JCIS open最新文献

{"title":"Chasing fractals: The forgotten conundrum of colloidal aggregates","authors":"Robert Botet","doi":"10.1016/j.jciso.2024.100107","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100107","url":null,"abstract":"","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000060/pdfft?md5=63e2f48168a0f745df2f5ae94a9d4748&pid=1-s2.0-S2666934X24000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-amorphous system of Bifonazole for improved in-vitro permeation and antifungal activity","authors":"Devanshi S. Shah ,&nbsp;Sharda Gurram ,&nbsp;Vitthal N. Gadlawar ,&nbsp;Durgesh K. Jha ,&nbsp;Siddhi P. Kamble ,&nbsp;Purnima D. Amin","doi":"10.1016/j.jciso.2024.100108","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100108","url":null,"abstract":"<div><p>Bifonazole (BF), belonging to the newer class of antifungal drugs, is being widely explored for topical administration for fungal infections. It has proven to have better efficiency than other older drugs. However, it's low solubility poses a challenge in the formulation and, therefore, in the drug product's efficacy. Intending to harness the benefits of the drug, the objective of the current study was to prepare a supersaturated system of the drug with a coformer. A co-amorphous system (CAS) of BF and citric acid (CA) was prepared using solvent evaporation to achieve better permeation and antimicrobial efficacy after topical application. The prepared system was evaluated for its solid-state properties by DSC, XRD, and FTIR. The theoretical values of the glass transition temperature, as calculated by the Gordon-Taylor equation, correlated well with the observations of the thermal analysis. The prepared system was dispersed in propylene glycol to perform in-vitro permeation studies wherein enhanced permeation properties were noted. The CAS showed better antifungal properties against A. niger owing to better release and solubility of the drug. Thus, It was concluded that a co-amorphous system of BF is a promising formulation strategy for topical drug delivery.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000072/pdfft?md5=e5c1d9a95772bce9be433d3b537f403e&pid=1-s2.0-S2666934X24000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139999509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained release of acyclovir from alginate-gellan gum and alginate-xanthan gum microbeads","authors":"Sudipta Das ,&nbsp;Arnab Samanta ,&nbsp;Sawan Das ,&nbsp;Amit Kumar Nayak","doi":"10.1016/j.jciso.2024.100106","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100106","url":null,"abstract":"<div><p>In the current research, acyclovir-loaded microbeads were formulated via ionotropic gelation using sodium alginate-gellan gum and sodium alginate-xanthan gum. In the preparation of these acyclovir-loaded microbeads, aluminium chloride and barium chloride were used as cross-linking agents. All these ionotropically-gelled acyclovir-loaded alginate-gellan gum microbeads and alginate-xanthan gum microbeads exhibited good percent yields (85.07 ± 1.58 to 92.17 ± 3.02%) and drug entrapment efficiencies (74.09 ± 1.38 to 95.16 ± 3.37%). Acyclovir-loaded alginate-gellan gum microbeads exhibited comparatively smaller average particle sizes (0.54 ± 0.02 to 0.71 ± 0.03 mm) than those of acyclovir-loaded alginate-xanthan gum microbeads (0.60 ± 0.02 to 0.82 ± 0.04 mm). Acyclovir-loaded alginate-xanthan gum microbeads exhibited comparatively higher swelling than that of acyclovir-loaded alginate-gellan gum microbeads. A sustained pattern of acyclovir release over 240 min was noticed by these microbeads. Surface morphology analysis of the best microbeads formulation (on the basis of sustained acyclovir release data) was done by scanning electron microscopy (SEM). These kinds of ionotropically-gelled alginate-based microbeads might be advantageous to facilitate enhanced patient compliances with minimal dosing frequency and enhanced oral bioavailability.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000059/pdfft?md5=e099090f47f9871527ed8cb5b5e885c8&pid=1-s2.0-S2666934X24000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139749498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoughts on specific ion effects","authors":"Epameinondas Leontidis","doi":"10.1016/j.jciso.2024.100104","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100104","url":null,"abstract":"","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000035/pdfft?md5=f39aadee07b533e0b92ac42141df6579&pid=1-s2.0-S2666934X24000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139737793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New solution of the non-linear Poisson-Boltzmann differential equation for solid particle dispersions in dissymmetrical electrolytes","authors":"Tayssir