{"title":"Insights Into Skin-Lightening Practices of Hijra and Transgender Communities in India.","authors":"Sriram Palepu, Vasudeva Murthy Sindgi, Aylur Kailasom Srikrishnan, Carrie Kovarik","doi":"10.2196/66822","DOIUrl":"10.2196/66822","url":null,"abstract":"<p><strong>Unlabelled: </strong>A large proportion of transgender women in Hyderabad, India (150/223, 67.3%) expressed interest in a wide range of topical, oral, and intravenous medications for skin lightening; however, despite government regulations and the potential health risks, persistent demand for skin lightening underscores the need for better patient education and safer skin care practices for this marginalized community.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e66822"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Quality of Dermatology Match Information on Social Media Platforms: Cross-Sectional Analysis.","authors":"Anjali D'Amiano, Jack Kollings, Joel Sunshine","doi":"10.2196/65217","DOIUrl":"10.2196/65217","url":null,"abstract":"","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e65217"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermatologic Research in Displaced Populations: Importance, Challenges, and Proposed Solutions.","authors":"Derek Maas, Jackleen S Marji","doi":"10.2196/64828","DOIUrl":"https://doi.org/10.2196/64828","url":null,"abstract":"<p><strong>Unlabelled: </strong>Displaced populations face complex dermatologic challenges. Contributing factors include low immunization rates, poor sanitation, crowded living conditions, and physical abuse. Chronic inflammatory conditions and infectious diseases, including fungal infections and scabies, are prevalent. Research is crucial to reduce the spread of disease, improve care in these populations, and develop sustainable frameworks for long-term dermatologic health care in crisis settings. The paucity of dermatologist support in this field exacerbates the issue. Ethical considerations include nonmaleficence and culturally sensitive practices, and proposed solutions include trauma-informed care training, advocacy for equitable research funding, teledermatology, and the development of shared international screening guidelines. Further research is essential to enhance dermatologic care for displaced populations.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e64828"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring Nonresponse to Botulinum Toxin in Aesthetics: Narrative Review of Key Trigger Factors and Effective Management Strategies.","authors":"George Kroumpouzos, Fernando Silikovich","doi":"10.2196/69960","DOIUrl":"https://doi.org/10.2196/69960","url":null,"abstract":"<p><strong>Background: </strong>Nonresponse to botulinum toxin type A (BoNT-A) has been reported in both medical and aesthetic applications. Secondary nonresponse (SNR) occurs when BoNT-A is initially effective before failure commences at a later point. Most reported cases involve SNR in aesthetics. Several aspects of this complication remain elusive or controversial.</p><p><strong>Objective: </strong>We aimed to address unanswered questions regarding the prevalence and etiology of SNR. Additionally, we investigated the immunogenicity of BoNT-A formulations, mainly focusing on the development of neutralizing antibodies that hinder the toxin's pharmacologic effects. Furthermore, we sought to examine the management strategies for SNR.</p><p><strong>Methods: </strong>The PubMed and Google Scholar databases were searched from inception for articles on nonresponse to BoNT-A therapy. Articles were evaluated based on their contribution to the field. Expert opinions and panel recommendations regarding management and data gaps were also included in the review.</p><p><strong>Results: </strong>There are limited data on SNR prevalence in aesthetic applications compared to therapeutic uses. Trigger factors of SNR include improper handling of BoNT-A; incorrect injection practices; and impurities present in the formulation, such as clostridial complexing proteins that may increase immunogenicity. Other contributing factors include infection; patient characteristics; and treatment parameters that encompass an increased frequency of BoNT-A injections (ie, <3 months apart), higher cumulative dosages, elevated treatment dosages, and booster injections (retreatment within 3 weeks of the initial injection). Neutralizing antibodies developed with first-generation formulations, such as onabotulinumtoxinA and abobotulinumtoxinA that contain clostridial proteins, but not with second-generation BoNT-As, such as incobotulinumtoxinA and daxibotulinumtoxinA, which lack these proteins. Among patients who developed SNR after using first-generation BoNT-A for aesthetic purposes, switching to incobotulinumtoxinA therapy did not result in the development of immune responses. Switching to a protein-free BoNT-A formulation such as incobotulinumtoxinA upon development of SNR has been advocated. To effectively manage SNR, it is crucial to minimize the identified trigger factors.</p><p><strong>Conclusions: </strong>Nonresponse to BoNT-A is gaining importance in aesthetic treatments. Considering the potential for immunogenicity is essential when selecting a BoNT-A formulation. Preventing SNR is crucial, given the lack of solid data on effective treatments.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e69960"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Courtney Chau, Hao Feng, Gabriela Cobos, Joyce Park
