Journal of trace elements and minerals最新文献

{"title":"Enhanced antibacterial effect of natural tannin stabilized silver nano particles against human pathogens: A target toward FtsZ proteins","authors":"","doi":"10.1016/j.jtemin.2024.100200","DOIUrl":"10.1016/j.jtemin.2024.100200","url":null,"abstract":"<div><h3>Background</h3><div>Tannins are the polyphenolic group of plant compounds having strong antimicrobial potential. Research on human pathogens using silver nanoparticles for antimicrobial purposes has opened up new possibilities in nanomedicine.</div></div><div><h3>Objective</h3><div>The present study was concerned with combining the effectiveness of the two by the green synthesis of silver nanoparticles with plant tannin.</div></div><div><h3>Methods</h3><div>Synthesis of silver nanoparticles was done based on the tannin content of the selected plants. Characterization of the synthesized nanoparticles has been performed through UV–VIS, FTIR spectroscopy, Zeta potential, XRD analysis and FEGSEM imaging. The antibacterial potentiality of the nanoparticles was checked against two most susceptible bacteria <em>Staphylococcus epidermidis</em> and <em>Salmonella typhi</em>.</div></div><div><h3>Results</h3><div>Among the studied plants, <em>Phyllanthus emblica</em> showed highest tannin content and best bactericidal properties. The nanoparticles synthesized with <em>P. emblica</em> showed the highest zone of inhibition against the studied bacteria. An in-silico comparative molecular docking study of the bioactive compounds from the selected plants was performed against the FtsZ protein of <em>S. epidermidis</em> and YfdX protein of <em>S. typhi.</em> Three compounds namely Isocorilagin,1(β), 6-di-o-galloylglucose and Hamamelitannin appeared as the best inhibitors of the said proteins and among them, Isocorilagin, a natural tannin showed the best docking score of -10.2 Kcal/mol with FtsZ protein. Further molecular dynamics simulation studies of the FtsZ protein-Isocorilagin complex support its stability indicating Isocorilagin as the natural inhibitor of the pathogenic bacterial protein FtsZ.</div></div><div><h3>Conclusion</h3><div>These results concluded that synthesis of nanoparticles with plant tannin is a cost effective green approach and the synthesised nanoparticles appear as efficient antimicrobial agent.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatotoxicity induced by subacute exposure of Mancozeb and Arsenic in Wistar rats: Mitigating effect of quercetin and catechin","authors":"","doi":"10.1016/j.jtemin.2024.100199","DOIUrl":"10.1016/j.jtemin.2024.100199","url":null,"abstract":"<div><h3>Background</h3><div>Widespread use of Mancozeb (MZ) fungicide in endemic areas having high levels of arsenic (As⁺³) in the groundwater is likely to cause toxicosis in humans and animals. Therefore, the present study aimed to determine the hepatotoxic effect of MZ and As⁺³ interaction in Wistar rats and mitigating potential of quercetin and catechin on such toxicity.</div></div><div><h3>Methods</h3><div>Sixty adult rats were randomly divided into 10 groups of 6 animals each. Group I served as control and group II was exposed to MZ (800 mg kg^-1, PO). Groups III, IV, and V were provided drinking water containing As⁺³ at the rate of 10, 50 and 100 µg L^-1, respectively. Groups VI, VII, and VIII were given drinking water containing As⁺³ at 10, 50 and 100 µg L^-1, respectively, along with MZ. Groups IX and X received drinking water contaminated with 100 µg L^-1, As⁺³ and MZ along with quercetin or catechin (50 mg kg^-1 each), respectively.</div></div><div><h3>Results</h3><div>Significant (p &lt;0.05) alterations in hepatic biomarkers in blood, liver antioxidant status and hepatic histoarchitecture were observed in animals treated with individual toxicants in a dose-dependent manner, however, such toxicity-induced changes were more severe in co-exposed rats. The administration of quercetin or catechin significantly mitigated the dual toxicant administration-driven changes in biochemical markers of hepatic damage, hepatic antioxidant profile and liver histomorphology.</div></div><div><h3>Conclusions</h3><div>Both quercetin and catechin proved beneficial in reducing toxicant-induced oxidation-mediated hepatic damage as demonstrated by alleviation in altered levels of determinants of hepatic biochemical and oxidative stress parameters in addition to restoration of toxicant-induced histological alterations of hepatic tissue.