Journal of clinical & experimental immunology最新文献

{"title":"Study on Preparation of New Purified Vero Cell Rabies Vaccine","authors":"","doi":"10.33140/jcei.04.04.04","DOIUrl":"https://doi.org/10.33140/jcei.04.04.04","url":null,"abstract":"Rabies is a 100% vaccine-preventable disease. A cheap, rabies vaccine for humans that could be used in mass vaccination\u0000campaigns would be a valuable weapon against rabies. Despite the existence of safe and effective vaccines, rabies disease\u0000still causes an estimated more human deaths a year in the endemic areas in Asia and Africa. Rabies virus is single stranded\u0000negative sense RNA from genus lyssavirus and _ family rhabdoviridae.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78947477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biostatistical Analysis on Chronic Disease Risk","authors":"B. Zhao, X. Jiang, J. Cao, K. Huang","doi":"10.33140/jcei.04.04.02","DOIUrl":"https://doi.org/10.33140/jcei.04.04.02","url":null,"abstract":"Introduction: Approximately one-third of all college students aged 18-29 were classified as overweight or obese, increasing their\u0000risk for chronic disease. Nutritional knowledge is an important first step to developing strategist to improve the food choices\u0000of college students and promote healthy lifestyle behaviors. Therefore, the purpose of this study was to determine the current\u0000nutritional knowledge of students enrolled in courses within the Human Performance and Leisure Studies (HPLS) Department\u0000at Hubei University of Technology (HBUT).\u0000Methods: Paper based surveys were used to administer the 56-question Nutritional Knowledge Questionnaire (NKQ) for students\u0000enrolled in HPLS courses in spring 2017.\u0000Results: Response rate was 65.6% (n=236). Gender distribution was equal among the surveyed students (45.3% male vs. 53.8%\u0000females). The majority reported majoring in sports science and fitness management (SSFM) (76.7%), were between 18-24 years\u0000old (86.9%) with a self-identified ethnic origin of Chinese Xinjiang person (89.8%). The average nutritional knowledge score\u0000was 49.2 +/- 9.8 or 44.8%. Knowledge of diet-disease relationship was higher in females (5.4 +/- 1.9) compared to males (4.8\u0000+/- 2.3), p = 0.03.\u0000Conclusion: In this study, we found a need to improve nutritional knowledge in college students enrolled in select HPLS courses\u0000in the spring of 2017 at HBUT. The findings highlight a gap in nutrition education and the opportunity to develop courses or\u0000programs aimed at healthful eating for students majoring in SSFM or attending HBUT.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85071834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of External Ventricular Drainage in Spontaneous Intracerebral\u0000Haemorrhage with Ventricular Extension in different GCS Score","authors":"","doi":"10.33140/jcei.04.03.05","DOIUrl":"https://doi.org/10.33140/jcei.04.03.05","url":null,"abstract":"Background: Intracerebral Haemorrhage (ICH) is a medical emergency of the highest degree with frequent early neurological\u0000deterioration or death. External ventricular drainage (EVD) is the procedure of choice for the treatment of spontaneous\u0000intracerebral haemorrhage with ventricular extension or blood within the ventricles, acute hydrocephalus and increased\u0000intracranial pressure in patients of intracerebral haemorrhage and subarachnoid haemorrhage (SAH) with hydrocephalus and\u0000its sequelae.\u0000Objective: The aim and objective of this study was to predict the outcome of pre operative GCS following external ventricular\u0000drainage in spontaneous intracerebral haemorrhage with ventricular extension.\u0000Method: In this was prospective observational studies, a total number of 60 cases were taken purposively for a period of July,\u00002015- March, 2017 diagnosed by CT scan of brain at Department of Neurosurgery, Dhaka Medical College Hospital. All the\u0000patients, fulfilling the inclusion and exclusion criteria, were enrolled for the study. For assessing outcome of EVD in post operative\u0000patients and evaluating the efficacy of EVD surgery in follow ups. Glasgow Coma Scale and Glasgow Outcome Scale scoring\u0000method for patient assessment were used for outcome of EVD surgery.\u0000Result: A total of 60 patients were included in this study, age range was 45 to 86 years. Majority patients, 24 (40.0%) were from\u000061-70 years of age. The mean age was found 62.0±20. It was observed that 24 (40.00%) patients had GCS 5. GCS 6 was observed\u0000in 14(23.33%) patients. GCS 5 and 6 were not found post operatively in any cases. GCS 7 was observed in 14 (23.33%) cases.\u0000Whereas, GCS 8, 9, 10 were found in 11 (18.33%), 13 (21.66%), 10(16.66%) cases respectively and 4 cases were died on first\u0000post operative day. In most cases GCS level rose to 2 points. GOS at 7th POD died total 12 (20.00%) cases. It was observed\u0000that 48 (80.00%) patients were alive Moderate disability existed in 12(25.00%) cases. Again, severe disability and persistent\u0000vegetative cases observed in 14(29.16%), 9(18.75%) cases. Glasgow Outcome Scale at 3 months follow up of my study patients,\u0000it was observed that total died patients 16 (26.66%).