JVS-vascular science最新文献

{"title":"Pathological PERK/ATF4 Activation in Vascular Smooth Muscle Cells Drives Abdominal Aortic Aneurysm Development","authors":"Brennan Callow, Kevin Dale Mangum, Tyler Bauer, Xianying Xing, Mary O'Riordan, Johann Gudjonsson, Andrea T. Obi, Katherine A. Gallagher, Frank M. Davis","doi":"10.1016/j.jvssci.2024.100249","DOIUrl":"10.1016/j.jvssci.2024.100249","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling Varicose Vein Using Induced Pluripotent Stem Cells","authors":"Chikage Noishiki, Shaunak S. Adkar, David Wu, Lu Liu, Naima C. Turbes, Dipti Tripathi, Amit Manhas, Dilip Thomas, Karim Sallam, Jason T. Lee, Nick J. Leeper, Derek Klarin, Eri Fukaya, Nazish Sayed","doi":"10.1016/j.jvssci.2024.100265","DOIUrl":"10.1016/j.jvssci.2024.100265","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100265"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Endothelial Cell-Mediated Efferocytosis Promotes Abdominal Aortic Aneurysm Formation","authors":"Jeff Arni C. Valisno, Gang Su, Paolo Bellotti, Jonathan Krebs, Guoshuai Cai, Guanyi Lu, Ashish K. Sharma, Gilbert R. Upchurch Jr.","doi":"10.1016/j.jvssci.2024.100244","DOIUrl":"10.1016/j.jvssci.2024.100244","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia","authors":"Amy L. Lu ,&nbsp;Li Yin PhD ,&nbsp;Yitao Huang BS ,&nbsp;Zain Husain Islam ,&nbsp;Rohan Kanchetty ,&nbsp;Campbell Johnston ,&nbsp;Kaijie Zhang MD ,&nbsp;Xiujie Xie PhD ,&nbsp;Ki Ho Park PhD ,&nbsp;Charles E. Chalfant PhD ,&nbsp;Bowen Wang PhD","doi":"10.1016/j.jvssci.2024.100214","DOIUrl":"10.1016/j.jvssci.2024.100214","url":null,"abstract":"<div><h3>Background</h3><p>Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosis is intimal hyperplasia (IH), in which the hyperproliferative and migratory vascular smooth muscle cell (VSMC) accumulate excessively in the tunica intima. 6-Phosphogluconate dehydrogenase (6PGD), sometimes referred to as PGD, is one of the critical enzymes in pentose phosphate pathway (PPP). In this study, we sought to probe whether 6PGD is aberrantly regulated in IH and contributes to VSMC phenotypic switching.</p></div><div><h3>Methods</h3><p>We used clinical specimens of diseased human coronary arteries with IH lesions and observed robust upregulation of 6PGD at protein level in both the medial and intimal layers in comparison with healthy arterial segments.</p></div><div><h3>Results</h3><p>6PGD activity and protein expression were profoundly stimulated upon platelet-derived growth factor-induced VSMC phenotypic switching. Using gain-of-function (dCas9-mediated transcriptional activation) and loss-of-function (small interfering RNA-mediated) silencing, we were able to demonstrate the pathogenic role of 6PGD in driving VSMC hyperproliferation, migration, dedifferentiation, and inflammation. Finally, we conducted a rat model of balloon angioplasty in the common carotid artery, with Pluronic hydrogel-assisted perivascular delivery of <em>Physcion</em>, a selective 6PGD inhibitor with poor systemic bioavailability, and observed effective mitigation of IH.</p></div><div><h3>Conclusions</h3><p>We contend that aberrant 6PGD expression and activity—indicative of a metabolic shift toward pentose phosphate pathway—could serve as a new disease-driving mechanism and, hence, an actionable target for the development of effective new therapies for IH and restenosis after endovascular interventions.