Mia Panlilio, Rebecca Bolen, Olnita Martini, Alexa Bonk, John Tedesco
{"title":"Navigating the Intersection of Radiofrequency Microneedling and Surgical Facelifts: Scoping Review.","authors":"Mia Panlilio, Rebecca Bolen, Olnita Martini, Alexa Bonk, John Tedesco","doi":"10.2196/78385","DOIUrl":"https://doi.org/10.2196/78385","url":null,"abstract":"<p><strong>Background: </strong>Optimal management of facial skin laxity requires a nuanced approach by health care providers working in aesthetics. Radiofrequency microneedling (RFMN) devices have emerged as a popular noninvasive treatment for facial rejuvenation and improving skin laxity. While RFMN has demonstrated efficacy in enhancing skin tightening and complementing aesthetic procedures, its long-term impact on subsequent surgical facelifts remains uncertain.</p><p><strong>Objective: </strong>The objective of this scoping review is to explore the interplay between RFMN and surgical facelift outcomes, with a focus on potential complications such as excessive skin tightening, dermal scarring, and altered tissue planes that may pose surgical challenges.</p><p><strong>Methods: </strong>A search using PubMed and Google Scholar was conducted, and articles were selected from peer-reviewed journals based on specific inclusion and exclusion criteria. Only articles available in English were selected. In total, 21 articles were included in this scoping review.</p><p><strong>Results: </strong>Papers included in this review discussed the mechanisms of action involved with RFMN, RFMN-related tissue changes, and how these changes could impact future facelift procedures. Most of the papers found that RFMN may drastically alter multiple tissue planes involved in facelift procedures due to collagen deposition through multiple tissue layers and increased tissue fibrosis. Patient factors influencing the effectiveness of RFMN and its role in facial rejuvenation were also examined, emphasizing the importance of navigating patient-specific demographics as a future consideration when creating an individualized treatment plan for each patient.</p><p><strong>Conclusions: </strong>Patients should be informed that RFMN may lead to dermal fibrosis, tissue adhesions, and altered superficial musculoaponeurotic system composition, which could interfere with future facelift procedures and the patient's desired treatment goals. This emphasizes the importance of detailed discussion between the patient and health care provider to improve pretreatment consultation, increase patient education, and set realistic expectations. Further research is needed to determine optimal timing and treatment strategies for patients considering both RFMN and surgical facelifts to achieve the best aesthetic outcomes.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e78385"},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jade Howard, Nourine A H Kamili, Hala Idris, Loren D Krueger
{"title":"Public Interest in Janus Kinase (JAK) IInhibitors for Alopecia Areata: A Google Trend Analysis.","authors":"Jade Howard, Nourine A H Kamili, Hala Idris, Loren D Krueger","doi":"10.2196/75119","DOIUrl":"https://doi.org/10.2196/75119","url":null,"abstract":"<p><strong>Unlabelled: </strong>Public interest in Janus kinase (JAK) inhibitors for alopecia areata increased following media coverage and the 2022 US Food and Drug Administration (FDA) approval of baricitinib, highlighting the need for patient education and physician guidance on appropriate indications and treatment selection for hair loss disorders.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e75119"},"PeriodicalIF":0.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tim C H Hoogenboom, Pablo García Martínez, Piyush Mahapatra, Nurul Ain Nizar
{"title":"Community-Based Teledermatology for Urgent Suspected Skin Cancer: Health Economic Cost-Comparison and Discrete Event Simulation Study.","authors":"Tim C H Hoogenboom, Pablo García Martínez, Piyush Mahapatra, Nurul Ain Nizar","doi":"10.2196/86402","DOIUrl":"10.2196/86402","url":null,"abstract":"<p><strong>Background: </strong>The increasing incidence and financial burden of skin cancer place immense pressure on the UK's National Health Service (NHS). Systemic challenges, including dermatologist shortages and long waiting lists, complicate timely assessment of skin lesions for patients under the urgent suspected cancer pathway. While teledermatology offers an innovative solution compared to traditional face-to-face appointments, standard teledermatology models still face limitations in addressing health care access barriers. Community-based decentralized models may reduce such barriers, but the cost and operational impact of such specific models remain largely underresearched.