{"title":"Authors' Reply: The Importance of Comparing New Technologies (AI) to Existing Tools for Patient Education on Common Dermatologic Conditions: A Commentary.","authors":"Courtney Chau, Hao Feng, Gabriela Cobos, Joyce Park","doi":"10.2196/72540","DOIUrl":"10.2196/72540","url":null,"abstract":"","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e72540"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Importance of Comparing New Technologies (AI) to Existing Tools for Patient Education on Common Dermatologic Conditions: A Commentary.","authors":"Parker Juels","doi":"10.2196/71768","DOIUrl":"10.2196/71768","url":null,"abstract":"","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e71768"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derek Nguyen, Jennifer Javaheri, Ruth Sanchez, Vy Han
{"title":"Popular Treatments of Psoriasis on Social Media: Google Trends Analysis.","authors":"Derek Nguyen, Jennifer Javaheri, Ruth Sanchez, Vy Han","doi":"10.2196/70067","DOIUrl":"10.2196/70067","url":null,"abstract":"<p><strong>Unlabelled: </strong>This study analyzes the most commonly mentioned psoriasis treatments on Facebook and Reddit forums, tracking their popularity over time by using Google Trends.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e70067"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brad Partridge, Nicole Gillespie, H Peter Soyer, Victoria Mar, Monika Janda
{"title":"Exploring the Views of Dermatologists, General Practitioners, and Melanographers on the Use of AI Tools in the Context of Good Decision-Making When Detecting Melanoma: Qualitative Interview Study.","authors":"Brad Partridge, Nicole Gillespie, H Peter Soyer, Victoria Mar, Monika Janda","doi":"10.2196/63923","DOIUrl":"10.2196/63923","url":null,"abstract":"<p><strong>Background: </strong>Evidence that artificial intelligence (AI) may improve melanoma detection has led to calls for increased human-AI collaboration in clinical workflows. However, AI-based support may entail a wide range of specific functions for AI. To appropriately integrate AI into decision-making processes, it is crucial to understand the precise role that clinicians see AI playing within their clinical deliberations.</p><p><strong>Objective: </strong>This study aims to provide an in-depth understanding of how a range of clinicians involved in melanoma screening and diagnosis conceptualize the role of AI within their decision-making and what these conceptualizations mean for good decision-making.</p><p><strong>Methods: </strong>This qualitative exploration used in-depth individual interviews with 30 clinicians, predominantly from Australia and New Zealand (n=26, 87%), who engaged in melanoma detection (n=17, 57% dermatologists; n=6, 20% general practitioners with an interest in skin cancer; and n=7, 23% melanographers). The vast majority of the sample (n=25, 83%) had interacted with or used 2D or 3D skin imaging technologies with AI tools for screening or diagnosis of melanoma, either as part of testing through clinical AI reader studies or within their clinical work.</p><p><strong>Results: </strong>We constructed the following 5 themes to describe how participants conceptualized the role of AI within decision-making when it comes to melanoma detection: theme 1 (integrative theme)-the importance of good clinical judgment; theme 2-AI as just one tool among many; theme 3-AI as an adjunct after a clinician's decision; theme 4-AI as a second opinion for unresolved decisions; theme 5-AI as an expert guide before decision-making. Participants articulated a major conundrum-AI may benefit inexperienced clinicians when conceptualized as an \"expert guide,\" but overreliance, deskilling, and a failure to recognize AI errors may mean only experienced clinicians should use AI \"as a tool.\" However, experienced clinicians typically relied on their own clinical judgment, and some could be wary of allowing AI to \"influence\" their deliberations. The benefit of AI was often to reassure decisions once they had been reached by conceptualizing AI as a kind of \"checker,\" \"validator,\" or in a small number of equivocal cases, as a genuine \"second opinion.\" This raised questions about the extent to which experienced clinicians truly seek to \"collaborate\" with AI or use it to inform decisions.</p><p><strong>Conclusions: </strong>Clinicians conceptualized AI support in an array of disparate ways that have implications for how AI should be incorporated into clinical workflows. A priority for clinicians is the conservation of good clinical acumen, and our study encourages a more focused engagement with users about the precise way to incorporate AI into the clinical decision-making process for melanoma detection.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e63923"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitin Chetla, Matthew Chen, Joseph Chang, Aaron Smith, Tamer Rajai Hage, Romil Patel, Alana Gardner, Bridget Bryer
{"title":"Assessing the Diagnostic Accuracy of ChatGPT-4 in Identifying Diverse Skin Lesions Against Squamous and Basal Cell Carcinoma.","authors":"Nitin Chetla, Matthew Chen, Joseph Chang, Aaron Smith, Tamer Rajai Hage, Romil Patel, Alana Gardner, Bridget Bryer","doi":"10.2196/67299","DOIUrl":"10.2196/67299","url":null,"abstract":"<p><strong>Unlabelled: </strong>Our study evaluates the diagnostic accuracy of ChatGPT-4o in classifying various skin lesions, highlighting its limitations in distinguishing squamous cell carcinoma from basal cell carcinoma using dermatoscopic images.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e67299"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}