Journal of cellular immunology最新文献_第10页

The Interplay between Transcription Factor SALL4 and Histone Modifiers in Hematopoietic Stem and Progenitor Cells. 造血干细胞和祖细胞中转录因子SALL4与组蛋白修饰因子的相互作用。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.073

Hiro Tatetsu, Daniel G Tenen, Li Chai

{"title":"The Interplay between Transcription Factor SALL4 and Histone Modifiers in Hematopoietic Stem and Progenitor Cells.","authors":"Hiro Tatetsu, Daniel G Tenen, Li Chai","doi":"10.33696/immunology.3.073","DOIUrl":"https://doi.org/10.33696/immunology.3.073","url":null,"abstract":"Currently, there is a growing need for culturing hematopoietic stem/progenitor cells (HSPCs) ex vivo for various clinical applications such as HSPC transplantation and gene therapy. For many patients with hematologic, genetic, and immune diseases, HSPC transplants can be a life-saving treatment. There are over 20,000 patients in the US receiving HSPC transplantation yearly [1]. About two-thirds of these cases are autologous and the rest are allogeneic transplants. The sources of the HSPCs are from peripheral blood mobilized stem/progenitor cells (PBSC), cord blood (CB) and bone marrow (BM). Umbilical cord blood can be an excellent HSPC donor source; however, its use is severely constrained by the limited HSPC numbers in one single cord blood unit. Developing technologies that allow ex vivo expansion of cord blood will be highly beneficial for the clinical application of HSPC transplants. In addition, there is a growing need for culturing PBSC in vitro for transplant-related applications such as gene therapy or genome-editing via TALENs or CRISPR/Cas9 [2,3]. Furthermore, the same PBSC in vitro culture technique can be used for HSCP expansion for poor autologous mobilizations to avoid additional collections. Establishing culture conditions that can maintain and expand HSPCs from PBSC ex vivo will be beneficial to these clinical applications.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"3 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38897045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Immune Cells and Transcriptional Signatures Revealed Novel Regulators and Predict Clinical Response to Biologic Therapy in Ulcerative Colitis. 免疫细胞和转录特征揭示了溃疡性结肠炎的新调节因子并预测了生物治疗的临床反应。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.116

Suzana D Savkovic

引用次数: 0

Exploring and Targeting the Tumor Immune Microenvironment of Neuroblastoma. 神经母细胞瘤肿瘤免疫微环境的探索与靶向

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.111

Katherine E Masih, Jun S Wei, David Milewski, Javed Khan

{"title":"Exploring and Targeting the Tumor Immune Microenvironment of Neuroblastoma.","authors":"Katherine E Masih, Jun S Wei, David Milewski, Javed Khan","doi":"10.33696/immunology.3.111","DOIUrl":"10.33696/immunology.3.111","url":null,"abstract":"Pediatric neuroblastoma is a heterogenous disease that accounts for significant morbidity and mortality in children. Deep genomic and transcriptomic profiling of patient tumors has revealed a low mutational burden and a paucity of therapeutic targets. Furthermore, different molecular subtypes, such as MYCN amplification, have been associated with adverse outcomes. Using whole transcriptome sequencing, we previously explored the immune microenvironment of neuroblastoma subtypes and discovered its association with clinical outcome. Specifically, we found that patients with tumors infiltrated by higher levels of cytotoxic lymphocytes had a better overall survival. Additionally, we found that a high MYCN gene expression signature in MYCN-non-amplified tumors is an independent predictor of adverse outcome. However, signatures of tumor infiltrating cytotoxic immune cells in this subtype of tumors predict an improved outcome. While this is clinically informative, it does not provide a full picture of the dynamics underlying the biology of tumor immune microenvironment and how to use this information to improve patient outcomes. Here, we highlight our previous work and current approaches using immunotherapy in neuroblastoma and explore our current understanding of the immune biology of these tumors. We further describe how this correlates with patient outcome, and how this information can be used to develop novel immunotherapeutic strategies for pediatric patients with neuroblastoma.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"3 1","pages":"305-316"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49253441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic. 环境富集及其对偏头痛的益处：树突状细胞胞外囊泡是一种有效的模拟物

Journal of cellular immunology Pub Date : 2021-01-01

Kae Myriam Pusic, Lisa Won, Richard Paul Kraig, Aya Darinka Pusic

引用次数: 0

The Role of Myeloid Populations during Perinatal Liver Injury and Repair. 髓系群体在围产期肝损伤和修复中的作用。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.076

