JVS-vascular science最新文献

{"title":"Endothelial Mixed Lineage Leukemia 1 (kmt2a/MLL1) as a Central Mediator of Immunothrombosis During SARS-CoV-2 Infection","authors":"Nathaniel Parchment, Sriganesh Sharma, Kiran Kumar, Sabrina Rocco, Oscar Yesid Moreno, Catherine Luke, Katherine A. Gallagher, Peter Henke, Andrea T. Obi","doi":"10.1016/j.jvssci.2024.100246","DOIUrl":"10.1016/j.jvssci.2024.100246","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100246"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creation of Lymphatic Endothelial Cells From Induced Pluripotent Stem Cells For Use In Regenerative Therapy For Lymphedema","authors":"Katherine Owsiany, Sean Carr, Michael Tu, Katherine Hekman","doi":"10.1016/j.jvssci.2024.100233","DOIUrl":"10.1016/j.jvssci.2024.100233","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum vitamin D with diagnosis and growth of abdominal aortic aneurysm","authors":"Shivshankar Thanigaimani PhD ,&nbsp;Rachel E. Neale PhD ,&nbsp;Mary Waterhouse PhD ,&nbsp;Joseph V. Moxon PhD ,&nbsp;Bu B. Yeap PhD ,&nbsp;Paul E. Norman PhD ,&nbsp;Leon Flicker PhD ,&nbsp;Graeme J. Hankey PhD ,&nbsp;Jason Jenkins PhD ,&nbsp;Frank Quigley PhD ,&nbsp;Michael W. Clarke PhD ,&nbsp;Jonathan Golledge MA, FRCS, FRACS","doi":"10.1016/j.jvssci.2024.100208","DOIUrl":"10.1016/j.jvssci.2024.100208","url":null,"abstract":"<div><h3>Objective</h3><p>We examined the associations between 25-hydroxy vitamin D (25(OH)D₃) concentration and the diagnosis and growth of abdominal aortic aneurysm (AAA).</p></div><div><h3>Methods</h3><p>AAA cases and healthy controls were recruited from vascular centers or the community. A subset of participants with AAA were monitored by repeat ultrasound examination to assess AAA growth. Serum 25(OH)D₃ concentration was measured using a validated mass spectrometry method and categorized into guideline-recommended cut-points after deseasonalization. The associations between deseasonalized 25(OH)D₃ concentration and AAA diagnosis and growth were examined using logistic regression and linear mixed effects modeling.</p></div><div><h3>Results</h3><p>A total of 4673 participants consisting of 873 (455 controls and 418 cases) from Queensland and 3800 (3588 controls and 212 cases) from Western Australia were recruited. For every 1 standard deviation increase in 25(OH)D₃ concentration, odds of AAA diagnosis was significantly reduced in both Queensland (adjusted odds ratio: 0.81; 95% confidence interval [CI]: 0.69-0.95; <em>P</em> = .009) and Western Australia (adjusted odds ratio: 0.80; 95% CI: 0.68-0.94; <em>P</em> = .005) cohorts. A subset of 310 eligible participants with small AAA from both regions were followed for a median of 4.2 (interquartile range: 2.0-5.8) years. Compared with vitamin D sufficient participants (50 to ˂75 nmol/L), annual mean AAA growth was significantly greater in those with higher vitamin D (≥75 nmol/L) (adjusted mean difference: 0.1 mm/y, 95% CI: 0.1-0.2; <em>P</em> &lt; .001).</p></div><div><h3>Conclusions</h3><p>High 25(OH)D₃ concentration was paradoxically associated with a lower likelihood of AAA diagnosis and faster AAA growth. Further research is needed to resolve these conflicting findings.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000191/pdfft?md5=53c6dec97c18728032cf8eccf8832233&pid=1-s2.0-S2666350324000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidemia impairs collateral artery formation after hindlimb ischemia: Adding insult to injury","authors":"Ali H. Hakim MD ,&nbsp;Luke Brewster MD PhD","doi":"10.1016/j.jvssci.2024.100204","DOIUrl":"10.1016/j.jvssci.2024.100204","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000154/pdfft?md5=7b018c4ad32d4f691f057388c4cad510&pid=1-s2.0-S2666350324000154-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A central arteriovenous fistula reduces systemic hypertension in a mouse model","authors":"Anand Brahmandam MD ,&nbsp;Rafael Alves BM ,&nbsp;Hao Liu (刘灏) MD ,&nbsp;Luis Gonzalez PhD ,&nbsp;Yukihiko Aoyagi (青栁 幸彦) MD ,&nbsp;Yuichi Ohashi (大橋 