JVS-vascular science最新文献

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Antidiabetic Agent, Canagliflozin, Is a Potent Vasodilator of the Coronary Microvasculature 抗糖尿病药物卡格列净是一种强效的冠状动脉微血管扩张剂
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100179
Debolina Banerjee, Hang Xing, Jun Feng, Frank Sellke
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引用次数: 0
Microbe-derived Butyrate Activation of Free Fatty Acid Receptor-3 Reduces Neointimal Hyperplasia after Arterial Injury by Regulating Immune Response Transcription Networks in Endothelial Cells 微生物衍生的丁酸盐激活游离脂肪酸受体-3,通过调节内皮细胞的免疫反应转录网络减少动脉损伤后的新内膜增生
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100144
Jonathan Jung , Sarbjeet Niraula , James Du , Vivek Pamulapati , Jae Woong Jang , Liqun Xiong , M. Luisa Iruela-Arispe , Michael R. MacArthur , Karen J. Ho
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引用次数: 0
Purinergic Receptor P2Y6 Mediates Perfusion Recovery After Femoral Artery Ligation 嘌呤能受体 P2Y6 介导股动脉结扎后的灌注恢复
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100171
Rohan N. Kulkarni , Dylan McCreary , Nolan Skirtich , Michael Calderon , Ryan M. McEnaney
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引用次数: 0
The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and Is Associated With Blood Pressure 组蛋白去甲基化酶 JMJD3 调控平滑肌分化并与血压有关
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100149
Kevin Mangum, Amrita Joshi, Sonya Wolf, Emily Barrett, Jadie Moon, Bethany Moore, Andrea T. Obi, Frank Davis, Katherine A. Gallagher
{"title":"The Histone Demethylase JMJD3 Regulates Smooth Muscle Differentiation and Is Associated With Blood Pressure","authors":"Kevin Mangum, Amrita Joshi, Sonya Wolf, Emily Barrett, Jadie Moon, Bethany Moore, Andrea T. Obi, Frank Davis, Katherine A. Gallagher","doi":"10.1016/j.jvssci.2023.100149","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100149","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000536/pdfft?md5=8256b9a4b886d0a68e2a5171059a36e6&pid=1-s2.0-S2666350323000536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Info for readers 读者须知
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/S2666-3503(23)00090-1
{"title":"Info for readers","authors":"","doi":"10.1016/S2666-3503(23)00090-1","DOIUrl":"https://doi.org/10.1016/S2666-3503(23)00090-1","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000901/pdfft?md5=284d5d8af825949e51552ff5f69a85ab&pid=1-s2.0-S2666350323000901-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Events of interest 感兴趣的活动
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/S2666-3503(23)00091-3
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引用次数: 0
Genome-wide Association Study of Intracranial Aneurysms Reveals Shared Heritability With Aortic Aneurysms and Atherosclerosis 颅内动脉瘤全基因组关联研究揭示了主动脉瘤和动脉粥样硬化的共同遗传性
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100160
Shaunak Adkar , Julie Lynch , Sharika Bamezai , Sabina Sorondo , Ryan Choi , Michael Levin , Scott M. Damrauer , Saiju Pyarajan , Philip S. Tsao , Stephen Skirboll , Nick J. Leeper , Derek Klarin
{"title":"Genome-wide Association Study of Intracranial Aneurysms Reveals Shared Heritability With Aortic Aneurysms and Atherosclerosis","authors":"Shaunak Adkar , Julie Lynch , Sharika Bamezai , Sabina Sorondo , Ryan Choi , Michael Levin , Scott M. Damrauer , Saiju Pyarajan , Philip S. Tsao , Stephen Skirboll , Nick J. Leeper , Derek Klarin","doi":"10.1016/j.jvssci.2023.100160","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100160","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000640/pdfft?md5=6a55a4435a65814778e2127e6157f893&pid=1-s2.0-S2666350323000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Basis of Thoracic Aortic Aneurysms in a Large Unselected Clinical Population 未经选择的大量临床人群中胸主动脉瘤的遗传基础
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100164
Hannah S. Mirshahi, Jeremy S. Haley, Diane T. Smelser, Evan J. Ryer, James R. Elmore, David J. Carey
