JCIS open最新文献_第3页

Inverting g(r) to u(r): The test-particle insertion method 将g(r)逆化为u(r)：测试粒子插入法

JCIS open Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/j.jciso.2025.100156

Clare R. Rees-Zimmerman , Angus Heafield , Daniel Ellerbeck , Adam Edward Stones , Roel P.A. Dullens , Dirk G.A.L. Aarts

{"title":"Inverting g(r) to u(r): The test-particle insertion method","authors":"Clare R. Rees-Zimmerman , Angus Heafield , Daniel Ellerbeck , Adam Edward Stones , Roel P.A. Dullens , Dirk G.A.L. Aarts","doi":"10.1016/j.jciso.2025.100156","DOIUrl":"10.1016/j.jciso.2025.100156","url":null,"abstract":"<div><div>Inverting the radial distribution function, <span><math><mrow><mi>g</mi><mrow><mo>(</mo><mi>r</mi><mo>)</mo></mrow></mrow></math></span>, to a pair potential, <span><math><mrow><mi>u</mi><mrow><mo>(</mo><mi>r</mi><mo>)</mo></mrow></mrow></math></span>, can be achieved by a variety of methods. Test-particle insertion has recently emerged as an efficient inverse method for finding <span><math><mrow><mi>u</mi><mrow><mo>(</mo><mi>r</mi><mo>)</mo></mrow></mrow></math></span>. The method can analyse both simulated and experimental data, and the only input required is equilibrium snapshots of particle coordinates. This paper explains the method in detail and its implementation, sharing example code. We demonstrate intricacies in the number and placement of test particles and their effect on efficiency, as well as practical advice for applying the method to experimental data. This includes strategies and code for dealing with non-periodic boundary conditions, choice of inversion cutoff distance and the effect of particles sticking. We also discuss how the method performs at higher density and its limitations.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"20 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer cell microenvironment-responsive bio-metal-organic frameworks for anticancer drug delivery 肿瘤细胞微环境响应型生物金属-有机骨架抗癌药物传递

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-08-22 DOI: 10.1016/j.jciso.2025.100149

Asuka Inada, Hirona Yoshinaka, Misa Kikuchi, Tatsuya Oshima

{"title":"Cancer cell microenvironment-responsive bio-metal-organic frameworks for anticancer drug delivery","authors":"Asuka Inada, Hirona Yoshinaka, Misa Kikuchi, Tatsuya Oshima","doi":"10.1016/j.jciso.2025.100149","DOIUrl":"10.1016/j.jciso.2025.100149","url":null,"abstract":"<div><div>A glutathione (GSH)-responsive metal-organic framework (MOF) was developed using biocompatible L-cystine and Zn for targeted doxorubicin (DOX) delivery. This strategy enhances drug release in the microenvironment while minimizing systemic toxicity. Disulfide-containing MOFs were synthesized using L-cystine as the ligand and Zn as the metal node. A one-pot method was developed to encapsulate DOX during synthesis. The redox-responsive behavior of the resulting DOX@MOF-Zn(cystine) was evaluated under physiological and tumor-mimicking conditions. In vitro assays revealed that the disulfide bonds in L-cystine ligand facilitate MOF degradation in the presence of GSH, triggering DOX release. DOX@MOF-Zn(cystine) exhibited significantly enhanced release under conditions mimicking the tumor microenvironment (pH 5.4, 20 mM GSH) compared to physiological conditions (pH 7.4, no GSH). Cell viability assays demonstrated minimal toxicity for blank MOFs and strong DOX-dependent anticancer effects from DOX@MOF-Zn(cystine). These findings suggest DOX@MOF-Zn(cystine) is an effective GSH-responsive drug delivery system for targeted cancer therapy.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous hard carbon derived from coconut biomass waste as electrode material for supercapacitor 从椰子生物质废料中提取多孔硬碳作为超级电容器电极材料

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-08-20 DOI: 10.1016/j.jciso.2025.100147

Muhammadin Hamid , Indri Dayana , Habib Satria , Dadan Ramdan , Junaidi , Muhammad Fadlan Siregar , Dewi Sholeha , Juliaster Marbun , Hadi Wijoyo

