JCIS openPub Date : 2025-09-25DOI: 10.1016/j.jciso.2025.100156
Clare R. Rees-Zimmerman , Angus Heafield , Daniel Ellerbeck , Adam Edward Stones , Roel P.A. Dullens , Dirk G.A.L. Aarts
{"title":"Inverting g(r) to u(r): The test-particle insertion method","authors":"Clare R. Rees-Zimmerman , Angus Heafield , Daniel Ellerbeck , Adam Edward Stones , Roel P.A. Dullens , Dirk G.A.L. Aarts","doi":"10.1016/j.jciso.2025.100156","DOIUrl":"10.1016/j.jciso.2025.100156","url":null,"abstract":"<div><div>Inverting the radial distribution function, <span><math><mrow><mi>g</mi><mrow><mo>(</mo><mi>r</mi><mo>)</mo></mrow></mrow></math></span>, to a pair potential, <span><math><mrow><mi>u</mi><mrow><mo>(</mo><mi>r</mi><mo>)</mo></mrow></mrow></math></span>, can be achieved by a variety of methods. Test-particle insertion has recently emerged as an efficient inverse method for finding <span><math><mrow><mi>u</mi><mrow><mo>(</mo><mi>r</mi><mo>)</mo></mrow></mrow></math></span>. The method can analyse both simulated and experimental data, and the only input required is equilibrium snapshots of particle coordinates. This paper explains the method in detail and its implementation, sharing example code. We demonstrate intricacies in the number and placement of test particles and their effect on efficiency, as well as practical advice for applying the method to experimental data. This includes strategies and code for dealing with non-periodic boundary conditions, choice of inversion cutoff distance and the effect of particles sticking. We also discuss how the method performs at higher density and its limitations.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"20 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JCIS openPub Date : 2025-09-09DOI: 10.1016/j.jciso.2025.100155
Sri Juari Santosa , Muhammad Hadi , Adhi Dwi Hatmanto , Salwaa Mumtaazah Darmanastri , Eny Kusrini , Khoirina Dwi Nugrahaningtyas , Anwar Usman
{"title":"A novel eco-friendly method for synthesizing silver nanoparticles (AgNPs)-decorated chitosan film having high antibacterial efficacy","authors":"Sri Juari Santosa , Muhammad Hadi , Adhi Dwi Hatmanto , Salwaa Mumtaazah Darmanastri , Eny Kusrini , Khoirina Dwi Nugrahaningtyas , Anwar Usman","doi":"10.1016/j.jciso.2025.100155","DOIUrl":"10.1016/j.jciso.2025.100155","url":null,"abstract":"<div><div>A novel eco-friendly method was established to synthesize ultra-small silver nanoparticles (AgNPs)-decorated chitosan films with strong antibacterial activity. The AgNPs were produced by reducing AgNO<sub>3</sub> with glucose derived from sucrose hydrolysis under alkaline conditions (pH ∼12.06) in a chitosan matrix, yielding spherical particles (∼8.6 nm) at an optimal 1:4 Ag<sup>+</sup> to sucrose molar ratio. Mixing the resulting Chit-AgNPs colloid with glycerol in equal volumes produced a biodegradable Chit-AgNPs/G1 film with mechanical properties that meet biodegradable plastic standards. Antibacterial tests against <em>B. subtilis</em> and <em>E. coli</em> revealed that the film exhibited markedly higher efficacy than its precursors and was comparable or even superior to standard controls (amoxicillin and betadine). Overall, the Chit-AgNPs/G1 film demonstrates exceptional antibacterial performance, positioning it as one of the most effective chitosan–AgNP composites reported to date.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"20 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JCIS openPub Date : 2025-09-06DOI: 10.1016/j.jciso.2025.100154
Hangyu Chen , Xiaodong Jia , Michael Fairweather , Timothy N. Hunter
