{"title":"Mobile Health App as an Auxiliary Tool in Management of Atopic Dermatitis in Children: Randomized Controlled Trial.","authors":"Alex Zvulunov, Stepan Lenevich, Natalia Migacheva","doi":"10.2196/60479","DOIUrl":"10.2196/60479","url":null,"abstract":"<p><strong>Background: </strong>Mobile health apps can boost treatment adherence and support disease management at home. The Atopic App and web-based Atopic School patient education program offer a chance to enhance adherence to atopic dermatitis (AD) management.</p><p><strong>Objective: </strong>We aim to evaluate the feasibility, acceptability, and preliminary efficacy of the Atopic App mobile health intervention in the managing of AD in children.</p><p><strong>Methods: </strong>A randomized controlled study in children with AD divided participants into 3 groups: a control group (no app), an observational group with the app, and an interventional group with investigator supervision. Patients were examined at screening and follow-up visits 1 and 2 at 3-month intervals. Outcome measures included SCORAD (Scoring Atopic Dermatitis) for objective severity and Patient-Oriented Eczema Measure (POEM) for subjective effectiveness. Statistical analysis used paired t tests (2-tailed), the Mann-Whitney U test, and multiple regression.</p><p><strong>Results: </strong>Fifty-eight participants entered this study (38 boys and 20 girls): group 1 (control) comprised 17 patients, while experimental groups 2 and 3 consisted of 20 and 21 patients, respectively. The rates of missed appointments were similar and statistically insignificant across the groups. All groups showed a significant decrease in SCORAD and POEM scores (P<.05). Usage of the app for ≥8 days showed a more significant decrease in severity scores compared to those who used it for ≤7 days, or did not use it at all. Participants who used the app for ≥8 days had a median SCORAD of 6.25 (95% CI 4.6-14.1; IQR 4-16.3) at visit 1, significantly lower than nonusers (17.9, 95% CI 13.9-24.0; IQR 13.9-24; P=.03) and those using it ≤7 days (13, 95% CI 9.35-27; IQR 7.2-27; P=.04). Their median POEM of 2 (95% CI 1.0-4.5; IQR 1-5.3) was also significantly lower than those using the app ≤7 days (9, 95% CI 2-12; IQR 2-12; P=.04) and lower, though not significantly, than nonusers (7, 95% CI 1-9; IQR 1-9; P=.14). Additionally, using the Atopic App for ≥8 days after the screening visit strongly predicted a decrease in both SCORAD and POEM scores (P=.01 and P=.04, respectively). The time since the screening visit significantly predicted increased outcome scores, while prescriptions of topical calcineurin inhibitors, oral antihistamines, and oral antibiotics were weak and insignificant predictors of score changes.</p><p><strong>Conclusions: </strong>Our findings indicate that the Atopic App is helpful tool in managing AD in children, and they underscore the potential of mobile health interventions in the disease management.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e60479"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patterns of Public Interest in Lipomas and Lipoma-Removal Procedures: Google Trends Analysis.","authors":"Keenan Duggal","doi":"10.2196/62993","DOIUrl":"10.2196/62993","url":null,"abstract":"<p><strong>Background: </strong>Lipomas are benign tumors composed of encapsulated adipocytes. Although relatively common, uncertainty remains about the population-level prevalence, the etiology, and the degree of public interest in lipomas and associated removal procedures.</p><p><strong>Objective: </strong>The spatiotemporal patterns of public interest in lipomas and lipoma removal procedures were characterized.</p><p><strong>Methods: </strong>Google Trends data that report the relative search volume (RSV) of Google queries pertaining to lipomas and their removal procedures at national and international levels were analyzed. To contextualize these trends, the RSV for lipomas was compared to that of several other common dermatological conditions in the United States.</p><p><strong>Results: </strong>In the United States, lipomas have consistently generated lower levels of public interest than other common dermatological conditions, but interest in the condition has been rising since the mid-2010s. Across the world, public interest in lipomas appears to be the highest in pockets of Eastern Europe, whereas in the United States, relative interest has been higher in Midwestern and Southern states. In addition, the interest in lipoma removal procedures has risen steadily from 2004 to the present, with particularly high RSVs coming from Southwestern states.</p><p><strong>Conclusions: </strong>Dermatologists and plastic surgeons should be aware of the increasing public interest in lipomas and lipoma-removal procedures. Clinical awareness is especially important in states with an elevated interest in lipomas and their associated removal procedures.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e62993"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Courtney A Chau, Hao Feng, Gabriela Cobos, Joyce Park
