Journal of clinical and translational pathology最新文献

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Pathological Changes of Adult Mitral Valves after Failed CorMatrix ECM Repair. CorMatrix ECM修复失败后成人二尖瓣的病理变化。

Journal of clinical and translational pathology Pub Date : 2021-01-01 Epub Date: 2021-08-24 DOI: 10.14218/jctp.2021.00009

Baidarbhi Chakraborty, He Wang

{"title":"Pathological Changes of Adult Mitral Valves after Failed CorMatrix ECM Repair.","authors":"Baidarbhi Chakraborty, He Wang","doi":"10.14218/jctp.2021.00009","DOIUrl":"https://doi.org/10.14218/jctp.2021.00009","url":null,"abstract":"Background and objectives: CorMatrix acts as a tissue scaffold and is intended to promote the proliferation of small vessels and tissue remodeling to replicate normal tissue function.Methods: At Temple University Hospital, Philadelphia, PA, USA from 2013 to 2016, CorMatrix material was utilized during mitral valve anterior leaflet augmentation repair in 25 adult patients, and four patients required repeat interventions at 4-12 months (8.25 ± 4.35 months) after the initial repair. This study evaluated the pathological changes in four patients.Results: Histological examination of the CorMatrix showed matrix degradation in all cases. At 4 months after repair, mixed acute and chronic inflammatory cells that included eosinophils were visible within the matrix, which was more severe around the suture material. Later, the extent of inflammation abated and became more chronic with macrophage dominance. Some macrophages and multinucleated cells were visible deep in the matrix. The neovascularization was limited to the tissue-matrix boundary at early time points; the more mature vessels with dilated lumens extended deeper into the matrix as time increased, combined with some elongated fibroblast-like cells. In addition, marked acute and chronic inflammation with neutrophil and eosinophil infiltrate was identified in the surrounding native tissue at 4 months, especially around the suture material. Marked granulomatous inflammation was identified in all cases, with prominent multinucleated giant cells present at later time points (50%). Immunohistochemical staining for CD68 and CD163 showed prominent M2 macrophages in the CorMatrix and surrounding tissue.Conclusions: Our results demonstrated time-dependent changes in failed CorMatrix repaired valves after mitral valve repair, with macrophages and neovascularization in the matrix 12 months after the initial repair.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"1 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/b8/nihms-1735673.PMC8697744.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39765670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Liver Involvement by Perforated Peptic Ulcer: A Systematic Review. 穿孔性消化性溃疡累及肝脏:一项系统综述。

Journal of clinical and translational pathology Pub Date : 2021-01-01 Epub Date: 2021-06-04 DOI: 10.14218/jctp.2021.00007

Jingjing Jiao, Lanjing Zhang

{"title":"Liver Involvement by Perforated Peptic Ulcer: A Systematic Review.","authors":"Jingjing Jiao, Lanjing Zhang","doi":"10.14218/jctp.2021.00007","DOIUrl":"https://doi.org/10.14218/jctp.2021.00007","url":null,"abstract":"Background and objective: Liver penetration by a confined perforation of peptic ulcer is a rare but severe event. Its clinical and pathological features are unclear.Methods: In total, 41 qualified English publications were identified using the PubMed database and one in-house case.Results: Among the 42 patients, 20 patients had liver involvement by a perforated duodenal ulcer and 22 by a gastric ulcer. Among the 23 cases of known ulcer histology, 2 ulcers were malignant and were adenocarcinomas in the gastric remnant and the remaining 21 ulcers were confirmed as histologically benign (for frequency of malignancy in duodenal versus gastric ulcers, p = 0.48). The presence of hepatocytes was the clue of diagnosis for 19 cases. The median ages of the patients were 64.5 years (95% Confidence Intervals [CI] 53.40-71.90) for duodenal ulcer and 65.5 years (95% CI: 59.23-70.95) for gastric ulcer, respectively. The male to female ratio was 1.5:1 for duodenal ulcers and 2:1 for gastric ulcers. Patients with liver involvement of a perforated gastric ulcer were more likely to have a larger ulcer (median largest dimension, 4.75 cm versus 2.5 cm, p = 0.014). Female patients with liver involvement of a gastric ulcer were older than male patients (median age 72 versus 60 years, p = 0.045). There were no differences in gender, region (Asia, Europe, America versus others), use of non-steroidal anti-inflammatory drugs (n = 15), H. Pylori positivity (n = 10), possible history of peptic ulcer disease (n = 19) or mortality (n = 32) between duodenal and gastric ulcers.Conclusions: Careful histologic examination, clinicopathological correlation, and immunohistochemistry are critical to establish the diagnosis and avoid misdiagnosing liver involvement as malignancy.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"1 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/3b/nihms-1716510.PMC8681229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39740514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The launch of Journal of Clinical and Translational Pathology 《临床与转化病理学杂志》创刊

Journal of clinical and translational pathology Pub Date : 2021-01-01 DOI: 10.14218/jctp.2021.00016

引用次数: 0

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