JVS-vascular science最新文献_第8页

A new large animal model in venous thromboembolism 静脉血栓栓塞症的新型大型动物模型

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100201

Marianna Pavlyha MD , Alan Dardik MD, PhD

引用次数: 0

Hypoxia inducible factor 1-alpha in the pathogenesis of abdominal aortic aneurysms in vivo: A narrative review 腹主动脉瘤体内发病机制中的 HIF-1α：叙述性综述

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2023.100189

Peter James Bruhn MD , Majken Lyhne Jessen MD , Jonas Eiberg MD, PhD , Qasam Ghulam MD, PhD

{"title":"Hypoxia inducible factor 1-alpha in the pathogenesis of abdominal aortic aneurysms in vivo: A narrative review","authors":"Peter James Bruhn MD , Majken Lyhne Jessen MD , Jonas Eiberg MD, PhD , Qasam Ghulam MD, PhD","doi":"10.1016/j.jvssci.2023.100189","DOIUrl":"10.1016/j.jvssci.2023.100189","url":null,"abstract":"<div><p>Abdominal aortic aneurysms (AAAs) are relatively common, primarily among older men, and, in the case of rupture, are associated with high mortality. Although procedure-related morbidity and mortality have improved with the advent of endovascular repair, noninvasive treatment and improved assessment of AAA rupture risk should still be sought. Several cellular pathways seem contributory to the histopathologic changes that drive AAA growth and rupture. Hypoxia inducible factor 1-alpha (HIF-1α) is an oxygen-sensitive protein that accumulates in the cytoplasm under hypoxic conditions and regulates a wide array of downstream effectors to hypoxia. Examining the potential role of HIF-1α in the pathogenesis of AAAs is alluring, because local hypoxia is known to be present in the AAA vessel wall. A systematic scoping review was performed to review the current evidence regarding the role of HIF-1α in AAA disease in vivo. After screening, 17 studies were included in the analysis. Experimental animal studies and human studies show increased HIF-1α activity in AAA tissue compared with healthy aorta and a correlation of HIF-1α activity with key histopathologic features of AAA disease. In vivo HIF-1α inhibition in animals protects against AAA development and growth. One study reveals a positive correlation between HIF-1α–activating genetic polymorphisms and the risk of AAA disease in humans. The main findings suggest a causal role of HIF-1α in the pathogenesis of AAAs in vivo. Further research into the HIF-1α pathway in AAA disease might reveal clinically applicable pharmacologic targets or biomarkers relevant in the treatment and monitoring of AAA disease.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000937/pdfft?md5=e74bfdf09e3161db2aaec1f065cf1e87&pid=1-s2.0-S2666350323000937-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new rat model of aortic sympathetic denervation 一种新的大鼠主动脉交感神经剥夺模型

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100205

Marianna Pavlyha MD , Alan Dardik MD, PhD

引用次数: 0

Validating Artificial Intelligence-Assisted Classification of Peripheral Arterial Disease Lesion Composition From 9.4 Tesla Magnetic Resonance Imaging With Histology 人工智能辅助外周动脉病变病变组成分类的9.4特斯拉磁共振成像组织学验证

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100256

Judit Csore, Christof Karmonik, Bright Benfor, Peter Osztrogonacz, Trisha Roy

引用次数: 0

Aortic Arch Endovascular Stent Grafts With Zone 0 Proximal Landing Zones For Geometrically Complex Aortas 0区近端着陆区的主动脉弓血管内支架移植治疗几何形状复杂的主动脉

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100266

Kelly Twohig, Joseph Pugar, Ian McDougall, Luka Pocivavsek

引用次数: 0

Nano-Based Perivascular Intervention Sustains a Nine-Month Long-Term Suppression of Intimal Hyperplasia in Vein Grafts 纳米血管周围干预维持9个月长期抑制血管移植物内膜增生

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100223

Yitao Huang, Takuro Shirasu, Go Urabe, Nisakorn Yodsanit, Matthew Stratton, Matthew Joseph, Ruosen Xie, Yuyuan Wang, Lynn M. Marcho, Jing Li, Runze Tang, Ki Ho Park, Bowen Wang, K. Craig Kent, Shaoqin Gong, Lian-Wang Guo

引用次数: 0

Toll-like receptor 4, a potential therapeutic target of lower limb ischemic myopathy that raises further questions Toll-Like 受体 4--下肢缺血性肌病的潜在治疗靶点，引发更多疑问

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100195

Ali H. Hakim MD , Ulf Hedin MD, PhD

引用次数: 0

Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model 猪双心室压力-容积环路的技术和分析方法，包括完全血管内、经皮闭胸大型动物模型

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100190

David P. Stonko MD, MS , Mathieu C. Rousseau MD , Colin Price BS , Amy Benike MS , Rebecca N. Treffalls BS , Nichole E. Brunton DO , Dorian Rosen PhD , Jonathan J. Morrison MBChB, PhD

{"title":"Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model","authors":"David P. Stonko MD, MS , Mathieu C. Rousseau MD , Colin Price BS , Amy Benike MS , Rebecca N. Treffalls BS , Nichole E. Brunton DO , Dorian Rosen PhD , Jonathan J. Morrison MBChB, PhD","doi":"10.1016/j.jvssci.2024.100190","DOIUrl":"10.1016/j.jvssci.2024.100190","url":null,"abstract":"<div><p>Pressure-volume (PV) loop analysis is a sophisticated invasive approach to quantifying load-dependent and independent measures of cardiac function. Biventricular (BV) PV loops allow left and right ventricular function to be quantified simultaneously and independently, which is important for conditions and certain physiologic states, such as ventricular decoupling or acute physiologic changes. BV PV loops can be performed in an entirely endovascular, percutaneous, and closed-chest setting. This technique is helpful in a survival animal model, as a percutaneous monitoring system during endovascular device experiments, or in cases where chest wall compliance is being tested or may be a confounder. In this article, we describe the end-to-end implementation of a completely endovascular, totally percutaneous, and closed-chest large animal model to obtain contemporaneous BV PV loops in 40 to 70 kg swine. We describe the associated surgical and technical challenges and our solutions to obtaining endovascular BV PV loops, closed-chest cardiac output, and stroke volume (including validation of the correction factor necessary for thermodilution), as well as how to perform endovascular inferior vena cava occlusion in this swine model. We also include techniques for data acquisition and analysis that are required for this method.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000014/pdfft?md5=e902bcba624ca754a31ab13d638a2cee&pid=1-s2.0-S2666350324000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Chronic E-cigarette Nicotine Exposure On A Mouse Model of Hind-limb Ischemia 慢性电子烟尼古丁暴露对小鼠后肢缺血模型的影响

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100238

Maryam Amirahmadi, Philip S. Tsao

引用次数: 0

Knockout of P27Kip1 Accelerates Topical Elastase/3-aminopropionitrile Fumarate Salt-Induced Abdominal Aortic Aneurysm Rupture In Mice 敲除P27Kip1加速外用Elastase/3-氨基丙腈富马酸盐诱导的小鼠腹主动脉瘤破裂

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100252

Keisuke Kamada, Hong Niu, Kevin Kim, Hui Liu, Gale L. Tang

引用次数: 0