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000257/pdfft?md5=015a2d171ee9d906e05a42573e145c34&pid=1-s2.0-S2666350324000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Neointimal hyperplasia after carotid transection and anastomosis surgery is associated with degradation of decorin and platelet-derived growth factor signaling” [JVS–Vascular Science 2 (2021) 2 - 12]","authors":"Roshan J. D'Cruz MD ,&nbsp;Valerie B. Sampson PhD ,&nbsp;Carly A. Askinas MD ,&nbsp;Rebecca A. Scott PhD ,&nbsp;Karyn G. Robinson MS ,&nbsp;Claude A. Beaty MD ,&nbsp;Anne M. Hesek AS ,&nbsp;Robert E. Akins PhD, FAHA","doi":"10.1016/j.jvssci.2024.100216","DOIUrl":"10.1016/j.jvssci.2024.100216","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surgeon-scientist's approach to improving arteriovenous fistula patency","authors":"Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100207","DOIUrl":"10.1016/j.jvssci.2024.100207","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635032400018X/pdfft?md5=2180a3dc765c68551038549c6179d79f&pid=1-s2.0-S266635032400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms","authors":"Carly Thaxton MD ,&nbsp;Masaki Kano MD, PhD ,&nbsp;Daniel Mendes-Pinto MD, PhD ,&nbsp;Túlio Pinho Navarro MD, PhD ,&nbsp;Toshiya Nishibe MD, PhD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100209","DOIUrl":"10.1016/j.jvssci.2024.100209","url":null,"abstract":"<div><p>Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be associated with postsurgical events and has been suggested to be a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair of aneurysms decreases aortic stiffness, implantation of a rigid endograft is associated with increased aortic stiffness after endovascular aneurysm repair (EVAR). This review provides an overview of aortic wall physiology and the contemporary understanding of aortic stiffness and its implications for patients undergoing abdominal aortic aneurysm repair. Recent data suggests that increased central arterial stiffness, estimated preoperatively using the pulse wave velocity (PWV), may predict aneurysm sac behavior after EVAR, with elevated preoperative PWV associated with less sac shrinkage, and even sac enlargement, after EVAR. With the development of several simple noninvasive methods to measure PWV, such as brachial-ankle PWV and single cuff brachial oscillometry, there may be a role for monitoring ambulatory PWV to predict outcomes after EVAR. Additionally, because aortic stiffness is associated with adverse cardiovascular outcomes, and EVAR increases aortic stiffness, assessment of aortic stiffness before aortic interventions may help to guide therapeutic decisions as well as surveillance protocols, leading to optimized patient outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000208/pdfft?md5=1cd6d8eee65627db4bd2b983b5be5f8c&pid=1-s2.0-S2666350324000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic Low- And High-degree Carotid Stenoses Exhibit Similar Features of Plaque Instability","authors":"Paul Shlemoun,&nbsp;Sofie Hellberg,&nbsp;Katarina Waden,&nbsp;Otto Bergman,&nbsp;Mariette Lengquist,&nbsp;Andrew J. Buckler,&nbsp;Ljubica Matic,&nbsp;Melody Chemaly,&nbsp;David Marlevi,&nbsp;Ulf Hedin","doi":"10.1016/j.jvssci.2024.100260","DOIUrl":"10.1016/j.jvssci.2024.100260","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix Metalloproteinase Inhibition in Rat Abdominal Aortic Aneurysm","authors":"Mohamed Zaghloul,&nbsp;Santiago Elizondo-Benedetto,&nbsp;Batool Arif,&nbsp;Gyu Seong Heo,&nbsp;Hannah Luehmann,&nbsp;Yongjian Liu,&nbsp;Robert J. Gropler,&nbsp;Mehran M. Sadeghi,&nbsp;Mohamed A. Zayed","doi":"10.1016/j.jvssci.2024.100247","DOIUrl":"10.1016/j.jvssci.2024.100247","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering Prosthetic Bypass Graft To Artery Anastomosis Dynamics At The Molecular Level: A Single-nuclei And Spatial Transcriptomics Analysis","authors":"Lucas Mota,&nbsp;Marina Michaud,&nbsp;Mojtaba Bakhtiari,&nbsp;John Tomeo,&nbsp;Mauricio Contreras,&nbsp;Leena Pradhan,&nbsp;Frank W. Logerfo,&nbsp;Patric Liang","doi":"10.1016/j.jvssci.2024.100226","DOIUrl":"10.1016/j.jvssci.2024.100226","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}