Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development.

Changhao Cui, Chen Wang, Min Cao, Xunlei Kang
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引用次数: 2

Abstract

Ca2+/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunctional Ca2+/CaM-dependent protein kinases (CaMKs) are critical intermediates of this signaling and play key roles in cancer development. The most investigated CaMKs in leukemia, especially myeloid leukemia, are CaMKI, CaMKII, and CaMKIV. The function and mechanism of these kinases in leukemia development are summarized in this study.

Abstract Image

Abstract Image

白血病发展中的Ca2+/钙调素依赖蛋白激酶。
Ca2+/calmodulin (CaM)信号传导对于广泛的细胞功能是重要的。这一信号在肿瘤进展(如增殖、侵袭和迁移)中的作用已经被认识到,这并不奇怪。然而,它在白血病中的作用还没有得到很好的认识。多功能Ca2+/ cam依赖性蛋白激酶(CaMKs)是该信号传导的关键中间体,在癌症发展中起关键作用。在白血病,特别是髓性白血病中研究最多的camk是CaMKI、CaMKII和CaMKIV。本文就这些激酶在白血病发生中的作用及机制作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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