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Would It be Possible for a SARS-CoV-2 Infection to Affect the Male Reproductive System? SARS-CoV-2感染会影响男性生殖系统吗?
Journal of cellular immunology Pub Date : 2023-10-03 DOI: 10.33696/immunology.5.173
Kaveh Rahimi, Akram Ebrahimifar, Mehri Rahimi
{"title":"Would It be Possible for a SARS-CoV-2 Infection to Affect the Male Reproductive System?","authors":"Kaveh Rahimi, Akram Ebrahimifar, Mehri Rahimi","doi":"10.33696/immunology.5.173","DOIUrl":"https://doi.org/10.33696/immunology.5.173","url":null,"abstract":"The male reproductive system may be affected by the systemic infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The precise mechanisms of male reproductive impairment are not well known. There are two possible mechanisms for the effect of SARS-CoV-2 on the male reproductive system either directly through the impact of the angiotensin-converting enzyme 2 (ACE2) receptor on testicular tissue or indirectly through the effect of the secondary autoimmune response on testicular functions. The second mechanism is more likely. Extensive studies need to be conducted on the impact of SARS-CoV-2 on the functional characteristics of sperm and the results of natural fertilization or assisted reproductive technology.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135697313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluoxetine is Antimicrobial and Modulates the Antibiotic Resistance Status of Bacteria 氟西汀具有抗菌作用，可调节细菌对抗生素的耐药性
Journal of cellular immunology Pub Date : 2023-09-28 DOI: 10.33696/immunology.5.172
Alison M Mackay
{"title":"Fluoxetine is Antimicrobial and Modulates the Antibiotic Resistance Status of Bacteria","authors":"Alison M Mackay","doi":"10.33696/immunology.5.172","DOIUrl":"https://doi.org/10.33696/immunology.5.172","url":null,"abstract":"","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135387137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Regulation Impact of Naringenin-loaded Chitosan Nanoparticles on Succinate Dehydrogenase Activity in Cancer Cells 柚皮素壳聚糖纳米颗粒对肿瘤细胞琥珀酸脱氢酶活性的调控作用
Journal of cellular immunology Pub Date : 2023-09-27 DOI: 10.33696/immunology.5.169
Eman M. Ragab, Abeer A. Khamis, Doaa M. El Gamal, Tarek M. Mohamed
{"title":"The Regulation Impact of Naringenin-loaded Chitosan Nanoparticles on Succinate Dehydrogenase Activity in Cancer Cells","authors":"Eman M. Ragab, Abeer A. Khamis, Doaa M. El Gamal, Tarek M. Mohamed","doi":"10.33696/immunology.5.169","DOIUrl":"https://doi.org/10.33696/immunology.5.169","url":null,"abstract":"Oxidative phosphorylation dysregulation (OXPHOS) has been demonstrated to be essential for the development of cancer. Therefore, it may be argued that chaperone and deacetylase activities modulate OXPHOS activity. For instance, a complicated network of interactions connects a cell’s bioenergetic features and neoplastic potential through the imbalance of sirtuin 3 (SIRT3) and succinate dehydrogenase (SDH) enzymatic activity in mitochondria. The studies outlined in this review indicate that targeting SDH regulators is a promising novel therapeutic strategy for this extremely resistant disease. Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. A naturally occurring flavonoid called naringenin (NAR) has been extensively investigated for its pharmacological properties, which include anti-tumor actions. However, due to its low bioavailability in this situation, nanoencapsulation is designed to improve NAR anticancer efficacy. NAR can be encapsulated by chitosan nanoparticles-TPP conjugates, thereby improving NAR cellular absorption and cytotoxicity against cancer cells. Consequently, we proposed naringenin nanoparticles as a novel therapeutic target for SDH regulators in cancer.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135580787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulated CXCL12 Expression in Osteoblasts Promotes B-lymphocytes Preferentially Homing to the Bone Marrow in MRL/lpr Mice 成骨细胞中CXCL12表达失调促进MRL/lpr小鼠b淋巴细胞优先归巢到骨髓
Journal of cellular immunology Pub Date : 2023-08-02 DOI: 10.33696/immunology.5.168
Wenjuan Zheng, Yu Tang, Mengwei Cheng, Cui Ma, X. Fei, W. Shi