{"title":"Porous hard carbon derived from coconut biomass waste as electrode material for supercapacitor","authors":"Muhammadin Hamid , Indri Dayana , Habib Satria , Dadan Ramdan , Junaidi , Muhammad Fadlan Siregar , Dewi Sholeha , Juliaster Marbun , Hadi Wijoyo","doi":"10.1016/j.jciso.2025.100147","DOIUrl":"10.1016/j.jciso.2025.100147","url":null,"abstract":"<div><div>The synthesis of porous hard carbon from coconut biomass waste using physical activation through pyrolysis and chemical activation with orange juice as an organic activator at varying temperatures, including 500 °C, 600 °C, and 700 °C, has been carried out. The purpose of this research is to develop materials for faradaic-type supercapacitor electrodes based on these temperature variations. Characterization and testing methods used include X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). BET analysis showed that the PHC-700 sample exhibited a relatively high specific surface area with porous characteristics and a narrow pore size distribution around 17–18 nm. The PHC-700 sample also exhibited the best electrochemical performance with a specific capacitance of 485.23 F/g and a total resistance of 24.29 Ω. GCD measurements revealed stable triangular curves, indicating good charge-discharge reversibility and confirming the superior capacitive behavior of PHC-700. The study confirmed that the higher the temperature used, the better the supercapacitor electrode obtained. This is evidenced by the pores on the surface that help improve the quality of the electrode and the XRD test results which are directly proportional to the increase in temperature. It is hoped that this research can enhance understanding of supercapacitor electrode applications.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foam-based microbially-induced calcite precipitation 基于泡沫的微生物诱导方解石沉淀

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-08-25 DOI: 10.1016/j.jciso.2025.100145

Margaux Ceccaldi , Coralie Menuisier , Vincent Langlois , Marielle Guéguen , Yoan Péchaud , Daniel Grande , Sébastien Vincent-Bonnieu , Olivier Pitois

{"title":"Foam-based microbially-induced calcite precipitation","authors":"Margaux Ceccaldi , Coralie Menuisier , Vincent Langlois , Marielle Guéguen , Yoan Péchaud , Daniel Grande , Sébastien Vincent-Bonnieu , Olivier Pitois","doi":"10.1016/j.jciso.2025.100145","DOIUrl":"10.1016/j.jciso.2025.100145","url":null,"abstract":"<div><div>Building on the development history of the Microbially Induced Calcite Precipitation (MICP) method and recent insights into the organization of liquid and bubbles within pore spaces filled with liquid foam, we hypothesize a potential synergy between MICP and liquid foam for enhancing soil properties. We assess the respiration and calcification capabilities of the bacterium Sporosarcina pasteurii in various foaming solutions formulated with bio-based surfactants. The most promising formulations are then used for in-situ observations of bacteria-induced calcification within foam-embedded 2D granular packings. We observe that maltoside-type AlkylPolyGlucosides with relatively short chains, in particular, enable optimal calcification in less than an hour. In the granular packing, the foam spontaneously creates liquid zones enriched with bacteria at the inter-grain contacts. As a result, instead of being distributed across the entire porous space, calcification is localized in these zones, promoting the formation of solid bridges (CaCO<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>). This suggests that the foam-based MICP method could represent a relevant variation of the original approach, though this remains to be confirmed at larger scales through mechanical testing on representative soil samples.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible-light-driven methanol photo-reforming over cobalt oxides nanofibers: Insights into synthesis, bandgap engineering, and catalytic efficiency 钴氧化物纳米纤维上的可见光驱动甲醇光重整：对合成、带隙工程和催化效率的见解

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-08-23 DOI: 10.1016/j.jciso.2025.100148

