JVS-vascular science最新文献

{"title":"A central arteriovenous fistula reduces systemic hypertension in a mouse model","authors":"Anand Brahmandam MD ,&nbsp;Rafael Alves BM ,&nbsp;Hao Liu (刘灏) MD ,&nbsp;Luis Gonzalez PhD ,&nbsp;Yukihiko Aoyagi (青栁 幸彦) MD ,&nbsp;Yuichi Ohashi (大橋 雄一) MD ,&nbsp;John T. Langford MD ,&nbsp;Carly Thaxton MD ,&nbsp;Ryosuke Taniguchi (谷口 良輔) MD, PhD ,&nbsp;Weichang Zhang (张惟常) MD, PhD ,&nbsp;Hualong Bai (白华龙) MD, PhD ,&nbsp;Bogdan Yatsula PhD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100191","DOIUrl":"10.1016/j.jvssci.2024.100191","url":null,"abstract":"<div><h3>Objective</h3><p>A central arteriovenous fistula (AVF) has been proposed as a potential novel solution to treat patients with refractory hypertension. We hypothesized that venous remodeling after AVF creation in the hypertensive environment reduces systemic blood pressure but results in increased AVF wall thickness compared with remodeling in the normotensive environment.</p></div><div><h3>Methods</h3><p>A central AVF was performed in C57BL6/J mice previously made hypertensive with angiotensin II (Ang II); mice were sacrificed on postoperative day 7 or 21.</p></div><div><h3>Results</h3><p>In mice treated with Ang II alone, the mean systolic blood pressure increased from 90 ± 5 mmHg to 160 ± 5 mmHg at day 21; however, in mice treated with both Ang II and an AVF, the blood pressure decreased with creation of an AVF. There were significantly more PCNA-positive cells, SM22α/PCNA-positive cells, collagen I deposition, and increased Krüppel-like Factor 2 immunoreactivity in hypertensive mice with an AVF compared with normotensive mice with an AVF.</p></div><div><h3>Conclusions</h3><p>These data show that a central AVF decreases systemic hypertension as well as induces local alterations in venous remodeling.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000026/pdfft?md5=60786e70b011585e96e3a0ee22d68666&pid=1-s2.0-S2666350324000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-First Approach to Rare and Common Variant Risk of Thoracic Aortic Aneurysm and Dissection","authors":"John Depaolo,&nbsp;Gina M. Biagetti,&nbsp;Renae Judy,&nbsp;Sarah Abramowitz,&nbsp;Nimesh Desai,&nbsp;Wilson Y. Szeto,&nbsp;Joseph E. Bavaria,&nbsp;Michael Levin,&nbsp;Dongchuan Guo,&nbsp;Dianna M. Milewicz,&nbsp;Scott M. Damrauer","doi":"10.1016/j.jvssci.2024.100243","DOIUrl":"10.1016/j.jvssci.2024.100243","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion Site-Specific Mass Spectrometry Analysis of Human Carotid Plaques Reveals Strongest Association of the Necrotic Core And Fibrous Cap Proteome With Plaque Stability","authors":"Nadja Sachs,&nbsp;Ankit Sinha,&nbsp;Elena Kratz,&nbsp;Jessica Pauli,&nbsp;Marie-Luise Engl,&nbsp;Hanna Winter,&nbsp;Hans-Henning Eckstein,&nbsp;Matthias Mann,&nbsp;Lars Maegdefessel","doi":"10.1016/j.jvssci.2024.100235","DOIUrl":"10.1016/j.jvssci.2024.100235","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid Cell Lgr4 Contributes to Atherosclerotic Lesion Formation","authors":"Ishita Kathuria,&nbsp;Ravi Varma Aithabathula,&nbsp;Naveed Pervaiz,&nbsp;Britney Le,&nbsp;Ki-Suk Kim,&nbsp;Jiqiu Wang,&nbsp;Udai P. Singh,&nbsp;Bhupesh Singla","doi":"10.1016/j.jvssci.2024.100263","DOIUrl":"10.1016/j.jvssci.2024.100263","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of the Aim2 Inflammasome in Skeletal is Modulated by Surgical Bypass And is a Target to Reduce Ischemic Myopathy in Pad","authors":"Bowen Xie,&nbsp;Edwyn Assaf,&nbsp;Ricardo Ferrari,&nbsp;George Casale,&nbsp;Iraklis I. Pipinos,&nbsp;Ulka Sachdev","doi":"10.1016/j.jvssci.2024.100228","DOIUrl":"10.1016/j.jvssci.2024.100228","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Knockout of the ETS Transcription Factor ERG Promotes Loss of Endothelial Cell Identity and Endothelial Cell Dysfunction in an Aortic Endothelial Cell Model Relevant For Atherosclerosis","authors":"Kristen Schulz,&nbsp;Steven R. Botts,&nbsp;Kai Ellis,&nbsp;Nadiya Khyzha,&nbsp;Rathnakumar Kumaragurubaran,&nbsp;Michael Wilson,&nbsp;Kathryn L. Howe,&nbsp;Jason E. Fish","doi":"10.1016/j.jvssci.2024.100262","DOIUrl":"10.1016/j.jvssci.2024.100262","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tgfb-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair","authors":"Kevin Dale Mangum,&nbsp;Tyler Bauer,&nbsp;Amrita Joshi,&nbsp;William Melvin,&nbsp;Emily Barrett,&nbsp;Sonya Wolf,&nbsp;Jadie Moon,&nbsp;James Shadiow,&nbsp;Andrea T. Obi,&nbsp;Johann Gudjonsson,&nbsp;Frank Davis,&nbsp;Katherine