Journal of clinical & experimental immunology最新文献

{"title":"Bitter Gourd relish and Pulse Rate Relationship","authors":"","doi":"10.33140/jcei.04.01.11","DOIUrl":"https://doi.org/10.33140/jcei.04.01.11","url":null,"abstract":"The objective of present project “Bitter Gourd relish and Pulse Rate Relationship” was to investigate the normal pulse rate of subjects and relate with likeliness of bitter gourd. Subjects that took part in this project were 219 in number. Pulse rate is a means of physical examination of patient’s body and diagnosing the problem. Pulse rate is the beats (blood pumping to body) of heart in a minute. The status (regular, fast, low, strong) of pulse indicated the physical state of subject. Bitter gourd, a vegetable enrich in phytonutrient, anti-oxidants, dietary fiber and vitamin C, also disliked by subjects because of its bitterness. A protocol was followed to find a relationship for pulse rate measurement and questionnaire. Assistance of every subject helped in survey completion. Results were obtained by t-Test and relationship was observed that helped in doing conclusion. P-value was nonsignificant which meant no relation between bitter gourd and pulse rate measurement.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77613650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audit to See the Effect of Nicotine Addiction on Pulse Rate","authors":"M. Qadir, Hina Batool","doi":"10.33140/jcei.04.01.04","DOIUrl":"https://doi.org/10.33140/jcei.04.01.04","url":null,"abstract":"Objective of present study was to see the effect of nicotine addiction on pulse rate. Nicotine can cause cardiovascular diseases and it also affect pulse rate by increasing its speed. So it was concluded that the docents who are addicted to tea have higher pulse rate and who are not addicted to tea they have normal or slow pulse rate.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83171835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal Immunopharmacotherapy of Autoimmune Diseases","authors":"","doi":"10.33140/jcei.04.01.08","DOIUrl":"https://doi.org/10.33140/jcei.04.01.08","url":null,"abstract":"The article aims to analyze pathogenetic mechanisms of autoimmune diseases development including disorders of both cellular and humoral immunity. The standard drug therapy with corticosteroids and cytostatic leads to a number of side effects such as lipid metabolism disorders (Kushing-syndrome), arterial hypertension, diabetes, and osteoporosis each of which is to be additionally treated. Chimeric monoclonal antibodies (rituximab, natalizumab, etc.) can also cause complications. Therefore apheresis therapy with removal of autoantibodies, circulating immune complexes and other pathological metabolites is pathogenetically justified. However, the greatest effect is reached by means of extracorporeal immunopharmacotherapy when, besides antibodies removal by means of plasmapheresis one performs selection of lymphocytes and their temporary incubation with corticosteroids and cytostatics, which are then returned to the patient. Such targeted immunosuppression is much more effective then “pulse therapy” with minimum negative consequences for the body. At the same time a supporting drug therapy can be carried out with half smaller doses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74824226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wheezing in Childhood- not Always Asthma -Review","authors":"Atiar Rahman, Nafisa Rahman","doi":"10.33140/jcei.04.01.05","DOIUrl":"https://doi.org/10.33140/jcei.04.01.05","url":null,"abstract":"Wheezing in infancy and childhood is a common condition; however it is not a single disorder and can be due to causes other than asthma. Wheezing is a musical, expiratory sound due to narrowing and hyper responsiveness of the intra-thoracic and extra thoracic airways. Not all wheezing is asthma. Wheezing-associated respiratory illnesses in children are often described as asthma; however while most children with asthma show symptoms of wheezing. Wheezing, coughing and breathlessness are common in young children, and can all be symptoms of conditions other than asthma. Bronchiolitis refers to a first episode of wheezing, with respiratory distress triggered by a viral infection. Episodic wheezing refers to discrete episodes of wheezing without intermittent symptoms. Unremitting wheezing refers to distinct episodes of wheezing with intermittent symptoms, such as coughing or wheezing at night or in response to exercise, crying, laughter, mist, or cold air. Environmental conditions that increase the rate of bacterial and viral infections are risk factors for transient wheezing, but its relationship to asthma remains unclear. Children with frequent simple colds and other common childhood infections in infancy are less likely to develop persistent wheezing in later childhood. Many preschool children with viral induced wheezing will outgrow these symptoms, and do not have asthma. Generally, asthma is identified by the presence of cough, wheeze and breathing difficulty, together with features of atopy (or a family history of atopy or asthma) and impaired lung function evidenced by spirometry. It is important to explain to parents/ carers that wheezing in an infant or preschooler does not mean the child will have asthma or allergies by primary school age. In preschool-aged children with recurrent wheeze (e.g. four or more episodes per year), consider using the Asthma Predictive Index, to estimate whether children are likely to have asthma during primary school years. Asthma Prediction Index has some major criteria and minor criteria. Major criteria are diagnosis of asthma in one or both parent, Diagnosis of atopic dermatitis during the first 3 yr. of life, Sensitization against >1 allergen, Minor criteria- Milk, egg, or peanut