JVS-vascular science最新文献

{"title":"Expression of the Aim2 Inflammasome in Skeletal is Modulated by Surgical Bypass And is a Target to Reduce Ischemic Myopathy in Pad","authors":"Bowen Xie, Edwyn Assaf, Ricardo Ferrari, George Casale, Iraklis I. Pipinos, Ulka Sachdev","doi":"10.1016/j.jvssci.2024.100228","DOIUrl":"10.1016/j.jvssci.2024.100228","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cd40 is Required For B1b Cell Homeostasis in Atherosclerosis","authors":"Katrin Nitz, Myrthe Reiche, Oom Pattarabajinard, Aditi Upadhye, Claudia van Tiel, Angela M. Taylor, Stephen G. Malin, Christoph J. Binder, Norbert Gerdes, Cornelia M. Weyand, Christian Weber, Dorothee Atzler, Coleen A. McNamara, Esther Lutgens","doi":"10.1016/j.jvssci.2024.100241","DOIUrl":"10.1016/j.jvssci.2024.100241","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tgfb-Whsc1 Axis Drives Macrophage to Myofibroblast Transition During Wound Repair","authors":"Kevin Dale Mangum, Tyler Bauer, Amrita Joshi, William Melvin, Emily Barrett, Sonya Wolf, Jadie Moon, James Shadiow, Andrea T. Obi, Johann Gudjonsson, Frank Davis, Katherine A. Gallagher","doi":"10.1016/j.jvssci.2024.100230","DOIUrl":"10.1016/j.jvssci.2024.100230","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small apolipoprotein(a) isoforms may predict primary patency following peripheral arterial revascularization","authors":"Marianna Pavlyha MD ,&nbsp;Madeleine Hunter MD ,&nbsp;Roman Nowygrod MD ,&nbsp;Virenda Patel MD, MPH ,&nbsp;Nicholas Morrissey MD ,&nbsp;Danielle Bajakian MD ,&nbsp;Yihao Li MS ,&nbsp;Gissette Reyes-Soffer MD","doi":"10.1016/j.jvssci.2024.100211","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100211","url":null,"abstract":"<div><h3>Background</h3><p>High lipoprotein (a) [Lp(a)] is associated with adverse limb events in patients undergoing lower extremity revascularization. Lp(a) levels are genetically pre-determined, with <em>LPA</em> gene encoding for two apolipoprotein (a) [apo(a)] isoforms. Isoform size variations are driven by the number of kringle IV type 2 (KIV-2) repeats. Lp(a) levels are inversely correlated with isoform size. In this study, we examined the role of Lp(a) levels, apo(a) size, and inflammatory markers with lower extremity revascularization outcomes.</p></div><div><h3>Methods</h3><p>Twenty-five subjects with chronic peripheral arterial disease (PAD) underwent open or endovascular lower extremity revascularization (mean age, 66.7 ± 9.7 years; Female = 12; Male = 13; Black = 8; Hispanic = 5; and White = 12). Pre- and postoperative medical history, self-reported symptoms, ankle-brachial indices (ABIs), and lower extremity duplex ultrasounds were obtained. Plasma Lp(a), apoB100, lipid panel, and pro-inflammatory markers (IL-6, IL-18, hs-CRP, TNFα) were assayed preoperatively. Isoform size was estimated using gel electrophoresis and weighted isoform size (<em>wIS</em>) calculated based on % isoform expression. Firth logistic regression was used to examine the relationship between Lp(a) levels and <em>wIS</em> with procedural outcomes: symptoms (better/worse), early primary patency at 2 to 4 weeks, ABIs, and reintervention within 3 to 6 months. We controlled for age, sex, history of diabetes, smoking, statin, antiplatelet, and anticoagulation use.</p></div><div><h3>Results</h3><p>Median plasma Lp(a) level was 108 (interrquartile range, 44-301) nmol/L. The mean apoB100 level was 168.0 ± 65.8 mg/dL. These values were not statistically different among races. We found no association between Lp(a) levels and w<em>IS</em> with measured plasma pro-inflammatory markers. However, smaller apo(a) <em>wIS</em> was associated with occlusion of the treated lesion(s) in the postoperative period (odds ratio, 1.97; 95% confidence interval, 1.01-3.86; <em>P</em> &lt; .05). The relationship of smaller apo(a) <em>wIS</em> with reintervention was not as strong (odds ratio, 1.57; 95% confidence interval, 0.96-2.56; <em>P</em> = .07). We observed no association between <em>wIS</em> with patient reported symptoms or change in ABIs.