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Dyslipidemia impairs collateral artery formation after hindlimb ischemia: Adding insult to injury 血脂异常会影响后肢缺血后的侧支动脉形成：雪上加霜
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100204
Ali H. Hakim MD , Luke Brewster MD PhD
{"title":"Dyslipidemia impairs collateral artery formation after hindlimb ischemia: Adding insult to injury","authors":"Ali H. Hakim MD , Luke Brewster MD PhD","doi":"10.1016/j.jvssci.2024.100204","DOIUrl":"10.1016/j.jvssci.2024.100204","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000154/pdfft?md5=7b018c4ad32d4f691f057388c4cad510&pid=1-s2.0-S2666350324000154-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A central arteriovenous fistula reduces systemic hypertension in a mouse model 中心动静脉瘘可降低小鼠模型的全身性高血压
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100191
Anand Brahmandam MD , Rafael Alves BM , Hao Liu (刘灏) MD , Luis Gonzalez PhD , Yukihiko Aoyagi (青栁 幸彦) MD , Yuichi Ohashi (大橋 雄一) MD , John T. Langford MD , Carly Thaxton MD , Ryosuke Taniguchi (谷口 良輔) MD, PhD , Weichang Zhang (张惟常) MD, PhD , Hualong Bai (白华龙) MD, PhD , Bogdan Yatsula PhD , Alan Dardik MD, PhD
{"title":"A central arteriovenous fistula reduces systemic hypertension in a mouse model","authors":"Anand Brahmandam MD ,&nbsp;Rafael Alves BM ,&nbsp;Hao Liu (刘灏) MD ,&nbsp;Luis Gonzalez PhD ,&nbsp;Yukihiko Aoyagi (青栁 幸彦) MD ,&nbsp;Yuichi Ohashi (大橋 雄一) MD ,&nbsp;John T. Langford MD ,&nbsp;Carly Thaxton MD ,&nbsp;Ryosuke Taniguchi (谷口 良輔) MD, PhD ,&nbsp;Weichang Zhang (张惟常) MD, PhD ,&nbsp;Hualong Bai (白华龙) MD, PhD ,&nbsp;Bogdan Yatsula PhD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100191","DOIUrl":"10.1016/j.jvssci.2024.100191","url":null,"abstract":"<div><h3>Objective</h3><p>A central arteriovenous fistula (AVF) has been proposed as a potential novel solution to treat patients with refractory hypertension. We hypothesized that venous remodeling after AVF creation in the hypertensive environment reduces systemic blood pressure but results in increased AVF wall thickness compared with remodeling in the normotensive environment.</p></div><div><h3>Methods</h3><p>A central AVF was performed in C57BL6/J mice previously made hypertensive with angiotensin II (Ang II); mice were sacrificed on postoperative day 7 or 21.</p></div><div><h3>Results</h3><p>In mice treated with Ang II alone, the mean systolic blood pressure increased from 90 ± 5 mmHg to 160 ± 5 mmHg at day 21; however, in mice treated with both Ang II and an AVF, the blood pressure decreased with creation of an AVF. There were significantly more PCNA-positive cells, SM22α/PCNA-positive cells, collagen I deposition, and increased Krüppel-like Factor 2 immunoreactivity in hypertensive mice with an AVF compared with normotensive mice with an AVF.</p></div><div><h3>Conclusions</h3><p>These data show that a central AVF decreases systemic hypertension as well as induces local alterations in venous remodeling.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000026/pdfft?md5=60786e70b011585e96e3a0ee22d68666&pid=1-s2.0-S2666350324000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Knockout of the ETS Transcription Factor ERG Promotes Loss of Endothelial Cell Identity and Endothelial Cell Dysfunction in an Aortic Endothelial Cell Model Relevant For Atherosclerosis 在与动脉粥样硬化相关的主动脉内皮细胞模型中，慢性敲除ETS转录因子ERG可促进内皮细胞身份丧失和内皮细胞功能障碍
