Journal of clinical & experimental immunology最新文献_第10页

Cholera Toxin B Subunit and Peptide LKEKK Inhibit TNF-α Signaling in Intestinal Epithelial Cells and Reduce Inflammation in a Mouse Model of Colitis 霍乱毒素B亚基和肽LKEKK抑制肠上皮细胞TNF-α信号并减轻结肠炎小鼠模型的炎症

Journal of clinical & experimental immunology Pub Date : 2019-01-01 DOI: 10.33140/jcei.04.04.03

Elena V Navolotskayaa, V. B. Sadovnikov, V. Lipkin, V. Zav'yalov

引用次数: 2

Disseminated Nontuberculous Mycobacteria in HIV-Infected Patients hiv感染患者的播散性非结核分枝杆菌

Journal of clinical & experimental immunology Pub Date : 2018-12-17 DOI: 10.33140/jcei.03.03.03

{"title":"Disseminated Nontuberculous Mycobacteria in HIV-Infected Patients","authors":"","doi":"10.33140/jcei.03.03.03","DOIUrl":"https://doi.org/10.33140/jcei.03.03.03","url":null,"abstract":"Nontuberculous mycobacteria are ubiquitous in the environment and are increasingly implicated in human diseases worldwide. Currently, there are more than 150 species of Mycobacterium and it is likely that more will be discovered. The rapid increase in identified species in recent years is due to improved culturing techniques and more precise differentiations of species. The application of highly active antiretroviral therapy for the treatment of HIV disease dramatically reduced rates of all opportunistic infections including nontuberculous mycobacteria. Despite this decline, nontuberculous mycobacterium remains one of the most commonly encountered opportunistic infections in AIDS patients. Disseminated nontuberculous mycobacteria infections are seen exclusively among immunocompromised hosts, including those with AID. Disseminated disease is most commonly seen in association with profound immunosuppression. In HIV infected patients, dissemination does not typically occur unless the CD-4+ T-lymphocyte count is below 50/uL. Structural lung disease, such as chronic obstructive pulmonary disease, silicosis, pneumoconiosis or prior TB infection, predisposes to pulmonary infection. Nodular bronchiectasis is very strongly associated with nontuberculous mycobacteria infections. Disseminated Mycobacterium avium complex disease was one of the first opportunistic infections recognized as part of the syndrome of AIDS .Interest in disseminated Mycobacterium avium and nontuberculous mycobacteria infections increased as a result of the HIV epidemic, and therapeutic strategies to treat and prevent these diseases must be focused. Prevention and treatment regimens were lifelong because cure of nontuberculous mycobacteria was not achievable in AIDS patients with profound immune suppression.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88000578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Predictive Clinical Value of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies as Diagnostic Tools in Cases with Non-Arthritic Chronic Hepatitis C Viral Disease 类风湿因子和抗瓜氨酸蛋白抗体作为非关节炎性慢性丙型肝炎病毒病诊断工具的预测临床价值

Journal of clinical & experimental immunology Pub Date : 2018-12-15 DOI: 10.33140/jcei/03/03/00001

{"title":"Predictive Clinical Value of Rheumatoid Factor and Anti-Citrullinated Protein Antibodies as Diagnostic Tools in Cases with Non-Arthritic Chronic Hepatitis C Viral Disease","authors":"","doi":"10.33140/jcei/03/03/00001","DOIUrl":"https://doi.org/10.33140/jcei/03/03/00001","url":null,"abstract":"Background: Rheumatoid arthritis is a chronic immunological disease that causes destruction and deformity of joints. Chronic hepatitis C infection cases could develop rheumatic like clinical presenting profile. Raised rheumatoid factor in chronic HCV infection considerably reduces the diagnostic privilege of rheumatoid factor for rheumatoid arthritis coexisting with HCV infection. Aim of the work: To determine the value of anti-citrullinated protein antibody levels in cases having chronic HCV infection in comparison to rheumatoid factor. Methodology: The research team recruited 150 non-arthritic study subjects having chronic hepatitis C virus infection rheumatoid factor and anti-citrullinated protein antibody levels were assayed for all study subjects for statistical analysis. Results: Rheumatoid factor +ve study subjects had statistically significantly more frequent within female gender. (p value=0.027) Rheumatoid factor high +ve cases had statistically significantly had more frequent fatty liver and higher platelets than on high RF +ve cases. (P value =0.020, <0.038 consecutively) Conclusion: HCV cases with joint involvement were not implemented in the current research study that prevented statistical estimation of the sensitivity of anti-citrullinated protein antibody for arthritis in this cohort. Racial and ethnic differences should be put in consideration in future research studies that are recommended to be multi centric in fashion.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87690754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Prevalence of Anaemia among Reproductive Age Group (16-45 Yrs) of Womenin the RMG Concentrated Area, Savar, Dhaka 达卡萨瓦尔RMG集中地区育龄妇女(16-45岁)贫血患病率