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium involvement in social behavior and in the treatment of some psychological disorders. A review","authors":"","doi":"10.1016/j.jtemin.2024.100194","DOIUrl":"10.1016/j.jtemin.2024.100194","url":null,"abstract":"<div><h3>Background</h3><div>Social behavior is generally defined as all behavior that influences, or is influenced by, other members of the same species. This behavior is essential for social life and the evolution of society. Numerous factors influence this behavior. One of the factors that are important for social behavior and that modulates many of the neural mechanisms involved in the production of social behavior is formed by magnesium (Mg) and other bivalent cations in the brain.</div></div><div><h3>Methods</h3><div>In this review, the results of some articles included in the international databases were used.</div></div><div><h3>Results</h3><div>Mg has an essential modulating role for a large part of the elements that are part of social behavior such as: aggression, memory and cognition, eating behavior, addictions and others. Memory disorders, cognition, all forms of addiction are important psychiatric diseases, but they also have a strong impact on social behavior. The main mechanisms by which Mg is involved in social behavior are: the modulation of the presynaptic release of some brain neurotransmitters, synaptic neuroplasticity, the modification of the affinity of some neuronal receptors for their agonists, the transduction of the biological signal after stimulating the receptors, the activity of some neuronal enzymes. Magnesium decreases intraspecific and interspecific aggression, improves memory and eating behavior, reduces the intensity of addictions and the vulnerability of people at risk of becoming addicted, improves attention deficit in children and reduces anxiety.</div></div><div><h3>Conclusions</h3><div>Correcting the high frequency of chronic Mg deficiency in today's society is strictly necessary and must be done as soon as possible. This normalization of the Mg level improves many of the elements of social behavior. Prevention and correction of Mg deficiency reduce the risk of developing serious diseases such as depression, addictions,memory disordres, anxiety states and other. The association of Mg with the drugs used to treat these diseases can be beneficial.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollution evaluation and health risks assessment of naturally occurring toxic metals in shallow groundwater: A study in southwestern tidal delta of Bangladesh","authors":"","doi":"10.1016/j.jtemin.2024.100197","DOIUrl":"10.1016/j.jtemin.2024.100197","url":null,"abstract":"<div><div>Groundwater is the main source of potable water in rural regions of Bangladesh. Still, contamination with potentially harmful metals due to natural processes and anthropogenic activities leads to various health impacts. The focus of this research was to determine the extent of metal contamination in shallow groundwater from three southwestern districts of Bangladesh and the health hazards associated with it. A comprehensive analysis of metal, including metalloid, copper (Cu), aluminum (Al), chromium (Cr), Arsenic (As), Manganese (Mn), and boron (B) was performed on a set of 51 samples. Groundwater samples were analyzed for contamination using Atomic Absorption Spectroscopy and a UV–VIS Spectrophotometer, with pollution levels assessed via indices like the Metal Evaluation Index, Nemerow Pollution Index, and Contamination Index. Human health risks were evaluated through Chronic Daily Intake, Hazard Quotient, and Hazard Index calculations following USEPA guidelines. The results indicate that arsenic levels exceeded 25 samples and manganese levels exceeded 34 samples in accordance with WHO drinking water standards. Boron (B) concentrations exceeded the threshold in seven samples, whereas Al, Cu, and Cr exceeded limits in only two samples. The metal evaluation index (MEI), Nemerow pollution index (NI), and degree of contamination (C_d) revealed moderate to severe contamination in groundwater and unsuitability for drinking purposes. Out of the 51 analyzed samples, 48 samples exhibited potential non-carcinogenic health risks for adults, while all samples exceeded the hazard index (HI) threshold value (01) for children. Concentrations of As and Mn were identified as the main contributing factors to the higher HI values in both adults and children. However, the concentrations of Cu, Al, Cr, and B in groundwater were not individually found to be as risky. This study provided valuable insights to conduct a future comprehensive investigation of the designated region to delineate safe and hazardous zones for the installation of shallow tubewells. Furthermore, there's a need to enhance public awareness regarding the long-term ramifications of consuming contaminated water.