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100262
Kristen Schulz, Steven R. Botts, Kai Ellis, Nadiya Khyzha, Rathnakumar Kumaragurubaran, Michael Wilson, Kathryn L. Howe, Jason E. Fish
{"title":"Chronic Knockout of the ETS Transcription Factor ERG Promotes Loss of Endothelial Cell Identity and Endothelial Cell Dysfunction in an Aortic Endothelial Cell Model Relevant For Atherosclerosis","authors":"Kristen Schulz,&nbsp;Steven R. Botts,&nbsp;Kai Ellis,&nbsp;Nadiya Khyzha,&nbsp;Rathnakumar Kumaragurubaran,&nbsp;Michael Wilson,&nbsp;Kathryn L. Howe,&nbsp;Jason E. Fish","doi":"10.1016/j.jvssci.2024.100262","DOIUrl":"10.1016/j.jvssci.2024.100262","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-First Approach to Rare and Common Variant Risk of Thoracic Aortic Aneurysm and Dissection 基因组优先研究胸主动脉瘤和夹层罕见和常见变异风险
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100243
John Depaolo, Gina M. Biagetti, Renae Judy, Sarah Abramowitz, Nimesh Desai, Wilson Y. Szeto, Joseph E. Bavaria, Michael Levin, Dongchuan Guo, Dianna M. Milewicz, Scott M. Damrauer
{"title":"Genome-First Approach to Rare and Common Variant Risk of Thoracic Aortic Aneurysm and Dissection","authors":"John Depaolo,&nbsp;Gina M. Biagetti,&nbsp;Renae Judy,&nbsp;Sarah Abramowitz,&nbsp;Nimesh Desai,&nbsp;Wilson Y. Szeto,&nbsp;Joseph E. Bavaria,&nbsp;Michael Levin,&nbsp;Dongchuan Guo,&nbsp;Dianna M. Milewicz,&nbsp;Scott M. Damrauer","doi":"10.1016/j.jvssci.2024.100243","DOIUrl":"10.1016/j.jvssci.2024.100243","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid Cell Lgr4 Contributes to Atherosclerotic Lesion Formation 髓样细胞Lgr4参与动脉粥样硬化病变的形成
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100263
Ishita Kathuria, Ravi Varma Aithabathula, Naveed Pervaiz, Britney Le, Ki-Suk Kim, Jiqiu Wang, Udai P. Singh, Bhupesh Singla
{"title":"Myeloid Cell Lgr4 Contributes to Atherosclerotic Lesion Formation","authors":"Ishita Kathuria,&nbsp;Ravi Varma Aithabathula,&nbsp;Naveed Pervaiz,&nbsp;Britney Le,&nbsp;Ki-Suk Kim,&nbsp;Jiqiu Wang,&nbsp;Udai P. Singh,&nbsp;Bhupesh Singla","doi":"10.1016/j.jvssci.2024.100263","DOIUrl":"10.1016/j.jvssci.2024.100263","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lesion Site-Specific Mass Spectrometry Analysis of Human Carotid Plaques Reveals Strongest Association of the Necrotic Core And Fibrous Cap Proteome With Plaque Stability 人类颈动脉斑块病变部位特异性质谱分析揭示坏死核心和纤维帽蛋白质组与斑块稳定性的最强关联
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100235
Nadja Sachs, Ankit Sinha, Elena Kratz, Jessica Pauli, Marie-Luise Engl, Hanna Winter, Hans-Henning Eckstein, Matthias Mann, Lars Maegdefessel
{"title":"Lesion Site-Specific Mass Spectrometry Analysis of Human Carotid Plaques Reveals Strongest Association of the Necrotic Core And Fibrous Cap Proteome With Plaque Stability","authors":"Nadja Sachs,&nbsp;Ankit Sinha,&nbsp;Elena Kratz,&nbsp;Jessica Pauli,&nbsp;Marie-Luise Engl,&nbsp;Hanna Winter,&nbsp;Hans-Henning Eckstein,&nbsp;Matthias Mann,&nbsp;Lars Maegdefessel","doi":"10.1016/j.jvssci.2024.100235","DOIUrl":"10.1016/j.jvssci.2024.100235","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of the Aim2 Inflammasome in Skeletal is Modulated by Surgical Bypass And is a Target to Reduce Ischemic Myopathy in Pad 搭桥手术调节骨组织中Aim2炎性小体的表达，是减轻肌垫缺血性肌病的靶点
