Journal of clinical & experimental immunology最新文献_第9页

A Still Rare Case of Congenital Afibrinogenemia 一例罕见的先天性纤维蛋白原血症

Journal of clinical & experimental immunology Pub Date : 2018-11-06 DOI: 10.33140/jcei/03/02/00002

I. Tlamçani, A. Krich, Fatima Zahrae El Hamdi, M. A. Hassani

引用次数: 0

Protective Effect of Myrianthus Arboreus Leaves Aqueous Extract in AcetaminophenInduced Liver Toxicity in Rats 豆蔻叶水提物对对乙酰氨基酚所致大鼠肝毒性的保护作用

Journal of clinical & experimental immunology Pub Date : 2018-11-01 DOI: 10.33140/jcei/03/02/00001

{"title":"Protective Effect of Myrianthus Arboreus Leaves Aqueous Extract in AcetaminophenInduced Liver Toxicity in Rats","authors":"","doi":"10.33140/jcei/03/02/00001","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00001","url":null,"abstract":"Owning to changes in living pattern of humans and constant environmental changes, different life challenging diseases now exist. Traditional system has clam that some of these diseases could be cured with plant. Plants and their components are source of large amount of drugs. This study was design to examine the protective effect of Myrianthus arboreus leaves extract against acetaminophen induced liver toxicity in rats. A suspension of 750 mg/kg acetaminophen was administered once every 72 hours to induce toxicity in the rats. Oral administration of 500, 1000 and 2000 mg/kg body weight of the extract and 100 mg/kg of silymarine (reference drug) were administered for 10 days. The result of effect of pretreatment with Myrianthus aboreus leaves on the enzyme makers of tissue damage in acetaminophen induced toxicity showed significant different when compared with the result of group induced without pretreatment. The values of AST, ALT and ALP in the untreated group significantly (p<0.05) increased. Elevated serum level in these enzymes revealed the integrity and functionality of the liver. Thus the increased value of these enzymes indicates damage to the liver by the induced acetaminophen. Also the values of non-enzyme markers (T.B., ALB and TG) for the treated groups decreased when compared with the untreated group. The significant different in the values between the groups pretreated with Myrianthus aboreus leaves and the untreated group showed that MA extract could protect the liver.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89580653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Q&A on the Paper of Kurukulasuriya et al. (2017) on IBD Vaccine Efficacy Againsta Canadian Variant IBDV Strain in Broiler Chickens Kurukulasuriya等人(2017)关于IBD疫苗对肉鸡加拿大变异IBDV株有效性的论文答疑

Journal of clinical & experimental immunology Pub Date : 2018-06-13 DOI: 10.33140/jcei/03/01/00003

{"title":"Q&A on the Paper of Kurukulasuriya et al. (2017) on IBD Vaccine Efficacy Against\u0000a Canadian Variant IBDV Strain in Broiler Chickens","authors":"","doi":"10.33140/jcei/03/01/00003","DOIUrl":"https://doi.org/10.33140/jcei/03/01/00003","url":null,"abstract":"Kurukulasuriya, et al. (2017) are reporting the efficacy of two IBD vaccines against an early (6 days post-hatch) challenge\u0000with a variant Canadian IBDV strain in broilers. A modified live vaccine(UNIVAX BD) administered by SQ route at 1 dayof-age delayed infection whereas an HVT-IBD vector vaccine (VAXXITEK HVT+IBD) administered in ovodid not protect.\u0000Furthermore, the authors suggested that the HVT-IBD vector induced immunosuppression responsible for an earlier IBDV\u0000challenge strain replication in the bursa.\u0000The data presented in the paper showed no evidence of VAXXITEK HVT+IBD vaccine take since the mean IBD ELISA\u0000antibody titer at D35 in the vaccinated/non-challenged group was not significantly different from that of the non-vaccinated\u0000group. It wasmuch lower than the expected one based on previous studies performed in the same conditions : in ovo\u0000vaccination of broilers [1,2]. Since there is no evidence of vaccine take, the other potential effects (immunosuppression and\u0000earlier IBDV replication in the bursa) observed in that group cannot be attributed to the vaccine.\u0000Since its launch in 2006 in Brazil, VAXXITEK HVT+IBD has been licensed in more than 75 countries and more than 80\u0000billion birds have been vaccinated. VAXXITEK HVT+IBD is protecting against a wide variety of IBDV strains including\u0000the classical, the very virulent and different variant strains. To our knowledge, noabsence of efficacy nor bursa depletions\u0000have been so far officially reported as long as the vaccine has been administered properlyto healthy embryonated eggs or\u0000to healthy one-day-old chicks.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76634613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expansion and productive HIV-1 infection of Foxp3 positive CD4 T cells at pleural sites of HIV/TB co-infection. 在HIV/TB合并感染的胸膜部位Foxp3阳性CD4 T细胞的扩增和产生性HIV-1感染