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total mercury and methylmercury levels in Brazilian Amazon fish: A scope review with meta-analysis and local population health risk assessment","authors":"","doi":"10.1016/j.jtemin.2024.100196","DOIUrl":"10.1016/j.jtemin.2024.100196","url":null,"abstract":"<div><h3>Introduction</h3><div>The Brazilian Amazon has one of the richest biomes and the largest source of freshwater on the planet. However, anthropogenic activities have also turned this region into one of the highest points of human exposure to mercury ever recorded. Therefore, the aim of the present work was to perform a scope review with meta-analysis in order to evaluate the total mercury (THg) and methylmercury (MeHg) levels in Brazilian Amazon fish, as well as to carry out a local population health risk assessment.</div></div><div><h3>Methods</h3><div>A literature search was systematically performed in research databases and gray literature, remaining 14 studies from 2017 to 2022 for final analysis. The studies were submitted to raw mean and subgroup meta-analysis, followed by a risk characterization and the calculation of a maximum safe consumption of fish for the Amazonian population.</div></div><div><h3>Results</h3><div>The selected studies covered 4 Amazonian states, as well as included the analysis of &gt;30 fish species of different trophic levels and sampling in &gt;15 cities. The overall total mercury mean obtained for Brazilian Amazon fish was 0.29 ug g⁻¹. Significant difference was observed between THg levels according to fish trophic level (<em>p</em> &lt; 0.05), which reinforces the MeHg biomagnification. When THg levels from all fish samples were pooled, it was not observed a significant difference among the Amazonian states and the fish sampling season. However, significant variations between microregions and species-specific variations over the seasons should not be discarded. All estimated daily methylmercury intake exceeded the reference dose of 0.1 ug kg BW⁻¹ day⁻¹, resulting in a hazard quotient (HQ) greater than 1 and indicating a risk of chronic exposure by the local population. The maximum safe consumption of fish calculated based on the overall total mercury mean was set as 31, 147 and 173 g week⁻¹ for children, adult women and adult men, respectively, which is much lower than the reality of consumption by the riverside communities (2870 g week⁻¹).</div></div><div><h3>Conclusion</h3><div>There is an urgent need to reduce Hg exposure levels in the region as well as to recommend other protective nutritional strategies to the local population such as defining the fish species with lower mercury contamination levels and their safe weekly consumption.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometric evaluation, source apportionment, and health risk analysis of natural spring water in Murree, outer Himalayas","authors":"","doi":"10.1016/j.jtemin.2024.100195","DOIUrl":"10.1016/j.jtemin.2024.100195","url":null,"abstract":"<div><h3>Introduction</h3><p>Contamination of water is a critical threat to human health at a global level. Water pollutants, such as heavy metals, can have adverse effects on the well-being of humans, animals, and the natural ecosystem of a region.</p></div><div><h3>Study Area</h3><p>Murree is the most visited tourist destination in Pakistan. The rural population of Murree uses natural spring water for drinking, household use, and irrigation.</p></div><div><h3>Methods</h3><p>This study assessed the elemental concentration of water from 20 natural springs in Murree using Inductively Coupled Plasma Optical Emission Spectroscopy. Source apportionment and spatial distribution of heavy metals were assessed using statistical approaches such as Pearson's correlation coefficient, principal component analysis, and interpolation. The study assessed the quality of water for drinking and irrigation in Murree's natural spring water using the metal index, sodium absorption ratio, magnesium absorption ratio, percentage sodium, Kelly's ratio, and salinity hazard. The health risks associated with heavy metals were assessed by computing Average daily dose, Hazard quotient, Hazard Index, and Cancer Risk.</p></div><div><h3>Results</h3><p>The mean concentration of metals in mgL^-1 varied in the following order: Ca (51.23) &gt; Na (22.3) &gt; Mg (16.26) &gt; Si (6.51) &gt; <em>K</em> (1.59) &gt; Se (1.17) &gt; Sr (0.48) &gt; Ba (0.209) &gt; Al (0.060) &gt; Li (0.015) &gt; Zn (0.005) &gt; Fe (0.0033) &gt; Ni (0.0032) &gt; Cr (0.001). Metal index was calculated for Al (0.3), Ba (0.29), Cr (0.024), Ni (0.14), Fe (0.004), Zn (0.002), Sr (0.07), Mg (0.32), and Ca (0.25), revealing low levels of metal pollution. The geology of the study area was identified as the primary source of heavy metals in the water. The estimated values of health hazards showed that ingestion is the primary exposure pathway, with children having a higher risk. The health hazards posed by the heavy metal contact from the waters of Murree are not alarming. Quality indices show that the irrigation water sourced from the natural springs is of satisfactory quality.