{"title":"Influence of wettability on diffusion limited nanoparticle adsorption at gas-liquid interfaces","authors":"Hangyu Chen , Xiaodong Jia , Michael Fairweather , Timothy N. Hunter","doi":"10.1016/j.jciso.2025.100154","DOIUrl":"10.1016/j.jciso.2025.100154","url":null,"abstract":"<div><div>This study investigates the influence of hydrophobicity on particle adsorption by examining the behavior of hydrophobized silica particles at air-water interfaces. Langmuir-Blodgett (LB) trough studies of butanol (‘SiO-butane’) and hexanol (‘SiO-hexane’) esterified particles provided contrasting behavior. The SiO-butane particles formed weaker particle layers that underwent partial collapse with compression, leading to formations significantly below hexagonal close-packed estimates. In contrast, the SiO-hexane particles exhibited improved monolayer behavior and longer-range stability. Droplet surface tensions demonstrated that the hydrophobic particles significantly altered the dynamic tension during adsorption, when methyl isobutyl carbinol (MIBC) was added as a co-surfactant. Short-term modeling elucidated the role of diffusion and energy barriers on adsorption dynamics, with SiO-hexane having reduced diffusion coefficients with respect to SiO-butane and unmodified particles. Despite this reduced diffusion, long-term modeling allowed calculation of adsorption coefficients (<em>k</em><sub><em>a</em></sub>), which for SiO-hexane particles were ∼200 × greater than for unmodified particles at low 0.1 wt% particle concentrations and over 1000 × greater at 2 wt%. Overall, the results provide quantitative insights into the profound influence of hydrophobicity on particle adsorption, particularly in crowded surface environments. Importantly, a diffusion-only mechanism is inadequate to explain adsorption dynamics for these larger colloids and the gravity-driven contribution must be considered in early-stage kinetics.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"20 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cross-linked chitosan-argan nutshell bio-composite beads: Optimization using Box-Behnken design and adsorption mechanism for Pb (II) and Cd (II) removal","authors":"Fatima Zahra Falah , Touria El Ghailassi , Samia Yousfi , Ahmed Moussaif , Mohamed Essalhi , Hasna Hamdane , Mouna Latifa Bouamrani","doi":"10.1016/j.jciso.2025.100152","DOIUrl":"10.1016/j.jciso.2025.100152","url":null,"abstract":"<div><div>Industrial heavy metal contamination in water poses a significant threat to both the environment and human health, necessitating the development of affordable and effective remediation solutions. This study introduces a novel chitosan–argan nutshell bio-composite bead cross-linked in situ with glutaraldehyde (CS/ANS@GA), which exhibits enhanced mechanical stability and serves as an eco-friendly adsorbent for the efficient removal of Pb (II) and Cd(II). The bio-composite beads were thoroughly characterized using swelling tests, XRD, FTIR, and SEM-EDX, confirming their semi-crystalline structure and functionalities, as well as their high porosity and accessible adsorption active sites. Response surface methodology was employed to optimize the effects of pH, adsorbent dose, and contact time to achieve high removal efficiencies of Pb (II) and Cd (II). The synthesized beads exhibited Sips isotherm behavior, indicating a heterogeneous surface with maximum adsorption capacities of 433 mg g<sup>−1</sup> (Pb) and 391 mg.g<sup>−1</sup> (Cd). Thermodynamic analysis revealed an endothermic and spontaneous process, while Avrami kinetics suggested a complex adsorption mechanism involving pore diffusion, electrostatic interactions, and hydrogen bonding. Remarkably, the CS/ANS@GA beads maintained an efficiency of over 90 % after three adsorption–desorption cycles. These results highlight the potential of CS/ANS@GA beads as a sustainable, high-performance material for removing heavy metals from water.