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Multimodal Approach with CAR-T and CAR-NK Cells for Synergistic Action toTreat Cancer CAR-T和CAR-NK细胞协同治疗癌症的多模式方法
Journal of clinical & experimental immunology Pub Date : 2019-04-09 DOI: 10.33140/jcei.04.03.02
{"title":"Multimodal Approach with CAR-T and CAR-NK Cells for Synergistic Action to\u0000Treat Cancer","authors":"","doi":"10.33140/jcei.04.03.02","DOIUrl":"https://doi.org/10.33140/jcei.04.03.02","url":null,"abstract":"Recent years have seen a craze about the T-cell immunotherapy for B-cell malignancies, and there is growing interest in NK-CAR therapy. In this paper, I discuss the similarities and differences between the CARs in the NK and T-Cells. Further, explore the possible theoretical concept of a multimodal approach towards treating cancer. Whether the two genetically modified cells could provide an added advantage acting synergistically to complement each other’s therapeutic qualities or counteract each other’s downfall. This short communication is an attempt to pique interest to understand the mechanisms of NK cell and T cell biological interaction in the presence of a therapeutic weapon “CAR” to target tumor.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85751480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Sea Star Igkappa Gene and The Ophuirid Igkappa Gene Vaccinations to HRP(Horse-radish Peroxydase) 海星Igkappa基因和Ophuirid Igkappa基因接种马萝卜过氧化物酶(HRP)的研究
Journal of clinical & experimental immunology Pub Date : 2019-04-01 DOI: 10.33140/jcei.04.03.01
M. Leclerc
{"title":"The Sea Star Igkappa Gene and The Ophuirid Igkappa Gene Vaccinations to HRP\u0000(Horse-radish Peroxydase)","authors":"M. Leclerc","doi":"10.33140/jcei.04.03.01","DOIUrl":"https://doi.org/10.33140/jcei.04.03.01","url":null,"abstract":"The main point of the sea star immunology, of the ophuirid immunology remain the discovery of the INVERTEBRATE PRIMITIVE\u0000ANTIBODY (IPA), the IGKAPPA GENES, with Ig sites which imply the COMPLEMENT SYSTEM, to be initiated: 9 component\u0000genes from C1 to C9 have been updated these last years, in sea star genome, in ophuirid one. These primitive antibodies were\u0000obtained after immunizations to the enzyme HRP (Horse-radish peroxydase). It is the first time we observe vaccinations in\u0000invertebrates. We have discovered, for the first time also, in these same Invertebrate a FC receptor gene, a Fab gene which\u0000corroborate the presence of IPA. The transcriptomes are given. It is the first time, we can speak of Adaptative Immunity, in\u0000Echinoderms, in Invertebrates Since many years, even since a century long, the notion of Antibody was out of the speech of\u0000immunologists. To speak of that made you as an outlaw. It is time to look with genomic studies which confirm which assert now\u0000evidence that 3 classes of Echinoderms out of 5 possess an Igkappa gene, a FC receptor gene. I recall these classent: the Asterids\u0000with Asterias rubens, the Ophuirids with Ophiocomina nigra and the Crinoïds.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82118124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Unique Vaccine with Multiple Applications 一种具有多种用途的独特疫苗
Journal of clinical & experimental immunology Pub Date : 2019-03-21 DOI: 10.33140/jcei.04.02.13
G. Talwar, J. C. Gupta, A. Krishnan, A. Mustafa, S. Zaheer, HK Kar, R. Mukherjee, R. Rani, S. Bhaskar, P. Reddi, V. Saini, Seyed Hasnain, A. Tyagi, Anil K Tyagi, Somesh Gupta, D. Nandi, Shilpi, Purswani
{"title":"A Unique Vaccine with Multiple Applications","authors":"G. Talwar, J. C. Gupta, A. Krishnan, A. Mustafa, S. Zaheer, HK Kar, R. Mukherjee, R. Rani, S. Bhaskar, P. Reddi, V. Saini, Seyed Hasnain, A. Tyagi, Anil K Tyagi, Somesh Gupta, D. Nandi, Shilpi, Purswani","doi":"10.33140/jcei.04.02.13","DOIUrl":"https://doi.org/10.33140/jcei.04.02.13","url":null,"abstract":"The immune system consists of molecules and cells (and their\u0000products) to keep the Body free of afflictions. Clinical problems arise\u0000as and when there is failure or inadequate immunological response.\u0000How can the immune system be fortified against an undesirable\u0000infection? This is done by making of a vaccine against that infection.\u0000This article describes the development of a Vaccine against Leprosy.\u0000Most of us (>90%) are immune to this disease. The few, who become\u0000victims to leprosy, manifest pitiable symptoms. Interestingly this\u0000vaccine has found multiple applications. It is a potent invigorator\u0000of immune responses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79909095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracorporeal Immunotherapy in Oncology 肿瘤体外免疫治疗
