Journal of clinical and translational pathology最新文献_第3页

Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations. 宫颈癌筛查指南、宫颈细胞学报告贝塞斯达系统和临床管理建议的更新。

Journal of clinical and translational pathology Pub Date : 2023-06-01 Epub Date: 2023-04-21 DOI: 10.14218/jctp.2023.00004

Tiannan Wang, Huina Zhang, Yang Liu, Chengquan Zhao

{"title":"Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations.","authors":"Tiannan Wang, Huina Zhang, Yang Liu, Chengquan Zhao","doi":"10.14218/jctp.2023.00004","DOIUrl":"10.14218/jctp.2023.00004","url":null,"abstract":"Over the past decades, cervical cancer has been a worldwide public health problem. Population-based early cancer risk detection and prevention approaches, including vaccination, cytology screening and human papilloma virus (HPV) detection, with the aligned clinical management, have formed a well-rounded high-quality implementation system for cervical cancer control, and revolutionarily improved the quality of life of women: (1) the success of cervical cancer screening practices, (2) standardization of The Bethesda system for reporting cervicovaginal cytology, (3) improvement in the understanding of HPV pathogenesis in cervical cancer, and (4) the development of appropriate management approaches have significantly decreased the disease burden of cervical cancer worldwide. This scoping review aimed to understand the evolvement of cervical cancer screening and management guidelines, describe the Bethesda cervical cytology reporting system, and HPV vaccines and tests, and highlight the key information of present policies and practices.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"3 2","pages":"75-83"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/7d/nihms-1895426.PMC10348779.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9880461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bethesda System for Reporting Thyroid Cytopathology–An Updated Review Bethesda系统报告甲状腺细胞病理学-最新综述

Journal of clinical and translational pathology Pub Date : 2023-04-22 DOI: 10.14218/jctp.2023.00005

Min Han, Fang Fan

引用次数: 3

Update on Selected Oncocytic Renal Cell Tumors 选择性嗜瘤性肾细胞肿瘤的最新进展

Journal of clinical and translational pathology Pub Date : 2023-03-27 DOI: 10.14218/jctp.2022.00032

Hui-zhi Zhang, Mingde Zhao, Zhe Zhang, D. Cao

引用次数: 1

Primary Mucosal Melanoma of the Penile Urethra: A Case Report of an Extremely Rare Disease with a Unique Molecular Profile 阴茎尿道原发性粘膜黑色素瘤：一例具有独特分子特征的极为罕见疾病的病例报告

Journal of clinical and translational pathology Pub Date : 2023-03-16 DOI: 10.14218/jctp.2023.00001

Suzanne J. Tintle, T. Vandergriff, Liwei Jia

引用次数: 0

Advances, Timely Topics, and Updates in Genitourinary Pathology 泌尿生殖系统病理学的进展、及时主题和更新

Journal of clinical and translational pathology Pub Date : 2023-03-10 DOI: 10.14218/jctp.2022.00034

P. Humphrey

引用次数: 0

Testicular Germ Cell Tumors with Somatic-type Malignancy 睾丸生殖细胞肿瘤伴躯体型恶性肿瘤

Journal of clinical and translational pathology Pub Date : 2023-02-22 DOI: 10.14218/jctp.2022.00028

Jiaming Fan, Y. Guan, C. Guo, G. Wang

引用次数: 1

Novel Urinary Liquid Biopsy Biomarkers and Their Role in Detecting Genitourinary Cancers 新型尿液活检生物标志物及其在泌尿生殖系统癌检测中的作用

Journal of clinical and translational pathology Pub Date : 2023-01-13 DOI: 10.14218/jctp.2022.00030

Blake Salfer, Feng Li, Yazhen Zhu, F. Deng, David T. W. Wong, Liying Zhang

引用次数: 0

Updates of Prostate Cancer from the 2022 World Health Organization Classification of the Urinary and Male Genital Tumors. 2022年世界卫生组织泌尿系和男性生殖器肿瘤分类中前列腺癌症的更新

Journal of clinical and translational pathology Pub Date : 2023-01-01 Epub Date: 2023-01-17 DOI: 10.14218/jctp.2022.00029

