Debolina Banerjee, Hang Xing, Jun Feng, Frank Sellke
{"title":"Antidiabetic Agent, Canagliflozin, Is a Potent Vasodilator of the Coronary Microvasculature","authors":"Debolina Banerjee, Hang Xing, Jun Feng, Frank Sellke","doi":"10.1016/j.jvssci.2023.100179","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100179","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000834/pdfft?md5=57045819df66120adb1a3dd423fc6c2e&pid=1-s2.0-S2666350323000834-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139107264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Jung , Sarbjeet Niraula , James Du , Vivek Pamulapati , Jae Woong Jang , Liqun Xiong , M. Luisa Iruela-Arispe , Michael R. MacArthur , Karen J. Ho
{"title":"Microbe-derived Butyrate Activation of Free Fatty Acid Receptor-3 Reduces Neointimal Hyperplasia after Arterial Injury by Regulating Immune Response Transcription Networks in Endothelial Cells","authors":"Jonathan Jung , Sarbjeet Niraula , James Du , Vivek Pamulapati , Jae Woong Jang , Liqun Xiong , M. Luisa Iruela-Arispe , Michael R. MacArthur , Karen J. Ho","doi":"10.1016/j.jvssci.2023.100144","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100144","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000482/pdfft?md5=256c59b9ef44f830c8190db4bed5e3b4&pid=1-s2.0-S2666350323000482-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139107307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaunak Adkar , Julie Lynch , Sharika Bamezai , Sabina Sorondo , Ryan Choi , Michael Levin , Scott M. Damrauer , Saiju Pyarajan , Philip S. Tsao , Stephen Skirboll , Nick J. Leeper , Derek Klarin
{"title":"Genome-wide Association Study of Intracranial Aneurysms Reveals Shared Heritability With Aortic Aneurysms and Atherosclerosis","authors":"Shaunak Adkar , Julie Lynch , Sharika Bamezai , Sabina Sorondo , Ryan Choi , Michael Levin , Scott M. Damrauer , Saiju Pyarajan , Philip S. Tsao , Stephen Skirboll , Nick J. Leeper , Derek Klarin","doi":"10.1016/j.jvssci.2023.100160","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100160","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000640/pdfft?md5=6a55a4435a65814778e2127e6157f893&pid=1-s2.0-S2666350323000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah S. Mirshahi, Jeremy S. Haley, Diane T. Smelser, Evan J. Ryer, James R. Elmore, David J. Carey
{"title":"Genetic Basis of Thoracic Aortic Aneurysms in a Large Unselected Clinical Population","authors":"Hannah S. Mirshahi, Jeremy S. Haley, Diane T. Smelser, Evan J. Ryer, James R. Elmore, David J. Carey","doi":"10.1016/j.jvssci.2023.100164","DOIUrl":"https://doi.org/10.1016/j.jvssci.2023.100164","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000688/pdfft?md5=8fb2a120f05fb4b5a9039cc07df12742&pid=1-s2.0-S2666350323000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arianna Forneris PhD , Richard Beddoes MSc , Mitchel Benovoy PhD , Peter Faris PhD , Randy D. Moore MD , Elena S. Di Martino PhD
{"title":"AI-powered assessment of biomarkers for growth prediction of abdominal aortic aneurysms","authors":"Arianna Forneris PhD , Richard Beddoes MSc , Mitchel Benovoy PhD , Peter Faris PhD , Randy D. Moore MD , Elena S. Di Martino PhD","doi":"10.1016/j.jvssci.2023.100119","DOIUrl":"10.1016/j.jvssci.2023.100119","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this study was to employ biomechanics-based biomarkers to locally characterize abdominal aortic aneurysm (AAA) tissue and investigate their relation to local aortic growth by means of an artificial intelligence model.</p></div><div><h3>Methods</h3><p>The study focused on a population of 36 patients with AAAs undergoing serial monitoring with electrocardiogram-gated multiphase computed tomography angiography acquisitions. The geometries of the aortic lumen and wall were reconstructed from the baseline scans and used for the baseline assessment of regional aortic weakness with three functional biomarkers, time-averaged wall-shear stress, in vivo principal strain, and intra-luminal thrombus thickness. The biomarkers were encoded as regional averages on axial and circumferential sections perpendicularly to the aortic centerline. Local diametric growth was obtained as difference in diameter between baseline and follow-up at the level of each axial section. An artificial intelligence model was developed to predict accelerated aneurysmal growth with the Extra Trees algorithm used as a binary classifier where the positive class represented regions that grew more than 2.5 mm/year. Additional clinical biomarkers, such as maximum aortic diameter at baseline, were also investigated as predictors of growth.</p></div><div><h3>Results</h3><p>The area under the curve for the constructed receiver operating characteristic curve for the Extra Trees classifier showed a very good performance in predicting relevant aortic growth (area under the curve = 0.92), with the three biomechanics-based functional biomarkers being objectively selected as the main predictors of growth.</p></div><div><h3>Conclusions</h3><p>The use of features based on the functional and local characterization of the aortic tissue resulted in a superior performance in terms of growth prediction when compared with models based on geometrical assessments. With rapid growth linked to increasing risk for patients with AAAs, the ability to access functional information related to tissue weakening and disease progression at baseline has the potential to support early clinical decisions and improve disease management.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"4 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/45/main.PMC10470267.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}