Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique最新文献

{"title":"Comparison of the effects of ivermectin, permethrin, and gamma benzene hexachloride alone and with that of combination therapy for the management of scabies.","authors":"S. Dey, S. Agarwal, S. Sagar","doi":"10.47750/jptcp.2022.845","DOIUrl":"https://doi.org/10.47750/jptcp.2022.845","url":null,"abstract":"RESULTS\u0000The present study compared three scabicidal agents alone or with combination, the currently considered medicine of choice permethrin, oral ivermectin, and gamma benzene hexachloride in the local population of India. A total of 120 patients were studied. They were randomly divided into four groups -Group A, Group B, Group C, and Group D. Group A received topical 5% permethrin and oral placebo. Group B was given topical placebo cream and oral ivermectin in two dose regimen. Group C received topical 1% gamma benzene hexachloride with oral placebo, and Group D was given topical 5% permethrin and oral ivermectin. The improvement of lesions and pruritus were assessed in the next three follow-ups, i.e., on the 7th day, 14th day, and 28th day along with any adverse drug reactions (ADRs). It was found that Group A had 83%, 90%, 97%, and Group B had 70%, 81%, and 91% improvement of lesions in the three follow-ups respectively. Group C showed 57%, 70%, 86%, and Group D had 82%, 90%, 97% efficiency to decrease lesion count (p>0.05) respectively. Again, Group A observed 77%, 88%, and 94% improvement in pruritus in subsequent follow-ups, while for Group B it was 63%, 76%, and 86%. Group C had 55%, 71%, 85% efficiency, and Group D had recorded 77%, 88%, and 94% improvement to decrease pruritus (p>0.05). The incidence of adverse effects was found to be less in Group B, Group C, and Group D when compared to Group A.\u0000\u0000\u0000CONCLUSION\u0000Group D or a combination therapy was a better choice for scabies in comparison to other monotherapy due to its better efficacy and safety profile.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"249 1","pages":"e87-e96"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79087380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical correlation of cervical cancer screening using Pap smear test.","authors":"Y. Sharif","doi":"10.47750/jptcp.2022.892","DOIUrl":"https://doi.org/10.47750/jptcp.2022.892","url":null,"abstract":"BACKGROUND AND OBJECTIVES\u0000Cervical cancer (CC) has a long preinvasive stage, which allows for preventive detection and possible cure. In this study, this stage was a target stage to investigate women with precancerous lesions by applying the Papanicolaou (Pap) smear test and comduct performing a correlation study.s.\u0000\u0000\u0000PATIENTS AND METHODS\u0000A 2-year cross-sectional study was conducted, in which 200 married women (21-60 years old) participated in the investigation, which included women with Pap test abnormal results (atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs)). These results were used to perform a polymerase chain reaction (PCR) test to detect the presence of human papillomavirus (HPV) of (6 and 11), a low-risk type, and (16 and 18), a high-risk type with colposcopy examination and colposcopy-guided biopsy, if needed for women with abnormal colposcopy outcomes. The treatment, per severity and disease stage, was applied.\u0000\u0000\u0000RESULTS\u0000The clinical presentation and Pap smear results of women enrolled in the study were as follows: 82.5% women were asymptomatic, postcoital bleeding (PCB) was seen in 17.0%, and intermenstrual bleeding was seen in a single case (0.5%). The history of sexually transmitted diseases was seen in 2.5% of the subjects. Pap smear results were as follows: no remarkable pathology was seen in 36.0%, inflammatory evidence was seen in 32.0%, ASCUS was seen in 19.0%, LSIL was seen in 7.5%, and HSIL was seen in 5.5% of the subjects. Regarding the HPV, the infection was negative in 95.0%, low-risk virus strains were seen in 1.5%, and high-risk viruses were seen in 3.5%. Low-risk HPV included 6, 11, and 42, whereas the high-risk group included five cases of HPV16 and two cases of HPV 18.\u0000\u0000\u0000CONCLUSIONS\u0000The present work presents the Pap smear test as a highly useful, easy, technically safe, and cost-effective tool for detecting cervical epithelial precancerous lesions, which can be used as a routine screening technique for better treatment outcomes and reducing mortality rates. The power of detection of these lesions can be potentiated when using the Pap test and HPV-PCR test together.