Journal of clinical & experimental immunology Pub Date : 2018-12-15 DOI: 10.33140/jcei/03/03/00002

引用次数: 0

Anti-Gbm Disease in Children: Outcomes and Association with Systemic Vasculitis 儿童抗gbm疾病:结局及与全身性血管炎的关系

Journal of clinical & experimental immunology Pub Date : 2018-11-30 DOI: 10.33140/jcei/03/02/00006

引用次数: 0

The Prevalence of Undernutrition and Associated Factors among Children AgedOne to Five Years in Siyambalanduwa MOH Area 西扬巴兰杜瓦卫生部辖区1 - 5岁儿童营养不良发生率及相关因素

Journal of clinical & experimental immunology Pub Date : 2018-11-28 DOI: 10.33140/jcei/03/02/00005

{"title":"The Prevalence of Undernutrition and Associated Factors among Children Aged\u0000One to Five Years in Siyambalanduwa MOH Area","authors":"","doi":"10.33140/jcei/03/02/00005","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00005","url":null,"abstract":"Aim: High prevalence of child undernutrition is a well-known issue in rural areas of Si Lanka. Identification of real\u0000burden, underlying specific causes and addressing those issues will help to improve the nutritional status of those\u0000children.\u0000Objective: To describe the prevalence of undernutrition and associated factors among children aged one to five years\u0000in Siyambalanduwa MOH area.\u0000Methodology: A community based cross-sectional study was conducted among 421 child-mother pairs in Siyambalanduwa\u0000MOH area using two stage cluster sampling method. Data collection done by using pre tested interviewer administered\u0000questionnaire. Relevant anthropometric measurements were done according to WHO slandered guidelines. Statistical\u0000analysis was done using SPSS 20. The chi-square test was used, and P<0.05 was considered for statistically significant.\u0000Results: Overall 41% of children aged 1-5 years were undernourished in Siyambalanduwa MOH area. Among the\u0000study subjects 24% were underweight, 25.7% were stunted, 16.4% were wasted, 9.2% were both underweight &\u0000stunted, 6.8% were both, underweight & wasted, 0.5% were both stunted & wasted and 9.9% were underweight &\u0000stunted g & wasted. Only the low total monthly income (P<0.001) and low birth weight (P<0.001) were significantly\u0000associated with child undernutrition.\u0000Conclusions and recommendations: Prevalence of undernutrition among children aged 1-5 years is unacceptably\u0000high and urgent efforts to reduce undernutrition should be a priority. Future studies should focus on assessing how\u0000to reduce the burden of undernutrition with low cost interventions.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77387023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Quality Improvement Project to Increase the Rate of HPV Vaccination Initiation in Adolescents 提高青少年HPV疫苗接种率的质量改进项目

Journal of clinical & experimental immunology Pub Date : 2018-11-26 DOI: 10.33140/jcei/03/02/00004