{"title":"The Comparative Sufficiency of ChatGPT, Google Bard, and Bing AI in Answering Diagnosis, Treatment, and Prognosis Questions About Common Dermatological Diagnoses.","authors":"Courtney A Chau, Hao Feng, Gabriela Cobos, Joyce Park","doi":"10.2196/60827","DOIUrl":"10.2196/60827","url":null,"abstract":"<p><strong>Unlabelled: </strong>Our team explored the utility of unpaid versions of 3 artificial intelligence chatbots in offering patient-facing responses to questions about 5 common dermatological diagnoses, and highlighted the strengths and limitations of different artificial intelligence chatbots, while demonstrating how chatbots presented the most potential in tandem with dermatologists' diagnosis.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e60827"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin Johny Varghese, Som Singh, Emily Kamali, Fahad Qureshi, Aleena Jamal, Fawad Qureshi
{"title":"Modern Digital Query Analytics of Patient Education Materials on Acanthosis Nigricans: Systematic Search and Content Analysis.","authors":"Kevin Johny Varghese, Som Singh, Emily Kamali, Fahad Qureshi, Aleena Jamal, Fawad Qureshi","doi":"10.2196/60210","DOIUrl":"10.2196/60210","url":null,"abstract":"<p><strong>Background: </strong>Online digital materials are integral to patient education and health care outcomes in dermatology. Acanthosis nigricans (AN) is a common condition, often associated with underlying diseases such as insulin resistance. Patients frequently search the internet for information related to this cutaneous finding. To our knowledge, the quality of online educational materials for AN has not been systematically examined.</p><p><strong>Objective: </strong>The primary objective of this study was to profile the readability and quality of the content of publicly available digital educational materials on AN and identify questions frequently asked by patients.</p><p><strong>Methods: </strong>This study analyzed publicly available internet sources to identify the most frequent questions searched by patients regarding AN using the Google Rankbrain algorithm. Furthermore, available articles on AN were evaluated for quality and reading level using metrics such as the Brief DISCERN score, and readability was determined using three specific scales including the Flesch-Kincaid score, Gunning Fog index, and the Coleman-Liau index, based on literature.</p><p><strong>Results: </strong>Patients most frequently accessed facts on AN from government sources, which comprised 30% (n=15) of the analyzed sources. The available articles did not meet quality standards and were at a reading level not appropriate for the general public. The majority of articles (n=29/50, 58%) had substandard Brief DISCERN scores, failing to meet the criteria for good quality.</p><p><strong>Conclusions: </strong>Clinicians should be aware of the paucity of valuable online educational material on AN and educate their patients accordingly.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"8 ","pages":"e60210"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Depth Estimation and Visualization of Dermatological Lesions: Development and Usability Study.","authors":"Pranav Parekh, Richard Oyeleke, Tejas Vishwanath","doi":"10.2196/59839","DOIUrl":"10.2196/59839","url":null,"abstract":"<p><strong>Background: </strong>Thus far, considerable research has been focused on classifying a lesion as benign or malignant. However, there is a requirement for quick depth estimation of a lesion for the accurate clinical staging of the lesion. The lesion could be malignant and quickly grow beneath the skin. While biopsy slides provide clear information on lesion depth, it is an emerging domain to find quick and noninvasive methods to estimate depth, particularly based on 2D images.</p><p><strong>Objective: </strong>This study proposes a novel methodology for the depth estimation and visualization of skin lesions. Current diagnostic methods are approximate in determining how much a lesion may have proliferated within the skin. Using color gradients and depth maps, this method will give us a definite estimate and visualization procedure for lesions and other skin issues. We aim to generate 3D holograms of the lesion depth such that dermatologists can better diagnose melanoma.