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"41 1","pages":"e1-e8"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73879846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of multidisciplinary collaborative nursing combined with cognitive stimulation therapy on cognitive function, quality of life, and daily activities in patients with Alzheimer's disease.","authors":"Li Shuzhen,&nbsp;Wu Wei,&nbsp;Ge Hongyan,&nbsp;Wang Ruiying,&nbsp;Zamzaliza Abdul Mulud","doi":"10.47750/jptcp.2022.990","DOIUrl":"https://doi.org/10.47750/jptcp.2022.990","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative condition that disrupts neuropsychological activity and hinders the development of mental capacity. Efficient AD therapy is a major challenge in biological studies. Alzheimer's condition cannot be cured with any particular medication. The purpose of this study is to investigate the impact of multidisciplinary collaborative nursing and cognitive stimulation therapy (MCN- CST) on daily activities, quality of life, and cognitive performance in AD patients. The inclusion/exclusion method is initially used to gather information about AD patients. Control and investigative teams were formed with its own set of functions. The control group gets a regular course of treatment, whereas, the investigation group receives MCN-CST. To ensure that our study is as practical and useful, we compare our findings to existing nursing approaches. The ANOVA and Chi-Square tests are used to assess the conditions of Alzheimer's patients. There was a scientifically significant improvement in the overall level of their medical condition after implementing MCN-CST. Nursing protocols developed MCN-CST is beneficial in improving patients' quality of life, cognitive function, and daily activities. It is encouraged to do intensive research using many samples drawn from a wider range of people.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 4","pages":"e86-e96"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10473310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the Effectiveness of Drug No. 1 on the Model of Alkaline Eye Burn in Rabbits.","authors":"Pletnev Vladimir Vladimirovich","doi":"10.47750/jptcp.2022.884","DOIUrl":"https://doi.org/10.47750/jptcp.2022.884","url":null,"abstract":"Studies have shown that 0.05 mL/kg of drug No. 1 as 1:15 dilution with sterile saline solution has anti-inflammatory, wound-healing, and angioprotective effects if instilled in both eyes of rabbits twice a day for 30 days after an alkaline burn. A stimulation of reparative processes in the cornea was observed with the test dose of drug No. 1. This was manifested by accelerating the recovery of defects in the anterior epithelium and stroma, reducing the frequency of formation of deep defects and the severity of inflammatory reaction and vascularization, and inhibiting the formation of turbidity of its lower intensity and area. A tendency to restore laminarity of the stroma was determined by the action of drug No. 1 throughout the observation period. This contributed to a decrease in the degree of vascularization and prevented ulceration and perforation of the cornea. By the end of experiment, a restoration of strong epithelial-stromal relationships in the experimental group, compared to the control group, was observed due to formation of normal architectonics of fibrous components of intercellular substance. A more pronounced proliferative activity, with an increase in the layering of limbal epithelial cells, was noted in the limbal zone of the cornea in the experimental group rabbits compared to the control group.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"42 1","pages":"e26-e39"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77339275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the application effect of cognitive stimulation therapy in patients with Alzheimer's disease based on expert consultation and semistructured interviews.","authors":"Li Shuzhen,&nbsp;Ge Hongyan,&nbsp;Wu Wei,&nbsp;Wang Ruiying,&nbsp;Zamzaliza Abdul Mulud","doi":"10.47750/jptcp.2022.991","DOIUrl":"https://doi.org/10.47750/jptcp.2022.991","url":null,"abstract":"<p><p>The awareness and utilization of psychological therapies for Alzheimer's disease have increased significantly in recent years. Limitations on the utilization of pharmacological therapy for Alzheimer's disease in China have corresponded with this surge in greater studies in the field. For individuals who have Alzheimer's disease, cognitive stimulation therapy (CST) is a quick self-help that is founded on the theories of quality and cognitive functioning. People with Alzheimer's disease often participate in cognitive behavioral programs; however, their expense has never been studied. Being part of a meta-analysis, we analyze the application effectiveness of a CST program that is based on recent research for Alzheimer's disease patients. A CST group therapy was given to 91 Alzheimer's patients, who resided in healthcare settings or the general public, multiple times per week for 8 weeks; the other 70 people with Alzheimer's disease got a medical therapy. Costs were computed, and resource utilization was tracked for 8 weeks both before and after the therapy. It was determined by a value study. In the value study, cognition and quality of life were the major and tertiary outcomes, respectively. Contours of cost-effectiveness and acceptance were drawn. It was driven based on expert consultation and semistructured interviews. In Alzheimer's disease, CST improves intelligence and standard of living, and there was no difference in implementation expenditures between the categories. Regarding both outcome metrics, there is a significant chance that CST seems to be more expensive than conventional therapy within realistic expectations. The efficacy of CST for Alzheimer's patients is superior to conventional treatment, and it could be the greater value. The outcomes contrast well with pharmacological studies for Alzheimer's. Many people with Alzheimer's disease may benefit significantly from CST groups.