JVS-vascular science最新文献_第6页

Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair 针对患者的计算流模拟揭示了瓣膜和分支血管内动脉瘤修复术在主动脉瓣旁血流动力学方面的显著差异

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2023.100183

Kenneth Tran MD , Celine Deslarzes-Dubuis MD , Sebastien DeGlise MD , Adrien Kaladji MD , Weiguang Yang PhD , Alison L. Marsden PhD , Jason T. Lee MD

{"title":"Patient-specific computational flow simulation reveals significant differences in paravisceral aortic hemodynamics between fenestrated and branched endovascular aneurysm repair","authors":"Kenneth Tran MD , Celine Deslarzes-Dubuis MD , Sebastien DeGlise MD , Adrien Kaladji MD , Weiguang Yang PhD , Alison L. Marsden PhD , Jason T. Lee MD","doi":"10.1016/j.jvssci.2023.100183","DOIUrl":"10.1016/j.jvssci.2023.100183","url":null,"abstract":"<div><h3>Background</h3><p>Endovascular aneurysm repair with four-vessel fenestrated endovascular aneurysm repair (fEVAR) or branched endovascular aneurysm repair (bEVAR) currently represent the forefront of minimally invasive complex aortic aneurysm repair. This study sought to use patient-specific computational flow simulation (CFS) to assess differences in postoperative hemodynamic effects associated with fEVAR vs bEVAR.</p></div><div><h3>Methods</h3><p>Patients from two institutions who underwent four-vessel fEVAR with the Cook Zenith Fenestrated platform and bEVAR with the Jotec E-xtra Design platform were retrospectively selected. Patients in both cohorts were treated for paravisceral and extent II, II, and V thoracoabdominal aortic aneurysms. Three-dimensional finite element volume meshes were created from preoperative and postoperative computed tomography scans. Boundary conditions were adjusted for body surface area, heart rate, and blood pressure. Pulsatile flow simulations were performed with equivalent boundary conditions between preoperative and postoperative states. Postoperative changes in hemodynamic parameters were compared between the fEVAR and bEVAR groups.</p></div><div><h3>Results</h3><p>Patient-specific CFS was performed on 20 patients (10 bEVAR, 10 fEVAR) with a total of 80 target vessels (40 renal, 20 celiac, 20 superior mesenteric artery stents). bEVAR was associated with a decrease in renal artery peak flow rate (−5.2% vs +2.0%; <em>P</em> < .0001) and peak pressure (−3.4 vs +0.1%; <em>P</em> < .0001) compared with fEVAR. Almost all renal arteries treated with bEVAR had a reduction in renal artery perfusion (n = 19 [95%]), compared with 35% (n = 7) treated with fEVAR. There were no significant differences in celiac or superior mesenteric artery perfusion metrics (<em>P</em> = .10-.27) between groups. Time-averaged wall shear stress in the paravisceral aorta and branches also varied significantly depending on endograft configuration, with bEVAR associated with large postoperative increases in renal artery (+47.5 vs +13.5%; <em>P</em> = .002) and aortic time-averaged wall shear stress (+200.1% vs −31.3%; <em>P</em> = .001) compared with fEVAR. Streamline analysis revealed areas of hemodynamic abnormalities associated with branched renal grafts which adopt a U-shaped geometry, which may explain the observed differences in postoperative changes in renal perfusion between bEVAR and fEVAR.</p></div><div><h3>Conclusions</h3><p>bEVAR may be associated with subtle decreases in renal perfusion and a large increase in aortic wall shear stress compared with fEVAR. CFS is a novel tool for quantifying and visualizing the unique patient-specific hemodynamic effect of different complex EVAR strategies.</p></div><div><h3>Clinical Relevance</h3><p>This study used patient-specific CFS to compare postoperative hemodynamic effects of four-vessel fenestrated endovascular aneurysm repair (fEVAR) and branched endovascular aneurysm repair ","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000871/pdfft?md5=a80815d2199cb6cf5b972868ccdb2934&pid=1-s2.0-S2666350323000871-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139298688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling Varicose Vein Using Induced Pluripotent Stem Cells 利用诱导多能干细胞模拟静脉曲张