sensitization. Associated with respiratory infections, Eosinophilia >4%. In the first 3 years of life if anyone who have 1 major criteria or 2 minor criteria is present in one episode, the possibility of asthma in 6-13 years is 59% but 2 episodes possibility is 77%. Investigation -Chest X-Ray, spirometry, CT scan of Chest and Fiberoptic Bronchoscope. It is usually not necessary if history of “classic” asthma or, patient response to salbutamol and or steroid; then only spirometry should be done. But need other investigation when Chronic cough (>1 month), recurrent pneumonia, persistent signs or symptoms are seen despite therapy. Bronchomalacia, esophageal dilatation, foreign body aspiration, vocal cord dysfunction, viral pneumonia alle","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78078392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Inter-Connection between Suriphobia and Individual’s Blood Glucose Level: A Questionnaire Centred Project","authors":"Ghalia Batool Alvi, M. Qadir, Baber Ali","doi":"10.33140/jcei.04.01.09","DOIUrl":"https://doi.org/10.33140/jcei.04.01.09","url":null,"abstract":"Blood sugar level is actually the estimation of the total glucose sugar content in the one’s blood. Insulin and Glucagon are the two key hormones responsible for maintaining homeostasis which sustain blood glucose level. Hypoglycemia and Hyperglycemia are the two conditions associated with blood sugar level. In case of hypoglycemia, blood glucose level falls below the normal level of glucose in the blood while hyperglycemia is the condition of elevated blood glucose level than the normal range. Different tests are available to test the blood glucose level of an individual. The central objective of this project was to assess the inter-connection between one’s being suriphobic and their blood sugar level at fasting. Phobia is a word associated with the condition of extreme fear from a series of specified events. Suriphobia or mice fear is the term used for those individuals who extremely fear from mice, rats, rodents etc. This study was a questionnaire based project to assess the fact that if there is any inter-connection between people’s being suriphobic and their blood glucose level at fasting. For this purpose blood sugar level of the sample population was calculated using Glucometer. Statistical Analysis point towards the significant results if this study as the calculated p-value was exact of the standard p¬-value which is p ≤ 0.05. Therefore, the fact that there is a significant relation between individual’s being Suriphobe and their Blood Glucose Level at fasting is proved.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83881634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibody Responses Specific to Hepatitis B Virus Vaccine in Children Exposed InUtero to Antiretroviral Therapy","authors":"T. Tchouangueu, L. B. Mabeku, A. Lissom, Loveline N. Ngu, S. B. Tchuandom, J. Tchadji, L. Djukouo, C. S. S. Ngane, Alfred A Ngoh, Herve F. Ouambo, Georgia Ambada, Anna Gutiérrez, C. Esimone, Chae Gyu Park, A. B. Waffo, G. Nchinda","doi":"10.33140/jcei.04.04.01","DOIUrl":"https://doi.org/10.33140/jcei.04.04.01","url":null,"abstract":"The use of antiretroviral (ARV) has been one of the most effective means of preventing vertical transmission of the human immunodeficiency virus (HIV) to exposed children born of HIV infected mothers. Nevertheless, responses to childhood vaccination against Hepatitis B virus (HBV) infections remain suboptimal in HIV exposed uninfected children irrespective of maternal ARV prophylaxis. In a cross-sectional study we have assessed the impact of in-utero exposure to ARV on paediatric HBV vaccination. Anti-HBV surface antigen specific antibodies (anti-HBs abs) were measured in plasma specimens from 44 healthy children unexposed to both HIV and ARV (HU), 25 HIV-exposed uninfected children naïve to intrauterine exposure to ARV (HEU.AR - ), 29 ARV and HIV-exposed uninfected children during pregnancy (HEU.ARV +), 50 children vertically infected with HIV but naïve to intrauterine exposure to ARV (HEI.ARV - ) and 22 children vertically infected with HIV with in utero exposure to ARV (HEI.ARV +). The protective seroconversion rate after childhood HBV vaccination (anti-HBs ≥10 mUI/ml) among HEU.ARV + children (58%) was significantly lower relative to both HEU.ARVc - (100%, P=0.0010) and the healthy unexposed children (92 %, P=0.0069). Similarly, HEI.ARV + children also had significantly lower anti-HBs IgM antibody responses when compared to both HU (p=0.0003) and HEI.ARV - (0.0001) children respectively. Thus in-utero exposure to ARV probably contributes in reducing HBV vaccine antibody response rate in both HIV exposed uninfected and vertically infected children after childhood vaccination. Nevertheless, the overall impact of ARV was to improve anti-HBs IgG responses in HIV infected children suggesting a possible role in immune reconstitution leading to improved IgG antibody responses.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82238565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholera Toxin B Subunit and Peptide LKEKK Inhibit TNF-α Signaling in Intestinal Epithelial Cells and Reduce Inflammation in a Mouse Model of Colitis","authors":"Elena V Navolotskayaa, V. B. Sadovnikov, V. Lipkin, V. Zav'yalov","doi":"10.33140/jcei.04.04.03","DOIUrl":"https://doi.org/10.33140/jcei.04.04.03","url":null,"abstract":"Cholera toxin B subunit (CT-B) and synthetic peptide LKEKK corresponding to the sequence 16-20 of thymosin-α1 and the sequence 131-135 of interferon-α2 (the concentration range of 100-5000 µM) significantly reduced TNF-α-stimulated pro-inflammatory cytokine expression and increases the expression of the anti-inflammatory cytokine IL-10 in human Caco-2 intestinal epithelial cells. In a mouse model of dextran sodium sulfate-induced colitis CT-B and peptide, LKEKK (20 mg/kg body weight orally for 14 days) decreased the production of TNF-α and IL-6, as well as the severity of inflammation. Thus, CT-B and peptide LKEKK are able to suppress inflammation in vitro and in vivo.