Journal of cellular immunology最新文献_第5页

Manufacturing of Human T-lymphoid Progenitors from Two Different Hematopoietic Stem Cell Sources and Perspective for New Immunotherapies 两种不同造血干细胞来源制造人t淋巴细胞祖细胞及新免疫疗法的前景

Journal of cellular immunology Pub Date : 2022-09-28 DOI: 10.33696/immunology.4.144

P. Gaudeaux, R. D. Moirangthem, Pauline Rault, H. Sadek, F. Carbone, Marieke, Lavaert, A. Joshi, T. Taghon, I. André, O. Nègre, T. Soheili

{"title":"Manufacturing of Human T-lymphoid Progenitors from Two Different Hematopoietic Stem Cell Sources and Perspective for New Immunotherapies","authors":"P. Gaudeaux, R. D. Moirangthem, Pauline Rault, H. Sadek, F. Carbone, Marieke, Lavaert, A. Joshi, T. Taghon, I. André, O. Nègre, T. Soheili","doi":"10.33696/immunology.4.144","DOIUrl":"https://doi.org/10.33696/immunology.4.144","url":null,"abstract":"Manufacturing of Human T-lymphoid Progenitors from Two Different Hematopoietic Stem Cell Sources and Perspective for New Immunotherapies. Abstract The adaptive immune system depends on the efficient response of lymphocytes, protecting the organism from infection or malignant diseases. T-cell immunodeficiency, innate or acquired, put the patient at risk for developing opportunistic infections and cancers. We previously described a novel approach to overcome the major limitations of T-cell immunotherapy and hematopoietic stem cell transplant (HSCT) by transplanting human T-lymphoid progenitors (HTLP), with the aim to achieve shortened immune reconstitution and fully functional naïve T-cell repertoire in immunodeficient or immunocompromised patients. By complementing our DL4-based cell culture with TNFα we developed and scaled-up clinical strategies involving hematopoietic stem and progenitor cells (HSPC) differentiated into T-lymphoid progenitors. We discuss here recent advances made in the characterization of different cell sources used as starting materials for T-lymphoid progenitors manufacturing, as well as gene modification of these cells, highlighting new perspectives for the development of therapeutical strategies.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46813582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improvement of the Specificity of the Indirect BAT for the Diagnosis of Peanut Allergy; the BA(Blocking Antibodies)-BAT 间接BAT对花生过敏诊断特异性的提高BA(阻断抗体)-BAT

Journal of cellular immunology Pub Date : 2022-09-28 DOI: 10.33696/immunology.4.143

Janneke Ruinemans-Koerts, Monique van Uum-Otters, Don van Baar, J. V. Neerven, Judit Wesseling

{"title":"Improvement of the Specificity of the Indirect BAT for the Diagnosis of Peanut Allergy; the BA(Blocking Antibodies)-BAT","authors":"Janneke Ruinemans-Koerts, Monique van Uum-Otters, Don van Baar, J. V. Neerven, Judit Wesseling","doi":"10.33696/immunology.4.143","DOIUrl":"https://doi.org/10.33696/immunology.4.143","url":null,"abstract":"These false-positive outcomes can be a consequence of IgE binding to an epitope in the food protein used in these tests that may be inactivated after consumption due to food processing or digestion. Alternatively, the BAT protocol can be less sensitive to interference of inhibiting factors such as allergen specific IgG4 and IgA produced during tolerance development due to e.g. consumption of trace amounts of allergen. However, the influence of inhibiting factors can be detected when allergens are pre-incubated with serum, allowing IgG/IgA binding to allergens, before addition to basophils, as shown by the fact that a decrease in basophil sensitivity to Ara h2 predicted sustained unresponsiveness after peanut oral immunotherapy [4]. In our recent study on the indirect BAT for the diagnosis of peanut allergy we observed a few false-positive BAT outcomes [3]. We hypothesized that these false-positive BAT outcomes might among others be due to inhibiting factors, like IgG4 and IgA, produced during natural tolerance development which effect on basophil activation can’t be adequately detected in the regular BAT protocol. Therefore, we re-analysed with a modified indirect BAT protocol (called “BA(blocking antibodies)-BAT”) the serum samples (n=3) from our indirect BAT peanut study with a false-positive BAT Ara h2 or Ara h6 outcome.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44749271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence, Pathogenicity and Plasticity: The Role of IL-23 in Th17 Fate 持久性、致病性和可塑性：IL-23在Th17细胞命运中的作用

