Journal of hazardous materials advances最新文献

{"title":"Recent advances on photocatalytic geopolymer on the degradation of organic pollutants: A review","authors":"Noorulayuni Atiqah Yaacob ,&nbsp;Mohd Mustafa Al Bakri Abdullah ,&nbsp;Liew Yun Ming ,&nbsp;Shafiq Ishak ,&nbsp;Petrica Vizureanu ,&nbsp;Harun Tanyildizi ,&nbsp;Thanongsak Imjai ,&nbsp;Mohamad Anuar Kamaruddin ,&nbsp;Rosnita Mohamed","doi":"10.1016/j.hazadv.2025.100946","DOIUrl":"10.1016/j.hazadv.2025.100946","url":null,"abstract":"<div><div>The widespread occurrence of organic pollutants, particularly antibiotic and dye residues, in both aquatic and terrestrial ecosystems pose a significant environmental threat and contributes to the concerning increase in human health risks. Often, these persistent contaminants are not eliminated by conventional water treatment methods. Thus, the effective management of organic pollutants in water is indeed a complex and ongoing issue, requiring significant attention from academic researchers. Indeed, geopolymer-based photocatalysts have gained popularity as a promising and eco-friendly approach for the treatment of organic pollutants in water in recent years. However, despite the growing interest, literature details on the application of geopolymer in photodegradation of organic pollutants is insufficient. Therefore, this review highlights the recent advancements in the development of geopolymer-based photocatalysts on organic pollutants degradation and the geopolymerization process. In addition, the operational parameters influencing photocatalytic degradation such as effect of pH, catalyst dosage, and initial concentration of pollutants are briefly reviewed to highlight the significance of the parameters that critically impacted the photocatalytic degradation efficiency. The fundamental mechanism of organic pollutants, recent advances, and practical application of photocatalytic degradation are also discussed. This would aid in setting the trajectory for providing references on efficient geopolymer-based photocatalysts, establishing new insights and potential applications for effective wastewater remediation.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100946"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective activated nutrient components of coal gangue with thermal modification and its passivation of lead ions","authors":"Wang Li ,&nbsp;Chenxi Shao ,&nbsp;Xiaobo Zhu ,&nbsp;Xueyu Bai","doi":"10.1016/j.hazadv.2025.100965","DOIUrl":"10.1016/j.hazadv.2025.100965","url":null,"abstract":"<div><div>Coal gangue is used as raw material to enhance its nutritional component activity and adsorption performance for lead ions (Pb²⁺) through thermal modification, which may be applied in the remediation of polluted soil. The effects of different modification conditions on the content of available silicon, phosphorus, and potassium in coal gangue and the removal rate of Pb²⁺ in a solution system were investigated. The adsorption mechanism of Pb²⁺ by thermally modified coal gangue was analyzed by using XRD, XPS, SEM-EDS, and other characterization methods. The results show that under suitable modification conditions, the contents of available silicon, potassium and phosphorus in modified coal gangue roasted at 600 °C (Ca-CG-600) were 10,375 mg/kg, 268 mg/kg and 6.1 mg/kg, respectively, whereas those in raw coal gangue were 388 mg/kg, 169 mg/kg and 2.6 mg/kg, respectively. The release of available nutrient elements was promoted due to the destruction of kaolinite (Al₂[Si₂O₅](OH)₄), muscovite (KAl₂[AlSi₃O₁₀](OH)₂) and monetite (Ca(H₂PO₄)H₂O) in the coal gangue. The pore structure of activated coal gangue was increased, which facilitated the adsorption of Pb²⁺. The removal rate of Pb²⁺ reached 99.6 % under the optimal adsorption conditions with Ca-CG-600. The adsorption of Pb²⁺ by Ca-CG-600 mainly occurred via ion exchange with Ca²⁺ and Na⁺ in NaCaAlSi₃O₈(OH), forming Pb_6.34Al_12.7Si_11.3O₄₈. Additionally, precipitates such as Pb₂[CO₃]Cl₂ and PbSO₄ formed through the combination of Pb²⁺ with CO₃^2- and SO₄^2-. This study may provide new insights into the comprehensive utilization of coal gangue and efficient removal of Pb²⁺.