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100265

Chikage Noishiki, Shaunak S. Adkar, David Wu, Lu Liu, Naima C. Turbes, Dipti Tripathi, Amit Manhas, Dilip Thomas, Karim Sallam, Jason T. Lee, Nick J. Leeper, Derek Klarin, Eri Fukaya, Nazish Sayed

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Three-Dimensional Characterization of Sex Differences in Abdominal Aortic Aneurysm Progression Via Vascular Deformation Mapping 通过血管变形测绘对腹主动脉瘤进展的性别差异进行三维表征

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100251

Drew Braet, Luciano Delbono, Greg Spahlinger, Nathan Graham, Akul Arora, C. Alberto Figueroa, Jonathan Eliason, Nicholas S. Burris

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Inhibition of Endothelial Cell-Mediated Efferocytosis Promotes Abdominal Aortic Aneurysm Formation 抑制内皮细胞介导的efferocysis促进腹主动脉瘤形成

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100244

Jeff Arni C. Valisno, Gang Su, Paolo Bellotti, Jonathan Krebs, Guoshuai Cai, Guanyi Lu, Ashish K. Sharma, Gilbert R. Upchurch Jr.

引用次数: 0

Pathological PERK/ATF4 Activation in Vascular Smooth Muscle Cells Drives Abdominal Aortic Aneurysm Development 血管平滑肌细胞病理性PERK/ATF4激活驱动腹主动脉瘤的发展

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100249

Brennan Callow, Kevin Dale Mangum, Tyler Bauer, Xianying Xing, Mary O'Riordan, Johann Gudjonsson, Andrea T. Obi, Katherine A. Gallagher, Frank M. Davis

引用次数: 0

The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia 6- 磷酸葡萄糖酸脱氢酶在血管平滑肌细胞表型转换和血管成形术诱导的内膜增生中的作用

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100214

Amy L. Lu , Li Yin PhD , Yitao Huang BS , Zain Husain Islam , Rohan Kanchetty , Campbell Johnston , Kaijie Zhang MD , Xiujie Xie PhD , Ki Ho Park PhD , Charles E. Chalfant PhD , Bowen Wang PhD

{"title":"The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia","authors":"Amy L. Lu , Li Yin PhD , Yitao Huang BS , Zain Husain Islam , Rohan Kanchetty , Campbell Johnston , Kaijie Zhang MD , Xiujie Xie PhD , Ki Ho Park PhD , Charles E. Chalfant PhD , Bowen Wang PhD","doi":"10.1016/j.jvssci.2024.100214","DOIUrl":"10.1016/j.jvssci.2024.100214","url":null,"abstract":"<div><h3>Background</h3><p>Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosis is intimal hyperplasia (IH), in which the hyperproliferative and migratory vascular smooth muscle cell (VSMC) accumulate excessively in the tunica intima. 6-Phosphogluconate dehydrogenase (6PGD), sometimes referred to as PGD, is one of the critical enzymes in pentose phosphate pathway (PPP). In this study, we sought to probe whether 6PGD is aberrantly regulated in IH and contributes to VSMC phenotypic switching.</p></div><div><h3>Methods</h3><p>We used clinical specimens of diseased human coronary arteries with IH lesions and observed robust upregulation of 6PGD at protein level in both the medial and intimal layers in comparison with healthy arterial segments.</p></div><div><h3>Results</h3><p>6PGD activity and protein expression were profoundly stimulated upon platelet-derived growth factor-induced VSMC phenotypic switching. Using gain-of-function (dCas9-mediated transcriptional activation) and loss-of-function (small interfering RNA-mediated) silencing, we were able to demonstrate the pathogenic role of 6PGD in driving VSMC hyperproliferation, migration, dedifferentiation, and inflammation. Finally, we conducted a rat model of balloon angioplasty in the common carotid artery, with Pluronic hydrogel-assisted perivascular delivery of <em>Physcion</em>, a selective 6PGD inhibitor with poor systemic bioavailability, and observed effective mitigation of IH.</p></div><div><h3>Conclusions</h3><p>We contend that aberrant 6PGD expression and activity—indicative of a metabolic shift toward pentose phosphate pathway—could serve as a new disease-driving mechanism and, hence, an actionable target for the development of effective new therapies for IH and restenosis after endovascular interventions.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000257/pdfft?md5=015a2d171ee9d906e05a42573e145c34&pid=1-s2.0-S2666350324000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction notice to “Neointimal hyperplasia after carotid transection and anastomosis surgery is associated with degradation of decorin and platelet-derived growth factor signaling” [JVS–Vascular Science 2 (2021) 2 - 12] 颈动脉横断和吻合手术后的新内膜增生与去甲斑素降解和血小板衍生生长因子信号传导有关》的撤稿通知 [JVS-Vascular Science 2 (2021) 2 - 12]