\u0000Conclusion: According to my study, majority of the study patients survived following EVD in spontaneous ICH with ventricular\u0000extension but most cases was unfavorable outcome which was statistically","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86275597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Intraoperative Hypothermia Review of the Molecular Mechanisms of\u0000Action in Therapeutic Hypothermia","authors":"","doi":"10.33140/jcri.04.03.03","DOIUrl":"https://doi.org/10.33140/jcri.04.03.03","url":null,"abstract":"During surgery the patient may lose heat during and after surgery\u0000through the contribution of several factors: ambient temperature,\u0000cold fluid infusion, the position on the operating table, surgical\u0000skin preparation methods, type of surgery, conventional surgery\u0000or laparoscopy, and the loss increase of the heat by opening the\u0000serous cavities, thoracic or abdominal [1]. They add other factors,\u0000depending on patients: the elderly are more prone to heat loss,\u0000sex; women lose less heat, the existence of associated diseases, as\u0000peripheral vascular diseases, endocrine diseases, cachexia, physical\u0000constitution or presence of pregnancy. Temperature of the patient’s\u0000body lowers in relation to prolonged patient stay in a cool room of\u0000resuscitation. The heat loss of the skin tissue in the operating room\u0000is important and is expressed at approximately 100 W [2]. More\u0000important than the relationship between temperature of the operating\u0000room and patient’s skin, the microclimate, which is established\u0000between operators fields and patient. Another important factor is\u0000body surface area exposed having significant area reported at weight.\u0000Hypothermia is aggravated by cold fluid administration, abdominal\u0000or thoracic wounds. The use of cold solutions in urologic surgery\u0000exposes the central temperature drop, which is more marked if\u0000intervention is performed under epidural anesthesia [3]. In epidural\u0000anesthesia, hypothermia is due to redistribution of heat between\u0000the center and periphery, the thighs being established to intense\u0000vasodilatation and heat loss [4, 5]. All measures taken to prevent\u0000heat loss are important for prevention of coagulation disorders.\u0000Hypothermia reduces oxygen release in half, reducing the liver’s\u0000ability to metabolize citrate and lactic acid and cause arrhythmia.\u0000The existence of hypothermia in surgical patient reflects failure\u0000thermoregulatory mechanisms [1-3].","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80635108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Approach with CAR-T and CAR-NK Cells for Synergistic Action to\u0000Treat Cancer","authors":"","doi":"10.33140/jcei.04.03.02","DOIUrl":"https://doi.org/10.33140/jcei.04.03.02","url":null,"abstract":"Recent years have seen a craze about the T-cell immunotherapy for B-cell malignancies, and there is growing interest in NK-CAR therapy. In this paper, I discuss the similarities and differences between the CARs in the NK and T-Cells. Further, explore the possible theoretical concept of a multimodal approach towards treating cancer. Whether the two genetically modified cells could provide an added advantage acting synergistically to complement each other’s therapeutic qualities or counteract each other’s downfall. This short communication is an attempt to pique interest to understand the mechanisms of NK cell and T cell biological interaction in the presence of a therapeutic weapon “CAR” to target tumor.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85751480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sea Star Igkappa Gene and The Ophuirid Igkappa Gene Vaccinations to HRP\u0000(Horse-radish Peroxydase)","authors":"M. Leclerc","doi":"10.33140/jcei.04.03.01","DOIUrl":"https://doi.org/10.33140/jcei.04.03.01","url":null,"abstract":"The main point of the sea star immunology, of the ophuirid immunology remain the discovery of the INVERTEBRATE PRIMITIVE\u0000ANTIBODY (IPA), the IGKAPPA GENES, with Ig sites which imply the COMPLEMENT SYSTEM, to be initiated: 9 component\u0000genes from C1 to C9 have been updated these last years, in sea star genome, in ophuirid one. These primitive antibodies were\u0000obtained after immunizations to the enzyme HRP (Horse-radish peroxydase). It is the first time we observe vaccinations in\u0000invertebrates. We have discovered, for the first time also, in these same Invertebrate a FC receptor gene, a Fab gene which\u0000corroborate the presence of IPA. The transcriptomes are given. It is the first time, we can speak of Adaptative Immunity, in\u0000Echinoderms, in Invertebrates Since many years, even since a century long, the notion of Antibody was out of the speech of\u0000immunologists. To speak of that made you as an outlaw. It is time to look with genomic studies which confirm which assert now\u0000evidence that 3 classes of Echinoderms out of 5 possess an Igkappa gene, a FC receptor gene. I recall these classent: the Asterids\u0000with Asterias rubens, the Ophuirids with Ophiocomina nigra and the Crinoïds.