Journal of cellular immunology Pub Date : 2022-09-28 DOI: 10.33696/immunology.4.140

Jens C. Kleiner, Christian F. Krebs

引用次数: 0

Microbial Resistance to Photodynamic Therapy 微生物对光动力疗法的耐药性

Journal of cellular immunology Pub Date : 2022-09-12 DOI: 10.33696/immunology.4.139

A. Mackay

{"title":"Microbial Resistance to Photodynamic Therapy","authors":"A. Mackay","doi":"10.33696/immunology.4.139","DOIUrl":"https://doi.org/10.33696/immunology.4.139","url":null,"abstract":"Microbial resistance to antibiotics has become a major area of research having caused over a million human deaths in 2019. At present, lower respiratory infection is the most burdensome disease. Antimicrobial Photodynamic Therapy (PDT) is regularly reported not to cause resistance in any pathogen, and to eradicate both microbes that are susceptible to antibiotics and those that are resistant. However, evidence now suggests that resistance to photosensitiser drugs at low concentrations is possible, and that tolerance to the reactive oxygen species (ROS) created during subsequent light exposure will occur eventually. Additionally, an increased optical fluence and the addition of medication have been necessary to destroy antibiotic resistant strains of Staphylococcus Aureus . Research has mostly focussed on bacteria, though the importance of fungi is highlighted here given the ubiquity of clinical manifestations like mycosis and urinary tract infection. Proposed next steps are the definition of terminology and methodology for experiments on microbial resistance/tolerance to PDT, varying the photosensitiser used for repeat PDT while controlling oxygen and salt levels, and alternative treatments including the interception of neuroimmunological signalling. Similar to the ESKAPE ranking of antibiotic resistant pathogens, a list summarising the degree of microbial resistance to PDT may have a place.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42938350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

BIOMODULINA T® Modulates Lymphocyte Compartments in Institutionalized Cuban Geriatric Patients BIOMODULINA T®调节古巴住院老年患者的淋巴细胞区室

Journal of cellular immunology Pub Date : 2022-07-30 DOI: 10.33696/immunology.4.135

Imilla Casado Hernández, V. M. Suárez, Elizabeth Hernández Ramos, Yenisey Triana Marrero, Gabriela Díaz Domínguez, Yaneisy Duarte Pérez, Mary Carmen Reyes Zamora, Sahily Estradé Fernandez, Consuelo Milagros Macías Abraham, Luis Felipe Heredia Guerra

{"title":"BIOMODULINA T® Modulates Lymphocyte Compartments in Institutionalized Cuban Geriatric Patients","authors":"Imilla Casado Hernández, V. M. Suárez, Elizabeth Hernández Ramos, Yenisey Triana Marrero, Gabriela Díaz Domínguez, Yaneisy Duarte Pérez, Mary Carmen Reyes Zamora, Sahily Estradé Fernandez, Consuelo Milagros Macías Abraham, Luis Felipe Heredia Guerra","doi":"10.33696/immunology.4.135","DOIUrl":"https://doi.org/10.33696/immunology.4.135","url":null,"abstract":"Modulates Compartments in Abstract BIOMODULINA T® is a biological immunomodulator of natural origin, not blood derived, which promises to be a strategy for immune restoration in the elderly, in the midst of the worldwide epidemiological crisis due to the SARS-CoV-2 virus. This research aimed to determine the changes induced by BT in the distribution of lymphocyte compartments of institutionalized Cuban geriatric patients. The significant expansion of the naïve CD4 + and CD8 + , CD19 + , NK T cells and of the CD3 + HLA-DR + and CD3 + CD25 + activation populations was observed; while the rest of the populations of T, B compartments, the T population that co-express CD4 and CD8, and the CD4-CD8-TCRαβ + T cells did not show significant changes. BT had an effect on the immune restoration of T and B lymphocyte populations of Cuban older adults. It modulates the immune response and inflammation, restores immunity, and can contribute to a strategy to prevent and treat COVID-19 in elderly.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46120478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Nonagenarian’s View of Dietary Impacts on Cellular Immunology 饮食对细胞免疫的影响

