Journal of clinical & experimental immunology最新文献_第10页

Antibody Responses Specific to Hepatitis B Virus Vaccine in Children Exposed InUtero to Antiretroviral Therapy 子宫内接受抗逆转录病毒治疗的儿童乙肝病毒疫苗特异性抗体反应

Journal of clinical & experimental immunology Pub Date : 2019-01-01 DOI: 10.33140/jcei.04.04.01

T. Tchouangueu, L. B. Mabeku, A. Lissom, Loveline N. Ngu, S. B. Tchuandom, J. Tchadji, L. Djukouo, C. S. S. Ngane, Alfred A Ngoh, Herve F. Ouambo, Georgia Ambada, Anna Gutiérrez, C. Esimone, Chae Gyu Park, A. B. Waffo, G. Nchinda

{"title":"Antibody Responses Specific to Hepatitis B Virus Vaccine in Children Exposed InUtero to Antiretroviral Therapy","authors":"T. Tchouangueu, L. B. Mabeku, A. Lissom, Loveline N. Ngu, S. B. Tchuandom, J. Tchadji, L. Djukouo, C. S. S. Ngane, Alfred A Ngoh, Herve F. Ouambo, Georgia Ambada, Anna Gutiérrez, C. Esimone, Chae Gyu Park, A. B. Waffo, G. Nchinda","doi":"10.33140/jcei.04.04.01","DOIUrl":"https://doi.org/10.33140/jcei.04.04.01","url":null,"abstract":"The use of antiretroviral (ARV) has been one of the most effective means of preventing vertical transmission of the human immunodeficiency virus (HIV) to exposed children born of HIV infected mothers. Nevertheless, responses to childhood vaccination against Hepatitis B virus (HBV) infections remain suboptimal in HIV exposed uninfected children irrespective of maternal ARV prophylaxis. In a cross-sectional study we have assessed the impact of in-utero exposure to ARV on paediatric HBV vaccination. Anti-HBV surface antigen specific antibodies (anti-HBs abs) were measured in plasma specimens from 44 healthy children unexposed to both HIV and ARV (HU), 25 HIV-exposed uninfected children naïve to intrauterine exposure to ARV (HEU.AR - ), 29 ARV and HIV-exposed uninfected children during pregnancy (HEU.ARV +), 50 children vertically infected with HIV but naïve to intrauterine exposure to ARV (HEI.ARV - ) and 22 children vertically infected with HIV with in utero exposure to ARV (HEI.ARV +). The protective seroconversion rate after childhood HBV vaccination (anti-HBs ≥10 mUI/ml) among HEU.ARV + children (58%) was significantly lower relative to both HEU.ARVc - (100%, P=0.0010) and the healthy unexposed children (92 %, P=0.0069). Similarly, HEI.ARV + children also had significantly lower anti-HBs IgM antibody responses when compared to both HU (p=0.0003) and HEI.ARV - (0.0001) children respectively. Thus in-utero exposure to ARV probably contributes in reducing HBV vaccine antibody response rate in both HIV exposed uninfected and vertically infected children after childhood vaccination. Nevertheless, the overall impact of ARV was to improve anti-HBs IgG responses in HIV infected children suggesting a possible role in immune reconstitution leading to improved IgG antibody responses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82238565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Disseminated Nontuberculous Mycobacteria in HIV-Infected Patients hiv感染患者的播散性非结核分枝杆菌

Journal of clinical & experimental immunology Pub Date : 2018-12-17 DOI: 10.33140/jcei.03.03.03