{"title":"Dysregulated CXCL12 Expression in Osteoblasts Promotes B-lymphocytes Preferentially Homing to the Bone Marrow in MRL/lpr Mice","authors":"Wenjuan Zheng, Yu Tang, Mengwei Cheng, Cui Ma, X. Fei, W. Shi","doi":"10.33696/immunology.5.168","DOIUrl":"https://doi.org/10.33696/immunology.5.168","url":null,"abstract":"Peripheral circulating B-lymphocytes and B-lymphocytes in the bone marrow (BM) show different responses to lymphotoxic or immunosuppressive agents. We explored the existence of a dysregulated distribution of B-lymphocytes between peripheral and BM compartments and the underlying mechanisms. The percentage of CXC chemokine receptor 4+ B (CXCR4+ B) cells was decreased in the peripheral blood (PB) and increased in the BM of MRL/lpr mice and SLE patients. CXC chemokine ligand 12 (CXCL12) production by BM osteoblasts (OBs) derived from MRL/lpr mice and SLE patients was higher than that obtained with C57BL/6 mice or healthy subjects. MRL/lpr-derived OBs demonstrated stronger chemotactic ability toward B-lymphocytes than control OBs, and more B-lymphocytes colocalized with OBs within the periosteal zone in MRL/lpr mice. Moreover, the CXCR4+ B cell percentages were negatively correlated with the serum immunoglobulin G concentration, and the BM CXCL12 levels were positively correlated with the systemic lupus erythematosus disease activity index score and anti-double stranded DNA titer and negatively correlated with the serum complement 3 concentration. In conclusion, our results indicate a shifted distribution of B-lymphocytes between the BM and peripheral compartments in SLE patients and MRL/lpr mice and that the upregulation of CXCL12 in OBs likely contributes to enhanced chemotactic migration and anchorage of B-lymphocytes to OBs.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46654472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sharing Weal and Woe: A Commentary on “Gasdermin E Regulates the Stability and Activation of EGFR in Human Non-Small Cell Lung Cancer Cells” 同甘共苦:《气皮蛋白E调控人非小细胞肺癌细胞EGFR的稳定性和活化》述评
Journal of cellular immunology Pub Date : 2023-07-17 DOI: 10.33696/immunology.5.167
Limei Xu, Xiangguo Liu
{"title":"Sharing Weal and Woe: A Commentary on “Gasdermin E Regulates the Stability and Activation of EGFR in Human Non-Small Cell Lung Cancer Cells”","authors":"Limei Xu, Xiangguo Liu","doi":"10.33696/immunology.5.167","DOIUrl":"https://doi.org/10.33696/immunology.5.167","url":null,"abstract":"Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of Non-Small Cell Lung Cancer Cells (NSCLC). Chemoresistance to tyrosine kinase inhibitors (TKIs), which is elicited by EGFR mutations, is a key challenge for NSCLC treatment. In the present study, we demonstrate a critical role of gasdermin E (GSDME), an important protein for pyroptosis, in the maintenance of EGFR stability and activation. We found that GSDME depletion suppressed the EGFR-mediated proliferation of NSCLC cells in vitro. GSDME knockdown downregulated the protein level of CCND1 and inhibited the phosphorylation of ERK1/2 in NSCLC cells. Mechanistically, both GSDME-FL and GSDME-N fragment physically interacted with EGFR. GSDME interacted with cytoplasmic fragment (CT) of EGFR. GSDME knockdown inhibited EGFR dimerization and phosphorylation at tyrosine 1173 (EGFRY1173), which could activate ERK1/2. GSDME knockdown promoted EGFR degradation and phosphorylation at tyrosine 1045 (EGFRY1045). Importantly, GSDME-FL increased the stability of EGFR, while the GSDME-N fragment induced EGFR degradation. Together, our results demonstrate that the GSDME-EGFR interaction plays an important role in NSCLC development, reveal a previously unrecognized link between GSDME and EGFR stability and offer new insight into cancer pathogenesis.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44144853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Potential of Probiotics in Boosting the Immune System's Response to Reduce the Severity of Malaria 探索益生菌在增强免疫系统反应以降低疟疾严重程度方面的潜力
Journal of cellular immunology Pub Date : 2023-05-24 DOI: 10.33696/immunology.5.166
Bamgbose Timothy, J. de la Fuente
{"title":"Exploring the Potential of Probiotics in Boosting the Immune System's Response to Reduce the Severity of Malaria","authors":"Bamgbose Timothy, J. de la Fuente","doi":"10.33696/immunology.5.166","DOIUrl":"https://doi.org/10.33696/immunology.5.166","url":null,"abstract":". Exploring the Potential of Probiotics in Boosting the Immune System's Response to Reduce the Severity of Malaria. J Cell Immunol. 2023;5","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44149643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Is Interstitial Macrophage Mainly Responsible for Lung Injury in SARS-CoV-2 Infection? 间质巨噬细胞是严重急性呼吸系统综合征冠状病毒2型感染肺损伤的主要原因吗？