Nasser A.M. Barakat, Aghareed M. Tayeb, Rahma Hamad, Rasha A. Hefny

{"title":"Visible-light-driven methanol photo-reforming over cobalt oxides nanofibers: Insights into synthesis, bandgap engineering, and catalytic efficiency","authors":"Nasser A.M. Barakat, Aghareed M. Tayeb, Rahma Hamad, Rasha A. Hefny","doi":"10.1016/j.jciso.2025.100148","DOIUrl":"10.1016/j.jciso.2025.100148","url":null,"abstract":"<div><div>Photocatalytic methanol photo-reforming stands as a promising avenue for sustainable hydrogen production, with potential applications in clean energy generation. In this study, we investigate the utilization of CoO/Co<sub>3</sub>O<sub>4</sub> nanofibers as a photocatalyst for methanol photo-reforming, evaluating its performance under different reaction conditions. The synthesized nanofibers are employed with both pure methanol and methanol/water mixtures and compared against TiO<sub>2</sub> nanoparticles for reference. Gas evolution rates and composition are analyzed to elucidate the catalytic behavior of the nanofibers. Results reveal that the CoO/Co<sub>3</sub>O<sub>4</sub> nanofibers exhibit superior catalytic activity, yielding high gas evolution rates with pure methanol; 600 mmol/g<sub>cat</sub>·s. However, the addition of water leads to a sharp decrease in gas production rate (66.9 mmol/g<sub>cat</sub>.s), attributed to competitive water adsorption on the catalyst surface and drastic change in the reaction kinetics. Gas analysis demonstrates the predominant production of carbon monoxide and hydrogen with pure methanol, while carbon dioxide is detected in the presence of water. In contrast, TiO<sub>2</sub> nanoparticles primarily yield carbon dioxide and hydrogen, with no carbon monoxide detected. These findings provide valuable insights into the catalytic mechanisms and selectivity of nanofiber-based catalysts for methanol photo-reforming, paving the way for the development of efficient and selective photocatalytic systems for sustainable energy production.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clear-cut synthesis of silver nanoparticles using glycerol as a multipurpose medium toward catalytic hydrogenation and antibacterial 用甘油作为催化加氢和抗菌的多用途介质合成纳米银

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-05-27 DOI: 10.1016/j.jciso.2025.100141

Van-Hoa Nguyen , Hoa-Hung Lam , Minh-Tam K. Nguyen , Thi-An-Sa Do , Hong-Phuong Phan , Trung Dang-Bao

{"title":"A clear-cut synthesis of silver nanoparticles using glycerol as a multipurpose medium toward catalytic hydrogenation and antibacterial","authors":"Van-Hoa Nguyen , Hoa-Hung Lam , Minh-Tam K. Nguyen , Thi-An-Sa Do , Hong-Phuong Phan , Trung Dang-Bao","doi":"10.1016/j.jciso.2025.100141","DOIUrl":"10.1016/j.jciso.2025.100141","url":null,"abstract":"<div><div>Adapting for a green and safe protocol, this work developed a straightforward polyol method for synthesizing spherical silver nanoparticles (AgNPs), with a median size of 12.2 nm in glycerol at a low temperature (60 °C). The multipurpose nature of glycerol, acting as both a reductant and an immobilizer, was explored, demonstrating the long-term stability of AgNPs in the resulting colloidal solution. The stability of AgNPs in glycerol was also contrasted with their stability in water and other polyols. The multiple applications of AgNPs in glycerol included their use as antibacterial agents (against both <em>E. coli</em> and <em>S. aureus</em> strains) and as an eco-friendly catalyst. At room temperature, the selective hydrogenation of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) obeyed a pseudo first-order kinetic model, exhibiting a rate constant of 0.1064 min<sup>−1</sup>. The kinetic and thermodynamic results confirmed that the rate-determining step involved an electron-transfer process from adsorbed hydrogen to 4-nitrophenolate on the AgNPs surface. Utilizing glycerol as a non-toxic solvent, this colloidal AgNPs solution can be easily stored and directly used without any additional purification.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encapsulation of Mucuna pruriens seed extract using nanocellulose and its evaluation for Parkinson's treatment 纳米纤维素包封麻瓜籽提取物及其对帕金森病治疗效果的评价

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-07-21 DOI: 10.1016/j.jciso.2025.100144

Ratnaningsih Eko Sardjono , Ramdhan Gunawan , Asep Kadarohman , Budiman Anwar , Hamidie Ronald Daniel Ray , Suci Nur Vikasari , Erdiwansyah , Siti Fatimah , Young Gun Ko