{"title":"Disseminated Nontuberculous Mycobacteria in HIV-Infected Patients","authors":"","doi":"10.33140/jcei.03.03.03","DOIUrl":"https://doi.org/10.33140/jcei.03.03.03","url":null,"abstract":"Nontuberculous mycobacteria are ubiquitous in the environment and are increasingly implicated in human diseases worldwide. Currently, there are more than 150 species of Mycobacterium and it is likely that more will be discovered. The rapid increase in identified species in recent years is due to improved culturing techniques and more precise differentiations of species. The application of highly active antiretroviral therapy for the treatment of HIV disease dramatically reduced rates of all opportunistic infections including nontuberculous mycobacteria. Despite this decline, nontuberculous mycobacterium remains one of the most commonly encountered opportunistic infections in AIDS patients. Disseminated nontuberculous mycobacteria infections are seen exclusively among immunocompromised hosts, including those with AID. Disseminated disease is most commonly seen in association with profound immunosuppression. In HIV infected patients, dissemination does not typically occur unless the CD-4+ T-lymphocyte count is below 50/uL. Structural lung disease, such as chronic obstructive pulmonary disease, silicosis, pneumoconiosis or prior TB infection, predisposes to pulmonary infection. Nodular bronchiectasis is very strongly associated with nontuberculous mycobacteria infections. Disseminated Mycobacterium avium complex disease was one of the first opportunistic infections recognized as part of the syndrome of AIDS .Interest in disseminated Mycobacterium avium and nontuberculous mycobacteria infections increased as a result of the HIV epidemic, and therapeutic strategies to treat and prevent these diseases must be focused. Prevention and treatment regimens were lifelong because cure of nontuberculous mycobacteria was not achievable in AIDS patients with profound immune suppression.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88000578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Predictive Clinical Value of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies as Diagnostic Tools in Cases with Non-Arthritic Chronic Hepatitis C Viral Disease 类风湿因子和抗瓜氨酸蛋白抗体作为非关节炎性慢性丙型肝炎病毒病诊断工具的预测临床价值

Journal of clinical & experimental immunology Pub Date : 2018-12-15 DOI: 10.33140/jcei/03/03/00001

{"title":"Predictive Clinical Value of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies as Diagnostic Tools in Cases with Non-Arthritic Chronic Hepatitis C Viral Disease","authors":"","doi":"10.33140/jcei/03/03/00001","DOIUrl":"https://doi.org/10.33140/jcei/03/03/00001","url":null,"abstract":"Background: Rheumatoid arthritis is a chronic immunological disease that causes destruction and deformity of joints. Chronic hepatitis C infection cases could develop rheumatic like clinical presenting profile. Raised rheumatoid factor in chronic HCV infection considerably reduces the diagnostic privilege of rheumatoid factor for rheumatoid arthritis coexisting with HCV infection. Aim of the work: To determine the value of anti-citrullinated protein antibody levels in cases having chronic HCV infection in comparison to rheumatoid factor. Methodology: The research team recruited 150 non-arthritic study subjects having chronic hepatitis C virus infection rheumatoid factor and anti-citrullinated protein antibody levels were assayed for all study subjects for statistical analysis. Results: Rheumatoid factor +ve study subjects had statistically significantly more frequent within female gender. (p value=0.027) Rheumatoid factor high +ve cases had statistically significantly had more frequent fatty liver and higher platelets than on high RF +ve cases. (P value =0.020, <0.038 consecutively) Conclusion: HCV cases with joint involvement were not implemented in the current research study that prevented statistical estimation of the sensitivity of anti-citrullinated protein antibody for arthritis in this cohort. Racial and ethnic differences should be put in consideration in future research studies that are recommended to be multi centric in fashion.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87690754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Prevalence of Anaemia among Reproductive Age Group (16-45 Yrs) of Womenin the RMG Concentrated Area, Savar, Dhaka 达卡萨瓦尔RMG集中地区育龄妇女(16-45岁)贫血患病率

Journal of clinical & experimental immunology Pub Date : 2018-12-15 DOI: 10.33140/jcei/03/03/00002