Journal of cellular immunology Pub Date : 2023-04-29 DOI: 10.33696/immunology.5.165
José Guillermo Cabanillas López
{"title":"Is Interstitial Macrophage Mainly Responsible for Lung Injury in SARS-CoV-2 Infection?","authors":"José Guillermo Cabanillas López","doi":"10.33696/immunology.5.165","DOIUrl":"https://doi.org/10.33696/immunology.5.165","url":null,"abstract":"The course of the COVID-19 pandemic has led to high mortality rates worldwide, which justifies the development of various research studies aimed at elucidating the physiopathological mechanisms involved in the development of lung injury associated with this disease. The angiotensin-converting enzyme 2 (ACE2) receptor plays a leading role as the viral anchoring point necessary for viral replication to begin, so a thorough understanding of the regulatory mechanisms of this receptor is vital. Similarly, the distribution of ACE2 will justify the injury caused by SARS-CoV-2. Macrophages play a more significant role in lung injury since they allow the SARS-CoV-2 virus to reach tissues lacking ACE2 receptors and cause significant tissue damage. Therefore, all factors that influence macrophage migration and mobilization will be considered risk factors for the development of severe lung injury in COVID-19.","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47370156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Granulocyte-Colony Stimulating Factor (G-CSF) in Immune Regulation and Neuroprotection 粒细胞集落刺激因子(G-CSF)在免疫调节和神经保护中的作用
Journal of cellular immunology Pub Date : 2023-03-23 DOI: 10.33696/immunology.5.156
{"title":"Role of Granulocyte-Colony Stimulating Factor (G-CSF) in Immune Regulation and Neuroprotection","authors":"","doi":"10.33696/immunology.5.156","DOIUrl":"https://doi.org/10.33696/immunology.5.156","url":null,"abstract":"","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45214069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular Hyaluronan Synthesis Impairs Hematopoiesis in Diabetes that can be Prevented by Heparin 细胞内透明质酸合成损害糖尿病患者造血功能，可通过肝素预防
Journal of cellular immunology Pub Date : 2023-03-23 DOI: 10.33696/immunology.5.155
A. Wang, V. Hascall
{"title":"Intracellular Hyaluronan Synthesis Impairs Hematopoiesis in Diabetes that can be Prevented by Heparin","authors":"A. Wang, V. Hascall","doi":"10.33696/immunology.5.155","DOIUrl":"https://doi.org/10.33696/immunology.5.155","url":null,"abstract":"in Abstract Hyperglycemia in diabetes induces impairment of hematopoiesis, an important consequence in bone marrow (BM) that contributes to chronic complications in advanced diabetes. The alterations to blood cells associated with diabetes mellitus (DM) pathologies have been carefully and extensively documented, but the underlying mechanism(s) is still unclear. Our recent publication indicates that aberrant intracellular synthesis of hyaluronan (HA) by hyperglycemic dividing BM progenitors is the central mechanism involved. This study demonstrated that macrophages that divided from progenitor cells in hyperglycemia are pro-inflammatory (Mpi) and that the presence of low concentrations of heparin (~20 nM) prevented the intracellular HA synthesis and promoted a tissue repair (Mtr) phenotype. Here, we briefly describe how our new studies of abnormal intracellular hyaluronan synthesis impairs hematopoiesis in diabetes and its regulation by heparin","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44746691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Lipase Elevation to Diabetes – Pancreatic Involvement during Immune Checkpoint Inhibition 从脂肪酶升高到糖尿病——免疫检查点抑制过程中胰腺的参与
Journal of cellular immunology Pub Date : 2023-03-23 DOI: 10.33696/immunology.5.158
{"title":"From Lipase Elevation to Diabetes – Pancreatic Involvement during Immune Checkpoint Inhibition","authors":"","doi":"10.33696/immunology.5.158","DOIUrl":"https://doi.org/10.33696/immunology.5.158","url":null,"abstract":"","PeriodicalId":73644,"journal":{"name":"Journal of cellular immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45450113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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