JCIS open最新文献_第7页

A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression GM-CSF和DOX共递送纳米平台调节巨噬细胞极化以促进肿瘤抑制

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100081

Miao Wang , Jiayu Zhang , Jiaruo Tang , Xiaomeng Cai , Rui Dou , Chen Guo , Yi Hu , Jun Chen

{"title":"A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression","authors":"Miao Wang , Jiayu Zhang , Jiaruo Tang , Xiaomeng Cai , Rui Dou , Chen Guo , Yi Hu , Jun Chen","doi":"10.1016/j.jciso.2023.100081","DOIUrl":"10.1016/j.jciso.2023.100081","url":null,"abstract":"<div><p>The immunosuppressive tumor microenvironment often compromises chemotherapeutic efficacy. Tumor-associated macrophages (TAM) are a critical component of the tumor immune microenvironment, a large portion of which is in M2-polarization with immunosuppressive effects. Priming the TAM to M1 polarization is a promising strategy for reversing the immunosuppressive microenvironment for promoting tumor therapy. In this study, a co-delivery nanoplatform that integrates GM-CSF as an immune adjuvant with chemotherapy of DOX has been developed to enhance the efficacy of cancer therapy. The photothermal effect from embedded single-walled carbon nanotubes (SWCNTs) controlled the release of GM-CSF and DOX. The results of MB49 cells verified that the GM-CSF pre-treating macrophages enhanced the anti-proliferative efficacy of DOX. This improvement could be related to GM-CSF inducing macrophages to release TNF-α and other cytokines that prevent the growth of cancer cells. This work provides a facile method to prepare a protein/drug/hyperthermia co-delivery system, promising in cancer combined therapy through reversing the immunosuppressive tumor microenvironment.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41717163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis of MnO from pectin-driven sol-gel route for catalytic oxidation of toluene 果胶驱动溶胶-凝胶法合成甲苯催化氧化MnO

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2023.100076

Jinggang Zhao, Peifen Wang, Jing Wang, Xiaoxun Ma, Lei Shi, Guangwen Xu, A. Abudula, Guoqing Guan

引用次数: 1

Magnetic and photoactive colloidal shuttles for active cargo transportation 用于主动货物运输的磁性和光活性胶体穿梭机

JCIS open Pub Date : 2023-04-01 DOI: 10.1016/j.jciso.2022.100071

Xinyuan Zhang, Zequ Chen, Yurou Li, Xiyue Li, Ruiyao Li, Jiayu Zhang, Muhammad Imran, Yongxiang Gao

{"title":"Magnetic and photoactive colloidal shuttles for active cargo transportation","authors":"Xinyuan Zhang, Zequ Chen, Yurou Li, Xiyue Li, Ruiyao Li, Jiayu Zhang, Muhammad Imran, Yongxiang Gao","doi":"10.1016/j.jciso.2022.100071","DOIUrl":"10.1016/j.jciso.2022.100071","url":null,"abstract":"<div><p>Colloidal shuttles are micro/nanoscale motors that display controllable cargo loading/release and programmable navigation, which are emerging delivery vehicles at the small scale. Here we present a hydrogen peroxide-fueled catalytic colloidal shuttle composed of a hematite cube half coated with platinum, i.e. a Pt/hematite Janus cube, which can be remotely controlled with ease by light and magnetic field. Interestingly, the dynamic behaviors of the Pt/hematite motor under light illumination in lower fuel concentration are similar to those Pt-based motors in higher fuel concentration without UV light, including the self-propulsion direction and the interaction with passive particles. In lower fuel concentration, we demonstrate the ability of the Pt/hematite motor for light-switchable cargo loading and release, and programmable and directional transportation of cargoes using the intrinsic magnetic property of hematite. Our work offers an efficient colloidal shuttle that operates at favorable fuel concentration and light intensity in comparison to earlier reported cargo-towing colloidal motors, which should find applications as microscale delivery vehicles, particularly for cargo transportation on microchips.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"9 ","pages":"Article 100071"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45276661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Zinc porphyrin covalent organic nanodisks synthesized from covalent organic frameworks and their photocatalytic antibacterial activity 由共价有机框架合成的锌卟啉共价有机纳米片及其光催化抗菌活性

JCIS open Pub Date : 2023-03-01 DOI: 10.1016/j.jciso.2023.100083

Xinxi Li, Zheming Su, M. Fujitsuka, Y. Osakada

引用次数: 0

Recent advances on graphene polymeric bionanoarchitectures for biomedicals 生物医学用石墨烯聚合物生物纳米结构研究进展

JCIS open Pub Date : 2023-01-01 DOI: 10.1016/j.jciso.2022.100070

Christopher Igwe Idumah

引用次数: 16

Micromechanics and strength of agglomerates produced by spray drying 喷雾干燥制备团聚体的微观力学与强度

JCIS open Pub Date : 2023-01-01 DOI: 10.1016/j.jciso.2022.100068

Lorenzo Vasquez Giuliano , Antonio Buffo , Marco Vanni , Graziano Frungieri

引用次数: 6

Analyzing the surfactant classification confusion through the HLD formulation equation 通过HLD配方方程分析表面活性剂的分类混乱

