JVS-vascular science最新文献

{"title":"Small apolipoprotein(a) isoforms may predict primary patency following peripheral arterial revascularization","authors":"Marianna Pavlyha MD ,&nbsp;Madeleine Hunter MD ,&nbsp;Roman Nowygrod MD ,&nbsp;Virenda Patel MD, MPH ,&nbsp;Nicholas Morrissey MD ,&nbsp;Danielle Bajakian MD ,&nbsp;Yihao Li MS ,&nbsp;Gissette Reyes-Soffer MD","doi":"10.1016/j.jvssci.2024.100211","DOIUrl":"https://doi.org/10.1016/j.jvssci.2024.100211","url":null,"abstract":"<div><h3>Background</h3><p>High lipoprotein (a) [Lp(a)] is associated with adverse limb events in patients undergoing lower extremity revascularization. Lp(a) levels are genetically pre-determined, with <em>LPA</em> gene encoding for two apolipoprotein (a) [apo(a)] isoforms. Isoform size variations are driven by the number of kringle IV type 2 (KIV-2) repeats. Lp(a) levels are inversely correlated with isoform size. In this study, we examined the role of Lp(a) levels, apo(a) size, and inflammatory markers with lower extremity revascularization outcomes.</p></div><div><h3>Methods</h3><p>Twenty-five subjects with chronic peripheral arterial disease (PAD) underwent open or endovascular lower extremity revascularization (mean age, 66.7 ± 9.7 years; Female = 12; Male = 13; Black = 8; Hispanic = 5; and White = 12). Pre- and postoperative medical history, self-reported symptoms, ankle-brachial indices (ABIs), and lower extremity duplex ultrasounds were obtained. Plasma Lp(a), apoB100, lipid panel, and pro-inflammatory markers (IL-6, IL-18, hs-CRP, TNFα) were assayed preoperatively. Isoform size was estimated using gel electrophoresis and weighted isoform size (<em>wIS</em>) calculated based on % isoform expression. Firth logistic regression was used to examine the relationship between Lp(a) levels and <em>wIS</em> with procedural outcomes: symptoms (better/worse), early primary patency at 2 to 4 weeks, ABIs, and reintervention within 3 to 6 months. We controlled for age, sex, history of diabetes, smoking, statin, antiplatelet, and anticoagulation use.</p></div><div><h3>Results</h3><p>Median plasma Lp(a) level was 108 (interrquartile range, 44-301) nmol/L. The mean apoB100 level was 168.0 ± 65.8 mg/dL. These values were not statistically different among races. We found no association between Lp(a) levels and w<em>IS</em> with measured plasma pro-inflammatory markers. However, smaller apo(a) <em>wIS</em> was associated with occlusion of the treated lesion(s) in the postoperative period (odds ratio, 1.97; 95% confidence interval, 1.01-3.86; <em>P</em> &lt; .05). The relationship of smaller apo(a) <em>wIS</em> with reintervention was not as strong (odds ratio, 1.57; 95% confidence interval, 0.96-2.56; <em>P</em> = .07). We observed no association between <em>wIS</em> with patient reported symptoms or change in ABIs.</p></div><div><h3>Conclusions</h3><p>In this small study, subjects with smaller apo(a) isoform size undergoing peripheral arterial revascularization were more likely to experience occlusion in the postoperative period and/or require reintervention. Larger cohort studies identifying the mechanism and validating these preliminary data are needed to improve understanding of long-term peripheral vascular outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000221/pdfft?md5=51b8275b14785503ef1bd582d15e92f7&pid=1-s2.0-S2666350324000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-Derived Mesenchymal Stem-Cell Therapy Improves Arteriogenesis, Hemodynamics, and Walking Performance in a Porcine Model of Peripheral Artery Disease","authors":"Ali Hani Hakim,&nbsp;Yuqian Tian,&nbsp;Katya Brunette,&nbsp;Julian K. Kim,&nbsp;Zhen Zhu,&nbsp;Song-young Park,&nbsp;George Casale,&nbsp;Mark A. Carlson,&nbsp;Iraklis I. Pipinos","doi":"10.1016/j.jvssci.2024.100257","DOIUrl":"10.1016/j.jvssci.2024.100257","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbial Markers Associated With Clinical Features of Peripheral Artery Disease","authors":"Sarbjeet Niraula,&nbsp;Spencer L. Stirewalt,&nbsp;Jonathan Jung,&nbsp;Megan E. Alagna,&nbsp;Jae Jang,&nbsp;Erik Wu,&nbsp;James Du,&nbsp;Liqun Xiong,&nbsp;Stefan J. Green,&nbsp;Patrick