Journal of clinical and translational pathology最新文献_第5页

Goblet Cell Adenocarcinoma of the Appendix: Diagnosis, Prognosis and Nomenclature 阑尾杯状细胞腺癌的诊断、预后及命名

Journal of clinical and translational pathology Pub Date : 2022-09-06 DOI: 10.14218/jctp.2022.00018

Hanlin L. Wang

引用次数: 0

Immune Checkpoint Inhibitor-Induced Hepatic Injury: A Clinicopathologic Review. 免疫检查点抑制剂诱发的肝损伤：临床病理学回顾

Journal of clinical and translational pathology Pub Date : 2022-09-01 Epub Date: 2022-09-26 DOI: 10.14218/jctp.2022.00017

Mehran Taherian, Deyali Chatterjee, Huamin Wang

{"title":"Immune Checkpoint Inhibitor-Induced Hepatic Injury: A Clinicopathologic Review.","authors":"Mehran Taherian, Deyali Chatterjee, Huamin Wang","doi":"10.14218/jctp.2022.00017","DOIUrl":"10.14218/jctp.2022.00017","url":null,"abstract":"Although immune checkpoint inhibitors (ICIs) have been a revolutionary milestone in immuno-oncology, immune-related adverse events (irAEs) may occur due to enhanced T cell activation and immune dysregulation. The irAEs can occur as early as within days to reportedly as late as up to 26 weeks. They may affect any organ system in the body, most commonly the luminal gastrointestinal tract, liver, skin, endocrine system, and lungs. The mechanisms of irAEs are complex and have not been fully understood. A breach of self-tolerance, which leads to autoantigen reactivity due to the enhanced activation and infiltration of T cells or the production of autoantibodies, and a non-specific autoinflammatory mechanism have been proposed. Limited data is available on the clinical and pathologic features of ICI-induced liver injury. This review presents an overview of the clinical and common histopathologic features and patterns of ICI-induced liver injury, the differential diagnoses, and the clinical management. Available data suggest that the histopathologic findings of ICI-induced hepatic injury are often non-specific and overlap with other challenging differential diagnoses. Therefore, a good knowledge of the histopathologic spectrum of ICI-induced hepatic injury and their differential diagnoses combined with the serological test results, clinical correlation, and communication with the clinical team is necessary to make an accurate and timely diagnosis.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"2 3","pages":"83-90"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/cd/nihms-1844355.PMC9815477.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10514988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis. 婴儿后巨细胞肝炎:文献综述和荟萃分析。

Journal of clinical and translational pathology Pub Date : 2022-09-01 DOI: 10.14218/jctp.2022.00016

Jingjing Jiao, Xuchen Zhang

{"title":"Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis.","authors":"Jingjing Jiao, Xuchen Zhang","doi":"10.14218/jctp.2022.00016","DOIUrl":"https://doi.org/10.14218/jctp.2022.00016","url":null,"abstract":"Post-infantile giant cell hepatitis (PIGCH) is a rare disease entity in adults with a multifactorial etiology and widely variable clinical courses and outcomes. The factors associated with the worse outcomes of this disease entity are still unclear. We identified 68 PIGCH patients by searching PubMed and performed meta-analysis. Among the 68 patients, 32% of the cases were associated with autoimmune disorders, followed by 21% associated with viral infections, 10% with medication, and 7% with malignancy. Twenty-four percent of the patients had more than one etiological factor, and 6% had other uncommon etiologies or an etiology that could not be identified. At the time of this report, 17 patients had died of the disease (poor outcome), and 51 patients remained alive with the disease (good outcome). Compared to the patients with a good outcome, the patients with a poor outcome were characterized by older age, lower levels of platelets and albumin, higher level of total bilirubin, and a diffuse distribution pattern of giant cells in the liver. There were no differences in gender distribution, aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, etiological distribution, or other histological features, including interface hepatitis, necrosis, lobular inflammation, portal inflammation, cholestasis, or fibrosis. Further studies would be needed to better understand the disease mechanisms and unmask any additional etiological factors and targeted therapies.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"2 3","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/c5/nihms-1880187.PMC10117396.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9388705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Histomorphology and Molecular Profiling of Well-Differentiated Squamous Cell Carcinoma of the Esophagus Including its Unusual Variants 高分化食管鳞状细胞癌及其异常变体的组织形态学和分子谱

