JVS-vascular science最新文献

{"title":"Akkermansia (Strain BAA835) and the Microbial ADP-Heptose Pathway Are Associated With Reduced Neointimal Hyperplasia After Arterial Injury","authors":"Karen J. Ho, Sarbjeet Niraula, Vivek Pamulapati, Jonathan Jung, Jae Woong Jang, Catherine Plunkett, Liqun Xiong, James Du, Raphael Valdivia, Stefan Green, Patrick Seed","doi":"10.1016/j.jvssci.2024.100221","DOIUrl":"10.1016/j.jvssci.2024.100221","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin Targeted Treatment Against Intimal Hyperplasia Using Unique Chitosan-PLGA Nanoparticles","authors":"Ashley Penton, Gloria Grace Poland, Maleen Cabe, Kelly Langert, Kristopher Maier, Vivian Gahtan","doi":"10.1016/j.jvssci.2024.100219","DOIUrl":"10.1016/j.jvssci.2024.100219","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Length and Proximal Extent of Occlusion Dictates Severity of Disease in a Mini-Swine Model of PAD","authors":"Ali Hani Hakim, Yuqian Tian, Al-Murtadha Al-Gahmi, Sara Cartwright, Jamal K. Salaymeh, Julian K. Kim, Zhen Zhu, George Casale, Iraklis I. Pipinos, Mark A. Carlson","doi":"10.1016/j.jvssci.2024.100227","DOIUrl":"10.1016/j.jvssci.2024.100227","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepcidin Loss Demonstrates Sex Dependent Differences in Aortic Aneurysm Size","authors":"Matthew Kazaleh, Rachel Gioscia-Ryan, Xiaohua Gao, Ashna Golla, Erik Scott, Sundaraman Swaminathan, Robert Hawkins, Gorav Ailawadi, Morgan Salmon","doi":"10.1016/j.jvssci.2024.100250","DOIUrl":"10.1016/j.jvssci.2024.100250","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the genetics of peripheral arterial disease","authors":"Cassius Iyad Ochoa Chaar MD, MS ,&nbsp;Tanner Kim MD ,&nbsp;Dana Alameddine MD ,&nbsp;Andrew DeWan PhD ,&nbsp;Raul Guzman MD ,&nbsp;Alan Dardik MD, PhD ,&nbsp;Holly K. Grossetta Nardini MLS ,&nbsp;Joshua D. Wallach PhD ,&nbsp;Iftikhar Kullo MD ,&nbsp;Michael Murray MD","doi":"10.1016/j.jvssci.2023.100133","DOIUrl":"10.1016/j.jvssci.2023.100133","url":null,"abstract":"<div><h3>Background</h3><p>Peripheral artery disease (PAD) impacts more than 200 million people worldwide. The understanding of the genetics of the disease and its clinical implications continue to evolve. This systematic review provides a comprehensive summary of all DNA variants that have been studied in association with the diagnosis and progression of PAD, with a meta-analysis of the ones replicated in the literature.</p></div><div><h3>Methods</h3><p>A systematic review of all studies examining DNA variants associated with the diagnosis and progression of PAD was performed. Candidate gene and genome-wide association studies (GWAS) were included. A meta-analysis of 13 variants derived from earlier smaller candidate gene studies of the diagnosis of PAD was performed. The literature on the progression of PAD was limited, and a meta-analysis was not feasible because of the heterogeneity in the criteria used to characterize it.</p></div><div><h3>Results</h3><p>A total of 231 DNA variants in 112 papers were studied for the association with the diagnosis of PAD. There were significant variations in the definition of PAD and the selection of controls in the various studies. GWAS have established 19 variants associated with the diagnosis of PAD that were replicated in several large patient cohorts. Only variants in intercellular adhesion molecule-1 (rs5498), IL-6 (rs1800795), and hepatic lipase (rs2070895) showed significant association with the diagnosis of PAD. However, these variants were not noted in the published GWAS.</p></div><div><h3>Conclusions</h3><p>Genetic research in the diagnosis of PAD has significant heterogeneity, but recent GWAS have demonstrated variants consistently associated with the disease. More research focusing on the progression of PAD is needed to identify patients at risk of adverse events and develop strategies that would improve their outcomes.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000378/pdfft?md5=97acbf5f67b9b955600edb1326df5a52&pid=1-s2.0-S2666350323000378-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of four-dimensional ultrasound strain analysis with computed tomography angiography wall stress simulations in abdominal aortic aneurysms","authors":"Wojciech Derwich MD, MHBA ,&nbsp;Manuel Schönborn MEng ,&nbsp;Christopher Blase RNDr ,&nbsp;Andreas Wittek Dr-Ing ,&nbsp;Kyriakos Oikonomou MD, PhD ,&nbsp;Dittmar Böckler MD, PhD, MHBA ,&nbsp;Philipp Erhart MD, PhD, MHBA","doi":"10.1016/j.jvssci.2024.100199","DOIUrl":"10.1016/j.jvssci.2024.100199","url":null,"abstract":"<div><h3>Objective</h3><p>Biomechanical modeling of infrarenal aortic aneurysms seeks to predict ruptures in advance, thereby reducing aneurysm-related deaths. As individual methods focusing on strain and stress analysis lack adequate discretization power, this study aims to explore multifactorial characterization for progressive aneurysmal degeneration. The study’s objective is to compare stress- and strain-related parameters in infrarenal aortic aneurysms.</p></div><div><h3>Methods</h3><p>Twenty-two patients with abdominal aortic aneurysms (AAAs) (mean maximum diameter, 53.2 ± 7.2 mm) were included in the exploratory study, examined by computed tomography angiography (CTA) and three-dimensional real-time speckle tracking ultrasound (4D-US). The conformity of aneurysm anatomy in 4D-US and CTA was determined with the mean point-to-point distance (MPPD). CTA was employed for each AAA to characterize stress-related indices using the semi-automated A4-clinics RE software. Five segmentations from one 4D-US examination were fused into one averaged model for strain analysis using MATLAB and the Abaqus solver.