Hamieh","doi":"10.1016/j.jciso.2024.100103","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100103","url":null,"abstract":"<div><p>A new mathematical solution to the non-linear Poisson-Boltzmann differential equation for solid-liquid dispersions in presence of different dissymmetrical electrolytes was given. The analytical expressions of the surface and charge density of solid particles were given. The variations of electrostatic potential <em>ψ</em> (<em>x</em>) and charge density <em>σ</em> (<em>x</em>) of dispersed particles against the distance <em>x</em> were obtained. For colloidal particles in presence of E(m-n) electrolytes with <span><math><mrow><mi>m</mi><mo>≠</mo><mi>n</mi></mrow></math></span> with <span><math><mrow><mi>m</mi><mo>≥</mo><mn>3</mn><mo>,</mo><mi>n</mi><mo>≥</mo><mn>3</mn></mrow></math></span> and for E(2–3) and E(3-2) electrolytes, the mean electrostatic potential as a function of the distance was numerically integrated by Mathematica program version 13.</p><p>The experimental study of silica suspensions in presence with the following electrolytes <span><math><mrow><mi>N</mi><mi>a</mi><mi>C</mi><mi>l</mi></mrow></math></span>, <span><math><mrow><msub><mrow><mi>N</mi><mi>a</mi></mrow><mn>2</mn></msub><msub><mrow><mi>S</mi><mi>O</mi></mrow><mn>4</mn></msub></mrow></math></span>, <span><math><mrow><mi>C</mi><mi>a</mi><msub><mrow><mi>C</mi><mi>l</mi></mrow><mn>2</mn></msub></mrow></math></span>, <span><math><mrow><msub><mrow><mi>N</mi><mi>a</mi></mrow><mn>3</mn></msub><msub><mrow><mi>P</mi><mi>O</mi></mrow><mn>4</mn></msub></mrow></math></span>, <span><math><mrow><mi>A</mi><mi>l</mi><msub><mrow><mi>C</mi><mi>l</mi></mrow><mn>3</mn></msub></mrow></math></span>, <span><math><mrow><msub><mrow><mi>A</mi><mi>l</mi></mrow><mn>2</mn></msub><msub><mrow><mo>(</mo><msub><mrow><mi>S</mi><mi>O</mi></mrow><mn>4</mn></msub><mo>)</mo></mrow><mn>3</mn></msub></mrow></math></span>, <span><math><mrow><msub><mrow><mi>C</mi><mi>a</mi></mrow><mn>3</mn></msub><msub><mrow><mo>(</mo><msub><mrow><mi>P</mi><mi>O</mi></mrow><mn>4</mn></msub><mo>)</mo></mrow><mn>2</mn></msub></mrow></math></span>, <span><math><mrow><msub><mrow><mi>N</mi><mi>a</mi></mrow><mn>4</mn></msub><msub><mrow><msub><mi>P</mi><mn>2</mn></msub><mi>O</mi></mrow><mn>7</mn></msub></mrow></math></span> and <span><math><mrow><msub><mrow><mi>N</mi><mi>a</mi></mrow><mn>5</mn></msub><msub><mrow><msub><mi>P</mi><mn>3</mn></msub><mi>O</mi></mrow><mn>10</mn></msub></mrow></math></span> led to confirm the theoretical predictions obtained from the analytical solution of Poisson-Boltzmann equation. The results obtained allowed to determine the surface potential as a function of pH of the suspension and the electrostatic potential versus the distance x. The variations of the dissociation coefficient of silica surfaces were determined. An important effect of the anion and cation valences of the dissymmetrical electrolytes on the surface charge density and potential was highlighted.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000023/pdfft?md5=2a145a52f361443b6d440aa34e67306f&pid=1-s2.0-S2666934X24000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139737792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions of α-Tocopherol in F127/lignin microemulsions: A DFT and semi-empirical study","authors":"Pouya Karimi ,&nbsp;Abbas Rahdar ,&nbsp;Francesco Baino","doi":"10.1016/j.jciso.2024.100105","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100105","url":null,"abstract":"<div><p>Tocopherols are fat soluble substances with antioxidant properties. The α-Tocopherol (T) is the major form of Tocopherols and can decrease the risk of cancer. F127-based and Lignin-based oil-in-water microemulsions seem to increase the bioavailability of T and cause better release of this therapeutic agent. Thus, T-loaded microemulsions were designed by means of density functional theory (DFT) and semi-empirical methods. Atoms in molecules (AIM), natural bond orbital (NBO) analyses, localized molecular orbital energy decomposition analysis (LMO-EDA), and density of states plots were employed to explore the effective factors on the strength of the interactions between surfactants and T. Results indicate that F127-T complexes are more stable than Lignin-T ones. Furthermore, the stable release of T in microemulsions is due to the electrostatic interactions between surfactants and T. Formation of hydrogen bond (HB) interactions between surfactants and T stabilizes the microemulsion system. These interplays are suggested to take part in the better function of T in microemulsions compared to free T. The semi-empirical study reveals that the heats of formation (ΔH_f values) of the F127-T complexes are less negative than those for the Lignin-T ones.