A. Gallagher","doi":"10.1016/j.jvssci.2024.100230","DOIUrl":"10.1016/j.jvssci.2024.100230","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cd40 is Required For B1b Cell Homeostasis in Atherosclerosis","authors":"Katrin Nitz,&nbsp;Myrthe Reiche,&nbsp;Oom Pattarabajinard,&nbsp;Aditi Upadhye,&nbsp;Claudia van Tiel,&nbsp;Angela M. Taylor,&nbsp;Stephen G. Malin,&nbsp;Christoph J. Binder,&nbsp;Norbert Gerdes,&nbsp;Cornelia M. Weyand,&nbsp;Christian Weber,&nbsp;Dorothee Atzler,&nbsp;Coleen A. McNamara,&nbsp;Esther Lutgens","doi":"10.1016/j.jvssci.2024.100241","DOIUrl":"10.1016/j.jvssci.2024.100241","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nr3c1-Sfrp1 Axis Regulates the Adipogenic Differentiation of Vcam1+ Fibro-adipogenic Progenitors in Chronic Limb-threatening Ischemia","authors":"Qunsheng Dai,&nbsp;Changxin Wan,&nbsp;Yueyuan Xu,&nbsp;Brianna Garrett,&nbsp;Leo Akers,&nbsp;Derek Peters,&nbsp;James Otto,&nbsp;Christopher D. Kontos,&nbsp;Jason Ji,&nbsp;Yarui Diao,&nbsp;Kevin W. Southerland","doi":"10.1016/j.jvssci.2024.100232","DOIUrl":"10.1016/j.jvssci.2024.100232","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small apolipoprotein(a) isoforms may predict primary patency following peripheral arterial revascularization","authors":"Marianna Pavlyha MD ,&nbsp;Madeleine Hunter MD ,&nbsp;Roman Nowygrod MD ,&nbsp;Virenda Patel MD, MPH ,&nbsp;Nicholas Morrissey MD ,&nbsp;Danielle Bajakian MD ,&nbsp;Yihao Li MS ,&nbsp;Gissette Reyes-Soffer MD","doi":"10.1016/j.jvssci.2024.100211","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100211","url":null,"abstract":"<div><h3>Background</h3><p>High lipoprotein (a) [Lp(a)] is associated with adverse limb events in patients undergoing lower extremity revascularization. Lp(a) levels are genetically pre-determined, with <em>LPA</em> gene encoding for two apolipoprotein (a) [apo(a)] isoforms. Isoform size variations are driven by the number of kringle IV type 2 (KIV-2) repeats. Lp(a) levels are inversely correlated with isoform size. In this study, we examined the role of Lp(a) levels, apo(a) size, and inflammatory markers with lower extremity revascularization outcomes.</p></div><div><h3>Methods</h3><p>Twenty-five subjects with chronic peripheral arterial disease (PAD) underwent open or endovascular lower extremity revascularization (mean age, 66.7 ± 9.7 years; Female = 12; Male = 13; Black = 8; Hispanic = 5; and White = 12). Pre- and postoperative medical history, self-reported symptoms, ankle-brachial indices (ABIs), and lower extremity duplex ultrasounds were obtained. Plasma Lp(a), apoB100, lipid panel, and pro-inflammatory markers (IL-6, IL-18, hs-CRP, TNFα) were assayed preoperatively. Isoform size was estimated using gel electrophoresis and weighted isoform size (<em>wIS</em>) calculated based on % isoform expression. Firth logistic regression was used to examine the relationship between Lp(a) levels and <em>wIS</em> with procedural outcomes: symptoms (better/worse), early primary patency at 2 to 4 weeks, ABIs, and reintervention within 3 to 6 months. We controlled for age, sex, history of diabetes, smoking, statin, antiplatelet, and anticoagulation use.</p></div><div><h3>Results</h3><p>Median plasma Lp(a) level was 108 (interrquartile range, 44-301) nmol/L. The mean apoB100 level was 168.0 ± 65.8 mg/dL. These values were not statistically different among races. We found no association between Lp(a) levels and w<em>IS</em> with measured plasma pro-inflammatory markers. However, smaller apo(a) <em>wIS</em> was associated with occlusion of the treated lesion(s) in the postoperative period (odds ratio, 1.97; 95% confidence interval, 1.01-3.86; <em>P</em> &lt; .05). The relationship of smaller apo(a) <em>wIS</em> with reintervention was not as strong (odds ratio, 1.57; 95% confidence interval, 0.96-2.56; <em>P</em> = .07). We observed no association between <em>wIS</em> with patient reported symptoms or change in ABIs.</p></div><div><h3>Conclusions</h3><p>In this small study, subjects with smaller apo(a) isoform size undergoing peripheral arterial revascularization were more likely to experience occlusion in the postoperative period and/or require reintervention. Larger cohort studies identifying the mechanism and validating these preliminary data are needed to improve understanding of long-term peripheral vascular outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000221/pdfft?md5=51b8275b14785503ef1bd582d15e92f7&pid=1-s2.0-S2666350324000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}