Journal of Yeungnam medical science最新文献_第3页

Unusual Serratia marcescens pleural infection in secondary spontaneous pneumothorax: a case report. 继发性自发性气胸并发罕见粘质沙雷菌胸膜感染1例。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.12701/jyms.2025.42.35

Asem Ali Ashraf, Sayantani Nag, Vimal Kumar Karnaker

{"title":"Unusual Serratia marcescens pleural infection in secondary spontaneous pneumothorax: a case report.","authors":"Asem Ali Ashraf, Sayantani Nag, Vimal Kumar Karnaker","doi":"10.12701/jyms.2025.42.35","DOIUrl":"10.12701/jyms.2025.42.35","url":null,"abstract":"Serratia marcescens is an opportunistic gram-negative pathogen that causes pneumonia, bloodstream infections, and urinary tract infections, particularly in individuals who are immunocompromised. Although commonly associated with pulmonary infections, its involvement in pneumothorax-related infections is exceedingly rare. Secondary spontaneous pneumothorax (SSP) is a life-threatening condition that can complicate underlying lung diseases, such as chronic obstructive pulmonary disease (COPD). This case report describes a rare presentation of S. marcescens infection in a patient with SSP complicated by a bronchopleural fistula. A 64-year-old male with a history of COPD, chronic smoking, and alcohol use presented with progressive dyspnea, cough, and left-sided chest pain. Clinical evaluation revealed tachypnea, tracheal deviation, and reduced breath sounds in the left lung. Laboratory investigations revealed leukocytosis with marked neutrophilia and an elevated erythrocyte sedimentation rate. Chest imaging confirmed pneumothorax, necessitating intercostal drain (ICD) placement. Pleural fluid cultures identified multidrug-resistant S. marcescens, prompting antibiotic escalation to intravenous meropenem and oral faropenem. Despite prolonged antimicrobial therapy and ICD placement, persistent pneumothorax with a bronchopleural fistula was noted. Bronchoscopy with Fogarty balloon placement and cyanoacrylate closure was performed. However, owing to financial constraints, the patient declined follow-up cultures and high-resolution computed tomography imaging, and was discharged with an ICD in situ. This case underscores the need for heightened clinical awareness of S. marcescens in pneumothorax-associated infections. Early microbiological identification and targeted therapy are crucial for the management of rare yet challenging presentations, particularly in resource-limited settings.","PeriodicalId":74020,"journal":{"name":"Journal of Yeungnam medical science","volume":"42 ","pages":"35"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 30-year-old male patient who experienced recurring weakness in bilateral upper and lower extremities: a clinical vignette. 一个30岁的男性患者谁经历了反复无力在双侧上肢和下肢：临床小插曲。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.12701/jyms.2025.42.27

Soo Hyun Ahn, Mathieu Boudier-Revéret, Seoyon Yang, Min Cheol Chang

引用次数: 0

Patient-specific predictors of successful frozen embryo transfer using the freeze-all protocol: a retrospective observational study. 使用冷冻全部方案成功冷冻胚胎移植的患者特异性预测因素：一项回顾性观察研究。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.12701/jyms.2025.42.28

Hyun Joo Lee, Eun Hee Yu, Jong Kil Joo

{"title":"Patient-specific predictors of successful frozen embryo transfer using the freeze-all protocol: a retrospective observational study.","authors":"Hyun Joo Lee, Eun Hee Yu, Jong Kil Joo","doi":"10.12701/jyms.2025.42.28","DOIUrl":"10.12701/jyms.2025.42.28","url":null,"abstract":"Background: The aim of this study was to examine various patient factors affecting first programmed embryo transfer (ET) outcomes under the freeze-all policy at a single tertiary university infertility center.Methods: This retrospective observational study reviewed the medical records of 243 couples who underwent their first ET using blastocysts collected under the freeze-all antagonist-controlled ovarian stimulation (COS) protocol from 2015 to 2023. Patients were grouped into pregnant and nonpregnant groups, and their data, including demographics, COS and ET outcomes, and embryo storage duration, were analyzed.Results: Patient body mass index, cause of infertility, follicle-to-oocyte index, distribution of blastocyst grades, number of transferred embryos, and embryo storage duration were not significantly different between the groups. In a simple comparative analysis, patients with successful clinical pregnancy tended to have significantly lower female and male age (33.83±3.67 and 35.32±4.54 years vs. 37.07±4.15 and 39.33±5.60 years, respectively), higher anti-Müllerian hormone levels (6.27±5.32 ng/mL vs. 4.14±3.82 ng/mL) and antral follicle counts (14.20±8.26 vs. 10.04±5.75), and higher numbers of retrieved oocytes and metaphase II oocytes (13.74±6.92 and 9.64±6.19 vs. 11.21±6.04 and 7.53±5.56, respectively). Multivariate logistic regression analysis of these variables revealed that only male age was a significant factor for successful clinical pregnancy (odds ratio, 4.768; 95% confidence interval, 1.252-18.162; p=0.022).Conclusion: During the first programmed ET using blastocysts collected under the freeze-all antagonist COS protocol, male age and correspondingly the quality of gametes for fertilization were crucial for successful pregnancy, having more importance than calculated female ovarian reserve and embryo storage duration.","PeriodicalId":74020,"journal":{"name":"Journal of Yeungnam medical science","volume":"42 ","pages":"28"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in hepatocellular carcinoma: hepatocarcinogenesis, role of exosomal noncoding RNAs, and diagnostic pathology. 肝细胞癌研究进展：肝癌发生、外泌体非编码 RNA 的作用以及病理诊断。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.12701/jyms.2024.01221