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000047/pdfft?md5=fb7a0d042622fb2e7d83843e91b410dd&pid=1-s2.0-S2666934X24000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photocatalytic degradation of organic pollutants in water using copper oxide (CuO) nanosheets for environmental application","authors":"Suresh Chandra Baral ,&nbsp;P. Maneesha ,&nbsp;Sayak Datta ,&nbsp;Kailash Dukiya ,&nbsp;Dilip Sasmal ,&nbsp;Koyal Suman Samantaray ,&nbsp;BR Vaishnavi Krupa ,&nbsp;Arup Dasgupta ,&nbsp;Somaditya Sen","doi":"10.1016/j.jciso.2024.100102","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100102","url":null,"abstract":"<div><p>Rapid, inexpensive, and low-power/solar light-driven photocatalytic degradation of organic pollutants to deal with annually produced trillion tons of synthetic dye wastewater to prevent water scarcity issues, ecotoxicological risks, and human health has always been challenging. To overcome this limitation, the present study synthesized earth-abundant, inexpensive copper oxide nanosheets using a simple single-step hydrothermal route. The structural, physicochemical, and functional properties of the nanosheets have been characterized using several characterization techniques. The photocatalytic activity was studied for two commonly industrially used organic dyes, Methylene Blue (MB) and Rhodamine B (RhB). The importance of this work is the usage of a cheap commercially available Phillips UV light (11 W) as well as direct sunlight. With several optimized conditions, almost complete degradation of both dyes was achieved within 35 minutes under low-power UV light and within 70 minutes by the direct illumination of natural sunlight. The enhanced photocatalytic performance can be correlated to the synergetic effect of a higher charge transfer mechanism, good catalytic ‘active surface area’ availability (13.2 m²/g), and several optimized parameters that affect the reaction efficacy. Additionally, five repeated uses of nanosheets without sacrificing performance confirmed their stability and sustainability as a promising candidate for large-scale industrial textile wastewater remedies.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000011/pdfft?md5=d3dfdabf0547c1641c3a1bc4f682b02a&pid=1-s2.0-S2666934X24000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: “Recent advances on graphene polymeric bionanoarchitectures for biomedicals” [JCISO 9 (2023) 100070]","authors":"Christopher Igwe Idumah","doi":"10.1016/j.jciso.2024.100111","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100111","url":null,"abstract":"","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X24000102/pdfft?md5=57379a0d4150c3c411499f6676a86446&pid=1-s2.0-S2666934X24000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: “Emerging advancements in xerogel polymeric bionanoarchitectures and applications” [JCISO 9 (2023) 100073]","authors":"Christopher Igwe Idumah","doi":"10.1016/j.jciso.2024.100114","DOIUrl":"https://doi.org/10.1016/j.jciso.2024.100114","url":null,"abstract":"","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X2400014X/pdfft?md5=42aede0fcb8db25f9da030f694ca205e&pid=1-s2.0-S2666934X2400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaporative phase separation in polymer microdroplets with confinement and internal flow","authors":"Mukesh Kumar,&nbsp;Maheshwar Gopu,&nbsp;Senthan Pugalneelam Parameswaran,&nbsp;Prerak Joshi,&nbsp;Dileep Mampallil","doi":"10.1016/j.jciso.2023.100101","DOIUrl":"https://doi.org/10.1016/j.jciso.2023.100101","url":null,"abstract":"<div><p>Evaporation can drive initially homogeneous multiphase liquid systems out of equilibrium to induce liquid-liquid phase separation (LLPS). Here, we demonstrate evaporative LLPS in microfluidic-generated emulsion microdroplets of polymer mixtures. The evaporation produces distinct polymer phases within the microdroplets. Phase separation occurs even with polymer combinations that do not form distinct phases in sessile droplet evaporation. We attribute this aspect to evaporation-driven solutal Marangoni flows and the interface capture accumulating the nuclei at the apex where the evaporation rate is the maximum. A fast coalescence and growth of the accumulated polymer nuclei occurs inside the droplets, unlike the capillary-flow-induced spread-out of the nuclei along the contact line in sessile drops. Our method of evaporation of the droplet cluster may facilitate studying LLPS in volume-limited environments and have implications for understanding LLPS in biological systems.</p></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666934X23000284/pdfft?md5=860700b5f5120db38d1265d7471e917e&pid=1-s2.0-S2666934X23000284-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138839207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}