Journal of clinical and translational pathology最新文献

Digital and Artificial Intelligence-based Pathology: Not for Every Laboratory - A Mini-review on the Benefits and Pitfalls of Its Implementation. 基于数字和人工智能的病理学：不适合每个实验室-对其实施的好处和陷阱的迷你回顾。

Journal of clinical and translational pathology Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.14218/jctp.2025.00007

Iris Z Shen, Lanjing Zhang

{"title":"Digital and Artificial Intelligence-based Pathology: Not for Every Laboratory - A Mini-review on the Benefits and Pitfalls of Its Implementation.","authors":"Iris Z Shen, Lanjing Zhang","doi":"10.14218/jctp.2025.00007","DOIUrl":"10.14218/jctp.2025.00007","url":null,"abstract":"Background and objectives: With the increasing use of artificial intelligence (AI) in diagnostics, AI algorithms have shown great potential in aiding diagnostics. As more of these algorithms are developed, there is overwhelming enthusiasm for implementing digital and artificial intelligence-based pathology (DAIP), but doubts and pitfalls are also emerging. However, few original or review articles address the limitations and practical aspects of implementing DAIP. In this review, we briefly examine the evidence related to the benefits and pitfalls of DAIP implementation and argue that DAIP is not suitable for every clinical laboratory.Methods: We searched the PubMed database using the following keywords: \"digital pathology,\" \"digital AI pathology,\" and \"AI pathology.\". Additionally, we incorporated personal experiences and manually searched related papers.Results: Ninety-two publications were found, of which 24 met the inclusion criteria. Many advantages of DAIP were discussed, including improved diagnostic accuracy and equity. However, several limitations of implementing DAIP exist, such as financial constraints, technical challenges, and legal/ethical concerns.Conclusions: We found a generally favorable but cautious outlook for the implementation of DAIP in the pathology workflow. Many studies have reported promising outcomes in using AI for diagnosis and analysis; however, there are also several noteworthy limitations in implementing DAIP. Therefore, a balance between the benefits and pitfalls of DAIP must be thoroughly articulated and examined in light of the institution's needs and goals before making the decision to implement DAIP. Approaches for mitigating machine learning biases were also proposed, and the adaptation and growth of the pathology profession were discussed in light of DAIP development and advances.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"5 2","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic Biliary Adenofibroma: Histological Characteristics, Diagnostic Challenges, and Its Role as a Precursor to Intrahepatic Cholangiocarcinoma. 肝胆道腺纤维瘤：组织学特征、诊断挑战及其作为肝内胆管癌前兆的作用。

Journal of clinical and translational pathology Pub Date : 2024-10-01 Epub Date: 2024-12-24 DOI: 10.14218/jctp.2024.00044

Xiaoyan Liao, Xuchen Zhang

{"title":"Hepatic Biliary Adenofibroma: Histological Characteristics, Diagnostic Challenges, and Its Role as a Precursor to Intrahepatic Cholangiocarcinoma.","authors":"Xiaoyan Liao, Xuchen Zhang","doi":"10.14218/jctp.2024.00044","DOIUrl":"https://doi.org/10.14218/jctp.2024.00044","url":null,"abstract":"Hepatic biliary adenofibroma is an exceedingly rare biliary neoplasm that primarily affects adults. It typically presents as a solitary mass composed of low-grade microcystic and tubuloglandular bile duct structures, which are lined by low columnar to cuboidal non-mucin-producing biliary epithelium and supported by abundant fibrous stroma. Histologically, it resembles the Von Meyenburg complex but is much larger in size and often shows cytologic atypia. Although considered benign, emerging case studies and analyses suggest that biliary adenofibroma may serve as a precursor lesion to intrahepatic cholangiocarcinoma. However, its extreme rarity, coupled with an incompletely understood histogenesis, perpetuates diagnostic uncertainty and may lead to misclassification with other similar entities. This review consolidates the current understanding of the histopathological and molecular characteristics of biliary adenofibroma, highlights its differential diagnosis, explores its potential progression to cholangiocarcinoma, and discusses unresolved questions while proposing future research directions.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"4 4","pages":"163-167"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The World Health Organization System for Reporting Pancreaticobiliary Cytopathology: Standardized Categories and Practical Approaches to Pancreatic Lesions. 世界卫生组织胰胆管细胞病理学报告系统：胰腺病变的标准化分类和实用方法。

Journal of clinical and translational pathology Pub Date : 2024-09-01 Epub Date: 2024-09-25 DOI: 10.14218/jctp.2024.00034

Minhua Wang, Maria D Lozano, Guoping Cai

引用次数: 0

Histopathologic Features and Differential Diagnosis in Challenging Cases of Nodular Lymphocyte Predominant B-cell Lymphoma/Nodular Lymphocyte Predominant Hodgkin Lymphoma. 结节性淋巴细胞为主的 B 细胞淋巴瘤/结节性淋巴细胞为主的霍奇金淋巴瘤疑难病例的组织病理学特征和鉴别诊断。