</p><p><strong>Objective: </strong>This study evaluated the differences in financial cost to the NHS and patient waiting times at the Northern Care Alliance NHS Foundation Trust by comparing a community-based teledermatology model using Pathpoint eDerma against the Trust's standard-of-care for patients in the urgent suspected skin cancer pathway.</p><p><strong>Methods: </strong>This study used an ambidirectional design involving 2 distinct analyses. The cost comparison analysis (CCA) compared costs incurred under the teledermatology model (intervention arm, n=563) against the Trust's standard care, represented by a synthetic comparator arm (n=4011). The discrete event simulation (DES) modeled the operational impact on patient waiting times over a 1-year period. Data for the intervention arm were collected prospectively from December 2022 to May 2023 for CCA and up to November 2023 for DES, while comparator data were collected retrospectively from September 2021 to December 2022. Publicly available resource costs were incorporated to ensure the robustness of the analyses.</p><p><strong>Results: </strong>The community-based teledermatology model was associated with significant improvements in both cost to the NHS and patient waiting times. The CCA revealed a mean cost saving of £45 (£1=US $1.24) per referral (95% CI £22-£60; P<.001). This cost saving was associated with a 26% reduction in the proportion of patients requiring a full diagnostic biopsy, falling from 48% (1925/4011) in standard care to 22% (124/563) in the teledermatology model as well as time savings in face-to-face clinics and administration. Furthermore, the DES demonstrated that, on average, the teledermatology pathways decreased the time to reach a clinical diagnosis by 9.90 (95% CI 9.64-10.16) days; to communicate a diagnosis to patients by 54.18 (95% CI 50.76-57.61) days; and to reach a histopathological diagnosis by 62.8 (95% CI 59.76-65.83) days compared to standard care.</p><p><strong>Conclusions: </strong>The implementation of the community-based teledermatology model appears to be a highly effective, cost-efficient strategy associated with shortened patient journeys. The intervention showed a faster initial triage phase, but the study identified the histopathology process as the next major sys","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e86402"},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalie Piserchio, Bailey Baratta, Benjamin Brooks, Brandon Muse, Katelin Ball
{"title":"Beta-Alanine and Aquagenic Pruritus: Proposed Neuroimmune Mechanism.","authors":"Natalie Piserchio, Bailey Baratta, Benjamin Brooks, Brandon Muse, Katelin Ball","doi":"10.2196/90737","DOIUrl":"10.2196/90737","url":null,"abstract":"<p><strong>Unlabelled: </strong>Aquagenic pruritus (AP) is a rare itch disorder with limited effective treatments, and emerging clinical observations suggest that oral β-alanine may reduce symptoms. The purpose of this viewpoint is to propose a biologically plausible mechanism through which β-alanine may alleviate primary AP. We reviewed published case reports and patient-reported survey data describing β-alanine use in AP and integrated these clinical observations with experimental data on MAS-related G protein-coupled receptor D (MrgprD)-expressing sensory neurons and their role in mast-cell regulation. Published case reports describe marked improvement in water-induced pruritus following prophylactic oral β-alanine administration, and a recent survey of patients with idiopathic AP reported substantial symptom relief among β-alanine users. Preclinical data indicate that MrgprD-neuronal glutamate release suppresses mast cell hyperresponsiveness, suggesting a potential pathway for the observed antipruritic effect. Additional mechanisms, including β-alanine metabolism to carnosine and its potential mast cell-stabilizing effects, may also contribute. β-alanine may act through modulation of a nonhistaminergic neuroimmune circuit and represents a promising therapeutic candidate for further investigation in AP.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e90737"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vanessa R Weir, Emily A Cowen, Trina Salvador, Mary D Sun, Lilly Gu, Maura C Gillis, Nicholas R Kurtansky, Veronica Rotemberg, Allan C Halpern
