayPro and the Zenith grafts. Cutting balloon provides more ideal fenestration dimensions in the Endurant IIs and might be preferred. It determines excessive damages in the monofilament graft and should, therefore, be avoided.</div></div><div><h3>Clinical Relevance</h3><div>Electrified wire in situ fenestration is an emerging, low-cost alternative for urgent aortic branch revascularization, but optimal postfenestration dilation remains undefined. This study provides practical guidance on balloon selection according to graft fabric. Cutting balloons may improve fenestration enlargement and reduce the risk of bridging stent stenosis in multifilament grafts such as Endurant IIs, while causing excessive damage in monofilament devices. Tailoring dilation strategy to graft type may enhance safety, durability, and procedural success in emergency endovascular aortic repair.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100417"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147650118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TET2-mutant clonal hematopoiesis is associated with peripheral bypass graft occlusion: A multicenter retrospective cohort pilot study","authors":"Elena Streck MD,&nbsp;Manuela Harloff PhD,&nbsp;Dennis Freuer PhD,&nbsp;Sebastian Dintner PhD,&nbsp;Dimitrios Dedegkikas MD,&nbsp;Dominik Jost MD,&nbsp;Elisabeth Kling MD,&nbsp;Bruno Märkl MD,&nbsp;Martin Trepel MD,&nbsp;Alexander Hyhlik-Dürr MD,&nbsp;Rainer Claus MD","doi":"10.1016/j.jvssci.2026.100442","DOIUrl":"10.1016/j.jvssci.2026.100442","url":null,"abstract":"<div><h3>Objective</h3><div>Clonal hematopoiesis of indeterminate potential (CHIP), defined by somatic mutations in hematopoietic cells, is associated with cardiovascular disease through proinflammatory mechanisms. We investigated whether CHIP, and specifically <em>TET2</em> mutations, is associated with peripheral bypass graft occlusion in patients with peripheral arterial disease.</div></div><div><h3>Methods</h3><div>In this multicenter, retrospective cohort pilot study, 47 patients with peripheral arterial disease who had undergone femoropopliteal or femorocrural bypass grafting were analyzed. CHIP status was assessed from peripheral blood using a 40-gene myeloid sequencing panel. Time-to-event analyses were performed using Kaplan-Meier survival analysis and multivariable Cox proportional hazards regression adjusted for diabetes and smoking status.</div></div><div><h3>Results</h3><div>Of 47 patients, 33 had bypass graft occlusion and 14 had patent grafts. CHIP was detected in 14 individuals (29.8%). The mutational spectrum differed markedly between groups: in the patent graft group, all CHIP mutations were in <em>DNMT3A</em>, whereas <em>TET2</em> was the most frequently mutated gene in the occlusion group (7 of 17 mutations; 41%). All five <em>TET2</em>-mutant patients belonged to the occlusion group. Cell sorting revealed CHIP variants predominantly in myeloid cells, natural killer cells, and B lymphocytes, with near-absence in T cells. Cox regression demonstrated a significant association between <em>TET2</em> mutation and bypass occlusion (hazard ratio, 6.70; 95% confidence interval, 1.96-22.96; <em>P</em> = .003).</div></div><div><h3>Conclusions</h3><div><em>TET2</em> mutations are associated with peripheral bypass graft occlusion and may represent a novel biomarker for graft failure risk. These findings require validation in larger prospective studies.</div></div><div><h3>Clinical relevance</h3><div>Clonal hematopoiesis, particularly <em>TET2</em> mutations, is increasingly recognized as a driver of atherosclerotic cardiovascular disease and peripheral arterial disease (PAD). This pilot study extends that risk to the surgical setting, demonstrating a strong association between <em>TET2</em> mutations and peripheral bypass graft occlusion (hazard ratio, 6.70). If confirmed in larger prospective cohorts, preoperative <em>TET2</em> screening could identify a high-risk subgroup of patients with PAD requiring intensified postoperative imaging surveillance, more aggressive antithrombotic regimens, earlier reintervention thresholds, and consideration of targeted anti-inflammatory prophylaxis. Such gene-specific risk stratification could shift bypass care toward individualized, biomarker-guided management of patients with PAD undergoing revascularization.