{"title":"A Quality Improvement Project to Increase the Rate of HPV Vaccination Initiation in Adolescents","authors":"","doi":"10.33140/jcei/03/02/00004","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00004","url":null,"abstract":"The vaccination rate of the human papilloma virus vaccine [9vHPV] is low, with only 63% of eligible females and 50% eligible males receiving the vaccine in 2016. The aim of this quality improvement project was to increase the initiation rate of HPV vaccination at Smyrna Pediatrics by 20%, from 3.6% to 4.3% over four weeks. Two physicians, one nurse practitioner, and two medical assistants implemented this quality improvement initiative. There is a lack of education and standardized communication about HPV and 9vHPV to prevent against the virus. A standardized script was created so that all conversations between healthcare professionals and patients and their parents or guardians included the wording of the 9vHPV being recommended rather than optional. Educational material from the CDC was the standard handout given to each adolescent and their parent or guardian. Standardized education and communication was to be provided at each adolescent visit of the 125 eligible adolescents seen during the four-week implementation period, 4% (n = 5) agreed to receive the 9vHPV vaccine. With a baseline of 3.6% (n = 4), there was an 11.1% increase of initiation of 9vHPV. The use of standardized education documents presented to all patients and their parents or guardians established health education as the mainstay of the project and provided information about the importance of prevention and protection from the virus that the vaccine prevents. The implementation of results over a longer period of time may prove to be more effective for the practice’s increase of vaccination rates overall.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77094349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Monoclonal Antibody-Based Biosimilar GnRH Antagonist 一种新的基于单克隆抗体的GnRH生物类似药拮抗剂

Journal of clinical & experimental immunology Pub Date : 2018-11-20 DOI: 10.33140/jcei.03.02.07

Gregory M. Lee

引用次数: 0

Active Specific Immunotherapy (ASI) and Gcmaf Forte in Management of Metastatic Invasive Carcinoma–Overview of the Therapeutic Modalities and A Case Report 主动特异性免疫治疗(ASI)和Gcmaf - Forte在转移性浸润性癌治疗中的作用——治疗方式综述和一例报告

Journal of clinical & experimental immunology Pub Date : 2018-11-19 DOI: 10.33140/jcei/03/02/00003

R. Moya, Mike K. S. Chan, D. Klokol, S. Y. Pan

{"title":"Active Specific Immunotherapy (ASI) and Gcmaf Forte in Management of Metastatic Invasive Carcinoma–Overview of the Therapeutic Modalities and A Case Report","authors":"R. Moya, Mike K. S. Chan, D. Klokol, S. Y. Pan","doi":"10.33140/jcei/03/02/00003","DOIUrl":"https://doi.org/10.33140/jcei/03/02/00003","url":null,"abstract":"Metastatic cancer is often a fatal disease with low survival rate that in a course of its progression implies a pathogenic cascade involving inflammation, overexpression of reactive oxygen species, loss of DNA repair, genome instability, neoangiogenesis, epithelial infiltration, collagen destruction, and immunosuppression and apoptosis evasion by cancer cells. Understanding the cross-interaction mechanism between the immune co-stimulatory and inhibitory molecules on one side and tumors cells is a key point in the development of a successful immunotherapeutic strategy to fight aggressive cancers. The Active Specific Immunotherapy (ASI) and the GC protein Macrophage Activating Factor (GcMAF) are two immunotherapies capable of modulating the innate and adaptive immunity against cancer. The aim of this work is to present a case of an invasive metastatic carcinoma treated with ASI and GcMAF Forte and discuss the potentials of the individualized immunotherapy in advanced forms of cancer. Immunotherapy improves status of immune system and as a result it increases patient’s life span (and probably survival rate). In conclusion, the ASI and GcMAF Forte may offer a promising prospective immunological biomedical approach to boost immunity and enhance life expectancy in patients with metastatic cancer.","PeriodicalId":73657,"journal":{"name":"Journal of clinical & experimental immunology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75415427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Still Rare Case of Congenital Afibrinogenemia 一例罕见的先天性纤维蛋白原血症

Journal of clinical & experimental immunology Pub Date : 2018-11-06 DOI: 10.33140/jcei/03/02/00002

I. Tlamçani, A. Krich, Fatima Zahrae El Hamdi, M. A. Hassani

引用次数: 0