JVS-vascular science最新文献_第6页

Regulation of Endotheliopathy by Chromatin-associated Long Noncoding RNA 染色质相关长非编码 RNA 对内皮细胞病变的调控

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100167

Zhen B. Chen , Xiaofang Tang , Kiran Sriram , Yingjun Luo , Dongqiang Yuan , Naseeb Kaur Malhi , Xuejing Liu , Rama Natarajan

引用次数: 0

A Novel Model for Tracking Endothelial-derived Extracellular Vesicles in Murine Atherosclerotic Disease 跟踪小鼠动脉粥样硬化症中内皮细胞衍生的细胞外囊泡的新型模型

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100154

Sarvatit Patel , Mandy Kunze Guo , Leandro Breda , Kamalben Prajapati , Sneha Raju , Steven R. Botts , Garry Yu , Andrew Dudley , Corey A. Scipione , Jason Fish , Kathryn Howe

引用次数: 0

Endothelial Glucocorticoid Receptor Deficiency Affects Arteriovenous Fistula Maturation 内皮糖皮质激素受体缺陷影响动静脉瘘成熟

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100147

Weichang Zhang , Luis Gonzalez , Carly Thaxton , Yuichi Ohashi , Yukihiko Aoyagi , Yangzhouyun Xie , Yujun Cai , Chang Shu , Julie Goodwin , Alan Dardik

引用次数: 0

Inhibition of tiRNA-Gly-GCC Ameliorates Neointimal Formation Via Cbx3-mediated Vascular Smooth Muscle Cells Phenotypic Switching 抑制 tiRNA-Gly-GCC 可通过 Cbx3 介导的血管平滑肌细胞表型转换改善新内膜形成

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100178

Fengshi Li, Zhihua Rong, Changwei Liu

引用次数: 0

Endothelial-specific Nck1 Deletion Reduces Proinflammatory Endothelial Activation and Atherosclerosis Without Affecting Ischemic Angiogenesis 内皮细胞特异性 Nck1 基因缺失可降低促炎性内皮细胞活化和动脉粥样硬化，但不会影响缺血性血管生成

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100150

Cyrine Ben Dhaou, Mabruka Alfaidi, Elizabeth Denise Cockerham, Matthew L. Scott, Xinggui Shen, Arif Yurdagul Jr., Nabil Rashdan, Christopher B. Pattillo, Wayne W. Orr

引用次数: 0

Exercise Modulates Inflammatory, Cytokine, and Growth Factor Pathway Dysregulation in a Mouse Model of Aortic Dissection and Aneurysm 运动调节主动脉夹层和动脉瘤小鼠模型中的炎症、细胞因子和生长因子通路失调

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100156

Matthew D. Cahn , Jackie M. Zhang , Fenge Ni , Brajesh Lal , Dudley Strickland , Areck Ucuzian

引用次数: 0

Vascular Cell Adhesion Molecule 1-Positive Fibroadipogenic Progentiors Promote Adipogenesis in Chronic-Limb Threatening Ischemia Patients 血管细胞粘附分子 1 阳性纤维脂肪生成原促进慢性肢体缺血患者的脂肪生成

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100145

Kaileen Fei , Qunsheng Dai , Derek Peters , Yueyuan Xu , Brianna Garrett , James Otto , Christopher D. Kontos , Yarui Diao , Kevin Southerland

引用次数: 0

EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model EphB4单体在主动脉移植模型中抑制慢性移植物血管病变

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100109

John T. Langford MD , Luis Gonzalez PhD , Ryosuke Taniguchi MD, PhD , Anand Brahmandam MD , Weichang Zhang MD, PhD , Alan Dardik MD, PhD

{"title":"EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model","authors":"John T. Langford MD , Luis Gonzalez PhD , Ryosuke Taniguchi MD, PhD , Anand Brahmandam MD , Weichang Zhang MD, PhD , Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2023.100109","DOIUrl":"10.1016/j.jvssci.2023.100109","url":null,"abstract":"<div><p>T cells and macrophages play an important role in the formation of allograft vasculopathy, which is the predominant form of chronic rejection in cardiac transplants. Arteries express Ephrin-B2 as a marker of arterial identity, whereas circulating monocytes express the cognate receptor EphB4, which facilitates monocyte adhesion to the endothelial surface. Adherent monocytes transmigrate and differentiate into macrophages that activate T cells and are a main source of tissue damage during rejection. We hypothesized that inhibition of Ephrin-B2-EphB4 binding would decrease immune cell accumulation within a transplanted graft and prevent allograft vasculopathy. We used EphB4 monomer to inhibit Ephrin-B2-EphB4 binding in a rat infrarenal aortic transplant model. Rats treated with EphB4 monomer had fewer macrophages and T cells in the aortic allografts at 28 days, as well as significantly less neointima formation. These data show that the Ephin-B2-EphB4 axis may be an important target for prevention or treatment of allograft vasculopathy.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/97/main.PMC10372308.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9908732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of safety and performance of a new prototype self-expandable nitinol venous stent in an ovine model 新型自膨胀镍钛诺静脉支架原型在绵羊模型中的安全性和性能评价