</p><p><strong>Methods: </strong>We started by performing classification using a convolutional neural network (CNN), followed by using explainable artificial intelligence to localize the image features responsible for the CNN output. We used the gradient class activation map approach to perform localization of the lesion from the rest of the image. We applied computer graphics for depth estimation and developing the 3D structure of the lesion. We used the depth from defocus method for depth estimation from single images and Gabor filters for volumetric representation of the depth map. Our novel method, called red spot analysis, measures the degree of infection based on how a conical hologram is constructed. We collaborated with a dermatologist to analyze the 3D hologram output and received feedback on how this method can be introduced to clinical implementation.</p><p><strong>Results: </strong>The neural model plus the explainable artificial intelligence algorithm achieved an accuracy of 86% in classifying the lesions correctly as benign or malignant. For the entire pipeline, we mapped the benign and malignant cases to their conical representations. We received exceedingly positive feedback while pitching this idea at the King Edward Memorial Institute in India. Dermatologists considered this a potentially useful tool in the depth estimation of lesions. We received a number of ideas for evaluating the technique before it can be introduced to the clinical scene.</p><p><strong>Conclusions: </strong>When we map the CNN outputs (benign or malignant) to the corresponding hologram, we observe that a malignant lesion has a higher concentration of red spots (infection) in the upper and deeper portions of the skin, and that the malignant cases have deeper conical sections when compared with the benign cases. This proves that the qualitative results map with the initial classification performed by the neural model. The positive feedback provided by the dermatologist suggests that th","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"7 ","pages":"e59839"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher G Youn, Joo Yeon Kim, Vivian B Yang, Gordon H Bae
{"title":"Improving Affordability in Dermatology: Cost Savings in Mark Cuban Cost Plus Drug Company Versus GoodRx.","authors":"Christopher G Youn, Joo Yeon Kim, Vivian B Yang, Gordon H Bae","doi":"10.2196/64300","DOIUrl":"10.2196/64300","url":null,"abstract":"<p><strong>Unlabelled: </strong>This observational cost analysis was conducted to assess the efficacy of the Mark Cuban Cost Plus Drug Company (CostPlus) relative to GoodRx and found that CostPlus has significant potential to improve the financial burden of prescription medications within dermatology.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"7 ","pages":"e64300"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermatology in Student-Run Clinics in the United States: Scoping Review.","authors":"Samir Kamat, Aneesh Agarwal, Leore Lavin, Hannah Verma, Lily Martin, Jules B Lipoff","doi":"10.2196/59368","DOIUrl":"10.2196/59368","url":null,"abstract":"<p><strong>Background: </strong>Student-run clinics (SRCs) for dermatology hold potential to significantly advance skin-related health equity, and a comprehensive analysis of these clinics may inform strategies for optimizing program effectiveness.</p><p><strong>Objective: </strong>We aimed to perform a scoping review of the literature about dermatology SRCs across the United States.</p><p><strong>Methods: </strong>We conducted systematic literature searches of Ovid MEDLINE, Ovid Embase, and Scopus on March 1, 2023, and June 19, 2024. No date, language, or paper-type restrictions were included in the search strategy. A total of 229 references were uploaded to Covidence for screening by 2 independent reviewers (SK and LL), and 23 full-text documents were assessed for eligibility. After an additional 8 documents were identified through a gray literature search, a total of 31 studies were included in the final analysis. Inclusion criteria were as follows: (1) studies set in an SRC, which was operationally led by medical students and could render condition-relevant treatments to patients, with dermatology care; (2) published in English; (3) within the United States; (4) included characterization of any of the following: logistics, care, patients, or design; and (5) included all study or document types, including gray literature that was not peer reviewed (eg, conference abstracts, preprints, and letters to the editor). Exclusion criteria were (1) papers not published in English and (2) those with duplicated data or that were limited in scope or not generalizable. Data were extracted qualitatively using Microsoft Excel to categorize the studies by several domains, including clinic location, demographics, services offered, and barriers to care.