Shruti Rawal, Akm Khyrul Wara, Madhur Sachan, Camila de Oliveira Vaz, Vinay Randhawa, Mark W. Feinberg
{"title":"Therapeutic Delivery of MICRORNA-369-3p Promotes Atherosclerosis Regression in Diabetic Mice by Regulating Bone Marrow Myeloid Progenitors","authors":"Shruti Rawal, Akm Khyrul Wara, Madhur Sachan, Camila de Oliveira Vaz, Vinay Randhawa, Mark W. Feinberg","doi":"10.1016/j.jvssci.2024.100229","DOIUrl":"10.1016/j.jvssci.2024.100229","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Cruz-González MD , James F. Meschia MD , Benjamin J. Madden BSc , Mercedes Prudencio PhD , Camilo A. Polania-Sandoval MD , Janelle Hartwell BS , Eniola Oyefeso BS , Ranya Benchaaboune , Tara Brigham MLIS , Sukhwinder J.S. Sandhu MD , Cristine Charlesworth PhD, MS , Ganesh P. Pujari MD , Leonard Petrucelli PhD , Akhilesh Pandey MD, PhD , Young Erben MD
{"title":"Recent advances in proteomic analysis to study carotid artery plaques","authors":"Gabriel Cruz-González MD , James F. Meschia MD , Benjamin J. Madden BSc , Mercedes Prudencio PhD , Camilo A. Polania-Sandoval MD , Janelle Hartwell BS , Eniola Oyefeso BS , Ranya Benchaaboune , Tara Brigham MLIS , Sukhwinder J.S. Sandhu MD , Cristine Charlesworth PhD, MS , Ganesh P. Pujari MD , Leonard Petrucelli PhD , Akhilesh Pandey MD, PhD , Young Erben MD","doi":"10.1016/j.jvssci.2024.100215","DOIUrl":"10.1016/j.jvssci.2024.100215","url":null,"abstract":"<div><h3>Objective</h3><p>We sought to identify differentially expressed proteins in serum, plasma, and plaque samples of patients with carotid atherosclerotic lesions.</p></div><div><h3>Methods</h3><p>We performed a systematic review of the proteomic profile of serum, plasma, and plaque samples of patients with carotid artery disease. We included full-length peer-reviewed studies of adult humans and reported them using PRISMA guidelines. The quality of the design and content of the articles included in the review was assessed using the Newcastle-Ottawa scale.</p></div><div><h3>Results</h3><p>We included six peer-reviewed articles reporting protein expression in serum, plasma, or plaque samples from patients with carotid atherosclerosis. Three were single-center cross-sectional studies, two were single-center case-control studies, and one was a single-center cohort study. Thirty-six proteins were found to be expressed differentially when comparing samples from healthy subjects and individuals with diseased carotid vessels and between patients with symptomatic and asymptomatic carotid artery atherosclerotic lesions. Some of these were shown to be related to inflammatory or anti-inflammatory pathways in atherogenesis. CD5L and S100A12 were both found to be upregulated in patients with unstable plaque, the former owing to its anti-inflammatory properties and the latter for its pro-oxidant effects in atherosclerosis. ACTB is involved in cellular structure and integrity and was found to be downregulated in patients with ruptured carotid plaques.</p></div><div><h3>Conclusions</h3><p>Atherosclerotic carotid disease places the patient at increased risk of ischemic neurological events. Proteomics may help to understand their pathophysiological processes and can identify differential protein expression in blood samples from healthy subjects and patients with carotid artery plaques. This patient-centered approach will allow for the timely identification of individuals at higher risk of experiencing stroke.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666350324000269/pdfft?md5=0724ce0ddb26f766af2d098433cbd988&pid=1-s2.0-S2666350324000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thijs J. Sluiter MSc , Lucinda Cruddas MBBS , Federica Ninno MRes , Thomas Schmitz-Rixen MD, PhD , Janice Tsui MD, FRCS , Margreet R. de Vries PhD
{"title":"Basic Vascular Science 2024 Meeting","authors":"Thijs J. Sluiter MSc , Lucinda Cruddas MBBS , Federica Ninno MRes , Thomas Schmitz-Rixen MD, PhD , Janice Tsui MD, FRCS , Margreet R. de Vries PhD","doi":"10.1016/j.jvssci.2024.100210","DOIUrl":"10.1016/j.jvssci.2024.100210","url":null,"abstract":"<div><p>The Basic Vascular Science (BVS) meeting was set up to provide a forum for researchers and clinicians in the field to exchange knowledge and ideas and to foster cross-disciplinary collaborations. The BVS 2024 meeting was held in Berlin. Attended by vascular surgeons and physicians, interventional radiologists, basic science researchers, and engineers, the meeting continues to successfully attract both early career researchers and established clinician-scientists. Here, we report on the scientific sessions encompassing keynote lectures and oral presentations.</p></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266635032400021X/pdfft?md5=a901ea037bdb368d4a77d022a15f8357&pid=1-s2.0-S266635032400021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael G. Levin, Shaunak Adkar, Jonas Ghouse, John Depaolo, Ole BV. Pedersen, Sisse Ostrowski, Julie Lynch, Henning Bundgaard, Scott M. Damrauer, Derek Klarin
{"title":"Genetic Variation Associated With Progression and Severity of Peripheral Artery Disease","authors":"Michael G. Levin, Shaunak Adkar, Jonas Ghouse, John Depaolo, Ole BV. Pedersen, Sisse Ostrowski, Julie Lynch, Henning Bundgaard, Scott M. Damrauer, Derek Klarin","doi":"10.1016/j.jvssci.2024.100237","DOIUrl":"10.1016/j.jvssci.2024.100237","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143131244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaunak Adkar, Sabina Sorondo, Mozhgan Lotfi, Sharika Bamezai, Ryan Choi, Ole Dyg Pedersen, Sisse Ostrowski, Jonas Ghouse, Henning Bundgaard, Michael Levin, Scott M. Damrauer, Nicholas J. Leeper, Derek Klarin
{"title":"Soluble Guanylate Cyclase Activators as Potential Novel Pad Therapeutics","authors":"Shaunak Adkar, Sabina Sorondo, Mozhgan Lotfi, Sharika Bamezai, Ryan Choi, Ole Dyg Pedersen, Sisse Ostrowski, Jonas Ghouse, Henning Bundgaard, Michael Levin, Scott M. Damrauer, Nicholas J. Leeper, Derek Klarin","doi":"10.1016/j.jvssci.2024.100218","DOIUrl":"10.1016/j.jvssci.2024.100218","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jillian Poles, Lakshmi Arivazhagan, Vikas Kumar, Ann Marie Marie Schmidt
{"title":"Cofilin 1 Mediates Fatty Acid-Induced Foam Cell Formation And Inflammation In Mouse Bone Marrow-derived Macrophages","authors":"Jillian Poles, Lakshmi Arivazhagan, Vikas Kumar, Ann Marie Marie Schmidt","doi":"10.1016/j.jvssci.2024.100240","DOIUrl":"10.1016/j.jvssci.2024.100240","url":null,"abstract":"","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"5 ","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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