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73742522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Nontuberculous Mycobacteria in HIV-Infected Patients","authors":"","doi":"10.33140/jcei.03.03.03","DOIUrl":"https://doi.org/10.33140/jcei.03.03.03","url":null,"abstract":"Nontuberculous mycobacteria are ubiquitous in the environment and are increasingly implicated in human diseases worldwide. Currently, there are more than 150 species of Mycobacterium and it is likely that more will be discovered. The rapid increase in identified species in recent years is due to improved culturing techniques and more precise differentiations of species. The application of highly active antiretroviral therapy for the treatment of HIV disease dramatically reduced rates of all opportunistic infections including nontuberculous mycobacteria. Despite this decline, nontuberculous mycobacterium remains one of the most commonly encountered opportunistic infections in AIDS patients. Disseminated nontuberculous mycobacteria infections are seen exclusively among immunocompromised hosts, including those with AID. Disseminated disease is most commonly seen in association with profound immunosuppression. In HIV infected patients, dissemination does not typically occur unless the CD-4+ T-lymphocyte count is below 50/uL. Structural lung disease, such as chronic obstructive pulmonary disease, silicosis, pneumoconiosis or prior TB infection, predisposes to pulmonary infection. Nodular bronchiectasis is very strongly associated with nontuberculous mycobacteria infections. Disseminated Mycobacterium avium complex disease was one of the first opportunistic infections recognized as part of the syndrome of AIDS .Interest in disseminated Mycobacterium avium and nontuberculous mycobacteria infections increased as a result of the HIV epidemic, and therapeutic strategies to treat and prevent these diseases must be focused. Prevention and treatment regimens were lifelong because cure of nontuberculous mycobacteria was not achievable in AIDS patients with profound immune suppression.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88000578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Clinical Value of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies as Diagnostic Tools in Cases with Non-Arthritic Chronic Hepatitis C Viral Disease","authors":"","doi":"10.33140/jcei/03/03/00001","DOIUrl":"https://doi.org/10.33140/jcei/03/03/00001","url":null,"abstract":"Background: Rheumatoid arthritis is a chronic immunological disease that causes destruction and deformity of joints. Chronic hepatitis C infection cases could develop rheumatic like clinical presenting profile. Raised rheumatoid factor in chronic HCV infection considerably reduces the diagnostic privilege of rheumatoid factor for rheumatoid arthritis coexisting with HCV infection. Aim of the work: To determine the value of anti-citrullinated protein antibody levels in cases having chronic HCV infection in comparison to rheumatoid factor. Methodology: The research team recruited 150 non-arthritic study subjects having chronic hepatitis C virus infection rheumatoid factor and anti-citrullinated protein antibody levels were assayed for all study subjects for statistical analysis. Results: Rheumatoid factor +ve study subjects had statistically significantly more frequent within female gender. (p value=0.027) Rheumatoid factor high +ve cases had statistically significantly had more frequent fatty liver and higher platelets than on high RF +ve cases. (P value =0.020, <0.038 consecutively) Conclusion: HCV cases with joint involvement were not implemented in the current research study that prevented statistical estimation of the sensitivity of anti-citrullinated protein antibody for arthritis in this cohort. Racial and ethnic differences should be put in consideration in future research studies that are recommended to be multi centric in fashion.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87690754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Anaemia among Reproductive Age Group (16-45 Yrs) of Women\u0000in the RMG Concentrated Area, Savar, Dhaka","authors":"","doi":"10.33140/jcei/03/03/00002","DOIUrl":"https://doi.org/10.33140/jcei/03/03/00002","url":null,"abstract":"This was a retrospective study and record of hemoglobin level of reproductive age group (16-45 yrs) of women in\u0000the Ready Made Garment (RMG) concentrated area, Savar, Dhaka. Descriptive statistics were used. Results were\u0000expressed as percentages/proportions, means and average. The objective of this study is to determine prevalence of\u0000Anaemia among women of reproductive age group who are working in Garments. In this study hemoglobin level of\u0000one thousand one hundred and five women of reproductive age (16-45 years) were analyzed in lab. The prevalence\u0000rate of any anemia was 71.22%. The majority of anemic women were in the category of mild (53.48 %) to moderate\u0000(14.67%) and severe Anaemia was 3.07%. Though the most affected age group was 21-25 years but the difference\u0000noted was statistically significant. The study substantiates the existence of mild to moderate form of anemia among\u0000women of reproductive age and underlines the need for iron supplementation to all reproductive women especially\u0000during the antenatal period with more attention to the most affected regions of the country.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":"285 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85319785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}