{"title":"Remote Monitoring of Cryosurgery Response Using a Smartphone App: Prospective Study.","authors":"Vanessa R Weir, Emily A Cowen, Trina Salvador, Mary D Sun, Lilly Gu, Maura C Gillis, Nicholas R Kurtansky, Veronica Rotemberg, Allan C Halpern","doi":"10.2196/63467","DOIUrl":"10.2196/63467","url":null,"abstract":"<p><strong>Background: </strong>Cryosurgery is an effective treatment for benign lesions, although current unstandardized approaches may result in inadequate responses and unwanted adverse reactions. Monitoring treatment characteristics, lesion responses, and patient-reported outcomes using patient-derived mobile imaging may facilitate longitudinal treatment assessment.</p><p><strong>Objective: </strong>This study aimed to determine the reliability of metrics for assessing the response to cryosurgery in patients with actinic and seborrheic keratoses using remote photographic monitoring.</p><p><strong>Methods: </strong>Patients who were recommended cryosurgery by their physician for treating seborrheic and/or actinic keratoses (22 patients with 31 lesions) were enrolled. After treatment, participants took \"overview\" and \"close up\" photos of their lesion(s) and rated appearance, pain, and degree bothered on a custom smartphone app at eight posttreatment time points (days 0, 3, 7, 10, 14, 30, 60, and 90). After study completion, independent raters scored the images for local skin response (eg, erythema, scaling, crust, swelling, vesiculation, and erosion), cosmetic outcome (eg, hyperpigmentation, hypopigmentation, scarring, and atrophy), and lesion resolution.</p><p><strong>Results: </strong>The local skin response peaked 3 days after cryosurgery, with 26% (7/27) of patients reporting pain. There was substantial agreement between raters for lesion resolution (κ=0.71, 95% CI 0.62-0.79), erythema (κ=0.66, 95% CI 0.57-0.74), and the local skin response index (κ=0.69, 95% CI 0.61-0.77) as measured using the quadratic-weighted Cohen κ. Overall, 77% (151/195) of submitted photos were good quality, and most image-derived metrics showed higher agreement in good-quality photos (8/14, 57% metrics had moderate-substantial κ) compared to poor-quality photos (4/14, 29% metrics had moderate-substantial κ). The peak local skin response had a moderate positive association with the lesion response at 90 days (Spearman ρ=0.556, P=.01).</p><p><strong>Conclusions: </strong>This study demonstrates the utility of patient self-imaging for longitudinal assessment of the response to cryosurgery.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e63467"},"PeriodicalIF":0.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arsema K Zadu, Jordan Young, Janyla A Seltzer, Angel S Byrd, Cheri Frey
{"title":"The Role of TikTok in Education on Hidradenitis Suppurativa in Skin of Color: Cross-Sectional Analysis.","authors":"Arsema K Zadu, Jordan Young, Janyla A Seltzer, Angel S Byrd, Cheri Frey","doi":"10.2196/71566","DOIUrl":"10.2196/71566","url":null,"abstract":"<p><strong>Unlabelled: </strong>This study analyzed 50 TikTok videos returned by a search for \"hidradenitis suppurativa in Black skin,\" revealing that nearly half were patient-created, few had physician involvement (n=10, 20% dermatologists; n=7, 14% plastic surgeons), and few had commission-based (n=7, 14%) or sponsored content (n=2, 4%); they were predominantly patient testimonials on various treatments, highlighting the need for greater physician engagement to address patient needs, hidradenitis suppurativa product safety, and efficacy.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e71566"},"PeriodicalIF":0.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominique du Crest, Monisha Madhumita, Wendemagegn Enbiale, Jose Antonio Ruiz Postigo, Josep Malvehy, Shannon Wongvibulsin, Somesh Gupta, Harald Kittler, Charbel Skayem, Anjali Mahto, Adewole S Adamson, Jules B Lipoff, Art Papier, Hugues Cartier, Sébastien Garson, Esther Freeman
{"title":"AI and Digital Tools in Dermatology: Addressing Access and Misinformation.","authors":"Dominique du Crest, Monisha Madhumita, Wendemagegn Enbiale, Jose Antonio Ruiz Postigo, Josep Malvehy, Shannon Wongvibulsin, Somesh Gupta, Harald Kittler, Charbel Skayem, Anjali Mahto, Adewole S Adamson, Jules B Lipoff, Art Papier, Hugues Cartier, Sébastien Garson, Esther Freeman","doi":"10.2196/79044","DOIUrl":"10.2196/79044","url":null,"abstract":"<p><strong>Unlabelled: </strong>Digital dermatology, which is defined as the use of digital technologies that leverage individual- and population-level skin data to improve the diagnosis, treatment, and prevention of skin diseases, has emerged as a critical