C. Seed,&nbsp;Karen J. Ho","doi":"10.1016/j.jvssci.2024.100259","DOIUrl":"10.1016/j.jvssci.2024.100259","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Tlr4 Signaling Inhibits Thrombus Resolution in a Non-Monocyte Dependent Manner","authors":"Kiran Kumar,&nbsp;Oscar Yesid Moreno,&nbsp;Nathaniel Parchment,&nbsp;Sriganesh Sharma,&nbsp;Sabrina Rocco,&nbsp;Catherine Luke,&nbsp;Sylviane Lambert,&nbsp;Michael A. Holinstat,&nbsp;Frank Davis,&nbsp;Katherine A. Gallagher,&nbsp;Bethany Moore,&nbsp;Peter Henke,&nbsp;Andrea T. Obi","doi":"10.1016/j.jvssci.2024.100224","DOIUrl":"10.1016/j.jvssci.2024.100224","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Akkermansia (Strain BAA835) and the Microbial ADP-Heptose Pathway Are Associated With Reduced Neointimal Hyperplasia After Arterial Injury","authors":"Karen J. Ho,&nbsp;Sarbjeet Niraula,&nbsp;Vivek Pamulapati,&nbsp;Jonathan Jung,&nbsp;Jae Woong Jang,&nbsp;Catherine Plunkett,&nbsp;Liqun Xiong,&nbsp;James Du,&nbsp;Raphael Valdivia,&nbsp;Stefan Green,&nbsp;Patrick Seed","doi":"10.1016/j.jvssci.2024.100221","DOIUrl":"10.1016/j.jvssci.2024.100221","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin Targeted Treatment Against Intimal Hyperplasia Using Unique Chitosan-PLGA Nanoparticles","authors":"Ashley Penton,&nbsp;Gloria Grace Poland,&nbsp;Maleen Cabe,&nbsp;Kelly Langert,&nbsp;Kristopher Maier,&nbsp;Vivian Gahtan","doi":"10.1016/j.jvssci.2024.100219","DOIUrl":"10.1016/j.jvssci.2024.100219","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Length and Proximal Extent of Occlusion Dictates Severity of Disease in a Mini-Swine Model of PAD","authors":"Ali Hani Hakim,&nbsp;Yuqian Tian,&nbsp;Al-Murtadha Al-Gahmi,&nbsp;Sara Cartwright,&nbsp;Jamal K. Salaymeh,&nbsp;Julian K. Kim,&nbsp;Zhen Zhu,&nbsp;George Casale,&nbsp;Iraklis I. Pipinos,&nbsp;Mark A. Carlson","doi":"10.1016/j.jvssci.2024.100227","DOIUrl":"10.1016/j.jvssci.2024.100227","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepcidin Loss Demonstrates Sex Dependent Differences in Aortic Aneurysm Size","authors":"Matthew Kazaleh,&nbsp;Rachel Gioscia-Ryan,&nbsp;Xiaohua Gao,&nbsp;Ashna Golla,&nbsp;Erik Scott,&nbsp;Sundaraman Swaminathan,&nbsp;Robert Hawkins,&nbsp;Gorav Ailawadi,&nbsp;Morgan Salmon","doi":"10.1016/j.jvssci.2024.100250","DOIUrl":"10.1016/j.jvssci.2024.100250","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the genetics of peripheral arterial disease","authors":"Cassius Iyad Ochoa Chaar MD, MS ,&nbsp;Tanner Kim MD ,&nbsp;Dana Alameddine MD ,&nbsp;Andrew DeWan PhD ,&nbsp;Raul Guzman MD ,&nbsp;Alan Dardik MD, PhD ,&nbsp;Holly K. Grossetta Nardini MLS ,&nbsp;Joshua D. Wallach PhD ,&nbsp;Iftikhar Kullo MD ,&nbsp;Michael Murray MD","doi":"10.1016/j.jvssci.2023.100133","DOIUrl":"10.1016/j.jvssci.2023.100133","url":null,"abstract":"<div><h3>Background</h3><p>Peripheral artery disease (PAD) impacts more than 200 million people worldwide. The understanding of the genetics of the disease and its clinical implications continue to evolve. This systematic review provides a comprehensive summary of all DNA variants that have been studied in association with the diagnosis and progression of PAD, with a meta-analysis of the ones replicated in the literature.</p></div><div><h3>Methods</h3><p>A systematic review of all studies examining DNA variants associated with the diagnosis and progression of PAD was performed. Candidate gene and genome-wide association studies (GWAS) were included. A meta-analysis of 13 variants derived from earlier smaller candidate gene studies of the diagnosis of PAD was performed. The literature on the progression of PAD was limited, and a meta-analysis was not feasible because of the heterogeneity in the criteria used to characterize it.</p></div><div><h3>Results</h3><p>A total of 231 DNA variants in 112 papers were studied for the association with the diagnosis of PAD. There were significant variations in the definition of PAD and the selection of controls in the various studies. GWAS have established 19 variants associated with the diagnosis of PAD that were replicated in several large patient cohorts. Only variants in intercellular adhesion molecule-1 (rs5498), IL-6 (rs1800795), and hepatic lipase (rs2070895) showed significant association with the diagnosis of PAD. However, these variants were not noted in the published GWAS.