JCIS open Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100060

Jean-Louis Salager , Alain Graciaa , Ronald Marquez

{"title":"Analyzing the surfactant classification confusion through the HLD formulation equation","authors":"Jean-Louis Salager , Alain Graciaa , Ronald Marquez","doi":"10.1016/j.jciso.2022.100060","DOIUrl":"10.1016/j.jciso.2022.100060","url":null,"abstract":"<div><p>The qualitative presentation from Winsor on an interfacial balance of interactions between the surfactant and the oil and water phases has been transformed into a multivariable linear equation so-called hydrophilic-lipophilic deviation (HLD). This relation involves at least 6 independent variables (surfactant head and tail specifications, water salinity, oil nature, temperature, and pressure) with a MacLaurin series first order approximation, <em>i.e.</em>, a linear multivariable expression. After 40 years of practical experience, it can be said that the HLD relation matches well the experimental data, with only very few exceptions with complex mixtures. Herein, we clear the confusion concerning the meaning and the mathematical handling of the surfactant parameter in the HLD equation. We start with a presentation of simple surfactant systems with only 4 parameters (water salinity, oil nature, surfactant nature, and temperature) as was done 40 years ago. Later, we present a critical discussion on the surfactant term, concerning binary surfactant systems, and on strategies for applications in ternary surfactant mixtures. We have found that the surfactant parameters can only be compared in a series of surfactants with the same head group, where the surfactant parameter is a linear function of the surfactant tail length.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"8 ","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000186/pdfft?md5=6737f0c31bfd628c11a793971f3ec281&pid=1-s2.0-S2666934X22000186-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42082787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Resonant energy transfer between plasmonic silver and biomolecule for colour tuning and white light emission 等离子体银与生物分子之间的共振能量转移用于颜色调谐和白光发射

JCIS open Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100065

Jancy John , Rani Abraham , R. Jayakrishnan , Vinoy Thomas

引用次数: 0

Waterborne phenolic, triazine-based porous polymer particles for the removal of toxic metal ions 水性酚醛、三嗪基多孔聚合物颗粒，用于去除有毒金属离子

JCIS open Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100066

Konstantin B.L. Borchert , Robert Frenzel , Niklas Gerlach , Berthold Reis , Christine Steinbach , Benjamin Kohn , Ulrich Scheler , Simona Schwarz , Dana Schwarz

{"title":"Waterborne phenolic, triazine-based porous polymer particles for the removal of toxic metal ions","authors":"Konstantin B.L. Borchert , Robert Frenzel , Niklas Gerlach , Berthold Reis , Christine Steinbach , Benjamin Kohn , Ulrich Scheler , Simona Schwarz , Dana Schwarz","doi":"10.1016/j.jciso.2022.100066","DOIUrl":"10.1016/j.jciso.2022.100066","url":null,"abstract":"<div><p>Highly functional and also highly porous materials are presenting great advantages for applications in energy storage, catalysis and separation processes, which is why a continuous development of new materials can be seen. To create a material combining the promising potential interactions of triazine groups with the electrostatic or hydrogen bonding interactions of phenolic groups, a completely new polymeric resin was synthesized. From an eco-friendly dispersion polymerization in water, a copolymer network was obtained, which includes nine hydroxyl groups and one <em>s</em>-triazine ring per repetition unit. The polymer forms highly porous particles with specific surface areas up to 531 m<sup>2</sup>/g and a negative streaming potential over a great pH range. The adsorption isotherms of Ni<sup>2+</sup>, Cd<sup>2+</sup>, and Pb<sup>2+</sup> were studied in more detail achieving very good adsorption capacities (16 mg Ni<sup>2+</sup>/g, 24 mg Cd<sup>2+</sup>/g, and 90 mg Pb<sup>2+</sup>/g). Demonstrating excellent properties for adsorption applications. The adsorbent exhibited selectivity for the adsorption of Pb<sup>2+</sup> over more commonly occurring but non-toxic metal ions such as Fe<sup>2+</sup>, Ca<sup>2+</sup>, Mg<sup>2+</sup>, and K<sup>+</sup>. Furthermore, reusability of the material was demonstrated by facile, quantitative desorption of adsorbed Pb<sup>2+</sup> with a small amount of diluted HCl, circumventing organic chelators. Subsequently, adsorption was carried out without decrease in adsorption performance.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"8 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000241/pdfft?md5=347feee0f46542c8235b3a429e680797&pid=1-s2.0-S2666934X22000241-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49257432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Programmable and adaptable navigation of a magnetic and photoactive colloid 磁性和光活性胶体的可编程和适应性导航

JCIS open Pub Date : 2022-12-01 DOI: 10.1016/j.jciso.2022.100061

Yurou Li, Shuo Wang, Xinyuan Zhang, Yongxiang Gao

{"title":"Programmable and adaptable navigation of a magnetic and photoactive colloid","authors":"Yurou Li, Shuo Wang, Xinyuan Zhang, Yongxiang Gao","doi":"10.1016/j.jciso.2022.100061","DOIUrl":"10.1016/j.jciso.2022.100061","url":null,"abstract":"<div><p>Colloids that are able to navigate via predefined paths and adapt to complex environments hold great promises as miniaturized machines and model systems for active soft matter research. Here, we design an intelligent system that integrates dynamic magnetic field and light control with in-situ determination of particle position and velocity via Matlab-based image acquisition and analysis. We apply the system to realize programmable and feedback control over the motion of a magnetic and photoactive colloid. Specifically, we direct the active colloid into pentagram-like navigation, circular motion of various size, and spiral-like motion by changing the travelling direction, discretely or continuously, the self-propelled velocity, and a combination of the two, enabled by dynamic change of magnetic field, light intensity and both. Moreover, we demonstrate the ability of the system for on-the-fly self-correction to follow predefined path with high fidelity, and adaptability to complex surroundings with definable birdlike vision based on in-situ processing of information. We expect the programmability and adaptability of magnetic and photoactive colloids enabled by multiple handles, magnetic field and light, open up new opportunities for active soft matter research, including intelligent microrobotics, collective nonequilibrium dynamics and novel photonic fluids.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"8 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X22000198/pdfft?md5=943ad55d89c1574d61cd49ea10e1e2a1&pid=1-s2.0-S2666934X22000198-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47864885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2