{"title":"Encapsulation of Mucuna pruriens seed extract using nanocellulose and its evaluation for Parkinson's treatment","authors":"Ratnaningsih Eko Sardjono , Ramdhan Gunawan , Asep Kadarohman , Budiman Anwar , Hamidie Ronald Daniel Ray , Suci Nur Vikasari , Erdiwansyah , Siti Fatimah , Young Gun Ko","doi":"10.1016/j.jciso.2025.100144","DOIUrl":"10.1016/j.jciso.2025.100144","url":null,"abstract":"<div><div><em>Mucuna pruriens</em> (MP), a natural source of L-DOPA, holds potential as a Parkinson's disease (PD) treatment. This study developed two encapsulation systems for MP using nanocellulose (NC-MP) and nanocellulose-chitosan-tripolyphosphate (NCT-MP) to enhance therapeutic efficacy. The encapsulation process was performed via ultrasonication and characterized by FTIR, SEM, and TEM, revealing polydisperse spherical particles with sizes of 566.37 ± 37.41 nm (NC-MP) and 756.66 ± 51.44 nm (NCT-MP). The anti-parkinsonian effects were evaluated in a catalepsy-induced mouse model using the horizontal bar test. Both encapsulated systems significantly reduced catalepsy duration (∗p∗ < 0.001). NC-MP demonstrated superior efficacy at low doses (5–20 mg/kg), attributed to its smaller particle size and neutral charge, which may facilitate blood-brain barrier penetration. In contrast, NCT-MP showed enhanced effects at 25 mg/kg, likely due to chitosan's cationic charge promoting active transport and tripolyphosphate-mediated matrix stabilization. These findings highlight the potential of encapsulation systems to optimize MP's therapeutic profile, with formulation efficacy dependent on dosage requirements.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced biomedical performance of magnetic Fe3O4@chitosan nanocomposites: A comparative study of synthesis methods for hyperthermia and chemotherapy applications 磁性Fe3O4@chitosan纳米复合材料增强生物医学性能：热疗和化疗应用合成方法的比较研究

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-05-30 DOI: 10.1016/j.jciso.2025.100142

Ahmed F. Aman , Omayma A. Ghazy , Hoda Saleh , Ismaiel A. Ali , Neamat H. Ahmed , Sameh A. Rizk , Zakaria I. Ali

{"title":"Enhanced biomedical performance of magnetic Fe3O4@chitosan nanocomposites: A comparative study of synthesis methods for hyperthermia and chemotherapy applications","authors":"Ahmed F. Aman , Omayma A. Ghazy , Hoda Saleh , Ismaiel A. Ali , Neamat H. Ahmed , Sameh A. Rizk , Zakaria I. Ali","doi":"10.1016/j.jciso.2025.100142","DOIUrl":"10.1016/j.jciso.2025.100142","url":null,"abstract":"<div><div>This study investigates the synthesis of magnetite/chitosan nanocomposites (Fe<sub>3</sub>O<sub>4</sub>@CS) using <em>in-situ</em> and <em>ex-situ</em> methods. The nanocomposites were characterized by FTIR, XRD, TEM, and VSM analyses. Their potential in nanomedicine was assessed through chemosensitivity tests on Ehrlich ascites carcinoma (EAC) and hyperthermic performance under an alternating magnetic field. The particle size of Fe<sub>3</sub>O<sub>4</sub> nanoparticles was 10–20 nm and 20–40 nm for <em>in-situ</em> and <em>ex-situ</em> prepared samples as revealed by TEM images. FTIR indicated strong interactions between magnetite and chitosan, while XRD revealed a more uniform crystalline structure of Fe<sub>3</sub>O<sub>4</sub> nanoparticles in <em>ex-situ</em> prepared samples. VSM analysis showed higher magnetization saturation for the <em>ex-situ</em> samples, with magnetization decreasing as chitosan content increased. <em>In vitro</em> assays demonstrated that both synthesis routes influenced the cytotoxicity of the nanocomposites against EAC cells, with <em>in-situ</em> samples showing greater early-stage cytotoxicity causing 40 % reduction in cell viability at 10 μg/mL. Under an alternating magnetic field, Fe<sub>3</sub>O<sub>4</sub>@CS nanocomposites reached therapeutic hyperthermia temperatures, with <em>in-situ</em> samples achieving 40.1–41.4 °C and <em>ex-situ</em> samples reaching 41–43 °C. These results highlight the importance of synthesis method and chitosan content in tailoring Fe<sub>3</sub>O<sub>4</sub>@CS nanocomposites for efficient and targeted hyperthermia-based cancer treatment.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From surface design to cellular Response: Insights into aryl-functionalized iron oxide nanoparticles with and without protein corona 从表面设计到细胞反应：有或没有蛋白冠的芳基功能化氧化铁纳米颗粒的见解

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-07-17 DOI: 10.1016/j.jciso.2025.100143

Solange Mailen Selzer , Laura Vanesa Bonnet , María Belén Piccoli , Santiago Daniel Salas , Mauricio Galiano , Raquel Viviana Vico , Nancy Fabiana Ferreyra