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"20 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nano modified kaolin-based materials and their application: A review","authors":"Kedir Seid Mohammed , Minaleshewa Atlabachew , Getahun Worku Derbie , Biniam Abdu Berhie","doi":"10.1016/j.jciso.2025.100153","DOIUrl":"10.1016/j.jciso.2025.100153","url":null,"abstract":"<div><div>Kaolin, a natural clay mineral characterized by its kaolinite layers and silicate structure, exhibits high adsorbent properties, a low specific surface area, exceptional stability, and environmental friendliness. These attributes make kaolinite suitable for a wide range of applications. Conversely, the limited surface hydroxyl groups, low ion exchange capacity, and inability to absorb visible light indicate that pure kaolin or kaolinite is not an effective material for photocatalysis and performs inadequately in other applications. Fortunately, the unique physical and chemical properties of kaolinite render it as a suitable semiconductor carrier. By utilizing kaolin as a carrier, the poor activity, narrow spectral response, and limited electron transport of pure photocatalysts can be addressed, while also restricting the aggregation of nanoparticles. Thus, the usage of pure kaolin/kaolinite as a catalyst and adsorbent demonstrates to improve adsorption and catalytic performance, many modification techniques are now used, such as heat treatment (increases its surface area and porosity), acid modification (boosts the availability of active sites for improved adsorption and catalytic reactions), metal modification (introduces additional active sites), inorganic modification (improve thermal stability and photocatalytic performance), and organic modification (increase hydrophobicity). This review paper offers a structured overview of the use of kaolinite-supported nanocomposites across various applications, including adsorption, photocatalytic pollutant degradation, catalytic degradation, and antibacterial and antioxidant activities. The review also demonstrates the effectiveness and methods of combining nanomaterials with naturally occurring or modified kaolinite, as well as the limitations of kaolinite's present application and the mechanics underlying adsorption, catalytic, photocatalytic techniques and pollutant removal.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"20 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JCIS openPub Date : 2025-08-27DOI: 10.1016/j.jciso.2025.100151
Priyanshu Kumar Singh , J. Sunil
{"title":"Exploring the potential antibacterial mechanism of the goose eggshell-derived CaO nanoparticles for deactivation of pharmaceutical wastages and bacteria","authors":"Priyanshu Kumar Singh , J. Sunil","doi":"10.1016/j.jciso.2025.100151","DOIUrl":"10.1016/j.jciso.2025.100151","url":null,"abstract":"<div><div>Environmental contamination caused by pharmaceutical residues and textile dye effluents poses significant challenges due to their chemical stability, toxicity, and resistance to conventional treatment methods. This study investigates the green synthesis of calcium oxide (CaO) NPS derived from goose eggshells via thermal decomposition at 900 °C, and evaluates their efficacy in photocatalytic degradation and antibacterial applications. Comprehensive characterization using XRD, FTIR, FESEM, UV–Vis studies confirmed the successful formation of phase-pure, highly crystalline CaO NPS with an average particle size of 47.9 nm and a direct optical bandgap of 3.41 eV. The photocatalytic performance of the synthesized CaO Nanoparticles (NPs) was assessed through the degradation of Safranin dye (a model cationic dye) and the pharmaceutical compound Paracetamol under natural sunlight. The NPS achieved degradation efficiencies of 97.43 % for Safranin and 91.25 % for Paracetamol, following pseudo-first-order kinetics. The degradation rate constant for Safranin (2.896 × 10<sup>−2</sup> min<sup>−1</sup>) was higher than that for Paracetamol (1.551 × 10<sup>−2</sup> min<sup>−1</sup>), likely due to more favourable adsorption and stronger electrostatic interactions between the cationic dye molecules and the negatively charged CaO surface. In addition to their photocatalytic properties, the CaO NPS demonstrated significant antibacterial activity, particularly against Gram-positive <em>Staphylococcus aureus</em>, with a maximum zone of inhibition of 19.4 mm. The enhanced antibacterial performance is attributed to the nanoscale size, high surface reactivity, and the alkaline nature of CaO, which collectively disrupt bacterial membrane integrity. Overall, this work underscores the potential of bio-waste-derived CaO NPS as an environmentally sustainable, cost-effective, and multifunctional material for the dual purpose of wastewater remediation and microbial control.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JCIS openPub Date : 2025-08-26DOI: 10.1016/j.jciso.2025.100150