{"title":"Genetic Basis of Thoracic Aortic Aneurysms in a Large Unselected Clinical Population","authors":"Hannah S. Mirshahi, Jeremy S. Haley, Diane T. Smelser, Evan J. Ryer, James R. Elmore, David J. Carey","doi":"10.1016/j.jvssci.2023.100164","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100164","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000688/pdfft?md5=8fb2a120f05fb4b5a9039cc07df12742&pid=1-s2.0-S2666350323000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward a targeted approach to diabetes-related peripheral arterial occlusive disease 糖尿病相关外周动脉闭塞性疾病的靶向治疗
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100112
Rym El Khoury MD , Alan Dardik MD, PhD
{"title":"Toward a targeted approach to diabetes-related peripheral arterial occlusive disease","authors":"Rym El Khoury MD , Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2023.100112","DOIUrl":"10.1016/j.jvssci.2023.100112","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/79/main.PMC10366572.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-powered assessment of biomarkers for growth prediction of abdominal aortic aneurysms 人工智能评估腹主动脉瘤生长预测的生物标志物
JVS-vascular science Pub Date : 2023-01-01 DOI: 10.1016/j.jvssci.2023.100119
Arianna Forneris PhD , Richard Beddoes MSc , Mitchel Benovoy PhD , Peter Faris PhD , Randy D. Moore MD , Elena S. Di Martino PhD
{"title":"AI-powered assessment of biomarkers for growth prediction of abdominal aortic aneurysms","authors":"Arianna Forneris PhD ,&nbsp;Richard Beddoes MSc ,&nbsp;Mitchel Benovoy PhD ,&nbsp;Peter Faris PhD ,&nbsp;Randy D. Moore MD ,&nbsp;Elena S. Di Martino PhD","doi":"10.1016/j.jvssci.2023.100119","DOIUrl":"10.1016/j.jvssci.2023.100119","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study was to employ biomechanics-based biomarkers to locally characterize abdominal aortic aneurysm (AAA) tissue and investigate their relation to local aortic growth by means of an artificial intelligence model.</p></div><div><h3>Methods</h3><p>The study focused on a population of 36 patients with AAAs undergoing serial monitoring with electrocardiogram-gated multiphase computed tomography angiography acquisitions. The geometries of the aortic lumen and wall were reconstructed from the baseline scans and used for the baseline assessment of regional aortic weakness with three functional biomarkers, time-averaged wall-shear stress, in vivo principal strain, and intra-luminal thrombus thickness. The biomarkers were encoded as regional averages on axial and circumferential sections perpendicularly to the aortic centerline. Local diametric growth was obtained as difference in diameter between baseline and follow-up at the level of each axial section. An artificial intelligence model was developed to predict accelerated aneurysmal growth with the Extra Trees algorithm used as a binary classifier where the positive class represented regions that grew more than 2.5 mm/year. Additional clinical biomarkers, such as maximum aortic diameter at baseline, were also investigated as predictors of growth.</p></div><div><h3>Results</h3><p>The area under the curve for the constructed receiver operating characteristic curve for the Extra Trees classifier showed a very good performance in predicting relevant aortic growth (area under the curve = 0.92), with the three biomechanics-based functional biomarkers being objectively selected as the main predictors of growth.</p></div><div><h3>Conclusions</h3><p>The use of features based on the functional and local characterization of the aortic tissue resulted in a superior performance in terms of growth prediction when compared with models based on geometrical assessments. With rapid growth linked to increasing risk for patients with AAAs, the ability to access functional information related to tissue weakening and disease progression at baseline has the potential to support early clinical decisions and improve disease management.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/45/main.PMC10470267.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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