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100965"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motorcycle driving cycle and emission characteristics in urban and rural complex metropolitan","authors":"Jiun-Horng Tsai ,&nbsp;Yu-Chen Lai ,&nbsp;Zong-Jyun He ,&nbsp;Ying-Chun Chan ,&nbsp;Hung-Lung Chiang","doi":"10.1016/j.hazadv.2026.101031","DOIUrl":"10.1016/j.hazadv.2026.101031","url":null,"abstract":"<div><div>To quantify motorcycle emissions under realistic operating conditions, this study reproduces on-road riding behavior rather than relying solely on certification driving cycles. A localized real-world motorcycle driving cycle was developed for Yunlin City, where riding behavior is characterized by lower traffic density and frequent transient operations. Compared with the urban segment of the World Motorcycle Test Cycle (WMTC), the temporal shares of acceleration, cruising, and deceleration observed in Yunlin differed substantially, reflecting local traffic conditions, although the overall distributions of idling, acceleration, cruising, and deceleration were broadly comparable.</div><div>Exhaust emissions were measured from two motorcycles representing different regulatory phases. Under identical real-world operating conditions, the phase VII motorcycle exhibited mean exhaust concentrations of 0.39 % CO, 14.04 % CO₂, 23.82 ppm HC, and 64.91 ppm NOₓ, with a fuel consumption of 0.037 L·km⁻¹. In contrast, the phase IV motorcycle showed markedly higher pollutant levels—6.24 % CO, 10.85 % CO₂, 398.06 ppm HC, and 213.03 ppm NOₓ—and greater fuel use at 0.103 L·km⁻¹. On average, emissions from the phase IV motorcycle were 15.9 times higher for CO, 16.7 times for HC, and 3.28 times for NOₓ, while fuel consumption was 2.79 times higher and CO₂ emissions were 0.77 times lower than those of the phase VII motorcycle.</div><div>These results demonstrate that emission estimates derived from certification cycles may underestimate real-world motorcycle emissions, particularly for older vehicles. Incorporating localized driving behavior, such as that captured by the Yunlin Motorcycle Driving Cycle, is therefore essential for accurately characterizing in-use emissions and supporting effective emission assessment and regulatory planning in mixed urban–rural regions.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 101031"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluorooctanoic acid (PFOA) impairs motor neuron development and locomotor behavior in zebrafish larvae via ROS-mediated oxidative stress","authors":"Chen Chaojie ,&nbsp;Yuan Shanshan ,&nbsp;Liu Tong ,&nbsp;Cai Zhenzhen","doi":"10.1016/j.hazadv.2025.100990","DOIUrl":"10.1016/j.hazadv.2025.100990","url":null,"abstract":"<div><div>Perfluorooctanoic acid (PFOA), a widespread per- and polyfluoroalkyl substance (PFAS), is increasingly recognized as a developmental neurotoxicant. Although prenatal exposure has been linked to behavioral impairments, the mechanistic basis involving oxidative stress and motor neuron dysfunction remains unclear. In this study, we investigated the effect of early-life PFOA exposure on locomotor behavior, motor neuron morphology, oxidative stress biomarkers, and neurodevelopment-relate gene expression. Zebrafish embryos (AB strain and Tg(hb9:eGFP)) were exposed to PFOA (0, 10, 100, 1000 μg/L) from 2 h post-fertilization (hpf) to 168 hpf. Our results reveal that PFOA exposure led to a concentration-response reduction in locomotor activity at 168 hpf. In addition, motor neurons axonal arbor complexity was significantly decreased at 36 hpf. Further investigations showed that reactive oxygen species (ROS) levels were elevated in a concentration-dependent manner at 24 hpf, while malondialdehyde (MDA) content increased at 168 hpf, suggesting sustained lipid peroxidation. Moreover, the antioxidant protein Trx1 was up-regulated, together with perturbation of the transcriptional balance of antioxidant and pro-oxidant genes as well as neurodevelopment-related genes. Notably, N-acetylcysteine (NAC) co-treatment partially restored locomotor performance, supporting a central role of ROS-mediated oxidative stress in PFOA neurotoxicity. Collectively, these findings demonstrate that early-life PFOA exposure disrupts motor neuron development and behavior via redox imbalance and transcriptional dysregulation, providing new mechanistic insights into the developmental neurotoxicity of PFAS.