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Journal of clinical and translational pathology最新文献

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Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue. 雄激素驱动严重急性呼吸系统综合征冠状病毒2型进入蛋白在鼻腔组织中的表达
Journal of clinical and translational pathology Pub Date : 2023-01-01 Epub Date: 2023-05-01 DOI: 10.14218/jctp.2022.00031
Rong Rong Huang, Jenna M Giafaglione, Takao Hashimoto, Liying Zhang, Weibo Yu, Jianyu Rao, Joshua W Russo, Steven P Balk, Nicholas G Nickols, Mathew B Rettig, Andrew Goldstein, Huihui Ye
{"title":"Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue.","authors":"Rong Rong Huang, Jenna M Giafaglione, Takao Hashimoto, Liying Zhang, Weibo Yu, Jianyu Rao, Joshua W Russo, Steven P Balk, Nicholas G Nickols, Mathew B Rettig, Andrew Goldstein, Huihui Ye","doi":"10.14218/jctp.2022.00031","DOIUrl":"10.14218/jctp.2022.00031","url":null,"abstract":"<p><strong>Background and objectives: </strong>Men have higher morbidity and mortality from COVID-19 than women, possibly due to androgen receptor-regulated viral entry protein expression. This led to a clinical trial of androgen deprivation therapy (ADT), which has not shown a significant benefit in the outcomes among hospitalized male COVID-19 patients. The aim of this study was to explore biological explanations for the failure of ADT to mitigate clinical outcomes in men with severe COVID-19 by assessing the role of androgen in regulating viral entry protein expression in the upper and lower respiratory tract.</p><p><strong>Methods: </strong>Immunohistochemistry was used to assess the expression of transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) and how it correlated to androgen receptor expression in the sinonasal epithelium, minor salivary glands of the sinus, lacrimal glands, and lungs from mice pretreated with and without castration and ADT as well as the sinonasal epithelium obtained from healthy human donors and hospitalized COVID-19 patients.</p><p><strong>Results: </strong>In murine models, castration and ADT treatment downregulated the expression of TMPRSS2 and ACE2 in the sinonasal epithelium, minor salivary glands of the sinus, and lacrimal glands, but not in the lungs. Correlative analyses using human tissue also showed a potential role of ADT in men during the early sinonasal phase but not in the later lung phase of SARS-CoV-2 infection.</p><p><strong>Conclusions: </strong>Our study suggests a potential benefit of ADT in male patients with early COVID-19 when the virus enters the nasopharynx, but not in those with advanced disease. The downregulation of viral entry proteins in the upper respiratory system following androgen blockade may be a key mechanism for this effect.</p>","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47933068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interobserver Reproducibility of Quantifying Gleason Pattern 4 Cancer in Prostate Biopsy: Implications for Clinical Practice 前列腺活检中量化Gleason模式4癌症的观察者间重复性：对临床实践的启示
Journal of clinical and translational pathology Pub Date : 2022-12-27 DOI: 10.14218/jctp.2022.00026
Jianhong Li, M. Ettel, A. Amin, R. Bhalla, K. Das, F. Deng, Peng Lee, A. Matoso, J. Melamed, Savvas E Mendrinos, Wei Tian, O. Yaskiv, R. Shah, M. Zhou
{"title":"Interobserver Reproducibility of Quantifying Gleason Pattern 4 Cancer in Prostate Biopsy: Implications for Clinical Practice","authors":"Jianhong Li, M. Ettel, A. Amin, R. Bhalla, K. Das, F. Deng, Peng Lee, A. Matoso, J. Melamed, Savvas E Mendrinos, Wei Tian, O. Yaskiv, R. Shah, M. Zhou","doi":"10.14218/jctp.2022.00026","DOIUrl":"https://doi.org/10.14218/jctp.2022.00026","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47307495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudotumor Associated with a Bioabsorbable Screw in a Patient with Reconstructed Congenital Absence of the Anterior Cruciate Ligament: a Case report 假肿瘤合并生物可吸收螺钉治疗先天性前交叉韧带缺损1例
Journal of clinical and translational pathology Pub Date : 2022-12-15 DOI: 10.14218/jctp.2022.00024
Yaxia Zhang, T. Bauer, S. Rodeo
{"title":"Pseudotumor Associated with a Bioabsorbable Screw in a Patient with Reconstructed Congenital Absence of the Anterior Cruciate Ligament: a Case report","authors":"Yaxia Zhang, T. Bauer, S. Rodeo","doi":"10.14218/jctp.2022.00024","DOIUrl":"https://doi.org/10.14218/jctp.2022.00024","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45094395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review and Update on Epithelial Tumors of the Anal Canal 肛管上皮性肿瘤的研究进展