</p></div><div><h3>Results</h3><p>The mean MPPD between the adjacent points of the 4D-US and CTA-derived geometry was 1.8 ± 0.4 mm. The interclass correlation coefficients for all raters and all measurements for the maximum AAA diameter in 2D, 4D ultrasound, and CTA indicate moderate to good reliability (interclass correlation coefficient₁ 0.69 with 95% confidence interval [CI], 0.49-0.84; <em>P</em> &lt; .001). The peak wall stress (PWS) correlates fairly with the maximum AAA diameter in 2D-US (r = 0.54; <em>P</em> &lt; .01) and 4D-US (r = 0.53; <em>P</em> &lt; .05) and moderately strongly with the maximum exterior AAA diameter (r = 0.63; <em>P</em> &lt; .01). The peak wall rupture risk index shows a strong correlation with the PWS (ρ &gt; 0.9; <em>P</em> &lt; .001) and is influenced by anatomical parameters with equal strength. Isolated observation of the intraluminal thrombus does not provide significant information in the determination of PWS. The maximum AAA diameter in 2D-US shows a fair negative correlation with the mean circumferential, longitudinal and in-plane shear strain (ρ = −0.46; r = −0.45; ρ = −0.47; <em>P</em> &lt; .05 for all). The circumferential strain ratio as an indicator of wall motion heterogeneity increases with the aneurysm diameter (r = 0.47; <em>P</em> &lt; .05). The direct comparison of wall strain and wall stress indices shows no quantitative correlation.</p></div><div><h3>Conclusions</h3><p>The strain and stress analyses provide independent biomechanical information of AAAs. At the current stage of development, the two methods are considered complementary and may optimize a more patient-specific rupture risk prediction in the future.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000105/pdfft?md5=42932adee70e336a4d63c951df71ba17&pid=1-s2.0-S2666350324000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new large animal model in venous thromboembolism","authors":"Marianna Pavlyha MD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100201","DOIUrl":"10.1016/j.jvssci.2024.100201","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000129/pdfft?md5=e6ebf231f7fca24919583ae2373db5c7&pid=1-s2.0-S2666350324000129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140276996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia inducible factor 1-alpha in the pathogenesis of abdominal aortic aneurysms in vivo: A narrative review","authors":"Peter James Bruhn MD ,&nbsp;Majken Lyhne Jessen MD ,&nbsp;Jonas Eiberg MD, PhD ,&nbsp;Qasam Ghulam MD, PhD","doi":"10.1016/j.jvssci.2023.100189","DOIUrl":"10.1016/j.jvssci.2023.100189","url":null,"abstract":"<div><p>Abdominal aortic aneurysms (AAAs) are relatively common, primarily among older men, and, in the case of rupture, are associated with high mortality. Although procedure-related morbidity and mortality have improved with the advent of endovascular repair, noninvasive treatment and improved assessment of AAA rupture risk should still be sought. Several cellular pathways seem contributory to the histopathologic changes that drive AAA growth and rupture. Hypoxia inducible factor 1-alpha (HIF-1α) is an oxygen-sensitive protein that accumulates in the cytoplasm under hypoxic conditions and regulates a wide array of downstream effectors to hypoxia. Examining the potential role of HIF-1α in the pathogenesis of AAAs is alluring, because local hypoxia is known to be present in the AAA vessel wall. A systematic scoping review was performed to review the current evidence regarding the role of HIF-1α in AAA disease in vivo. After screening, 17 studies were included in the analysis. Experimental animal studies and human studies show increased HIF-1α activity in AAA tissue compared with healthy aorta and a correlation of HIF-1α activity with key histopathologic features of AAA disease. In vivo HIF-1α inhibition in animals protects against AAA development and growth. One study reveals a positive correlation between HIF-1α–activating genetic polymorphisms and the risk of AAA disease in humans. The main findings suggest a causal role of HIF-1α in the pathogenesis of AAAs in vivo. Further research into the HIF-1α pathway in AAA disease might reveal clinically applicable pharmacologic targets or biomarkers relevant in the treatment and monitoring of AAA disease.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000937/pdfft?md5=e74bfdf09e3161db2aaec1f065cf1e87&pid=1-s2.0-S2666350323000937-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new rat model of aortic sympathetic denervation","authors":"Marianna Pavlyha MD ,&nbsp;Alan Dardik MD, PhD","doi":"10.1016/j.jvssci.2024.100205","DOIUrl":"10.1016/j.jvssci.2024.100205","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000166/pdfft?md5=557a5ee8bf03c9370cb9fb68eab23552&pid=1-s2.0-S2666350324000166-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validating Artificial Intelligence-Assisted Classification of Peripheral Arterial Disease Lesion Composition From 9.4 Tesla Magnetic Resonance Imaging With Histology","authors":"Judit Csore,&nbsp;Christof Karmonik,&nbsp;Bright Benfor,&nbsp;Peter Osztrogonacz,&nbsp;Trisha Roy","doi":"10.1016/j.jvssci.2024.100256","DOIUrl":"10.1016/j.jvssci.2024.100256","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}