</p></div><div><h3>Conclusions</h3><p>Genetic research in the diagnosis of PAD has significant heterogeneity, but recent GWAS have demonstrated variants consistently associated with the disease. More research focusing on the progression of PAD is needed to identify patients at risk of adverse events and develop strategies that would improve their outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000378/pdfft?md5=97acbf5f67b9b955600edb1326df5a52&pid=1-s2.0-S2666350323000378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of four-dimensional ultrasound strain analysis with computed tomography angiography wall stress simulations in abdominal aortic aneurysms","authors":"Wojciech Derwich MD, MHBA ,&nbsp;Manuel Schönborn MEng ,&nbsp;Christopher Blase RNDr ,&nbsp;Andreas Wittek Dr-Ing ,&nbsp;Kyriakos Oikonomou MD, PhD ,&nbsp;Dittmar Böckler MD, PhD, MHBA ,&nbsp;Philipp Erhart MD, PhD, MHBA","doi":"10.1016/j.jvssci.2024.100199","DOIUrl":"10.1016/j.jvssci.2024.100199","url":null,"abstract":"<div><h3>Objective</h3><p>Biomechanical modeling of infrarenal aortic aneurysms seeks to predict ruptures in advance, thereby reducing aneurysm-related deaths. As individual methods focusing on strain and stress analysis lack adequate discretization power, this study aims to explore multifactorial characterization for progressive aneurysmal degeneration. The study’s objective is to compare stress- and strain-related parameters in infrarenal aortic aneurysms.</p></div><div><h3>Methods</h3><p>Twenty-two patients with abdominal aortic aneurysms (AAAs) (mean maximum diameter, 53.2 ± 7.2 mm) were included in the exploratory study, examined by computed tomography angiography (CTA) and three-dimensional real-time speckle tracking ultrasound (4D-US). The conformity of aneurysm anatomy in 4D-US and CTA was determined with the mean point-to-point distance (MPPD). CTA was employed for each AAA to characterize stress-related indices using the semi-automated A4-clinics RE software. Five segmentations from one 4D-US examination were fused into one averaged model for strain analysis using MATLAB and the Abaqus solver.</p></div><div><h3>Results</h3><p>The mean MPPD between the adjacent points of the 4D-US and CTA-derived geometry was 1.8 ± 0.4 mm. The interclass correlation coefficients for all raters and all measurements for the maximum AAA diameter in 2D, 4D ultrasound, and CTA indicate moderate to good reliability (interclass correlation coefficient₁ 0.69 with 95% confidence interval [CI], 0.49-0.84; <em>P</em> &lt; .001). The peak wall stress (PWS) correlates fairly with the maximum AAA diameter in 2D-US (r = 0.54; <em>P</em> &lt; .01) and 4D-US (r = 0.53; <em>P</em> &lt; .05) and moderately strongly with the maximum exterior AAA diameter (r = 0.63; <em>P</em> &lt; .01). The peak wall rupture risk index shows a strong correlation with the PWS (ρ &gt; 0.9; <em>P</em> &lt; .001) and is influenced by anatomical parameters with equal strength. Isolated observation of the intraluminal thrombus does not provide significant information in the determination of PWS. The maximum AAA diameter in 2D-US shows a fair negative correlation with the mean circumferential, longitudinal and in-plane shear strain (ρ = −0.46; r = −0.45; ρ = −0.47; <em>P</em> &lt; .05 for all). The circumferential strain ratio as an indicator of wall motion heterogeneity increases with the aneurysm diameter (r = 0.47; <em>P</em> &lt; .05). The direct comparison of wall strain and wall stress indices shows no quantitative correlation.</p></div><div><h3>Conclusions</h3><p>The strain and stress analyses provide independent biomechanical information of AAAs. At the current stage of development, the two methods are considered complementary and may optimize a more patient-specific rupture risk prediction in the future.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000105/pdfft?md5=42932adee70e336a4d63c951df71ba17&pid=1-s2.0-S2666350324000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}