Uttama Kumar Saint , Suresh Chandra Baral , Dilip Sasmal , P. Maneesha , Sayak Datta , Farzana Naushin , Somaditya Sen
{"title":"Effect of pH on photocatalytic degradation of methylene blue in water by facile hydrothermally grown TiO2 nanoparticles under natural sunlight","authors":"Uttama Kumar Saint , Suresh Chandra Baral , Dilip Sasmal , P. Maneesha , Sayak Datta , Farzana Naushin , Somaditya Sen","doi":"10.1016/j.jciso.2025.100150","DOIUrl":"10.1016/j.jciso.2025.100150","url":null,"abstract":"<div><div>Each year, the production of synthetic dye wastewater reaches a trillion tons. This poses a significant global challenge of water scarcity. Hence, wastewater must be treated to reverse to useable water and prevent water scarcity. Failing to achieve this reversal increases ecotoxicological risks and human health. Textile wastewater contains harmful dyes. Photocatalytic degradation of these dye-contaminated wastewater is one of the major pathways in achieving reversal. However, this process is time-consuming, requires high-power lamps, and is expensive. Here, we report the effect of TiO<sub>2</sub> nanostructures prepared by facile hydrothermal synthesis on the dye degradation of one of the most common industrial textile dyes, methylene blue (MB), under natural sunlight. The impact of particle size on the photocatalytic activity and photocarrier migration rate was thoroughly examined. The size and surface morphology of the TiO<sub>2</sub> nanostructures depended on the concentration of the precursor during synthesis. Also, the effect of the pH of the dye solution on adsorption and photocatalytic degradation has been evaluated. With several optimized conditions, almost complete dye degradation was achieved within 40 min under the direct illumination of natural sunlight. The enhanced photocatalytic performance could correlate to the synergetic effect of a higher charge transfer mechanism, good catalytically active surface area availability (386 m<sup>2</sup>/g), and several optimized parameters that affect the reaction efficacy. Additionally, repeated use of NPs (five times) without sacrificing performance confirmed their stability and sustainability as a promising candidate for large-scale industrial textile wastewater remedies.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JCIS openPub Date : 2025-08-25DOI: 10.1016/j.jciso.2025.100145
Margaux Ceccaldi , Coralie Menuisier , Vincent Langlois , Marielle Guéguen , Yoan Péchaud , Daniel Grande , Sébastien Vincent-Bonnieu , Olivier Pitois
{"title":"Foam-based microbially-induced calcite precipitation","authors":"Margaux Ceccaldi , Coralie Menuisier , Vincent Langlois , Marielle Guéguen , Yoan Péchaud , Daniel Grande , Sébastien Vincent-Bonnieu , Olivier Pitois","doi":"10.1016/j.jciso.2025.100145","DOIUrl":"10.1016/j.jciso.2025.100145","url":null,"abstract":"<div><div>Building on the development history of the Microbially Induced Calcite Precipitation (MICP) method and recent insights into the organization of liquid and bubbles within pore spaces filled with liquid foam, we hypothesize a potential synergy between MICP and liquid foam for enhancing soil properties. We assess the respiration and calcification capabilities of the bacterium Sporosarcina pasteurii in various foaming solutions formulated with bio-based surfactants. The most promising formulations are then used for in-situ observations of bacteria-induced calcification within foam-embedded 2D granular packings. We observe that maltoside-type AlkylPolyGlucosides with relatively short chains, in particular, enable optimal calcification in less than an hour. In the granular packing, the foam spontaneously creates liquid zones enriched with bacteria at the inter-grain contacts. As a result, instead of being distributed across the entire porous space, calcification is localized in these zones, promoting the formation of solid bridges (CaCO<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>). This suggests that the foam-based MICP method could represent a relevant variation of the original approach, though this remains to be confirmed at larger scales through mechanical testing on representative soil samples.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JCIS openPub Date : 2025-08-23DOI: 10.1016/j.jciso.2025.100148