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100442"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149050535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking intraluminal thrombus in abdominal aortic aneurysm","authors":"Salvatore T. Scali MD","doi":"10.1016/j.jvssci.2026.100431","DOIUrl":"10.1016/j.jvssci.2026.100431","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"7 ","pages":"Article 100431"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148735610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating compliance in three-dimensional-printed polymeric vascular grafts compared to human arteries and commercial grafts in a mock circulation loop compliance in three-dimensional-printed polymeric vascular grafts","authors":"Weichen Hong BS ,&nbsp;Vijay Tewari BS ,&nbsp;Huidan Yu PhD ,&nbsp;Jun Chen PhD ,&nbsp;Alan P. Sawchuk MD","doi":"10.1016/j.jvssci.2025.100291","DOIUrl":"10.1016/j.jvssci.2025.100291","url":null,"abstract":"<div><div>Compliance mismatch between native arteries and prosthetic grafts contribute to complications such as neointimal hyperplasia and pseudoaneurysms, leading to reduced graft patency. Three-dimensional (3D) printing offers a promising solution by flexibly customizing mechanical properties using elastic polymers. This study investigates whether 3D-printed polymeric grafts can better replicate native arterial compliance compared with commercial prosthetic grafts. We conducted compliance tests on human aortoiliac arteries, polytetrafluoroethylene (PTFE) grafts, Dacron grafts, and 3D-printed arteries with BioMed Elastic Resin within a mock circulation loop. All samples shared controlled geometry and were tested under the same physiological flow conditions. Pressure waveforms and key hemodynamic parameters were recorded and analyzed. The 3D-printed graft demonstrated a compliance of 0.49 cm³/mmHg, more closely matching the human artery than PTFE (0.38 cm³/mmHg) and Dacron (0.45 cm³/mmHg). Its mean arterial pressure (82 ± 0.6 mmHg) and peak pressure (40 ± 0.7 mmHg) in the flow loop also aligned more closely with the native artery compared with conventional grafts. Standard prosthetic graft materials have remained relatively static, whereas there has been immense advancement in new polymer technology. These polymers can match the compliance of native vessels, theoretically reducing complications associated with traditional grafts, and future work should investigate their biocompatibility, durability, and clinical feasibility.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"6 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JVS-VS 2.0","authors":"Alan Dardik MD, PhD ,&nbsp;Ronald L. Dalman MD","doi":"10.1016/j.jvssci.2025.100391","DOIUrl":"10.1016/j.jvssci.2025.100391","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"6 ","pages":"Article 100391"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the “slope of enlightenment”: The role of adiposity in abdominal aortic aneurysms","authors":"Drew J. Braet MD ,&nbsp;Moritz Lindquist Liljeqvist MD, PhD","doi":"10.1016/j.jvssci.2025.100289","DOIUrl":"10.1016/j.jvssci.2025.100289","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"6 ","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic subtype classification of type II endoleaks using time-enhanced curves and its association with aneurysmal enlargement","authors":"Kota Mitsui RT, BSc ,&nbsp;Yunosuke Nishihara MD, PhD ,&nbsp;Norisato Tsuda RT, MSc ,&nbsp;Manabu Sato MD, PhD","doi":"10.1016/j.jvssci.2025.100288","DOIUrl":"10.1016/j.jvssci.2025.100288","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to: (1) investigate the hemodynamic characteristics of type II endoleaks using mathematical simulations based on pharmacokinetic analysis; and (2) validate the simulation results using clinical data from four-dimensional computed tomography (4D-CT) to assess the relationship between time-enhanced curves (TECs) and aneurysm enlargement.