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100990"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the determinants of micro- and nanoplastics exposure among adults in Barcelona, Spain","authors":"Emma Calikanzaros ,&nbsp;Carolina Donat-Vargas ,&nbsp;Rafael de Cid ,&nbsp;Susana Iraola-Guzman ,&nbsp;Lourdes Arjona ,&nbsp;Marta Llorca ,&nbsp;Marinella Farré ,&nbsp;Cristina M Villanueva","doi":"10.1016/j.hazadv.2026.101002","DOIUrl":"10.1016/j.hazadv.2026.101002","url":null,"abstract":"<div><div>Micro- and nanoplastics (MNPs) are emerging contaminants present in food, water, and air, yet human exposure levels and key predictors remain poorly understood. We quantified MNP polymer concentrations in human biological samples, estimated dietary intake through food and beverages, and explored potential exposure determinants in a population-based cross-sectional study of 50 healthy adults in Barcelona, Spain. Stool, urine, tap water, and food samples were collected along with detailed dietary and lifestyle data. MNPs (size range: 0.7-20µm) were extracted using ultrasonic-assisted toluene extraction and analyzed via high-performance liquid chromatography using a size exclusion chromatography column coupled to high-resolution mass spectrometry (HPLC(SEC)-HRMS). Plastic additives were also screened in urine and tap water to assess their potential as proxies for MNP exposure. MNPs were detected in 52% of stool (median: 1.8 µg/kg) and urine (median: 22.7 µg/L) samples, with polyamide (PA), polyethylene (PE), and polypropylene (PP) as the most frequently identified polymers. Tap water contained MNPs in 26% of samples (median: 1.4 µg/L), primarily PE. Plastic additives were found in all urine and tap water samples, with diethyl phthalate (68%) and hexamethylcyclotrisiloxane (78%) being most prevalent. Plastic additives in urine showed poor concordance with MNPs in urine, suggesting they are poor exposure biomarkers. Estimated MNP intake from food (1.51 µg/kg body weight/day) greatly exceeded that from beverages (0.02 µg/kg bw/day), with animal products as the main contributors. Differences in MNP levels were observed by country of origin, recent consumption of meat, seafood, and eggs, and regular packaged food consumption.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 101002"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High organic carbon drives community shifts and biodiversity loss in benthic macroinvertebrates of Baiyangdian Lake, China","authors":"Fujie Zhai ,&nbsp;Chao Zhang ,&nbsp;Baoqing Shan","doi":"10.1016/j.hazadv.2025.100974","DOIUrl":"10.1016/j.hazadv.2025.100974","url":null,"abstract":"<div><div>Dissolved organic carbon (DOC) plays a pivotal role in driving biogeochemical and ecological processes in aquatic ecosystems, yet its role in structuring benthic communities in shallow eutrophic lakes remains poorly understood. This study investigated the effects of DOC and its fluorescent components on the benthic macroinvertebrate community in Baiyangdian Lake, a representative floodplain lake in northern China. DOC concentrations varied markedly across the lake, peaking at 91.87 mg L⁻¹ in the northern region, suggestive of active internal carbon cycling. Parallel Factor Analysis identified three fluorescent dissolved organic matter (DOM) components: humic-like C1 (24.35% of total fluorescence) and protein-like C2 and C3 (75.6%). Benthic assemblages were dominated by pollution- and semi-tolerant taxa, including Chironomidae and Tubificidae, whereas sensitive taxa were scarce. Canonical correspondence and Mantel tests identified total phosphorus, total nitrogen, organic matter, and protein-like component C2 were the primary drivers of community structure. The significant correlation between C2 and species richness (<em>r</em> = −0.462, <em>p</em> &lt; 0.001) suggests that refractory humic DOM may contribute to biodiversity loss. These findings provide insights for ecological restoration efforts and carbon management strategies in shallow eutrophic lakes.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 100974"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the endocrine-disrupting chemicals-lung adenocarcinoma in never-smokers: A mixture exposure and network toxicology study","authors":"Yuyu Zheng ,&nbsp;Xinyu Zhu ,&nbsp;Mengya Xu ,&nbsp;Kaiqin Huang ,&nbsp;Xinqi Jiang ,&nbsp;Wanlu Liu ,&nbsp;Baihao Lin ,&nbsp;Yujia Yang ,&nbsp;Hao Deng ,&nbsp;Nada Alhazmi ,&nbsp;Kang Liu ,&nbsp;Shengtao Ma ,&nbsp;Yansen Bai ,&nbsp;Hank-Han Wang","doi":"10.1016/j.hazadv.2026.101009","DOIUrl":"10.1016/j.hazadv.2026.101009","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of lung cancer in never-smokers (LCINS), predominantly manifesting as lung adenocarcinoma (LUAD) in females, has shown a steady rise. While endocrine-disrupting chemicals (EDCs) represent potential risk factors for LCINS, their specific contributions and underlying toxicological mechanisms remain poorly characterized.