</p><p><strong>Results: </strong>There are at least 19 dermatology SRCs across the United States. The most common conditions encountered included atopic dermatitis; acne; fungal infections; benign nevi; psoriasis; and neoplasms, such as basal cell carcinoma, squamous cell carcinoma, and melanoma. Key facilitators for the clinics included faculty oversight, attending physician participation for biopsy histopathology, and dedicated program coordinators. Major barriers included lack of follow-up, medication nonadherence, and patient no-shows.</p><p><strong>Conclusions: </strong>Dermatology SRCs serve a diverse patient population, many of whom are underrepresented in traditional dermatology settings. This scoping review provides insights to help build stronger program foundations that better address community dermatologic health needs.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"7 ","pages":"e59368"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mindy D Szeto, Lina Alhanshali, Chandler W Rundle, Madeline Adelman, Michelle Hook Sobotka, Emily Woolhiser, Jieying Wu, Colby L Presley, Jalal Maghfour, John Meisenheimer, Jaclyn B Anderson, Robert P Dellavalle
{"title":"Dermatologic Data From the Global Burden of Disease Study 2019 and the PatientsLikeMe Online Support Community: Comparative Analysis.","authors":"Mindy D Szeto, Lina Alhanshali, Chandler W Rundle, Madeline Adelman, Michelle Hook Sobotka, Emily Woolhiser, Jieying Wu, Colby L Presley, Jalal Maghfour, John Meisenheimer, Jaclyn B Anderson, Robert P Dellavalle","doi":"10.2196/50449","DOIUrl":"10.2196/50449","url":null,"abstract":"<p><strong>Unlabelled: </strong>The Global Burden of Disease (GBD) study aims to characterize the worldwide prevalence and morbidity of major diseases, while PatientsLikeMe (PLM) is an online community providing patient-generated insights into lived experiences; for dermatologic conditions, quantitative comparisons of GBD and PLM data revealed expected demographic differences but also notable correlations, highlighting their potential as complementary data sources elucidating unmet patient needs and priorities.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"7 ","pages":"e50449"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Isabel Belizario, Julius Garcia Gatmaitan, Johannes Dayrit
{"title":"Lichen Planus Pigmentosus and Vitiligo in a 61-Year-Old Filipino Man: Case Report.","authors":"Maria Isabel Belizario, Julius Garcia Gatmaitan, Johannes Dayrit","doi":"10.2196/50401","DOIUrl":"10.2196/50401","url":null,"abstract":"<p><strong>Unlabelled: </strong>Pigmentary disorders have been implicated in causing psychosocial turmoil in patients as they can cause some degree of cosmetic disfigurement. Lichen planus pigmentosus (LPP) presents as ashy, dermatosis-like eruptions on sun-exposed areas, particularly on the head, neck, and earlobes. On the other hand, vitiligo is a chronic disorder that appears as depigmented patches on the skin. A 61-year-old man with Fitzpatrick skin phototype IV presented to us initially with LPP but eventually also developed vitiligo. The patient was treated with low-dose oral isotretinoin for LPP and topical tacrolimus 0.1% ointment for both LPP and vitiligo with a good clinical outcome. One case of segmental vitiligo and zosteriform LPP, affecting a 22-year-old Indian woman, has been previously reported in the English-language literature. An autoimmune etiology that causes melanocytorrhagy may be a plausible hypothesis for the coexistence of these 2 conditions.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"7 ","pages":"e50401"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annie Chang, Jade Young, Andrew Para, Angela Lamb, Nicholas Gulati
{"title":"Efficacy of ChatGPT in Educating Patients and Clinicians About Skin Toxicities Associated With Cancer Treatment.","authors":"Annie Chang, Jade Young, Andrew Para, Angela Lamb, Nicholas Gulati","doi":"10.2196/54919","DOIUrl":"10.2196/54919","url":null,"abstract":"<p><strong>Unlabelled: </strong>This study investigates the application of ChatGPT, an artificial intelligence tool, in providing information on skin toxicities associated with cancer treatments, highlighting that while ChatGPT can serve as a valuable resource for clinicians, its use for patient education requires careful consideration due to the complex nature of the information provided.</p>","PeriodicalId":73553,"journal":{"name":"JMIR dermatology","volume":"7 ","pages":"e54919"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}