JVS-vascular science最新文献_第8页

Hypoxia inducible factor 1-alpha in the pathogenesis of abdominal aortic aneurysms in vivo: A narrative review 腹主动脉瘤体内发病机制中的 HIF-1α：叙述性综述

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2023.100189

Peter James Bruhn MD , Majken Lyhne Jessen MD , Jonas Eiberg MD, PhD , Qasam Ghulam MD, PhD

{"title":"Hypoxia inducible factor 1-alpha in the pathogenesis of abdominal aortic aneurysms in vivo: A narrative review","authors":"Peter James Bruhn MD , Majken Lyhne Jessen MD , Jonas Eiberg MD, PhD , Qasam Ghulam MD, PhD","doi":"10.1016/j.jvssci.2023.100189","DOIUrl":"10.1016/j.jvssci.2023.100189","url":null,"abstract":"<div><p>Abdominal aortic aneurysms (AAAs) are relatively common, primarily among older men, and, in the case of rupture, are associated with high mortality. Although procedure-related morbidity and mortality have improved with the advent of endovascular repair, noninvasive treatment and improved assessment of AAA rupture risk should still be sought. Several cellular pathways seem contributory to the histopathologic changes that drive AAA growth and rupture. Hypoxia inducible factor 1-alpha (HIF-1α) is an oxygen-sensitive protein that accumulates in the cytoplasm under hypoxic conditions and regulates a wide array of downstream effectors to hypoxia. Examining the potential role of HIF-1α in the pathogenesis of AAAs is alluring, because local hypoxia is known to be present in the AAA vessel wall. A systematic scoping review was performed to review the current evidence regarding the role of HIF-1α in AAA disease in vivo. After screening, 17 studies were included in the analysis. Experimental animal studies and human studies show increased HIF-1α activity in AAA tissue compared with healthy aorta and a correlation of HIF-1α activity with key histopathologic features of AAA disease. In vivo HIF-1α inhibition in animals protects against AAA development and growth. One study reveals a positive correlation between HIF-1α–activating genetic polymorphisms and the risk of AAA disease in humans. The main findings suggest a causal role of HIF-1α in the pathogenesis of AAAs in vivo. Further research into the HIF-1α pathway in AAA disease might reveal clinically applicable pharmacologic targets or biomarkers relevant in the treatment and monitoring of AAA disease.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350323000937/pdfft?md5=e74bfdf09e3161db2aaec1f065cf1e87&pid=1-s2.0-S2666350323000937-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new rat model of aortic sympathetic denervation 一种新的大鼠主动脉交感神经剥夺模型

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100205

Marianna Pavlyha MD , Alan Dardik MD, PhD

引用次数: 0

Aortic Arch Endovascular Stent Grafts With Zone 0 Proximal Landing Zones For Geometrically Complex Aortas

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100266

Kelly Twohig, Joseph Pugar, Ian McDougall, Luka Pocivavsek

引用次数: 0

Nano-Based Perivascular Intervention Sustains a Nine-Month Long-Term Suppression of Intimal Hyperplasia in Vein Grafts

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100223

Yitao Huang, Takuro Shirasu, Go Urabe, Nisakorn Yodsanit, Matthew Stratton, Matthew Joseph, Ruosen Xie, Yuyuan Wang, Lynn M. Marcho, Jing Li, Runze Tang, Ki Ho Park, Bowen Wang, K. Craig Kent, Shaoqin Gong, Lian-Wang Guo

引用次数: 0

Validating Artificial Intelligence-Assisted Classification of Peripheral Arterial Disease Lesion Composition From 9.4 Tesla Magnetic Resonance Imaging With Histology

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100256

Judit Csore, Christof Karmonik, Bright Benfor, Peter Osztrogonacz, Trisha Roy

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Toll-like receptor 4, a potential therapeutic target of lower limb ischemic myopathy that raises further questions Toll-Like 受体 4--下肢缺血性肌病的潜在治疗靶点，引发更多疑问

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100195

Ali H. Hakim MD , Ulf Hedin MD, PhD

引用次数: 0

Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model 猪双心室压力-容积环路的技术和分析方法，包括完全血管内、经皮闭胸大型动物模型

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100190

David P. Stonko MD, MS , Mathieu C. Rousseau MD , Colin Price BS , Amy Benike MS , Rebecca N. Treffalls BS , Nichole E. Brunton DO , Dorian Rosen PhD , Jonathan J. Morrison MBChB, PhD

{"title":"Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model","authors":"David P. Stonko MD, MS , Mathieu C. Rousseau MD , Colin Price BS , Amy Benike MS , Rebecca N. Treffalls BS , Nichole E. Brunton DO , Dorian Rosen PhD , Jonathan J. Morrison MBChB, PhD","doi":"10.1016/j.jvssci.2024.100190","DOIUrl":"10.1016/j.jvssci.2024.100190","url":null,"abstract":"<div><p>Pressure-volume (PV) loop analysis is a sophisticated invasive approach to quantifying load-dependent and independent measures of cardiac function. Biventricular (BV) PV loops allow left and right ventricular function to be quantified simultaneously and independently, which is important for conditions and certain physiologic states, such as ventricular decoupling or acute physiologic changes. BV PV loops can be performed in an entirely endovascular, percutaneous, and closed-chest setting. This technique is helpful in a survival animal model, as a percutaneous monitoring system during endovascular device experiments, or in cases where chest wall compliance is being tested or may be a confounder. In this article, we describe the end-to-end implementation of a completely endovascular, totally percutaneous, and closed-chest large animal model to obtain contemporaneous BV PV loops in 40 to 70 kg swine. We describe the associated surgical and technical challenges and our solutions to obtaining endovascular BV PV loops, closed-chest cardiac output, and stroke volume (including validation of the correction factor necessary for thermodilution), as well as how to perform endovascular inferior vena cava occlusion in this swine model. We also include techniques for data acquisition and analysis that are required for this method.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000014/pdfft?md5=e902bcba624ca754a31ab13d638a2cee&pid=1-s2.0-S2666350324000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smooth Muscle Cell Tgf-β Receptor Knockout Improves Arteriovenous Fistula Maturation Via Attenuation of Autophagy

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100222

Weichang Zhang, Hualong Bai, Luis Gonzalez, Zhuo Li, Yuichi Ohashi, Carly Thaxton, Yukihiko Aoyagi, Bogdan Yatsula, Masaki Kano, Yangzhouyun Xie, Yujun Cai, Shu Chang, Alan Dardik

引用次数: 0

Effect of Chronic E-cigarette Nicotine Exposure On A Mouse Model of Hind-limb Ischemia

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100238

Maryam Amirahmadi, Philip S. Tsao

引用次数: 0

Knockout of P27Kip1 Accelerates Topical Elastase/3-aminopropionitrile Fumarate Salt-Induced Abdominal Aortic Aneurysm Rupture In Mice

JVS-vascular science Pub Date : 2024-01-01 DOI: 10.1016/j.jvssci.2024.100252

Keisuke Kamada, Hong Niu, Kevin Kim, Hui Liu, Gale L. Tang

引用次数: 0