</div></div><div><h3>Methods</h3><div>We conducted a case-control study involving 196 LCINS cases (including 166 LUAD) and 191 healthy controls. Serum concentrations of 19 EDCs across five categories (alkylphenols, bisphenols, parabens, benzophenones, and antibacterial agents) were quantified. Associations were evaluated using both single-exposure models (logistic regression with FDR adjustment) and mixture exposure models (generalized weighted quantile sum, gWQS) to identify high-risk EDC categories and key individual EDC links to LUAD in never-smokers. Roles of systemic inflammation were assessed through effect modification and mediation analysis, and network toxicology approaches were employed to elucidate pathways and hub genes.</div></div><div><h3>Results</h3><div>EDC mixture showed significant positive associations with LUAD risk in never-smokers, particularly for Σalkylphenols (OR = 1.34, <em>q</em> &lt; 0.05) and Σbisphenols (OR = 1.28, <em>q</em> &lt; 0.05), with 4‑tert‑octylphenol (4‑tert‑OP) and bisphenol A (BPA) identified as key drivers. While neutrophil-to-lymphocyte ratio (NLR) exhibited a dose-dependent relationship with LCINS risk (OR = 1.38, <em>P</em> = 0.007), neither interaction (<em>P</em>_interaction &gt; 0.05) nor mediation (<em>P</em>_mediation &gt; 0.05) effect was observed between key EDCs and NLR. Integrative network toxicology revealed two mechanistic axes for 4‑tert‑OP/BPA-induced LUAD, including ligand-receptor interactions, cell proliferation, endocrine and cancer-related pathways. Hub gene analysis identified ESR1, AKT1, CASP3, and PTGS2 as central to BPA-LUAD associations, and AKT1, PTGS2, ESR1, MMP9, HSP90AA1, and BCL2 implicated in 4‑tert‑OP and LUAD interactions. These hub genes exhibited higher expressions in LUAD tissues and correlated with poor survival (HR &gt; 1, <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Our findings implicate alkylphenols (especially 4‑tert‑OP) and bisphenols (notably BPA) as key risk factors for LUAD in never-smokers, operating through endocrine disruption and carcinogenic pathways rather than systemic inflammation. The identified hub genes may serve as potential biomarkers for EDC-associated LUAD risk stratification.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 101009"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust Data driven modeling of Cd(II) adsorption on biochar","authors":"Ahmad Adel Abu-Shareha ,&nbsp;Raed Alfilh ,&nbsp;Araa Mohammed Yaseen ,&nbsp;Gadug Sudhamsu ,&nbsp;Prabhat Kumar Sahu ,&nbsp;Roselin Jenifer D ,&nbsp;Sumit Sharma ,&nbsp;Vatsal Jain ,&nbsp;Zarghuna Hekmatyar","doi":"10.1016/j.hazadv.2026.101004","DOIUrl":"10.1016/j.hazadv.2026.101004","url":null,"abstract":"<div><div>Cadmium toxicity presents a critical challenge for water security, driving the search for efficient biochar adsorbents. This study develops predictive machine learning models for Cd(II) removal using a homogenized global dataset of 1150 experimental records. Seven algorithms were optimized under five-fold cross-validation to estimate adsorption capacity from physicochemical and operational descriptors. Convolutional Neural Network (CNN), AdaBoost, and Random Forest (RF) achieved superior predictive consistency (<span><math><mrow><msup><mrow><mi>R</mi></mrow><mn>2</mn></msup><mo>&gt;</mo><mn>0.99</mn></mrow></math></span>), whereas SVR and MLP-ANN exhibited weak generalization. SHapley Additive exPlanations (SHAP) analysis revealed that carbon content and pyrolysis duration exert dominant negative effects on adsorption, contrasting with the positive influence of initial concentration. These opposing trends mechanistically highlight the trade-off between surface functionality and porosity. Overall, this work advances computational environmental research, offering a validated framework for the targeted design of biochars to maximize heavy metal sequestration.