Journal of clinical and translational pathology Pub Date : 2024-06-01 DOI: 10.14218/jctp.2024.00015

Yanna Ding, Elaine S Jaffe

{"title":"Histopathologic Features and Differential Diagnosis in Challenging Cases of Nodular Lymphocyte Predominant B-cell Lymphoma/Nodular Lymphocyte Predominant Hodgkin Lymphoma.","authors":"Yanna Ding, Elaine S Jaffe","doi":"10.14218/jctp.2024.00015","DOIUrl":"10.14218/jctp.2024.00015","url":null,"abstract":"Nodular lymphocyte predominant Hodgkin lymphoma was termed \"nodular lymphocyte predominant B-cell lymphoma\" in the International Consensus Classification (ICC), to emphasize clinical and biological differences from classic Hodgkin lymphoma (CHL). The abbreviation \"NLP\" represents both terms in the ICC and World Health Organization classifications. Variations in the growth pattern, originally reported as Fan patterns A-F, are designated as either grade 1 or grade 2 in the ICC. NLP is uncommon, and in some cases an accurate diagnosis is challenging. The objectives of this article were to review the histopathologic features of NLP and the differential diagnosis from other key entities including de novo T-cell/histiocyte-rich large B-cell lymphoma (THRLBL) and lymphocyte-rich classic Hodgkin lymphoma (LRCHL). Histologically, NLP Fan pattern E (THRLBL-like) can be indistinguishable from de novo THRLBL. However, focal nodular areas, clustering of tumor cells, presence of few admixed small B-cells or FDC meshworks, and T-cell rosettes favor NLP Fan pattern E and argue against de novo THRLBL. NLP may also be confused with LRCHL. Patients with NLP are younger than those with LRCHL, and LRCHL may show mediastinal involvement. In LRCHL, the nodular pattern often contains eccentrically located small regressed germinal centers and intact small dense FDC meshworks, in contrast to the expanded, and fragmented FDC meshworks in NLP. Neoplastic cells that are positive for CD30 and CD15 but negative for CD20 and CD79a are characteristic of LRCHL. Additionally, Fascin and Gata3 are commonly positive in LRCHL but usually negative in NLP.","PeriodicalId":73661,"journal":{"name":"Journal of clinical and translational pathology","volume":"4 2","pages":"61-69"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review and Update on Therapy of Gastrointestinal Tract Tumors: From the Bench to Clinical Practice 胃肠道肿瘤治疗回顾与更新：从工作台到临床实践

Journal of clinical and translational pathology Pub Date : 2024-05-15 DOI: 10.14218/jctp.2024.00007

M. J. Fernández-Aceñero, Desirée Hernández, Cristina Díaz del Arco

引用次数: 0

Updates from the 2022 WHO Classification of Kidney Epithelial Tumors 2022 年世界卫生组织肾上皮肿瘤分类》的更新内容

Journal of clinical and translational pathology Pub Date : 2024-05-15 DOI: 10.14218/jctp.2024.00002

Muhammed Mubarak, Rahma Rashid

引用次数: 0

Disseminated Carcinomatosis of Bone Marrow with or without an Unknown Primary Site: A Case Series 原发部位不明的骨髓播散性癌：病例系列

Journal of clinical and translational pathology Pub Date : 2024-05-14 DOI: 10.14218/jctp.2023.00064

Kenji Miki, M. Yamanishi, Satoko Mibayashi, Shinsaku Imashuku

引用次数: 0

Atypia of Undetermined Significance in Thyroid Fine Needle Aspiration Cytology Revisited 甲状腺细针抽吸细胞学中意义未定的非典型性再探讨

Journal of clinical and translational pathology Pub Date : 2024-05-06 DOI: 10.14218/jctp.2023.00062

M. J. Fernández-Aceñero, Salomé Merino, Desirée Hernández, Santiago Ochagavia, Melchor Sáiz-Pardo, Pablo Pérez Alonso, Tomas Ganado, Jesús Vega, C. D. Arco

引用次数: 0

A Case Report of ZC3H7B-BCOR High-grade Endometrial Stromal Sarcoma Expressing CD117 and DOG1: A Molecularly Confirmed Diagnostic Pitfall 一例表达 CD117 和 DOG1 的 ZC3H7B-BCOR 高级子宫内膜间质肉瘤病例报告：分子确证的诊断陷阱

Journal of clinical and translational pathology Pub Date : 2024-03-23 DOI: 10.14218/jctp.2023.00066

Yaxi Wang, Pei Yuan, Weihua Li, Hua Zeng, Jianming Ying

引用次数: 0

Somatic Copy Number Alterations and Mutation Landscape in Before and Post-treatment Malignant Rhabdoid Tumor 恶性横纹肌瘤治疗前和治疗后的体细胞拷贝数畸变和突变情况

Journal of clinical and translational pathology Pub Date : 2024-03-18 DOI: 10.14218/jctp.2023.00028

Yamin Ma, Madhurima Kaushal, Louis Dehner, John Pfeifer, Mai He

引用次数: 0