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 4","pages":"e97-e106"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10473312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New surgical technique in restoring the chin lost due to trauma by using a subperiosteal problast implant.","authors":"Sabah Hassan","doi":"10.47750/jptcp.2022.987","DOIUrl":"https://doi.org/10.47750/jptcp.2022.987","url":null,"abstract":"<p><p>Bone grafts are the most common techniques used in maxillofacial surgery in restoring any lost or defective bone. This novel surgical technique utilizes a new modified problast to restore the contour of the defected chin.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 4","pages":"e83-e85"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10762165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of vitamin C administration to women with history of premature preterm rupture of membrane in prevention of such event in current pregnancy: Randomized controlled clinical trial.","authors":"Alaq Saeed Abdulhussain","doi":"10.47750/jptcp.2022.985","DOIUrl":"https://doi.org/10.47750/jptcp.2022.985","url":null,"abstract":"<p><strong>Background: </strong>When rupture of membrane happens before onset of labor, the condition in obstetric practice is defined as \"Prelabor rupture of membranes (PROM)\" leading to leakage of amniotic fluid through ruptured chorioamniotic membranes and the conditions happens before 37 weeks of pregnancy the term \"preterm PROM (PPROM)\" is applied. Lack of vitamin C has been suggested as a predisposing factor and vitamin C supplementation has been suggested as a preventive measure.</p><p><strong>Aim of the study: </strong>This study was aimed to determine the efficacy and safety of administration of vitamin C women with history of premature preterm rupture of membrane in prevention of such event in current pregnancy.</p><p><strong>Patients and methods: </strong>The present randomized controlled clinical trial was performed in Maternity and Children Teaching Hospital in Al-Diwaniyah province in Iraq. It included 100 women with previous history of premature preborn rupture of membrane who were randomly allocated into two groups. The first group, the study group included 55 women who received vitamin C supplementation orally staring from 14 weeks gestation and the second group, the reference group was the placebo group (<i>n</i> = 45). Data regarding age, previous abortion, body mass index, number of previous pregnancies and previous abortions were obtained and outcome variables included gestational age at which rupture of membrane happened, gestational age at which delivery happened and birth weight were collected.</p><p><strong>Results: </strong>Vitamin C was able to significantly increase the GA at rupture or membrane (<i>p</i> = 0.033), form 29.00 ± 2.92 weeks to 30.11 ± 2.21 weeks. Vitamin C was also able to significantly increase the GA at birth (<i>p</i> = 0.019), form 32.04 ± 2.88 weeks to 33.31 ± 2.43 weeks. In addition, Vitamin C was also able to significantly increase the birth weight (<i>p</i> = 0.019) from 1951.10 ± 869.72 gram to 2409.10 ± 613.44 gram.</p><p><strong>Conclusion: </strong>Vitamin C Administration to women with previous history of Premature Preterm Rupture of Membrane is efficient and safe in prevention of such event in current pregnancy.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"29 4","pages":"e188-e194"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain tumor classification of magnetic resonance images using a novel CNN-based medical image analysis and detection network in comparison with AlexNet.","authors":"Mohan Ramya, Ganapathy Kirupa, A. Rama","doi":"10.47750/jptcp.2022.898","DOIUrl":"https://doi.org/10.47750/jptcp.2022.898","url":null,"abstract":"AIM\u0000This research work aims at developing an automatic medical image analysis and detection for accurate classification of brain tumors from a magnetic resonance imaging (MRI) dataset. We developed a new MIDNet18 CNN architecture in comparison with the AlexNet CNN architecture for classifying normal brain images from brain tumor images.\u0000\u0000\u0000MATERIALS AND METHODS\u0000The novel MIDNet18 CNN architecture comprises 14 convolutional layers, seven pooling layers, four dense layers, and one classification layer. The dataset used for this study has two classes: normal brain MR images and brain tumor MR images. This binary MRI brain dataset consists of 2918 images as the training set, 1458 images as the validation set, and 212 images as the test set. The independent sample size calculated was seven for each group, keeping GPower at 80%.\u0000\u0000\u0000RESULT\u0000From the experimental performance metrics, it could be inferred that our novel MIDNet18 achieved higher test accuracy, AUC, F1 score, precision, and recall over the AlexNet algorithm.