Joon Hyuk Choi

引用次数: 0

Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review. 以肝癌干细胞的细胞起源为重点的肝癌发生概述：叙事性综述。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.12701/jyms.2024.01088

Jong Ryeol Eun

{"title":"Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review.","authors":"Jong Ryeol Eun","doi":"10.12701/jyms.2024.01088","DOIUrl":"10.12701/jyms.2024.01088","url":null,"abstract":"Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers and generally has a poor prognosis. The hierarchical model, which posits that HCC originates from liver cancer stem cells (CSCs), is now widely accepted, as it is for other cancer types. As CSCs typically reside in the G0 phase of the cell cycle, they are resistant to conventional chemotherapy. Therefore, to effectively treat HCC, developing therapeutic strategies that target liver CSCs is essential. Clinically, HCCs exhibit a broad spectrum of pathological and clinical characteristics, ranging from well-differentiated to poorly differentiated forms, and from slow-growing tumors to aggressive ones with significant metastatic potential. Some patients with HCC also show features of cholangiocarcinoma. This HCC heterogeneity may arise from the diverse cellular origins of liver CSCs. This review explores the normal physiology of liver regeneration and provides a comprehensive overview of hepatocarcinogenesis, including cancer initiation, isolation of liver CSCs, molecular signaling pathways, and microRNAs. Additionally, the cellular origins of liver CSCs are reviewed, emphasizing hematopoietic and mesenchymal stem cells, along with the well-known hepatocytes and hepatic progenitor cells.","PeriodicalId":74020,"journal":{"name":"Journal of Yeungnam medical science","volume":" ","pages":"3"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium as an adjunct to nimodipine in subarachnoid hemorrhage: a meta-analysis. 镁作为尼莫地平辅助治疗蛛网膜下腔出血：荟萃分析。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-02-02 DOI: 10.12701/jyms.2025.42.26

Riva Satya Radiansyah, Yuri Pamungkas, Ilham Ikhtiar

{"title":"Magnesium as an adjunct to nimodipine in subarachnoid hemorrhage: a meta-analysis.","authors":"Riva Satya Radiansyah, Yuri Pamungkas, Ilham Ikhtiar","doi":"10.12701/jyms.2025.42.26","DOIUrl":"10.12701/jyms.2025.42.26","url":null,"abstract":"Background: Subarachnoid hemorrhage (SAH) is a devastating neurological condition with high morbidity and mortality rates. Although nimodipine is widely used in the management of SAH, the potential benefits of magnesium as adjunct therapy remain unclear. This meta-analysis aimed to evaluate the efficacy and safety of combining magnesium with nimodipine for the management of SAH.Methods: A comprehensive literature search was conducted using PubMed, ScienceDirect, Google Scholar, and the Cochrane Library. Randomized controlled trials and prospective cohort studies comparing magnesium plus nimodipine versus nimodipine alone in patients with SAH were included. Key outcomes included cerebral vasospasm (CV), delayed cerebral ischemia (DCI), functional outcomes, mortality, and adverse events.Results: Twelve studies involving 2,338 patients were included. The combination of magnesium and nimodipine significantly reduced the incidence of CV (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.29-0.95; p=0.03) and DCI (OR, 0.52; 95% CI, 0.31-0.87; p=0.01) compared to nimodipine alone. However, no significant differences were found in functional outcomes (modified Rankin Scale: OR, 0.97; p=0.75; Glasgow Outcome Scale: OR, 0.81; p=0.24), mortality (OR, 0.97; p=0.83), or secondary cerebral infarction (OR, 0.38; p=0.12). The incidence of adverse events was higher in the combination group; however, this difference was not statistically significant (OR, 3.14; p=0.33).Conclusion: Adding magnesium to nimodipine therapy in patients with SAH may help reduce CV and DCI incidence but does not significantly improve functional outcomes or mortality. Further large-scale studies are needed to optimize the dosing regimens and confirm these findings.","PeriodicalId":74020,"journal":{"name":"Journal of Yeungnam medical science","volume":"42 ","pages":"26"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrameniscal ossicle: an overlooked cause of knee pain. 半月板内听骨：膝关节疼痛的一个被忽视的原因。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-06-17 DOI: 10.12701/jyms.2025.42.38