</div></div><div><h3>Methods</h3><div>A mathematical model was created to simulate the hemodynamics of type II endoleaks, incorporating nine compartments representing various cardiovascular components. Simulations were performed under different conditions, leading to the classification of endoleaks into four hemodynamic types. Clinical data were collected from 45 patients who underwent 4D-CT scans at a single center between April 2017 and April 2022. The study cohort included two groups: 20 patients with type II endoleaks identified within 1 week after endovascular aortic repair and 25 patients with persistent type II endoleaks diagnosed during follow-up imaging ranging from 6 months to 9 years post endovascular aortic repair. To evaluate aneurysm volume changes, follow-up CT scans were conducted 6 months or 1 year after the 4D-CT. The primary outcome was evaluating the consistency between simulation results and clinical TEC data obtained from 4D-CT. The secondary outcomes assessed the relationship between individual TEC parameters derived from clinical TEC data and aneurysm enlargement.</div></div><div><h3>Results</h3><div>The mathematical simulations successfully classified type II endoleaks into four hemodynamic types. Clinical validation showed a high concordance between simulation and clinical TEC shapes. A significant difference was observed in various TEC parameters between the stable and enlarged groups. The simulation-based analysis revealed a strong association between aneurysm enlargement and the most informative parameters, including 80% enhancement duration (area under the curve [AUC], 0.88; sensitivity, 0.87; specificity, 0.80; 95% confidence interval [CI], 0.779-0.990; cutoff, 16.9), peak-to-peak time_feeder (AUC, 0.78; sensitivity, 0.93; specificity, 0.60; 95% CI, 0.621-0.937; cutoff, 13.0), and upslope (AUC, 0.86; sensitivity, 0.73; specificity, 0.93; 95% CI, 0.740-0.972; cutoff, 11.7).</div></div><div><h3>Conclusions</h3><div>This study utilized mathematical simulations and clinical validation to characterize the hemodynamics of type II endoleaks. The results demonstrate the strong association of TEC parameters, derived from 4D-CT, with aneurysm enlargement, highlighting their potential for guiding timely intervention in clinical practice.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"6 ","pages":"Article 100288"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose transporter 1 in vascular smooth muscle cells is dispensable for abdominal aortic aneurysm induced by angiotensin II","authors":"Keiichi Torimoto MD, PhD ,&nbsp;Hymavathi Reddy Vari PhD ,&nbsp;Yuki Nakayama MD, PhD ,&nbsp;Hirotoshi Utsunomiya PhD ,&nbsp;Masatoshi Takeda MD, PhD ,&nbsp;Tomoki Hashimoto MD, PhD ,&nbsp;Victor Rizzo PhD ,&nbsp;Satoru Eguchi MD, PhD","doi":"10.1016/j.jvssci.2024.100270","DOIUrl":"10.1016/j.jvssci.2024.100270","url":null,"abstract":"<div><div>Treatment with an inhibitor of glucose use via glucose transporters (GLUT) has been shown to attenuate experimental abdominal aortic aneurysm (AAA) development in mice. Vascular smooth muscle cell (VSMC) signaling seems to be essential for angiotensin II (Ang II)-induced AAA in mice. Accordingly, we have tested a hypothesis that VSMC silencing of the major GLUT, GLUT1, prevents AAA development and rupture in mice treated with Ang II plus β-aminopropionitrile. A mouse model of inducible VSMC GLUT1 deletion was created and aortic GLUT1 silencing was confirmed. Without Ang II plus β-aminopropionitrile treatment, no difference was observed regarding the external aortic diameter (control 1.06 ± 0.18 mm vs deletion 0.97 ± 0.26 mm) or systolic blood pressure (control 102 ± 9 mm Hg vs deletion 107 ± 11 mm Hg) between control or GLUT1-silenced mice. With treatment, control mice as well as VSMC GLUT1-silenced mice equally developed AAA (control 2.37 ± 0.75 mm vs deletion 2.41 ± 0.93 mm), whereas a tendency toward lower blood pressure was observed in GLUT1 silenced mice (control 150 ± 9 mm Hg vs deletion 135 ± 22 mm Hg). No significant difference was observed regarding the rate of rupture-dependent mortality. We concluded that VSMC GLUT1 is dispensable for AAA development induced by Ang II in mice.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"6 ","pages":"Article 100270"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}