</p></div><div><h3>Conclusion</h3><p>The study concluded that the spring water of Murree has low concentrations of heavy metals; their concentration is dependent upon the geology of the study area and is good for drinking and irrigation.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000806/pdfft?md5=c2bd617291a26907c4ee7a9174301f4c&pid=1-s2.0-S2773050624000806-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water hardness affecting glyphosate efficiency for weed control and tomato (Lycopersicon esculentum L.) yield production","authors":"","doi":"10.1016/j.jtemin.2024.100191","DOIUrl":"10.1016/j.jtemin.2024.100191","url":null,"abstract":"<div><h3>Background</h3><p>The reduced use of herbicides such as glyphosate (N-(phosphonomethyl)glycine), as an effective method for weed control in the field, is an important goal, which may be achieved by using sustainable strategies for crop production. In the arid and semi-arid areas due to the use of ground water for crop production, water hardness may affect glyphosate efficiency, which is of economic and environmental significance.</p></div><div><h3>Objectives and Methods</h3><p>The objective was to investigate how water hardness (0 (W1), 200 (W2), 300 (W3) and 400 mg <span>l</span>^-1 (W4)) affect the efficiency of glyphosate (0 (G1), 100 (G2), 150 (G3), 200 g ha^-1 (G4)) (0, 75, 112.5, 150 g ha^-1 acid equivalent) on weed growth (<em>Convolvulus arvensis, Malva sylvestris</em> and <em>Cynodon dactylon</em>) and tomato (<em>Lycopersicon esculentum</em> L.) yield in the field using a factorial experiment on the basis of a complete randomized block design with three replicates.</p></div><div><h3>Results</h3><p>The single and the interaction effects of water hardness and glyphosate significantly affected different weeds (158 g weed weight for W2G1, and 25.3 g for W1G4) and tomato plant measured parameters. Increasing water hardness decreased glyphosate efficiency in controlling weeds, but it enhanced plant height. Higher water hardness increased tomato leaf area, however, higher glyphosate rates decreased it. Treatments W1G2 (1617 g plot^-1) and W1G4 (220.8 g plot^-1) resulted in the highest and the least tomato yield, respectively. At the highest level of glyphosate, W2 resulted in the highest tomato yield, compared with the other treatments. The highest and the least plant dry weight was resulted by W4G2 (232.7 g) and W1G4 (196.8 g), respectively.</p></div><div><h3>Conclusion</h3><p>The proper concentrations of water hardness and glyphosate may efficiently control weeds and results in optimum tomato yield in the arid and semi-arid areas.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000764/pdfft?md5=f7e9affaafbfd27358dbee2c90176d83&pid=1-s2.0-S2773050624000764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative protective activity of aqueous Zingiber officinale root and Theobroma cacao seed extracts on lead acetate-induced cerebellar toxicity in rats","authors":"","doi":"10.1016/j.jtemin.2024.100190","DOIUrl":"10.1016/j.jtemin.2024.100190","url":null,"abstract":"<div><h3>Background</h3><p>Lead has been associated with human activities since time immemorial and is reported to induce antioxidant and neurobehavioral impairments in animals and humans. The present study examined and compared the protective activity of aqueous <em>Zingiber officinale</em> root (ZO) and <em>Theobroma cacao</em> seed (TC) extracts against Pb-induced cerebellar toxicity.</p></div><div><h3>Methodology</h3><p>Twenty-four rats, divided into four equal groups, received as follows: 1 ml H₂O/day; 100 mg.kg^-1 body weight (BW)/day of lead acetate (Pb) only; 500 mg.kg^-1 BW/day of ZO and 100 mg.kg^-1 BW/day of Pb; and 500 mg.kg^-1 BW/day of TC and 100 mg.kg^-1 BW/day of Pb, orally for twenty-eight days. Afterwards, neurobehavioural tests were conducted and the harvested cerebellums were used for antioxidant enzymes activity, Pb and lipid peroxidation concentrations as well as histological evaluations, following the sacrifice of experimental rats.</p></div><div><h3>Results</h3><p>Findings revealed significant neurobehavioural and antioxidant enzymes impairment, elevated levels of cerebellar Pb and lipid peroxidation, and microstructure alterations in the cerebellum of Pb-exposed rats. Although pretreatment with ZO and TC significantly attenuated these Pb-induced effects, ZO was more potent in its neuroprotective activity than TC.</p></div><div><h3>Conclusion</h3><p>Taken together, ZO and TC can be further developed as novel neuroprotective agents against Pb toxicity.