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 101004"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated target and suspect screening approach for PFAS monitoring in drinking water: A case study from the Basque Country (Spain)","authors":"Anne San Román ,&nbsp;Juan Francisco Ayala-Cabrera ,&nbsp;Belen González-Gaya ,&nbsp;Amaia Irizar ,&nbsp;Nestor Etxebarria ,&nbsp;Eunate Abilleira","doi":"10.1016/j.hazadv.2026.101049","DOIUrl":"10.1016/j.hazadv.2026.101049","url":null,"abstract":"<div><div>The widespread use of PFAS has led to their pervasive presence in the environment, with contamination levels shaped by both human and natural factors. Drinking water is a primary exposure route, since Drinking Water Treatment Plants (DWTPs) are unable to efficiently remove PFAS or, in some cases, increase PFAS levels after treatment. In this study, PFAS were analyzed in 29 water samples including raw, treated and tap water from a children’s cohort living place in Basque Country (INMA project, Spain), a population previously reported to accumulate PFAS. Analysis was conducted using high-performance liquid chromatography with high-resolution mass spectrometry, achieving detection limits of 0.002–1.2 ng/L and method quantification limits of 0.008–3.8 ng/L for 42 PFAS, respectively. Method performance met new PFAS regulatory standards, with satisfactory precision (2–29 %) and recovery rates (78–129 % across) confirmed by Water and Environmental Chemistry proficiency testing scheme (Aquacheck). The whole analytical method was applied in three different basins obtaining measurable PFAS levels in all sampling points. Nevertheless, total PFAS concentrations were below the maximum PFAS contaminant levels (total PFAS = 500 ng/L) set by the EU Drinking Water Directive. The assessment of the 3 water basins at consecutive years (2023 and 2024) showed comparable PFAS levels. However, in some cases PFAS levels increased after treatment in the DWTPs suggesting a source of PFAS contamination. Estimated daily intake for different PFAS families was also calculated, obtaining very different profiles, being PFCAs, PFSAs and FTCAs the main contributors to the total PFAS intake through drinking water. Comparison of drinking water and plasma data revealed no direct correlations, suggesting additional sources contribute to the PFAS burden in plasma. Finally, hazard indexes showed overall low hazard (HI &lt; 0.5) in the study area. On the other hand, suspect screening results showed the presence of 23 fluorinated features at different identification levels (2a to 4). The detected families were fluorinated sulfonic acids, quinolines, phosphonates, ketones, carboxylic acids, aldehydes, alcohols and esters suggesting that the current regulations and monitoring programs may be insufficient.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 101049"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent Invaders: the emerging impact of micro-, nanoplastics and plasticizers on human placental development and pregnancy outcomes","authors":"Masserdotti Alice ,&nbsp;Papait Andrea ,&nbsp;Ficai Sara ,&nbsp;Gasik Michael ,&nbsp;Antonietta Rosa Silini ,&nbsp;Parolini Ornella","doi":"10.1016/j.hazadv.2026.101034","DOIUrl":"10.1016/j.hazadv.2026.101034","url":null,"abstract":"<div><div>The placenta is a multifunctional organ essential for fetal growth, immune tolerance, and endocrine regulation. Increasing evidence indicates that micro- and nanoplastics (MNPs), and their chemical additives like bisphenols and phthalates can cross biological interfaces, accumulate in placental tissues, and impair their structure and function. Given the central role of the placenta in pregnancy maintenance, these findings raise concern regarding the potential consequences of ubiquitous plastic pollution for reproductive health.</div><div>This manuscript first provides a brief overview of placental architecture, and physiological roles, followed by a summary of the physicochemical characteristics of plastics, major routes of human exposure, and mechanisms of systemic transport and translocation to the placenta. The core of the review focuses on experimental evidence from <em>in vitro</em> and <em>in vivo</em> models describing how MNPs and chemicals are internalized by placental cells, alter cellular homeostasis, and impair vascular, metabolic, endocrine, and immune functions. Particular attention is given to size- and surface chemistry–dependent uptake, oxidative stress, inflammation, hormonal disruption, and epigenetic alterations. Finally, we identify key research gaps and outline future directions, including the need for environmentally relevant exposure models, studies on combined contaminant effects, biomarker development, and regulatory actions to reduce exposure. Through this synthesis, we aim to clarify current understanding of how pervasive plastic pollutants may threaten placental health and, ultimately, maternal and fetal well-being.</div></div>","PeriodicalId":73763,"journal":{"name":"Journal of hazardous materials advances","volume":"21 ","pages":"Article 101034"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}