Charles C Guo, Bogdan Czerniak

{"title":"Updates of Prostate Cancer from the 2022 World Health Organization Classification of the Urinary and Male Genital Tumors.","authors":"Charles C Guo, Bogdan Czerniak","doi":"10.14218/jctp.2022.00029","DOIUrl":"10.14218/jctp.2022.00029","url":null,"abstract":"Prostate cancer is a heterogeneous disease with a wide spectrum of pathological, clinical, and molecular features. The diagnosis and classification of prostate cancer have been constantly modified with the incorporation of new data. The 5th edition of the World Health Organization (WHO) Classification of Urinary and Genital Tumors was recently published six years after the 4th edition. In this new edition, the classification of prostate cancer has been refined in the diagnostic criteria, grading, nomenclature, and genomics. This paper reviews significant updates to the new WHO classification of prostate cancer, including high-grade prostatic intraepithelial neoplasia, acinar adenocarcinoma, intraductal carcinoma, ductal carcinoma, and neuroendocrine tumors. Controversial issues in the Gleason grading are discussed, such as intraductal carcinoma and tertiary grade. We also highlight distinct genetic and epigenetic alterations in prostate cancer that may contribute to its diverse clinicopathologic features. Overall, the 5th edition of the WHO classification provides a comprehensive assessment of prostate cancer with morphologic, immunohistochemical, genomic, and clinical data, which may represent an optimal paradigm for diagnosing and treating prostate cancer.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43556124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue. 雄激素驱动严重急性呼吸系统综合征冠状病毒2型进入蛋白在鼻腔组织中的表达

Journal of clinical and translational pathology Pub Date : 2023-01-01 Epub Date: 2023-05-01 DOI: 10.14218/jctp.2022.00031

Rong Rong Huang, Jenna M Giafaglione, Takao Hashimoto, Liying Zhang, Weibo Yu, Jianyu Rao, Joshua W Russo, Steven P Balk, Nicholas G Nickols, Mathew B Rettig, Andrew Goldstein, Huihui Ye

{"title":"Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue.","authors":"Rong Rong Huang, Jenna M Giafaglione, Takao Hashimoto, Liying Zhang, Weibo Yu, Jianyu Rao, Joshua W Russo, Steven P Balk, Nicholas G Nickols, Mathew B Rettig, Andrew Goldstein, Huihui Ye","doi":"10.14218/jctp.2022.00031","DOIUrl":"10.14218/jctp.2022.00031","url":null,"abstract":"Background and objectives: Men have higher morbidity and mortality from COVID-19 than women, possibly due to androgen receptor-regulated viral entry protein expression. This led to a clinical trial of androgen deprivation therapy (ADT), which has not shown a significant benefit in the outcomes among hospitalized male COVID-19 patients. The aim of this study was to explore biological explanations for the failure of ADT to mitigate clinical outcomes in men with severe COVID-19 by assessing the role of androgen in regulating viral entry protein expression in the upper and lower respiratory tract.Methods: Immunohistochemistry was used to assess the expression of transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) and how it correlated to androgen receptor expression in the sinonasal epithelium, minor salivary glands of the sinus, lacrimal glands, and lungs from mice pretreated with and without castration and ADT as well as the sinonasal epithelium obtained from healthy human donors and hospitalized COVID-19 patients.Results: In murine models, castration and ADT treatment downregulated the expression of TMPRSS2 and ACE2 in the sinonasal epithelium, minor salivary glands of the sinus, and lacrimal glands, but not in the lungs. Correlative analyses using human tissue also showed a potential role of ADT in men during the early sinonasal phase but not in the later lung phase of SARS-CoV-2 infection.Conclusions: Our study suggests a potential benefit of ADT in male patients with early COVID-19 when the virus enters the nasopharynx, but not in those with advanced disease. The downregulation of viral entry proteins in the upper respiratory system following androgen blockade may be a key mechanism for this effect.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":" ","pages":"49-58"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47933068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interobserver Reproducibility of Quantifying Gleason Pattern 4 Cancer in Prostate Biopsy: Implications for Clinical Practice 前列腺活检中量化Gleason模式4癌症的观察者间重复性：对临床实践的启示

Journal of clinical and translational pathology Pub Date : 2022-12-27 DOI: 10.14218/jctp.2022.00026

Jianhong Li, M. Ettel, A. Amin, R. Bhalla, K. Das, F. Deng, Peng Lee, A. Matoso, J. Melamed, Savvas E Mendrinos, Wei Tian, O. Yaskiv, R. Shah, M. Zhou

引用次数: 0