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000752/pdfft?md5=0c357d9ff6fd0234c75469d470eeaa28&pid=1-s2.0-S2773050624000752-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma volume is associated with micronutrient mass but not concentration in healthy US women of reproductive age","authors":"","doi":"10.1016/j.jtemin.2024.100187","DOIUrl":"10.1016/j.jtemin.2024.100187","url":null,"abstract":"<div><h3>Background</h3><p>Plasma transports nutrients and composes more than half of the volume of blood. A few prior studies suggest that plasma volume fluctuations may impact certain micronutrient concentrations. We hypothesized a slight negative correlation between plasma volume and micronutrient biomarkers throughout the menstrual cycle in healthy women of reproductive age (<em>n</em> = 45).</p></div><div><h3>Methods</h3><p>The study involved three visits during one menstrual cycle where fasting blood samples were taken to measure biomarker concentrations for zinc, copper, magnesium, manganese, iron, ferritin, retinol, and hemoglobin. A bolus dose of indocyanine green (ICG; equivalent to 0.25 mg.kg^-1 of body weight) was injected to measure plasma volume. The total circulating micronutrient biomarker mass was calculated using the plasma volume and biomarker concentration. We used Spearman's correlation and fractional polynomial regression techniques to assess the relationship between plasma volume and biomarker concentration and mass.</p></div><div><h3>Results</h3><p>Plasma volume ranged from 1210 to 3520 mL. During all three visits, the correlation between micronutrient biomarker concentrations and plasma volume ranged from -0.05 to 0.10 (all <em>P</em> &gt; 0.05); However, there was a strong positive correlation between biomarker mass and plasma volume, ranging from 0.26 to 0.95 (all <em>P</em> &lt; 0.05). Five of the eight biomarkers examined (zinc, copper, magnesium, retinol, and hemoglobin) showed a correlation coefficient &gt; 0.70 (<em>P</em> &lt; 0.001) between mass and plasma volume.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that biomarker concentrations are maintained across a range of plasma volume, suggesting that plasma volume may not be necessary to interpret micronutrient status in healthy non-pregnant women of reproductive age.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000727/pdfft?md5=e328a88e7fd970187f3d1b20655327ed&pid=1-s2.0-S2773050624000727-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical manifestation and management of hypomagnesemia in Theileria spp. infected periparturient Malabari goats","authors":"","doi":"10.1016/j.jtemin.2024.100192","DOIUrl":"10.1016/j.jtemin.2024.100192","url":null,"abstract":"<div><h3>Background</h3><p>Grass tetany or hypomagnesemia is a metabolic syndrome causing acute neurological manifestations in periparturient ruminants grazing on rapidly grown green pastures or cereal crops with high potassium or nitrogen content and low magnesium levels. Clinical reports of naturally occurring grass tetany in goats are least described in the literature and it is considered to be a rare disease. The present study documents the clinical manifestation and management of hypomagnesemia-associated excitatory neuropathy in two <em>Theileria</em> spp. infected Malabari goats presented to the small ruminant medicine OP unit of the University Veterinary Hospital and Teaching Veterinary Clinical Complex, Mannuthy, Thrissur, Kerala, India.</p></div><div><h3>Methods</h3><p>The first goat was in the last trimester of pregnancy and was showing signs of hyperesthesia, limping, difficulty in standing, and inappetence for the last six hours. The second goat was kidded six weeks back and was showing recurrent epileptic seizures and hyporexia from the previous day. Both the goats were kept on extensive grazing from the forest areas with unidentified lush vegetation. On clinical evaluation, both the goats were showing persistent excitatory neurological signs. Fecal examination, peripheral blood smear examination, PCR screening panel for hemoparasites, Complete Blood Count, and serum levels of calcium, magnesium, and glucose were evaluated.</p></div><div><h3>Results</h3><p>A significant reduction in serum magnesium levels was noted in both cases along with the varied glucose levels. <em>Theileria</em> spp. infection was noticed in blood smear examination and confirmed by PCR. The goats responded well to the therapy using MIFEX™ and other supportive medications and showed uneventful recovery.</p></div><div><h3>Conclusion</h3><p>It is suggested that the farmers should be vigilant enough while allowing goats to graze in unknown vegetation and prevent indiscriminate fodder intake during periods of drought. This is the first documented report of hypomagnesemic excitatory neurologic symptoms in <em>Theileria</em> spp. infected periparturient Malabari goats and showing response to appropriate therapy.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000776/pdfft?md5=ea3551b2b1cc80c0d5371197f8ba8355&pid=1-s2.0-S2773050624000776-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}