Yitao Huang, Takuro Shirasu, Go Urabe, Nisakorn Yodsanit, Matthew Stratton, Matthew Joseph, Ruosen Xie, Yuyuan Wang, Lynn M. Marcho, Jing Li, Runze Tang, Ki Ho Park, Bowen Wang, K. Craig Kent, Shaoqin Gong, Lian-Wang Guo
{"title":"Nano-Based Perivascular Intervention Sustains a Nine-Month Long-Term Suppression of Intimal Hyperplasia in Vein Grafts","authors":"Yitao Huang, Takuro Shirasu, Go Urabe, Nisakorn Yodsanit, Matthew Stratton, Matthew Joseph, Ruosen Xie, Yuyuan Wang, Lynn M. Marcho, Jing Li, Runze Tang, Ki Ho Park, Bowen Wang, K. Craig Kent, Shaoqin Gong, Lian-Wang Guo","doi":"10.1016/j.jvssci.2024.100223","DOIUrl":"10.1016/j.jvssci.2024.100223","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toll-like receptor 4, a potential therapeutic target of lower limb ischemic myopathy that raises further questions","authors":"Ali H. Hakim MD , Ulf Hedin MD, PhD","doi":"10.1016/j.jvssci.2024.100195","DOIUrl":"10.1016/j.jvssci.2024.100195","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000063/pdfft?md5=f8e84094eb706ee57b0a7c200c648cbb&pid=1-s2.0-S2666350324000063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David P. Stonko MD, MS , Mathieu C. Rousseau MD , Colin Price BS , Amy Benike MS , Rebecca N. Treffalls BS , Nichole E. Brunton DO , Dorian Rosen PhD , Jonathan J. Morrison MBChB, PhD
{"title":"Technical and analytical approach to biventricular pressure-volume loops in swine including a completely endovascular, percutaneous closed-chest large animal model","authors":"David P. Stonko MD, MS , Mathieu C. Rousseau MD , Colin Price BS , Amy Benike MS , Rebecca N. Treffalls BS , Nichole E. Brunton DO , Dorian Rosen PhD , Jonathan J. Morrison MBChB, PhD","doi":"10.1016/j.jvssci.2024.100190","DOIUrl":"10.1016/j.jvssci.2024.100190","url":null,"abstract":"<div><p>Pressure-volume (PV) loop analysis is a sophisticated invasive approach to quantifying load-dependent and independent measures of cardiac function. Biventricular (BV) PV loops allow left and right ventricular function to be quantified simultaneously and independently, which is important for conditions and certain physiologic states, such as ventricular decoupling or acute physiologic changes. BV PV loops can be performed in an entirely endovascular, percutaneous, and closed-chest setting. This technique is helpful in a survival animal model, as a percutaneous monitoring system during endovascular device experiments, or in cases where chest wall compliance is being tested or may be a confounder. In this article, we describe the end-to-end implementation of a completely endovascular, totally percutaneous, and closed-chest large animal model to obtain contemporaneous BV PV loops in 40 to 70 kg swine. We describe the associated surgical and technical challenges and our solutions to obtaining endovascular BV PV loops, closed-chest cardiac output, and stroke volume (including validation of the correction factor necessary for thermodilution), as well as how to perform endovascular inferior vena cava occlusion in this swine model. We also include techniques for data acquisition and analysis that are required for this method.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000014/pdfft?md5=e902bcba624ca754a31ab13d638a2cee&pid=1-s2.0-S2666350324000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139639781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Chronic E-cigarette Nicotine Exposure On A Mouse Model of Hind-limb Ischemia","authors":"Maryam Amirahmadi, Philip S. Tsao","doi":"10.1016/j.jvssci.2024.100238","DOIUrl":"10.1016/j.jvssci.2024.100238","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shruti Rawal, Akm Khyrul Wara, Madhur Sachan, Camila de Oliveira Vaz, Vinay Randhawa, Mark W. Feinberg
{"title":"Therapeutic Delivery of MICRORNA-369-3p Promotes Atherosclerosis Regression in Diabetic Mice by Regulating Bone Marrow Myeloid Progenitors","authors":"Shruti Rawal, Akm Khyrul Wara, Madhur Sachan, Camila de Oliveira Vaz, Vinay Randhawa, Mark W. Feinberg","doi":"10.1016/j.jvssci.2024.100229","DOIUrl":"10.1016/j.jvssci.2024.100229","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Cruz-González MD , James F. Meschia MD , Benjamin J. Madden BSc , Mercedes Prudencio PhD , Camilo A. Polania-Sandoval MD , Janelle Hartwell BS , Eniola Oyefeso BS , Ranya Benchaaboune , Tara Brigham MLIS , Sukhwinder J.S. Sandhu MD , Cristine Charlesworth PhD, MS , Ganesh P. Pujari MD , Leonard Petrucelli PhD , Akhilesh Pandey MD, PhD , Young Erben MD
{"title":"Recent advances in proteomic analysis to study carotid artery plaques","authors":"Gabriel Cruz-González MD , James F. Meschia MD , Benjamin J. Madden BSc , Mercedes Prudencio PhD , Camilo A. Polania-Sandoval MD , Janelle Hartwell BS , Eniola Oyefeso BS , Ranya Benchaaboune , Tara Brigham MLIS , Sukhwinder J.S. Sandhu MD , Cristine Charlesworth PhD, MS , Ganesh P. Pujari MD , Leonard Petrucelli PhD , Akhilesh Pandey MD, PhD , Young Erben MD","doi":"10.1016/j.jvssci.2024.100215","DOIUrl":"10.1016/j.jvssci.2024.100215","url":null,"abstract":"<div><h3>Objective</h3><p>We sought to identify differentially expressed proteins in serum, plasma, and plaque samples of patients with carotid atherosclerotic lesions.</p></div><div><h3>Methods</h3><p>We performed a systematic review of the proteomic profile of serum, plasma, and plaque samples of patients with carotid artery disease. We included full-length peer-reviewed studies of adult humans and reported them using PRISMA guidelines. The quality of the design and content of the articles included in the review was assessed using the Newcastle-Ottawa scale.</p></div><div><h3>Results</h3><p>We included six peer-reviewed articles reporting protein expression in serum, plasma, or plaque samples from patients with carotid atherosclerosis. Three were single-center cross-sectional studies, two were single-center case-control studies, and one was a single-center cohort study. Thirty-six proteins were found to be expressed differentially when comparing samples from healthy subjects and individuals with diseased carotid vessels and between patients with symptomatic and asymptomatic carotid artery atherosclerotic lesions. Some of these were shown to be related to inflammatory or anti-inflammatory pathways in atherogenesis. CD5L and S100A12 were both found to be upregulated in patients with unstable plaque, the former owing to its anti-inflammatory properties and the latter for its pro-oxidant effects in atherosclerosis. ACTB is involved in cellular structure and integrity and was found to be downregulated in patients with ruptured carotid plaques.</p></div><div><h3>Conclusions</h3><p>Atherosclerotic carotid disease places the patient at increased risk of ischemic neurological events. Proteomics may help to understand their pathophysiological processes and can identify differential protein expression in blood samples from healthy subjects and patients with carotid artery plaques. This patient-centered approach will allow for the timely identification of individuals at higher risk of experiencing stroke.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000269/pdfft?md5=0724ce0ddb26f766af2d098433cbd988&pid=1-s2.0-S2666350324000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}