雄一) MD ,&nbsp;John T. Langford MD ,&nbsp;Carly Thaxton MD ,&nbsp;Ryosuke Taniguchi (谷口 良輔) MD, PhD ,&nbsp;Weichang Zhang (张惟常) MD, PhD ,&nbsp;Hualong Bai (白华龙) MD, PhD ,&nbsp;Bogdan Yatsula PhD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100191","DOIUrl":"10.1016/j.jvssci.2024.100191","url":null,"abstract":"<div><h3>Objective</h3><p>A central arteriovenous fistula (AVF) has been proposed as a potential novel solution to treat patients with refractory hypertension. We hypothesized that venous remodeling after AVF creation in the hypertensive environment reduces systemic blood pressure but results in increased AVF wall thickness compared with remodeling in the normotensive environment.</p></div><div><h3>Methods</h3><p>A central AVF was performed in C57BL6/J mice previously made hypertensive with angiotensin II (Ang II); mice were sacrificed on postoperative day 7 or 21.</p></div><div><h3>Results</h3><p>In mice treated with Ang II alone, the mean systolic blood pressure increased from 90 ± 5 mmHg to 160 ± 5 mmHg at day 21; however, in mice treated with both Ang II and an AVF, the blood pressure decreased with creation of an AVF. There were significantly more PCNA-positive cells, SM22α/PCNA-positive cells, collagen I deposition, and increased Krüppel-like Factor 2 immunoreactivity in hypertensive mice with an AVF compared with normotensive mice with an AVF.</p></div><div><h3>Conclusions</h3><p>These data show that a central AVF decreases systemic hypertension as well as induces local alterations in venous remodeling.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000026/pdfft?md5=60786e70b011585e96e3a0ee22d68666&pid=1-s2.0-S2666350324000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nr3c1-Sfrp1 Axis Regulates the Adipogenic Differentiation of Vcam1+ Fibro-adipogenic Progenitors in Chronic Limb-threatening Ischemia","authors":"Qunsheng Dai,&nbsp;Changxin Wan,&nbsp;Yueyuan Xu,&nbsp;Brianna Garrett,&nbsp;Leo Akers,&nbsp;Derek Peters,&nbsp;James Otto,&nbsp;Christopher D. Kontos,&nbsp;Jason Ji,&nbsp;Yarui Diao,&nbsp;Kevin W. Southerland","doi":"10.1016/j.jvssci.2024.100232","DOIUrl":"10.1016/j.jvssci.2024.100232","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Knockout of the ETS Transcription Factor ERG Promotes Loss of Endothelial Cell Identity and Endothelial Cell Dysfunction in an Aortic Endothelial Cell Model Relevant For Atherosclerosis","authors":"Kristen Schulz,&nbsp;Steven R. Botts,&nbsp;Kai Ellis,&nbsp;Nadiya Khyzha,&nbsp;Rathnakumar Kumaragurubaran,&nbsp;Michael Wilson,&nbsp;Kathryn L. Howe,&nbsp;Jason E. Fish","doi":"10.1016/j.jvssci.2024.100262","DOIUrl":"10.1016/j.jvssci.2024.100262","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-First Approach to Rare and Common Variant Risk of Thoracic Aortic Aneurysm and Dissection","authors":"John Depaolo,&nbsp;Gina M. Biagetti,&nbsp;Renae Judy,&nbsp;Sarah Abramowitz,&nbsp;Nimesh Desai,&nbsp;Wilson Y. Szeto,&nbsp;Joseph E. Bavaria,&nbsp;Michael Levin,&nbsp;Dongchuan Guo,&nbsp;Dianna M. Milewicz,&nbsp;Scott M. Damrauer","doi":"10.1016/j.jvssci.2024.100243","DOIUrl":"10.1016/j.jvssci.2024.100243","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid Cell Lgr4 Contributes to Atherosclerotic Lesion Formation","authors":"Ishita Kathuria,&nbsp;Ravi Varma Aithabathula,&nbsp;Naveed Pervaiz,&nbsp;Britney Le,&nbsp;Ki-Suk Kim,&nbsp;Jiqiu Wang,&nbsp;Udai P. Singh,&nbsp;Bhupesh Singla","doi":"10.1016/j.jvssci.2024.100263","DOIUrl":"10.1016/j.jvssci.2024.100263","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion Site-Specific Mass Spectrometry Analysis of Human Carotid Plaques Reveals Strongest Association of the Necrotic Core And Fibrous Cap Proteome With Plaque Stability","authors":"Nadja Sachs,&nbsp;Ankit Sinha,&nbsp;Elena Kratz,&nbsp;Jessica Pauli,&nbsp;Marie-Luise Engl,&nbsp;Hanna Winter,&nbsp;Hans-Henning Eckstein,&nbsp;Matthias Mann,&nbsp;Lars Maegdefessel","doi":"10.1016/j.jvssci.2024.100235","DOIUrl":"10.1016/j.jvssci.2024.100235","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}