Berkay Yalçınkaya, Ahmet Furkan Çolak, Murat Kara

引用次数: 0

Comparison of ganglion cell-inner plexiform layer thickness among patients with intermittent exotropia according to fixation preference: a retrospective observational study. 根据固定偏好比较间歇性外斜患者神经节细胞-内丛样层厚度：一项回顾性观察研究。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.12701/jyms.2024.00864

Yeon Ju Lim, Soo Jung Lee

{"title":"Comparison of ganglion cell-inner plexiform layer thickness among patients with intermittent exotropia according to fixation preference: a retrospective observational study.","authors":"Yeon Ju Lim, Soo Jung Lee","doi":"10.12701/jyms.2024.00864","DOIUrl":"10.12701/jyms.2024.00864","url":null,"abstract":"Background: This study was performed to compare the thickness of the ganglion cell-inner plexiform layer (GCIPL) depending on the presence or absence of fixation preference in patients with intermittent exotropia (IXT) with refractive values close to emmetropia and with no amblyopia.Methods: The study recruited pediatric patients diagnosed with IXT with a spherical equivalent within ±1.25 diopter and no amblyopia. The patients were categorized into two groups: a monocular exotropia group with fixation preference and an alternating exotropia group without fixation preference. GCIPL thickness was measured using spectral domain optical coherence tomography, and the macula was divided into nine sectors according to the Early Treatment Diabetic Retinopathy Study (ETDRS). GCIPL thickness in each sector was compared between the monocular and alternating exotropia groups.Results: In the monocular exotropia group, GCIPL thickness was significantly thinner in the dominant eye than in the nondominant eye in the S1 sector (91.2±7.4 μm vs. 93.3±5.2 μm, p=0.019). However, in the alternating exotropia group, there were no significant differences between the eyes across all ETDRS sectors. When comparing the interocular differences in GCIPL thickness between the two groups, the monocular exotropia group (absolute value of the dominant eye minus the nondominant eye) exhibited significantly greater differences in several ETDRS sectors than the alternating exotropia group (absolute value of the right eye minus the left eye).Conclusion: The significant interocular difference in GCIPL thickness in the monocular exotropia group suggests that fixation preference may influence the anatomical structure of the macula in patients with IXT.","PeriodicalId":74020,"journal":{"name":"Journal of Yeungnam medical science","volume":" ","pages":"6"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral adrenal adenomas with autonomous cortisol secretion from both glands and autonomous aldosterone secretion from the left adrenal: a case report. 双侧肾上腺腺瘤伴双侧肾上腺自主分泌皮质醇和左肾上腺自主分泌醛固酮：1例报告。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-04-28 DOI: 10.12701/jyms.2025.42.33

Jung Eun Han, Soyeon Yoo, Sang Ah Lee, Gwanpyo Koh

{"title":"Bilateral adrenal adenomas with autonomous cortisol secretion from both glands and autonomous aldosterone secretion from the left adrenal: a case report.","authors":"Jung Eun Han, Soyeon Yoo, Sang Ah Lee, Gwanpyo Koh","doi":"10.12701/jyms.2025.42.33","DOIUrl":"https://doi.org/10.12701/jyms.2025.42.33","url":null,"abstract":"Primary aldosteronism (PA) is the most common cause of secondary hypertension and increases the morbidity and mortality associated with cardiovascular diseases. When PA coexists with autonomous cortisol secretion (ACS), the cardiovascular risk increases significantly, especially in cases of bilateral adrenal adenomas with asymmetric hormone secretion, which poses diagnostic and therapeutic challenges. A 50-year-old female presented with hypertension and hypokalemia. PA was diagnosed based on elevated aldosterone levels, suppressed plasma renin activity, and the results of various dynamic endocrine tests. Imaging revealed bilateral adrenal adenomas, and adrenal venous sampling (AVS) confirmed aldosterone hypersecretion from the left adrenal gland and cortisol hypersecretion from both adrenal glands. The patient subsequently underwent left adrenalectomy, which resolved the aldosterone hypersecretion and normalized blood pressure and potassium levels. However, the cortisol hypersecretion persisted. This case highlights the importance of AVS in identifying the sources of hormone secretion and enabling targeted surgical treatment while avoiding bilateral adrenalectomy, which can lead to lifelong adrenal insufficiency. Comprehensive endocrine evaluation, including ACS assessment, in patients with PA is essential to help reduce the cardiovascular risks associated with PA and ACS and thus improve treatment outcomes.","PeriodicalId":74020,"journal":{"name":"Journal of Yeungnam medical science","volume":"42 ","pages":"33"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Following the snow-covered path to home. 沿着白雪覆盖的小路回家。

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Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2024-11-13 DOI: 10.12701/jyms.2024.01382

引用次数: 0