\u0000\u0000\u0000CONCLUSION\u0000From the result, it can be concluded that MIDNet18 is significantly more accurate (independent sample t-test P<0.05) than AlexNet in classifying tumors from brain MRI images.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"741 1","pages":"e97-e108"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77507676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidemia and other parameters in women with pregnancy induced hypertension.","authors":"Alaa Saber Shihab, M. Hamdi, A. M. Jumaa, M. Marbut, Sahar Kamel Jwad","doi":"10.47750/jptcp.2022.900","DOIUrl":"https://doi.org/10.47750/jptcp.2022.900","url":null,"abstract":"BACKGROUND\u0000Several investigations have confirmed changes in lipid profiles and other markers (interleukin [IL]-6, C-reactive protein [CRP]) in women with pregnancy induced hypertension (PIH). Although, the cause an effect correlations between these lipid profiles and other markers with the PIH are yet unknown.\u0000\u0000\u0000AIM\u0000To study the relationship of serum lipid profile, CRP, and IL-6 with PIH.\u0000\u0000\u0000METHOD\u0000A cross-sectional study was done on 60 pregnant women with PIH treated in the General Salah Alden Hospital in Tikrit city, Iraq, from January 2021 to April 2021. Another group of 60 pregnant women who were normal, at the same period, were selected as the control group. The average age of the participants was (27.1 ± 5.0) years. All the blood samples taken were examined for lipid profile, CRP, and IL-6.\u0000\u0000\u0000RESULTS\u0000The results statistically showed significant differences in IL-6 level and CRP. Whereas, in the Lipid profile (triglyceride [TG], low density lipoprotein cholesterol [LDL-C], high density lipoprotein [HDL]-C, total cholesterol [TC], and very low density lipoprotein cholesterol [VLDL]) were found. Also, it was found that there were significant differences in PIH patients as compared to the control group.\u0000\u0000\u0000CONCLUSION\u0000The findings revealed that the lipid profile was aberrant, and the amount of IL-6 protein was positively linked with blood pressure.","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"1 1","pages":"e116-e121"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88772967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life among groups of foundling and delinquent children in comparison with mainstream children.","authors":"Abdulaziz Abdullah Alsaif,&nbsp;Thamer Adel Alkhadra,&nbsp;AlBandary Hassan AlJameel","doi":"10.47750/jptcp.2021.859","DOIUrl":"https://doi.org/10.47750/jptcp.2021.859","url":null,"abstract":"<p><strong>Aim: </strong>This study envisages understanding about the Oral Health-Related Quality of Life (OHRQoL) among groups of foundling and delinquent children and compares them with mainstream children in Riyadh, Saudi Arabia.</p><p><strong>Method: </strong>This is a cross-sectional, observational study of a group of foundling and delinquent children aged 11 to 14 years, in care houses in Riyadh, Saudi Arabia, and mainstream school children. Variables measured for each group were demographic data (age, gender), subjective oral health condition, and OHRQoL. An interview-based questionnaire was used for collecting the relevant data. The questionnaire was divided into four parts, oral symptoms, functional limitations, emotional well-being, and social well-being, with each response scored as per the following codes: (0) never, (1) once or twice, (2) sometimes, (3) often, and (4) every day. The top possible score for the total scale was 144, and the lowest was 0. A comparison group of mainstream school children was recruited from public schools. Data were analysed using SPSS version 25.0 statistical software, and one-way ANOVA was used for the analysis of data when three levels or more were categorical, and the response was numerical. A chi-square test was used to assess the correlation between any two categorical variables.</p><p><strong>Results: </strong>Out of the total 99 children, 33 were delinquents, 33 were foundling, and 33 were mainstream children included as a comparative group in the study. It was noted that the delinquents compared to the other children had significantly higher scores in accordance with the data collected, with a mean overall score of 30.61 compared to the score for foundling, which was 19.48, and mainstream children had a meager score of 9.18. Individual factorssuch as the oral symptoms, functional limitations, and emotional and social well-being were scored separately, with delinquents having the highest scores and mainstream children the least.</p><p><strong>Conclusions: </strong>Health, including oral health, is a right everyone is equally subjected to, and while the concept of OHRQoL is relatively new, delinquents and foundling are definitely subjected to poorer standards in terms of their oral hygiene, on-time treatment, and diagnosis, which further deteriorates their quality of life.</p>","PeriodicalId":73904,"journal":{"name":"Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique","volume":"28 2","pages":"e7-e16"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39632701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}