Journal of clinical and translational pathology Pub Date : 2022-08-31 DOI: 10.14218/jctp.2022.00019

Feng Yin, Wei Zheng, Sam Amofa-Ho, Xiuli Liu

引用次数: 0

Practical Issues of Ki-67 Evaluation in Breast Cancer Clinical Practice Ki-67在癌症临床实践中的应用问题

Journal of clinical and translational pathology Pub Date : 2022-06-30 DOI: 10.14218/jctp.2022.00012

Sean M. Hacking, Yihong Wang

引用次数: 1

Follicular Cell Derived Thyroid Carcinoma: Common Things Present in Uncommon Ways 滤泡细胞衍生的甲状腺癌:常见的东西以不寻常的方式出现

Journal of clinical and translational pathology Pub Date : 2022-06-28 DOI: 10.14218/jctp.2022.00013

J. Lai, F. Fang, L. Song, He Wang

引用次数: 0

Cystic Lung Diseases Causing Spontaneous Pneumothorax 囊性肺部疾病导致自发性胸腔积液

Journal of clinical and translational pathology Pub Date : 2022-06-28 DOI: 10.14218/jctp.2022.00011

Chen Zhang

{"title":"Cystic Lung Diseases Causing Spontaneous Pneumothorax","authors":"Chen Zhang","doi":"10.14218/jctp.2022.00011","DOIUrl":"https://doi.org/10.14218/jctp.2022.00011","url":null,"abstract":"Surgical specimens resulting from a spontaneous pneumo- thorax (SP) are commonly encountered in the general surgical pathology practice. Many of the SP cases are primary pneumothorax with no underlying lung diseases. Specimens with primary pneumothorax show nonspecific pneumotho- rax-related changes, which are important to recognize to exclude the true underlying lung diseases. A variety of dis- ease entities may lead to diffuse cystic changes in the lungs, causing secondary pneumothorax. Some of the diseases are progressive and can cause irreversible damage to the lungs if not treated timely. Diagnosis of cystic lung diseases caus- ing secondary pneumothorax is important for the treatment of the diseases and the prevention of future episodes of pneumothorax. Lymphangioleiomyomatosis and Langerhans cell histiocytosis are two common conditions causing diffuse cystic changes in the lungs. They are discussed in greater de-tail in this review, given their overlapping features in patient characteristics, radiological findings, and pathologic findings. a diagnosis of exclusion. Specimens from these patients will show a spectrum of pneumothorax-related changes, which are important to recognize to exclude the true underlying lung diseases. The pneumothorax-related changes include pleural fibrosis with or without blebs, thick-walled blood vessels, and eosinophilic-rich chronic inflammation. 6–8 The underlying lung parenchyma may show distal acinar em-physema and reactive pneumocyte hyperplasia.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46681125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Grade Invasive Triple Negative Breast Carcinoma 低级别浸润性三阴性乳腺癌

Journal of clinical and translational pathology Pub Date : 2022-06-02 DOI: 10.14218/jctp.2022.00010

Nada Shaker, Q. Ding, Yihong Wang, Zaibo Li

引用次数: 2

The Challenges and Opportunities of Translational Pathology. 转化病理学的挑战与机遇。

Journal of clinical and translational pathology Pub Date : 2022-06-01 Epub Date: 2022-02-23 DOI: 10.14218/jctp.2022.00001

Lanjing Zhang

引用次数: 0

Differential Diagnosis of High-grade Neuroendocrine Neoplasms in the Digestive System 消化系统高级神经内分泌肿瘤的鉴别诊断

Journal of clinical and translational pathology Pub Date : 2022-03-18 DOI: 10.14218/jctp.2022.00008

Zhaohai Yang

引用次数: 1