{"title":"From surface design to cellular Response: Insights into aryl-functionalized iron oxide nanoparticles with and without protein corona","authors":"Solange Mailen Selzer , Laura Vanesa Bonnet , María Belén Piccoli , Santiago Daniel Salas , Mauricio Galiano , Raquel Viviana Vico , Nancy Fabiana Ferreyra","doi":"10.1016/j.jciso.2025.100143","DOIUrl":"10.1016/j.jciso.2025.100143","url":null,"abstract":"<div><div>Iron oxide magnetic nanoparticles (IONPs) are widely utilized in biomedical and industrial applications due to their unique properties, including biocompatibility, superparamagnetism, and ease of functionalization. However, their behavior in biological environments is heavily influenced by surface functionalization and the formation of the protein corona. This study investigates the impact of aryl-functionalization of iron oxide nanoparticles with carboxylic and amine groups on colloidal stability, protein corona formation, and biological interactions. The IONPs were synthesized and characterized for their physicochemical properties, including size, zeta potential, magnetic properties, and dispersibility in different media. The interaction of the nanoparticles with dipalmitoylphosphatidylcholine monolayers, as a model membrane, was evaluated. Cytotoxicity and autophagy induction were assessed in Chinese hamster ovary (CHO-K1) and cervical cancer (HeLa) cells, respectively. The results demonstrate that surface functionalization significantly alters protein corona composition, which in turn modulates nanoparticle stability, cellular uptake, and biological responses. The aryl-functionalized nanoparticles exhibited reduced interactions with cell membranes compared to unfunctionalized counterparts, and also lower autophagy induction, emphasizing the importance of surface design in minimizing adverse effects.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogenic CuO-ZnO nanocomposites synthesized from Jatropha curcas for methylene blue dye degradation 麻疯树制备降解亚甲基蓝染料的CuO-ZnO纳米复合材料

JCIS open Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1016/j.jciso.2025.100146

Yojana Sharma , Vikas Anand , Vikas Dhiman , Pawan Heera

{"title":"Biogenic CuO-ZnO nanocomposites synthesized from Jatropha curcas for methylene blue dye degradation","authors":"Yojana Sharma , Vikas Anand , Vikas Dhiman , Pawan Heera","doi":"10.1016/j.jciso.2025.100146","DOIUrl":"10.1016/j.jciso.2025.100146","url":null,"abstract":"<div><div>The growing demand for sustainable nanomaterial synthesis has driven the development of green, bio-mediated approaches. In this study, CuO-ZnO nanocomposites (Cu<sub>x</sub>Zn<sub>1−x</sub>O; x = 0, 0.025, 0.05, 0.075, and 0.1) were synthesized via a phytochemical using the latex of <em>Jatropha curcas</em> an underexplored natural source as a <em>reducing, capping,</em> and <em>stabilizing agent</em>. This eco-friendly, latex-assisted approach avoids toxic chemicals and harsh synthesis conditions, making it fully compliant with green chemistry principles. The synthesized nanocomposites were systematically characterized to assess their structural and physicochemical properties. X-ray diffraction (XRD) confirmed the formation of a predominant hexagonal wurtzite ZnO phase with a secondary monoclinic CuO phase. Field emission scanning electron microscopy (FE-SEM) revealed quasi-spherical nanoparticles with well-defined facets, while energy-dispersive X-ray spectroscopy (EDS) verified the successful incorporation of Cu and Zn. Zeta potential analysis, UV–Visible spectroscopy, and FT-IR spectroscopy provided further insights into colloidal stability, optical properties and surface functionalities respectively. Among the synthesized materials, Cu<sub>0.05</sub>Zn<sub>0.95</sub>O exhibited the highest photocatalytic activity, achieving 88.7 % degradation of methylene blue with a kinetic rate constant of 0.01831 min<sup>−1</sup>. Reusability tests and scavenger studies confirmed the catalyst's durability and mechanistic reliability. To the best of our knowledge, there are very few or no reports employing <em>Jatropha curcas</em> latex for Cu-doped ZnO synthesis, particularly targeting photocatalytic applications, thereby demonstrating a novel eco-friendly pathway. Overall, this work demonstrates the efficacy of Jatropha-assisted green synthesis for producing stable and efficient CuO-ZnO nanocomposites, offering a promising solution for the photocatalytic treatment of dye-contaminated wastewater.</div></div>","PeriodicalId":73541,"journal":{"name":"JCIS open","volume":"19 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0