{"title":"The Prevalence of Anaemia among Reproductive Age Group (16-45 Yrs) of Women\u0000in the RMG Concentrated Area, Savar, Dhaka","authors":"","doi":"10.33140/jcei/03/03/00002","DOIUrl":"https://doi.org/10.33140/jcei/03/03/00002","url":null,"abstract":"This was a retrospective study and record of hemoglobin level of reproductive age group (16-45 yrs) of women in\u0000the Ready Made Garment (RMG) concentrated area, Savar, Dhaka. Descriptive statistics were used. Results were\u0000expressed as percentages/proportions, means and average. The objective of this study is to determine prevalence of\u0000Anaemia among women of reproductive age group who are working in Garments. In this study hemoglobin level of\u0000one thousand one hundred and five women of reproductive age (16-45 years) were analyzed in lab. The prevalence\u0000rate of any anemia was 71.22%. The majority of anemic women were in the category of mild (53.48 %) to moderate\u0000(14.67%) and severe Anaemia was 3.07%. Though the most affected age group was 21-25 years but the difference\u0000noted was statistically significant. The study substantiates the existence of mild to moderate form of anemia among\u0000women of reproductive age and underlines the need for iron supplementation to all reproductive women especially\u0000during the antenatal period with more attention to the most affected regions of the country.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"285 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85319785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Gbm Disease in Children: Outcomes and Association with Systemic Vasculitis 儿童抗gbm疾病:结局及与全身性血管炎的关系

Journal of clinical & experimental immunology Pub Date : 2018-11-30 DOI: 10.33140/jcei/03/02/00006

引用次数: 0

The Prevalence of Undernutrition and Associated Factors among Children AgedOne to Five Years in Siyambalanduwa MOH Area 西扬巴兰杜瓦卫生部辖区1 - 5岁儿童营养不良发生率及相关因素

Journal of clinical & experimental immunology Pub Date : 2018-11-28 DOI: 10.33140/jcei/03/02/00005

{"title":"The Prevalence of Undernutrition and Associated Factors among Children Aged\u0000One to Five Years in Siyambalanduwa MOH Area","authors":"","doi":"10.33140/jcei/03/02/00005","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00005","url":null,"abstract":"Aim: High prevalence of child undernutrition is a well-known issue in rural areas of Si Lanka. Identification of real\u0000burden, underlying specific causes and addressing those issues will help to improve the nutritional status of those\u0000children.\u0000Objective: To describe the prevalence of undernutrition and associated factors among children aged one to five years\u0000in Siyambalanduwa MOH area.\u0000Methodology: A community based cross-sectional study was conducted among 421 child-mother pairs in Siyambalanduwa\u0000MOH area using two stage cluster sampling method. Data collection done by using pre tested interviewer administered\u0000questionnaire. Relevant anthropometric measurements were done according to WHO slandered guidelines. Statistical\u0000analysis was done using SPSS 20. The chi-square test was used, and P<0.05 was considered for statistically significant.\u0000Results: Overall 41% of children aged 1-5 years were undernourished in Siyambalanduwa MOH area. Among the\u0000study subjects 24% were underweight, 25.7% were stunted, 16.4% were wasted, 9.2% were both underweight &\u0000stunted, 6.8% were both, underweight & wasted, 0.5% were both stunted & wasted and 9.9% were underweight &\u0000stunted g & wasted. Only the low total monthly income (P<0.001) and low birth weight (P<0.001) were significantly\u0000associated with child undernutrition.\u0000Conclusions and recommendations: Prevalence of undernutrition among children aged 1-5 years is unacceptably\u0000high and urgent efforts to reduce undernutrition should be a priority. Future studies should focus on assessing how\u0000to reduce the burden of undernutrition with low cost interventions.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77387023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Quality Improvement Project to Increase the Rate of HPV Vaccination Initiation in Adolescents 提高青少年HPV疫苗接种率的质量改进项目

Journal of clinical & experimental immunology Pub Date : 2018-11-26 DOI: 10.33140/jcei/03/02/00004