</p></div><div><h3>Conclusions</h3><p>In this small study, subjects with smaller apo(a) isoform size undergoing peripheral arterial revascularization were more likely to experience occlusion in the postoperative period and/or require reintervention. Larger cohort studies identifying the mechanism and validating these preliminary data are needed to improve understanding of long-term peripheral vascular outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000221/pdfft?md5=51b8275b14785503ef1bd582d15e92f7&pid=1-s2.0-S2666350324000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-Derived Mesenchymal Stem-Cell Therapy Improves Arteriogenesis, Hemodynamics, and Walking Performance in a Porcine Model of Peripheral Artery Disease","authors":"Ali Hani Hakim,&nbsp;Yuqian Tian,&nbsp;Katya Brunette,&nbsp;Julian K. Kim,&nbsp;Zhen Zhu,&nbsp;Song-young Park,&nbsp;George Casale,&nbsp;Mark A. Carlson,&nbsp;Iraklis I. Pipinos","doi":"10.1016/j.jvssci.2024.100257","DOIUrl":"10.1016/j.jvssci.2024.100257","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbial Markers Associated With Clinical Features of Peripheral Artery Disease","authors":"Sarbjeet Niraula,&nbsp;Spencer L. Stirewalt,&nbsp;Jonathan Jung,&nbsp;Megan E. Alagna,&nbsp;Jae Jang,&nbsp;Erik Wu,&nbsp;James Du,&nbsp;Liqun Xiong,&nbsp;Stefan J. Green,&nbsp;Patrick C. Seed,&nbsp;Karen J. Ho","doi":"10.1016/j.jvssci.2024.100259","DOIUrl":"10.1016/j.jvssci.2024.100259","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Tlr4 Signaling Inhibits Thrombus Resolution in a Non-Monocyte Dependent Manner","authors":"Kiran Kumar,&nbsp;Oscar Yesid Moreno,&nbsp;Nathaniel Parchment,&nbsp;Sriganesh Sharma,&nbsp;Sabrina Rocco,&nbsp;Catherine Luke,&nbsp;Sylviane Lambert,&nbsp;Michael A. Holinstat,&nbsp;Frank Davis,&nbsp;Katherine A. Gallagher,&nbsp;Bethany Moore,&nbsp;Peter Henke,&nbsp;Andrea T. Obi","doi":"10.1016/j.jvssci.2024.100224","DOIUrl":"10.1016/j.jvssci.2024.100224","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Akkermansia (Strain BAA835) and the Microbial ADP-Heptose Pathway Are Associated With Reduced Neointimal Hyperplasia After Arterial Injury","authors":"Karen J. Ho,&nbsp;Sarbjeet Niraula,&nbsp;Vivek Pamulapati,&nbsp;Jonathan Jung,&nbsp;Jae Woong Jang,&nbsp;Catherine Plunkett,&nbsp;Liqun Xiong,&nbsp;James Du,&nbsp;Raphael Valdivia,&nbsp;Stefan Green,&nbsp;Patrick Seed","doi":"10.1016/j.jvssci.2024.100221","DOIUrl":"10.1016/j.jvssci.2024.100221","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin Targeted Treatment Against Intimal Hyperplasia Using Unique Chitosan-PLGA Nanoparticles","authors":"Ashley Penton,&nbsp;Gloria Grace Poland,&nbsp;Maleen Cabe,&nbsp;Kelly Langert,&nbsp;Kristopher Maier,&nbsp;Vivian Gahtan","doi":"10.1016/j.jvssci.2024.100219","DOIUrl":"10.1016/j.jvssci.2024.100219","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Length and Proximal Extent of Occlusion Dictates Severity of Disease in a Mini-Swine Model of PAD","authors":"Ali Hani Hakim,&nbsp;Yuqian Tian,&nbsp;Al-Murtadha Al-Gahmi,&nbsp;Sara Cartwright,&nbsp;Jamal K. Salaymeh,&nbsp;Julian K. Kim,&nbsp;Zhen Zhu,&nbsp;George Casale,&nbsp;Iraklis I. Pipinos,&nbsp;Mark A. Carlson","doi":"10.1016/j.jvssci.2024.100227","DOIUrl":"10.1016/j.jvssci.2024.100227","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}