Journal of clinical and translational pathology Pub Date : 2022-12-13 DOI: 10.14218/jctp.2022.00027
Xiaoyan Liao
{"title":"A Review and Update on Epithelial Tumors of the Anal Canal","authors":"Xiaoyan Liao","doi":"10.14218/jctp.2022.00027","DOIUrl":"https://doi.org/10.14218/jctp.2022.00027","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45660409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prognosis and Immunotherapy Prediction Based on Immunogenic Cell Death-related lncRNA in Gastric Cancer 基于免疫原性细胞死亡相关lncRNA的癌症预后及免疫治疗预测
Journal of clinical and translational pathology Pub Date : 2022-12-08 DOI: 10.14218/jctp.2022.00022
Qinian Jiang, Zhengshan Liu, Hang Yang
{"title":"Prognosis and Immunotherapy Prediction Based on Immunogenic Cell Death-related lncRNA in Gastric Cancer","authors":"Qinian Jiang, Zhengshan Liu, Hang Yang","doi":"10.14218/jctp.2022.00022","DOIUrl":"https://doi.org/10.14218/jctp.2022.00022","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49584921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Clinical Significance of the Positive Surgical Margin and Dominant Tumor Laterality Following Radical Prostatectomy: A Retrospective Study 前列腺癌根治术后手术切缘阳性和显性肿瘤侧位的临床意义：回顾性研究
Journal of clinical and translational pathology Pub Date : 2022-11-22 DOI: 10.14218/jctp.2022.00023
Shulin Wu, Sharron X. Lin, G. Wirth, Alexander O. Subtelny, Min Lu, Jian Lu, Zongwei Wang, A. Olumi, D. Dahl, M. Blute, Chin-Lee Wu
{"title":"The Clinical Significance of the Positive Surgical Margin and Dominant Tumor Laterality Following Radical Prostatectomy: A Retrospective Study","authors":"Shulin Wu, Sharron X. Lin, G. Wirth, Alexander O. Subtelny, Min Lu, Jian Lu, Zongwei Wang, A. Olumi, D. Dahl, M. Blute, Chin-Lee Wu","doi":"10.14218/jctp.2022.00023","DOIUrl":"https://doi.org/10.14218/jctp.2022.00023","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46346717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Frequency of HES1 Loss in Colorectal Adenocarcinomas with RAS/BRAF Mutations 具有RAS/BRAF突变的结直肠癌中HES1的高频率缺失
Journal of clinical and translational pathology Pub Date : 2022-10-27 DOI: 10.14218/jctp.2022.00020
W. Chen, Lan Zhou, Wei Xin
{"title":"High Frequency of HES1 Loss in Colorectal Adenocarcinomas with RAS/BRAF Mutations","authors":"W. Chen, Lan Zhou, Wei Xin","doi":"10.14218/jctp.2022.00020","DOIUrl":"https://doi.org/10.14218/jctp.2022.00020","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48514651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Histopathological Evaluation of Recurrent Primary Biliary Cholangitis after Liver Transplantation 肝移植术后复发性原发性胆总管炎的组织病理学评价
Journal of clinical and translational pathology Pub Date : 2022-09-28 DOI: 10.14218/jctp.2022.00021
Wegahta Weldemichael, Dongwei Zhang, Jingmei Lin
{"title":"Histopathological Evaluation of Recurrent Primary Biliary Cholangitis after Liver Transplantation","authors":"Wegahta Weldemichael, Dongwei Zhang, Jingmei Lin","doi":"10.14218/jctp.2022.00021","DOIUrl":"https://doi.org/10.14218/jctp.2022.00021","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44417046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Entities and Emerging Issues in Gastrointestinal and Liver Pathology 胃肠道和肝脏病理学中罕见的实体和新出现的问题
Journal of clinical and translational pathology Pub Date : 2022-09-28 DOI: 10.14218/jctp.2022.00025
F. Yin, Huamin Wang
{"title":"Rare Entities and Emerging Issues in Gastrointestinal and Liver Pathology","authors":"F. Yin, Huamin Wang","doi":"10.14218/jctp.2022.00025","DOIUrl":"https://doi.org/10.14218/jctp.2022.00025","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42216797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Elevated Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 with 90-day Outcomes of Patients with Acute-on-chronic Liver Failure: A Cohort Study 骨髓细胞-1表达的血清可溶性触发受体升高与急慢性肝功能衰竭患者90天预后的相关性：一项队列研究
Journal of clinical and translational pathology Pub Date : 2022-09-27 DOI: 10.14218/jctp.2022.00015
Yue Huang, Jun-Jun Cai, T. Han
{"title":"Association of Elevated Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 with 90-day Outcomes of Patients with Acute-on-chronic Liver Failure: A Cohort Study","authors":"Yue Huang, Jun-Jun Cai, T. Han","doi":"10.14218/jctp.2022.00015","DOIUrl":"https://doi.org/10.14218/jctp.2022.00015","url":null,"abstract":"","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48373241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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