Nasser A.M. Barakat, Aghareed M. Tayeb, Rahma Hamad, Rasha A. Hefny
{"title":"Visible-light-driven methanol photo-reforming over cobalt oxides nanofibers: Insights into synthesis, bandgap engineering, and catalytic efficiency","authors":"Nasser A.M. Barakat, Aghareed M. Tayeb, Rahma Hamad, Rasha A. Hefny","doi":"10.1016/j.jciso.2025.100148","DOIUrl":"10.1016/j.jciso.2025.100148","url":null,"abstract":"<div><div>Photocatalytic methanol photo-reforming stands as a promising avenue for sustainable hydrogen production, with potential applications in clean energy generation. In this study, we investigate the utilization of CoO/Co<sub>3</sub>O<sub>4</sub> nanofibers as a photocatalyst for methanol photo-reforming, evaluating its performance under different reaction conditions. The synthesized nanofibers are employed with both pure methanol and methanol/water mixtures and compared against TiO<sub>2</sub> nanoparticles for reference. Gas evolution rates and composition are analyzed to elucidate the catalytic behavior of the nanofibers. Results reveal that the CoO/Co<sub>3</sub>O<sub>4</sub> nanofibers exhibit superior catalytic activity, yielding high gas evolution rates with pure methanol; 600 mmol/g<sub>cat</sub>·s. However, the addition of water leads to a sharp decrease in gas production rate (66.9 mmol/g<sub>cat</sub>.s), attributed to competitive water adsorption on the catalyst surface and drastic change in the reaction kinetics. Gas analysis demonstrates the predominant production of carbon monoxide and hydrogen with pure methanol, while carbon dioxide is detected in the presence of water. In contrast, TiO<sub>2</sub> nanoparticles primarily yield carbon dioxide and hydrogen, with no carbon monoxide detected. These findings provide valuable insights into the catalytic mechanisms and selectivity of nanofiber-based catalysts for methanol photo-reforming, paving the way for the development of efficient and selective photocatalytic systems for sustainable energy production.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cancer cell microenvironment-responsive bio-metal-organic frameworks for anticancer drug delivery","authors":"Asuka Inada, Hirona Yoshinaka, Misa Kikuchi, Tatsuya Oshima","doi":"10.1016/j.jciso.2025.100149","DOIUrl":"10.1016/j.jciso.2025.100149","url":null,"abstract":"<div><div>A glutathione (GSH)-responsive metal-organic framework (MOF) was developed using biocompatible L-cystine and Zn for targeted doxorubicin (DOX) delivery. This strategy enhances drug release in the microenvironment while minimizing systemic toxicity. Disulfide-containing MOFs were synthesized using L-cystine as the ligand and Zn as the metal node. A one-pot method was developed to encapsulate DOX during synthesis. The redox-responsive behavior of the resulting DOX@MOF-Zn(cystine) was evaluated under physiological and tumor-mimicking conditions. In vitro assays revealed that the disulfide bonds in L-cystine ligand facilitate MOF degradation in the presence of GSH, triggering DOX release. DOX@MOF-Zn(cystine) exhibited significantly enhanced release under conditions mimicking the tumor microenvironment (pH 5.4, 20 mM GSH) compared to physiological conditions (pH 7.4, no GSH). Cell viability assays demonstrated minimal toxicity for blank MOFs and strong DOX-dependent anticancer effects from DOX@MOF-Zn(cystine). These findings suggest DOX@MOF-Zn(cystine) is an effective GSH-responsive drug delivery system for targeted cancer therapy.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}