frontier for bridging persistent gaps in dermatologic care. This transformation holds particular promise for addressing long-standing inequities linked to geography, income, and skin type. According to the Global Burden of Disease 2023 study, skin and subcutaneous diseases remain among the most prevalent global health conditions, contributing substantially to disability-adjusted life years. Digital tools (including teledermatology, artificial intelligence [AI], and large language models) offer new ways to extend diagnosis, education, and patient empowerment to historically underserved populations. However, these same innovations risk amplifying disparities if they are not designed and deployed intentionally. Algorithmic bias, uneven digital access, and the absence of culturally responsive models can undermine progress. In this conceptual and narrative review, we draw on expert dialogues and illustrative literature, including multistakeholder exchanges at the Skin and Digital Summit (2023-2025) and related global forums, to examine how digital dermatology can promote equitable skin health. We focus on 3 interlinked priorities: expanding access through scalable digital platforms, ensuring AI fairness via comprehensive and diverse datasets, and countering dermatological misinformation. Central to the latter is a bot concept described here as a dynamic cycle that analyzes scientific literature; ranks evidence; translates complex research into clear language; and delivers trustworthy, personalized guidance to both consumers and clinicians. By embedding expert oversight and evidence prioritization, such tools can ensure that accurate, actionable information reaches users at the speed and scale of the internet. Drawing on case studies (including lessons from the World Health Organization's AI skin health app) and insights from the Skin and Digital Summit, we highlight both the transformative potential and the ethical complexities of these digital solutions. To navigate this evolving landscape, we propose the concept of radical dermatology, which confronts the reality that big tech is reshaping skin health whether we like it or not and insists that dermatologists and stakeholders lead the transformation through bold collaboration and unwavering clinical relevance.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e79044"},"PeriodicalIF":0.0,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monika Ziogaite, Sarah Mannlein, Nicole Bender, Scott J Mahlberg
{"title":"Chronic Facial Abscess Mimicking Cervicofacial Actinomyces From Dermal Filler Migration: Case Report.","authors":"Monika Ziogaite, Sarah Mannlein, Nicole Bender, Scott J Mahlberg","doi":"10.2196/80278","DOIUrl":"10.2196/80278","url":null,"abstract":"<p><strong>Unlabelled: </strong>Dermal fillers are commonly used for facial augmentation, but delayed complications such as granulomatous inflammation and filler migration can mimic chronic bacterial infections, such as cervicofacial actinomycosis, and lead to diagnostic misdirection. We present the case of a woman aged 56 years with a chronic, draining abscess on the right cheek that persisted for 3 years and was initially suspected to represent cervicofacial actinomycosis. Tissue cultures were negative, and histopathologic analysis following excisional biopsy revealed polymethyl methacrylate microspheres and hyaluronic acid surrounded by granulomatous inflammation and reactive lymphoid aggregates, consistent with a foreign body reaction to dermal filler. The patient experienced complete resolution after surgical excision. This case underscores the diagnostic challenges posed by delayed filler complications and highlights the importance of considering prior cosmetic procedures in patients with chronic facial abscesses.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e80278"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differences in Electronic Consultation Conversion Rates Between Advanced Practice Providers and Board-Certified Dermatologists.","authors":"Dakota Hitchcock, Sabrina Newman","doi":"10.2196/83922","DOIUrl":"10.2196/83922","url":null,"abstract":"<p><strong>Unlabelled: </strong>In this analysis of dermatology e-consults at a large academic health system, advanced practice providers had nearly threefold higher conversion rates to in-person visits compared to board-certified dermatologists, with potential implications for access and resource utilization.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"9 ","pages":"e83922"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}