{"title":"A Quality Improvement Project to Increase the Rate of HPV Vaccination Initiation in Adolescents","authors":"","doi":"10.33140/jcei/03/02/00004","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00004","url":null,"abstract":"The vaccination rate of the human papilloma virus vaccine [9vHPV] is low, with only 63% of eligible females and 50% eligible males receiving the vaccine in 2016. The aim of this quality improvement project was to increase the initiation rate of HPV vaccination at Smyrna Pediatrics by 20%, from 3.6% to 4.3% over four weeks. Two physicians, one nurse practitioner, and two medical assistants implemented this quality improvement initiative. There is a lack of education and standardized communication about HPV and 9vHPV to prevent against the virus. A standardized script was created so that all conversations between healthcare professionals and patients and their parents or guardians included the wording of the 9vHPV being recommended rather than optional. Educational material from the CDC was the standard handout given to each adolescent and their parent or guardian. Standardized education and communication was to be provided at each adolescent visit of the 125 eligible adolescents seen during the four-week implementation period, 4% (n = 5) agreed to receive the 9vHPV vaccine. With a baseline of 3.6% (n = 4), there was an 11.1% increase of initiation of 9vHPV. The use of standardized education documents presented to all patients and their parents or guardians established health education as the mainstay of the project and provided information about the importance of prevention and protection from the virus that the vaccine prevents. The implementation of results over a longer period of time may prove to be more effective for the practice’s increase of vaccination rates overall.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77094349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Monoclonal Antibody-Based Biosimilar GnRH Antagonist 一种新的基于单克隆抗体的GnRH生物类似药拮抗剂

Journal of clinical & experimental immunology Pub Date : 2018-11-20 DOI: 10.33140/jcei.03.02.07

Gregory M. Lee

引用次数: 0

Active Specific Immunotherapy (ASI) and Gcmaf Forte in Management of Metastatic Invasive Carcinoma–Overview of the Therapeutic Modalities and A Case Report 主动特异性免疫治疗(ASI)和Gcmaf - Forte在转移性浸润性癌治疗中的作用——治疗方式综述和一例报告

Journal of clinical & experimental immunology Pub Date : 2018-11-19 DOI: 10.33140/jcei/03/02/00003

R. Moya, Mike K. S. Chan, D. Klokol, S. Y. Pan

{"title":"Active Specific Immunotherapy (ASI) and Gcmaf Forte in Management of Metastatic Invasive Carcinoma–Overview of the Therapeutic Modalities and A Case Report","authors":"R. Moya, Mike K. S. Chan, D. Klokol, S. Y. Pan","doi":"10.33140/jcei/03/02/00003","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00003","url":null,"abstract":"Metastatic cancer is often a fatal disease with low survival rate that in a course of its progression implies a pathogenic cascade involving inflammation, overexpression of reactive oxygen species, loss of DNA repair, genome instability, neoangiogenesis, epithelial infiltration, collagen destruction, and immunosuppression and apoptosis evasion by cancer cells. Understanding the cross-interaction mechanism between the immune co-stimulatory and inhibitory molecules on one side and tumors cells is a key point in the development of a successful immunotherapeutic strategy to fight aggressive cancers. The Active Specific Immunotherapy (ASI) and the GC protein Macrophage Activating Factor (GcMAF) are two immunotherapies capable of modulating the innate and adaptive immunity against cancer. The aim of this work is to present a case of an invasive metastatic carcinoma treated with ASI and GcMAF Forte and discuss the potentials of the individualized immunotherapy in advanced forms of cancer. Immunotherapy improves status of immune system and as a result it increases patient’s life span (and probably survival rate). In conclusion, the ASI and GcMAF Forte may offer a promising prospective immunological biomedical approach to boost immunity and enhance life expectancy in patients with metastatic cancer.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75415427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Still Rare Case of Congenital Afibrinogenemia 一例罕见的先天性纤维蛋白原血症

Journal of clinical & experimental immunology Pub Date : 2018-11-06 DOI: 10.33140/jcei/03/02/00002

I. Tlamçani, A. Krich, Fatima Zahrae El Hamdi, M. A. Hassani

引用次数: 0