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100216

Roshan J. D'Cruz MD , Valerie B. Sampson PhD , Carly A. Askinas MD , Rebecca A. Scott PhD , Karyn G. Robinson MS , Claude A. Beaty MD , Anne M. Hesek AS , Robert E. Akins PhD, FAHA

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A surgeon-scientist's approach to improving arteriovenous fistula patency 外科医生-科学家改善动静脉瘘通畅的方法

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100207

Alan Dardik MD, PhD

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Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms 术前动脉僵硬度对腹主动脉瘤血管内修复患者的影响

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100209

Carly Thaxton MD , Masaki Kano MD, PhD , Daniel Mendes-Pinto MD, PhD , Túlio Pinho Navarro MD, PhD , Toshiya Nishibe MD, PhD , Alan Dardik MD, PhD

{"title":"Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms","authors":"Carly Thaxton MD , Masaki Kano MD, PhD , Daniel Mendes-Pinto MD, PhD , Túlio Pinho Navarro MD, PhD , Toshiya Nishibe MD, PhD , Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100209","DOIUrl":"10.1016/j.jvssci.2024.100209","url":null,"abstract":"<div><p>Arterial stiffening is associated with adverse cardiovascular patient outcomes; stiffness may also be associated with postsurgical events and has been suggested to be a fundamental mechanism in the pathogenesis of aortic aneurysms. Although open repair of aneurysms decreases aortic stiffness, implantation of a rigid endograft is associated with increased aortic stiffness after endovascular aneurysm repair (EVAR). This review provides an overview of aortic wall physiology and the contemporary understanding of aortic stiffness and its implications for patients undergoing abdominal aortic aneurysm repair. Recent data suggests that increased central arterial stiffness, estimated preoperatively using the pulse wave velocity (PWV), may predict aneurysm sac behavior after EVAR, with elevated preoperative PWV associated with less sac shrinkage, and even sac enlargement, after EVAR. With the development of several simple noninvasive methods to measure PWV, such as brachial-ankle PWV and single cuff brachial oscillometry, there may be a role for monitoring ambulatory PWV to predict outcomes after EVAR. Additionally, because aortic stiffness is associated with adverse cardiovascular outcomes, and EVAR increases aortic stiffness, assessment of aortic stiffness before aortic interventions may help to guide therapeutic decisions as well as surveillance protocols, leading to optimized patient outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000208/pdfft?md5=1cd6d8eee65627db4bd2b983b5be5f8c&pid=1-s2.0-S2666350324000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Symptomatic Low- And High-degree Carotid Stenoses Exhibit Similar Features of Plaque Instability 症状性颈动脉低度狭窄和高度狭窄表现出相似的斑块不稳定特征

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100260

Paul Shlemoun, Sofie Hellberg, Katarina Waden, Otto Bergman, Mariette Lengquist, Andrew J. Buckler, Ljubica Matic, Melody Chemaly, David Marlevi, Ulf Hedin

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