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100113

Mohammad Esmaeil Barbati MD , Beate Bechter-Hugl MD , Sarah Thomis MD , Benita Hermanns-Sachweh MD , Walter Coudyzer MD , Yan Yan BA , Soroosh Shekarchian MD , Houman Jalaie MD

{"title":"Evaluation of safety and performance of a new prototype self-expandable nitinol venous stent in an ovine model","authors":"Mohammad Esmaeil Barbati MD , Beate Bechter-Hugl MD , Sarah Thomis MD , Benita Hermanns-Sachweh MD , Walter Coudyzer MD , Yan Yan BA , Soroosh Shekarchian MD , Houman Jalaie MD","doi":"10.1016/j.jvssci.2023.100113","DOIUrl":"10.1016/j.jvssci.2023.100113","url":null,"abstract":"<div><h3>Objective</h3><p>Our study was a prospective in vivo study performed on an animal model to evaluate the safety and performance of a novel venous stent designed specifically for venous applications.</p></div><div><h3>Methods</h3><p>The novel stents were implanted in the inferior vena cava of nine sheep. The stents were deployed with different distances between the closed cell rings to test for if the segments might migrate after being deployed at maximal distance. Three different total lengths were 9, 11, and 13 cm. After 1, 3, and 6 months, vascular injury, thrombus, neointima coverage, and stent migration were evaluated through computed tomography venography and histopathology. Imaging, histology, and integration data were analyzed for each group.</p></div><div><h3>Results</h3><p>All stents were deployed successfully, and all sheep survived until the time of harvesting. In all cases, the native blood vessel sections were intact. The segmented stent parts showed a differently pronounced tissue coverage, depending on the duration of the implantation.</p></div><div><h3>Conclusions</h3><p>The new nitinol stent is safe and feasible to implant in the venous system with a rapid surface coverage. Alteration of stent length did not affect the development of neointimal formation and did not cause migration.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/35/main.PMC10318499.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of electrocardiogram-gated computed tomography reconstruction into 8 or 10 cardiac phases on cardiac-pulsatility-induced motion quantification of stent grafts in the aorta 心电图门控计算机断层扫描重建心脏8期或10期对主动脉支架移植心脏搏动诱导运动量化的影响

JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100131

Jaimy A. Simmering PhD , Deborah A. Zagers MSc , Robert H. Geelkerken PhD , Henny Kuipers BSc , Gerben A. te Riet o.g. Scholten MSc , Michel M.P.J. Reijnen PhD , Cornelis H. Slump PhD

{"title":"The influence of electrocardiogram-gated computed tomography reconstruction into 8 or 10 cardiac phases on cardiac-pulsatility-induced motion quantification of stent grafts in the aorta","authors":"Jaimy A. Simmering PhD , Deborah A. Zagers MSc , Robert H. Geelkerken PhD , Henny Kuipers BSc , Gerben A. te Riet o.g. Scholten MSc , Michel M.P.J. Reijnen PhD , Cornelis H. Slump PhD","doi":"10.1016/j.jvssci.2023.100131","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100131","url":null,"abstract":"<div><h3>Objective</h3><p>The goal of this study was to determine to what extent aortic stent graft motion quantification is comparable between electrocardiogram (ECG)-gated computed tomography (CT) scans with reconstructions into 8 and 10 cardiac phases on CT scanners from two different vendors.</p></div><div><h3>Methods</h3><p>An experimental setup that induces motion of an aortic stent graft, according to a predefined aortic blood pressure wave, was placed in two CT scanners of different vendors. The stent graft motion was captured using an ECG-gated CT technique and quantified using dedicated analysis algorithms. The calculated motion amplitudes and total traveled path lengths of stent segmentations were compared between scans reconstructed into 8 and 10 phases and between the scanners, after validation with sensor measurements and repeated measurements.</p></div><div><h3>Results</h3><p>No difference in motion amplitudes in z-direction (craniocaudal direction) was observed between the reconstructions into 8 and 10 phases (0.02 mm; 95% confidence interval [CI], –0.01 to 0.05 mm; <em>P</em> = .358). The z-amplitudes differed by 0.04 mm (95% CI, 0.01-0.07 mm; <em>P</em> = .003) between the different CT scanners. Path lengths differed 0.07 mm (95% CI, 0.01-to 0.13 mm; <em>P</em> = .013) between the reconstructions into 8 and 10 phases and 0.13 mm (95% CI, 0.06-0.17 mm; <em>P</em> < .001) between the different scanners.</p></div><div><h3>Conclusions</h3><p>The motion amplitudes can accurately be compared between 8 and 10 phases and between the two scanners, without differences larger than the voxel size of 0.3 × 0.3 × 0.5 mm. Clinical motion analysis results of different ECG-gated CT scans and CT scanners can be compared up to the accuracy of the CT scan.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000354/pdfft?md5=436e7fbbab4cd50b922f2bef3645a308&pid=1-s2.0-S2666350323000354-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92099223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1