Journal of cellular immunology Pub Date : 2022-06-30 DOI: 10.33696/immunology.4.136

B. Lands

{"title":"A Nonagenarian’s View of Dietary Impacts on Cellular Immunology","authors":"B. Lands","doi":"10.33696/immunology.4.136","DOIUrl":"https://doi.org/10.33696/immunology.4.136","url":null,"abstract":"Descriptions of immune functions and diets often use oversimplified terms that lead to misunderstandings plus expectations that conflict with reality. “ Unexpected events are a clear marker for the frontier of knowledge and a new opportunity to learn” [1]. Terms like lipid, fluidity, unsaturated, essential, lipoprotein, receptor, immune and inflammatory have many unmentioned components and attributes that may be either causal mediators or associated epiphenomena in heath disorders. Including neglected details can help investigators design dietary interventions with observed consequences that fit their expectations. Over the years, new evidence and explicit terminology allow expected outcomes for interventions to fit reality. A recent review, “ Lipid nutrition: ‘In silico’ studies and undeveloped experiments ” [1], describes some aspects of fatty acid chemistry and nutrition with important consequences on chronic immune-inflammatory processes. The review points to long-known details of lipid-protein interactions which younger colleagues can consider as they develop new experiments to gather evidence on how food choices might prevent healthy physiology from drifting into pathophysiology.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42459518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FLIP-expressing myeloid cells as driver of systemic immune disorders 表达FLIP的骨髓细胞作为系统免疫疾病的驱动因素

Journal of cellular immunology Pub Date : 2022-06-30 DOI: 10.33696/immunology.4.138

Alberto Atanasio, D. Rizzini, S. Ugel

{"title":"FLIP-expressing myeloid cells as driver of systemic immune disorders","authors":"Alberto Atanasio, D. Rizzini, S. Ugel","doi":"10.33696/immunology.4.138","DOIUrl":"https://doi.org/10.33696/immunology.4.138","url":null,"abstract":"The role of FLIP as a moonlighting protein is becoming progressively evident since this protein is often involved in various processes correlated to aberrant immunological responses independently from its function as master anti-apoptotic regulator. It has been uncovered that FLIP drives the acquisition of immunosuppression and inflammation-associated pathways in myeloid cells. The clinical picture raised during SARS-CoV-2 pandemic has given the possibility to deeply investigate FLIP involvement in releasing a systemic cytokine storm, also linked to a chronic inflammatory syndrome associated with immune suppression and cancer progression. Indeed, a FLIP/STAT3 axis orchestrates an aberrant inflammatory program in myeloid cells of COVID-19 patients and SARS-CoV-2 infected hACE2 transgenic mice. Moreover, the same activated FLIP/STAT3 axis was confirmed in a chimeric vFLIP mouse model, where vFLIP overexpression was restricted exclusively in myeloid cells by using a tissue-specific CRE-driver (e.g., LysMCre mice), validating this model as a feasible platform to study the late phase of COVID-19 disease. The STAT3 pro-inflammatory pathway triggered by the aberrant expression of FLIP in myeloid cells well correlates to the outcome of the cytokine release syndrome (CRS) that is the latest and most severe phase in COVID-19 disease confirming FLIP-mediated myeloid reprogramming as a cornerstone of systemic immune disorders.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45561195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncZFAS1 Inhibit MPP+-Induced Neuroinflammation Through TXNIP/MIB1 E3 Ubiquitin Ligase/NLRP3 Axis LncZFAS1通过TXNIP/MIB1 E3泛素连接酶/NLRP3轴抑制MPP+诱导的神经炎症

Journal of cellular immunology Pub Date : 2022-04-30 DOI: 10.33696/immunology.4.134

引用次数: 0

Sticky Interactions in Lupus Nephritis 狼疮性肾炎中的粘性相互作用

Journal of cellular immunology Pub Date : 2022-03-31 DOI: 10.33696/immunology.4.126

引用次数: 0

Towards a Better Understanding of Staphylococcus aureus Skin Infections-The Interactions with Dendritic Cells 更好地了解金黄色葡萄球菌皮肤感染——与树突状细胞的相互作用

Journal of cellular immunology Pub Date : 2022-03-31 DOI: 10.33696/immunology.4.127

引用次数: 0