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100228
Bowen Xie, Edwyn Assaf, Ricardo Ferrari, George Casale, Iraklis I. Pipinos, Ulka Sachdev
{"title":"Expression of the Aim2 Inflammasome in Skeletal is Modulated by Surgical Bypass And is a Target to Reduce Ischemic Myopathy in Pad","authors":"Bowen Xie,&nbsp;Edwyn Assaf,&nbsp;Ricardo Ferrari,&nbsp;George Casale,&nbsp;Iraklis I. Pipinos,&nbsp;Ulka Sachdev","doi":"10.1016/j.jvssci.2024.100228","DOIUrl":"10.1016/j.jvssci.2024.100228","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cd40 is Required For B1b Cell Homeostasis in Atherosclerosis 动脉粥样硬化中B1b细胞稳态需要Cd40
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100241
Katrin Nitz, Myrthe Reiche, Oom Pattarabajinard, Aditi Upadhye, Claudia van Tiel, Angela M. Taylor, Stephen G. Malin, Christoph J. Binder, Norbert Gerdes, Cornelia M. Weyand, Christian Weber, Dorothee Atzler, Coleen A. McNamara, Esther Lutgens
{"title":"Cd40 is Required For B1b Cell Homeostasis in Atherosclerosis","authors":"Katrin Nitz,&nbsp;Myrthe Reiche,&nbsp;Oom Pattarabajinard,&nbsp;Aditi Upadhye,&nbsp;Claudia van Tiel,&nbsp;Angela M. Taylor,&nbsp;Stephen G. Malin,&nbsp;Christoph J. Binder,&nbsp;Norbert Gerdes,&nbsp;Cornelia M. Weyand,&nbsp;Christian Weber,&nbsp;Dorothee Atzler,&nbsp;Coleen A. McNamara,&nbsp;Esther Lutgens","doi":"10.1016/j.jvssci.2024.100241","DOIUrl":"10.1016/j.jvssci.2024.100241","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Tgfb-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair Tgfb-Whsc1轴在伤口修复过程中驱动巨噬细胞向肌成纤维细胞转变
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100230
Kevin Dale Mangum, Tyler Bauer, Amrita Joshi, William Melvin, Emily Barrett, Sonya Wolf, Jadie Moon, James Shadiow, Andrea T. Obi, Johann Gudjonsson, Frank Davis, Katherine A. Gallagher
{"title":"The Tgfb-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair","authors":"Kevin Dale Mangum,&nbsp;Tyler Bauer,&nbsp;Amrita Joshi,&nbsp;William Melvin,&nbsp;Emily Barrett,&nbsp;Sonya Wolf,&nbsp;Jadie Moon,&nbsp;James Shadiow,&nbsp;Andrea T. Obi,&nbsp;Johann Gudjonsson,&nbsp;Frank Davis,&nbsp;Katherine A. Gallagher","doi":"10.1016/j.jvssci.2024.100230","DOIUrl":"10.1016/j.jvssci.2024.100230","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nr3c1-Sfrp1 Axis Regulates the Adipogenic Differentiation of Vcam1+ Fibro-adipogenic Progenitors in Chronic Limb-threatening Ischemia nr3c1 - strp1轴调控慢性肢体缺血中Vcam1+纤维脂肪祖细胞的成脂分化
JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100232
Qunsheng Dai, Changxin Wan, Yueyuan Xu, Brianna Garrett, Leo Akers, Derek Peters, James Otto, Christopher D. Kontos, Jason Ji, Yarui Diao, Kevin W. Southerland
{"title":"Nr3c1-Sfrp1 Axis Regulates the Adipogenic Differentiation of Vcam1+ Fibro-adipogenic Progenitors in Chronic Limb-threatening Ischemia","authors":"Qunsheng Dai,&nbsp;Changxin Wan,&nbsp;Yueyuan Xu,&nbsp;Brianna Garrett,&nbsp;Leo Akers,&nbsp;Derek Peters,&nbsp;James Otto,&nbsp;Christopher D. Kontos,&nbsp;Jason Ji,&nbsp;Yarui Diao,&nbsp;Kevin W. Southerland","doi":"10.1016/j.jvssci.2024.100232","DOIUrl":"10.1016/j.jvssci.2024.100232","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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