Journal of clinical & experimental immunology Pub Date : 2016-01-01 DOI: 10.33140/jcei/01/01/00003

C. Hirsch, J. Baseke, John Lusiba Kafuluma, M. Nserko, H. Mayanja-Kizza, Z. Toossi

{"title":"Expansion and productive HIV-1 infection of Foxp3 positive CD4 T cells at pleural sites of HIV/TB co-infection.","authors":"C. Hirsch, J. Baseke, John Lusiba Kafuluma, M. Nserko, H. Mayanja-Kizza, Z. Toossi","doi":"10.33140/jcei/01/01/00003","DOIUrl":"https://doi.org/10.33140/jcei/01/01/00003","url":null,"abstract":"BACKGROUND CD4 T-cells expressing Foxp3 are expanded systemically during active tuberculosis (TB) regardless of HIV-1 co-infection. Foxp3+ CD4 T cells are targets of HIV-1 infection. However, expansion of HIV-1 infected Foxp3+ CD4 T cells at sites of HIV/TB co-infection, and whether they contribute to promotion of HIV-1 viral activity is not known. METHODS Pleural fluid mononuclear cells (PFMC) from HIV/TB co-infected patients with pleural TB were characterized by immune-staining and FACS analysis for surface markers CD4, CD127, CCR5, CXCR4, HLA-DR and intracellular expression of Foxp3, HIVp24, IFN-γ and Bcl-2. Whole PFMC and bead separated CD4+CD25+CD127- T cells were assessed for HIV-1 LTR strong stop (SS) DNA by real-time PCR, which represents viral DNA post cell entry and initiation of reverse transcription. RESULTS High numbers of HIV-1 p24 positive Foxp3+ and Foxp3+CD127- CD4 T cells were identified in PFMC from HIV/TB co-infected subjects. CD4+Foxp3+CD127- T cells displayed high expression of the cellular activation marker, HLA-DR. Further, expression of the HIV-1 co-receptors, CCR5 and CXCR4, were higher on CD4+Foxp3+T cells compared to CD4+Foxp3- T cells. Purified CD4+CD25+CD127- T cells isolated from PFMC of HIV/TB co-infected patients, were over 90% CD4+Foxp3+T cells, and exhibited higher HIV-1 SS DNA as compared to whole PFMC, and as compared to CD4+CD25+CD127- T cells from an HIV-infected subject with pleural mesothelioma. HIV-1 p24+ Foxp3+ CD4+T cells from HIV/TB patients higher in Bcl-2 expression as compared to both HIV-1 p24+ Foxp3- CD4 T cells, and Foxp3+ CD4+T cells without HIV-p24 expression. CONCLUSION Foxp3+ CD4 T cells in PFMC from HIV/TB co-infected subjects are predisposed to productive HIV-1 infection and have survival advantage as compared to Foxp3 negative CD4 T cells.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"377 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84949486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Diagnostic Pattern of Adult Acute Leukemia in Benghazi Medical Center/ Libya 利比亚班加西医疗中心成人急性白血病的诊断模式

Journal of clinical & experimental immunology Pub Date : 1900-01-01 DOI: 10.33140/jcei.06.02.02