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82118124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Unique Vaccine with Multiple Applications","authors":"G. Talwar, J. C. Gupta, A. Krishnan, A. Mustafa, S. Zaheer, HK Kar, R. Mukherjee, R. Rani, S. Bhaskar, P. Reddi, V. Saini, Seyed Hasnain, A. Tyagi, Anil K Tyagi, Somesh Gupta, D. Nandi, Shilpi, Purswani","doi":"10.33140/jcei.04.02.13","DOIUrl":"https://doi.org/10.33140/jcei.04.02.13","url":null,"abstract":"The immune system consists of molecules and cells (and their\u0000products) to keep the Body free of afflictions. Clinical problems arise\u0000as and when there is failure or inadequate immunological response.\u0000How can the immune system be fortified against an undesirable\u0000infection? This is done by making of a vaccine against that infection.\u0000This article describes the development of a Vaccine against Leprosy.\u0000Most of us (>90%) are immune to this disease. The few, who become\u0000victims to leprosy, manifest pitiable symptoms. Interestingly this\u0000vaccine has found multiple applications. It is a potent invigorator\u0000of immune responses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79909095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal Immunotherapy in Oncology","authors":"","doi":"10.33140/jcei.04.02.09","DOIUrl":"https://doi.org/10.33140/jcei.04.02.09","url":null,"abstract":"Tumors development is closely related to the immune system state and in immunosuppression tumors occur many times more often. The quality of the immune defense depends on how the recognition system functions for malignized tumor cells and its timely destruction. However, the immunosuppression state may be a result of the tumor process itself. The tumor itself generates soluble molecules that inhibit the killer activity of lymphocytes and macrophages, which allows tumor cells to survive in the body. Therefore, it is justified to perform apheresis therapy aimed at removal of such inhibitors, and targeted restoration of cytotoxic activity of leukocytes, which should contribute to the tumor cells apoptosis. This method of extracorporeal immunopharmacotherapy is indicated not only in far-advanced cases, but also after any radical operations, when metastases are not detected and even chemotherapy is not carried out.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82441995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Connection between Normal Body Temperature and Chicken Likeness?","authors":"","doi":"10.33140/jcei.04.02.12","DOIUrl":"https://doi.org/10.33140/jcei.04.02.12","url":null,"abstract":"The objective of current study was to co-relate normal body temperature with chicken likeness. Body temperature is the normal temperature of the body. Usual body temperature may change in different situations such as by age, person, time of the day and activity. Thermometer is the instrument used to find out the temperature of the body. Total of 150 students took part in the recent study and they were the students of Bahauddin Zakariya University, Multan Pakistan. We arranged the instrument and then measured their body temperature. At the end we can concluded that there is a strong relation between these two variables. The male and female individuals with high body temperature are chicken lovers.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72845972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conjunction between the Ladyfinger Likeness and Human Normal Body Temperature in Fahrenheit","authors":"","doi":"10.33140/jcei.04.02.05","DOIUrl":"https://doi.org/10.33140/jcei.04.02.05","url":null,"abstract":"The purpose of this study was to show the conjunction between the ladyfinger likeness and human normal body temperature. Normal body temperature in human is the temperature range in Homo sapiens. Normal body temperature in human ranged as 97.7 to 99.5 ºF. It is balanced by the process of thermoregulation. The optimum temperature in the human is 98.6 ºF which is 37.0 in degrees. Ladyfinger is the vegetable which is used to cook. Ladyfinger also improves the vision quality because in it vitamin A is present. During the project designing, we designed the project related to the linkage of likeness of ladyfinger with the normal body temperature. 131 companions were joined in this project studies to whom we asked about their normal body temperatures. These companions were the undergraduate students of University. We took the thermometer. Then we selected the site at which we wanted to measure the temperature. Students came to us one by one. Firstly one student came to us. We placed the thermometer in the mouth. The readings appeared on the thermometer after few seconds and we calculated the reading and noted down on the page. It is excluded that there is no conjunction between the ladyfinger likeness and human normal body temperature.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75459172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}