Journal of clinical & experimental immunology Pub Date : 2019-03-06 DOI: 10.33140/jcei.04.02.09
{"title":"Extracorporeal Immunotherapy in Oncology","authors":"","doi":"10.33140/jcei.04.02.09","DOIUrl":"https://doi.org/10.33140/jcei.04.02.09","url":null,"abstract":"Tumors development is closely related to the immune system state and in immunosuppression tumors occur many times more often. The quality of the immune defense depends on how the recognition system functions for malignized tumor cells and its timely destruction. However, the immunosuppression state may be a result of the tumor process itself. The tumor itself generates soluble molecules that inhibit the killer activity of lymphocytes and macrophages, which allows tumor cells to survive in the body. Therefore, it is justified to perform apheresis therapy aimed at removal of such inhibitors, and targeted restoration of cytotoxic activity of leukocytes, which should contribute to the tumor cells apoptosis. This method of extracorporeal immunopharmacotherapy is indicated not only in far-advanced cases, but also after any radical operations, when metastases are not detected and even chemotherapy is not carried out.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82441995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What is the Connection between Normal Body Temperature and Chicken Likeness? 正常体温和鸡的长相有什么关系?
Journal of clinical & experimental immunology Pub Date : 2019-03-04 DOI: 10.33140/jcei.04.02.12
{"title":"What is the Connection between Normal Body Temperature and Chicken Likeness?","authors":"","doi":"10.33140/jcei.04.02.12","DOIUrl":"https://doi.org/10.33140/jcei.04.02.12","url":null,"abstract":"The objective of current study was to co-relate normal body temperature with chicken likeness. Body temperature is the normal temperature of the body. Usual body temperature may change in different situations such as by age, person, time of the day and activity. Thermometer is the instrument used to find out the temperature of the body. Total of 150 students took part in the recent study and they were the students of Bahauddin Zakariya University, Multan Pakistan. We arranged the instrument and then measured their body temperature. At the end we can concluded that there is a strong relation between these two variables. The male and female individuals with high body temperature are chicken lovers.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72845972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conjunction between the Ladyfinger Likeness and Human Normal Body Temperature in Fahrenheit 小指形与人体正常体温(华氏)的关联
Journal of clinical & experimental immunology Pub Date : 2019-03-02 DOI: 10.33140/jcei.04.02.05
{"title":"Conjunction between the Ladyfinger Likeness and Human Normal Body Temperature in Fahrenheit","authors":"","doi":"10.33140/jcei.04.02.05","DOIUrl":"https://doi.org/10.33140/jcei.04.02.05","url":null,"abstract":"The purpose of this study was to show the conjunction between the ladyfinger likeness and human normal body temperature. Normal body temperature in human is the temperature range in Homo sapiens. Normal body temperature in human ranged as 97.7 to 99.5 ºF. It is balanced by the process of thermoregulation. The optimum temperature in the human is 98.6 ºF which is 37.0 in degrees. Ladyfinger is the vegetable which is used to cook. Ladyfinger also improves the vision quality because in it vitamin A is present. During the project designing, we designed the project related to the linkage of likeness of ladyfinger with the normal body temperature. 131 companions were joined in this project studies to whom we asked about their normal body temperatures. These companions were the undergraduate students of University. We took the thermometer. Then we selected the site at which we wanted to measure the temperature. Students came to us one by one. Firstly one student came to us. We placed the thermometer in the mouth. The readings appeared on the thermometer after few seconds and we calculated the reading and noted down on the page. It is excluded that there is no conjunction between the ladyfinger likeness and human normal body temperature.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75459172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Normal Breathing Rate Can Affect Nail Biting Habit 正常呼吸频率如何影响咬指甲习惯