Anas Alkhani, Sarah Mohamedaly, Amar Nijagal

{"title":"The Role of Myeloid Populations during Perinatal Liver Injury and Repair.","authors":"Anas Alkhani, Sarah Mohamedaly, Amar Nijagal","doi":"10.33696/immunology.3.076","DOIUrl":"https://doi.org/10.33696/immunology.3.076","url":null,"abstract":"Perinatal liver inflammation can have life-threatening consequences, particularly in infants and young children. An example of a hepatic inflammatory disease during infancy is biliary atresia (BA), an obliterative cholangiopathy that rapidly progresses to hepatic fibrosis and liver failure. The aggressive nature of BA in neonates compared to the pathogenesis of inflammatory liver diseases in adults, suggests that the mechanisms responsible for restoring tissue homeostasis following inflammation are impaired in affected infants. This article reviews our recent findings demonstrating that the relative abundance of Ly6cLo non-classical monocytes promotes resolution of perinatal liver injury in a murine model of perinatal hepatic inflammation. Our research also identifies a potential co-regulatory role between neutrophils and non-classical monocytes. Further work is needed to understand how neutrophils regulate other myeloid populations during perinatal liver inflammation. Elucidating the mechanisms that govern perinatal liver injury and repair may lead to the development of immune-directed therapies that can be used to mitigate the devastating effects of diseases like BA.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"3 1","pages":"42-45"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33488828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospects of JAK Inhibition in the Framework of Bone Loss JAK在骨质流失框架中的抑制前景

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/IMMUNOLOGY.3.075

S. Adam, G. Schett, S. Frey

引用次数: 0

The Potential of Combination Therapies and Patient Stratification to Improve CCR2 Inhibition Therapeutics. 联合治疗和患者分层改善CCR2抑制治疗的潜力。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.099

Jason E Duex, Dan Theodorescu

引用次数: 1

Ca²⁺/calmodulin-dependent Protein Kinases in Leukemia Development. 白血病发展中的Ca2+/钙调素依赖蛋白激酶。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.091

Changhao Cui, Chen Wang, Min Cao, Xunlei Kang

引用次数: 2

Murine Models of Alcohol Consumption: Imperfect but Still Potential Source of Novel Biomarkers and Therapeutic Drug Discovery for Alcoholic Liver Disease. 小鼠酒精消费模型:不完善但仍然是酒精性肝病新生物标志物和治疗药物发现的潜在来源。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.096

Khaled Alharshawi, Costica Aloman

{"title":"Murine Models of Alcohol Consumption: Imperfect but Still Potential Source of Novel Biomarkers and Therapeutic Drug Discovery for Alcoholic Liver Disease.","authors":"Khaled Alharshawi, Costica Aloman","doi":"10.33696/immunology.3.096","DOIUrl":"https://doi.org/10.33696/immunology.3.096","url":null,"abstract":"Animal models of liver disease are fundamentally important to strengthen our knowledge and understanding of human liver diseases. Murine models of alcohol consumption are utilized to investigate alcoholic liver injury to develop new therapeutic targets. The well accepted and commonly used murine models of chronic alcohol consumption are Meadows-Cook (MC) and Lieber-DeCarli (LD). LD model is based on an isocaloric high-fat liquid diet, but mice under the MC model fed on a regular chow diet with alcohol added to the drinking water. Alcoholic liver disease in real world is frequently diagnosed in patients with obesity and high fat intake, mirroring LD diet. The overlap of the specific effect of ethanol and obesity is difficult to differentiate by clinician and pathologist. In this commentary, we will further discuss our research findings comparing MC and LD as a tool to dissect early alcohol versus increased fat intake detrimental effects on the liver. The critical analysis of these two models could provide evidence to differentiate the specific impact of alcohol on the liver from the combined influence of alcohol and diet. Ultimately, these investigations could uncover potential biomarkers and therapeutic targets for personalized type of alcoholic liver injury.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"3 3","pages":"177-181"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39259031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Importance of miRNA Identification During Respiratory Viral Infections. 呼吸道病毒感染期间 miRNA 鉴定的重要性。

Journal of cellular immunology Pub Date : 2021-01-01 DOI: 10.33696/immunology.3.101

Ivan Martinez-Espinoza, Ma Del Rocio Banos-Lara, Antonieta Guerrero-Plata

引用次数: 0