{"title":"Diagnostic Pattern of Adult Acute Leukemia in Benghazi Medical Center/ Libya","authors":"","doi":"10.33140/jcei.06.02.02","DOIUrl":"https://doi.org/10.33140/jcei.06.02.02","url":null,"abstract":"Objective: To study the demographic characters and diagnostic tools of acute leukemia among adults in Benghazi/ Libya. Patients and Method: A retrospective cross sectional analysis of 54 cases of AML and ALL was conducted at hematology department at Benghazi medical center (BMC) from January 2013 to December 2014. Demographic data, Complete Blood Picture (CBC), Peripheral Blood Film (PBF), Bone Marrow Aspiration (BMA), immunophenotyping as well as cytogenetic if applicable were evaluated. Result: Forty-two (77.8%) were diagnosed as AML and twelve (22.2%) as ALL. The median age for diagnosis of AML was 43 years. with male to female ratio 1.3:1 while for ALL the median age was 20 years, and male to female ratio was 2:1. Anemia was noted in (90.5%) and (100%) for AML and ALL, respectively. Thrombocytopenia was detected in (83%) for both types. Almost half of AML patients (47%) and (41%) of ALL cases presented with leukocytosis. Blasts were detected in more than two third (74%) of PBF of AML and (75%) in ALL patients. CD13 and CD33 and cyMPO were the most common positive myeloid presenting antigens. However, in ALL B-lymphoid markers CD10 and CD19 were the major positive antigens. Conclusion: AML was most common than ALL in adults, AML was common in middle age while ALL in young age group. Hematology departments require urgent improvement of diagnostic services in Libya in order to ensure good clinical management.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89867161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study of Clinical-Pathological Discrepancies in Autopsies 尸检临床病理差异的研究

Journal of clinical & experimental immunology Pub Date : 1900-01-01 DOI: 10.33140/jcei.06.02.03

{"title":"Study of Clinical-Pathological Discrepancies in Autopsies","authors":"","doi":"10.33140/jcei.06.02.03","DOIUrl":"https://doi.org/10.33140/jcei.06.02.03","url":null,"abstract":"Background: Autopsy is a traditional method in pathology for the study of diseases or injuries, being key to elucidate the cause of death. However, the number of autopsies has been decreasing progressively. Design and Context: Retrospective cross-sectional study to analyze the presence of discrepancy between clinical and pathological diagnoses as to the cause of death according to the Goldman criteria, verify the epidemiological profile of the main causes of death, and tabulate the number of procedures conducted annually. Method: Analyzing clinical records and autopsy reports from the Department of Pathology and Legal Medicine of the Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) from 1963 to 2012 and performing statistical analysis on the data collected. Results: The predominant age group was of dead fetuses (30.6% of all cases). The main cause of death was infection (68.4% of diagnoses). After a peak in the early 1980s, there was a progressive drop in the rates of postmortem examination. In the 1990s, the average number of autopsies fell by 58% in relation to the previous decade, and the last decade of the Century registered a decrease of 80% as compared to the average of the 1980s. According to the Goldman criteria, there was discrepancy between ante- and postmortem diagnoses as to the cause of death in 26.2% of the cases. Conclusion: The rates of discrepancy between clinical diagnoses and autopsy findings regarding the cause of death remain high, even though medicine has become more and more advanced in technology.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74139460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stroke and Adverse Effects on The Immune and Cardiovascular Systems: The Danger of the Rise and Use of Psychedelic Drugs for Depression and PTSD 中风和对免疫和心血管系统的不良影响:抑郁症和创伤后应激障碍致幻剂的增加和使用的危险

Journal of clinical & experimental immunology Pub Date : 1900-01-01 DOI: 10.33140/jcei.06.02.01

引用次数: 0

Low ASH1L Expression as Potential Diagnostic and Prognostic Biomarker for Renal Cell Carcinoma 低ASH1L表达作为肾细胞癌的潜在诊断和预后生物标志物

Journal of clinical & experimental immunology Pub Date : 1900-01-01 DOI: 10.33140/jcei.06.02.05

引用次数: 0