Journal of clinical & experimental immunology Pub Date : 2019-03-02 DOI: 10.33140/jcei.04.02.06
{"title":"How Normal Breathing Rate Can Affect Nail Biting Habit","authors":"","doi":"10.33140/jcei.04.02.06","DOIUrl":"https://doi.org/10.33140/jcei.04.02.06","url":null,"abstract":"Objective of the present study was to find the effects of normal breathing rate on nail biting habit. In present study, total 140 subjects participated. These all participants were the students of Bahauddin Zakariya University, Multan, Pakistan. In present study, survey based training had given an important advancement. Watch was used to calculate normal human breathing rate per minute. Subjects were allowed to sit in normal condition. Then one by one their breathing rate was calculated. After that asked question from them about their nail biting habit and put their breathing rate values in yes or no portion according to their answers. Concluded from recent research that there is no effect of normal breathing rate on nail biting habit","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83913325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connection of Body Temperature with Fear of Rides 体温与乘坐恐惧的关系
Journal of clinical & experimental immunology Pub Date : 2019-03-02 DOI: 10.33140/jcei.04.02.07
{"title":"Connection of Body Temperature with Fear of Rides","authors":"","doi":"10.33140/jcei.04.02.07","DOIUrl":"https://doi.org/10.33140/jcei.04.02.07","url":null,"abstract":"The present study was done in order to evaluate connection between body temperature and fear of rides. About 120 disciples of Baha Uddin Zakariya University took part in this study. Isothermal, also known as the normal temperature of body is one of the most important factors in maintaining the metabolic activities of the body that are vital for life. It normal value is 37 °C. It can be measured by using mercury thermometer [1]. It is measured on certain body positions like forehead, mouth and rectum. Fear of rides is common among people who have other phobias like claustrophobia, acrophobia etc. Those people whose body temperature is 97 are more afraid of rides as compared to those people who have low body temperature.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Survey to Evaluate the Impact of Ailurophobia on Blood Oxygen Level 恐恐症对血氧水平影响的调查研究
Journal of clinical & experimental immunology Pub Date : 2019-03-02 DOI: 10.33140/jcei.04.02.08
{"title":"A Survey to Evaluate the Impact of Ailurophobia on Blood Oxygen Level","authors":"","doi":"10.33140/jcei.04.02.08","DOIUrl":"https://doi.org/10.33140/jcei.04.02.08","url":null,"abstract":"The blood oxygen level is a measure of amount of oxygen circulation in the blood. The blood oxygen level test also known as ‘blood gas analysis’ estimates the proper working of the lungs and it performs different measurements. Pulse oximeter, a noninvasive device that helps to detect or estimate the level of carbon dioxide and oxygen saturation in the blood. Normal pulse oximeter reading has a range of 95 to 100 percent. 200 individuals were selected and asked about the fear of cats and their peripheral oxygen saturation was estimated using pulse oximeter device. The results calculated from M Stat software and student’s t-test revealed that there is a significant impact of cat phobia on peripheral oxygen saturation. The calculated p-value was significant depicting the correlation between blood oxygen level and ailurophobia.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80540910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation of Temperature and Study 温度与研究的关系
Journal of clinical & experimental immunology Pub Date : 2019-03-01 DOI: 10.33140/jcei.04.02.02
{"title":"Relation of Temperature and Study","authors":"","doi":"10.33140/jcei.04.02.02","DOIUrl":"https://doi.org/10.33140/jcei.04.02.02","url":null,"abstract":"Objective of the study was to correlate study and temperature. A processor is connected to the sensors for draining the output signal to decide a body temperature of the person apply a scale mapping of a majority of target temperatures to correspondent output signals taken over a predestined range of surrounding temperatures. The motive for the study asserts some theoretic form. It was concluded from the study that male with low temperature study more and female with high temperature study more.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"430 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83598180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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