JAR life最新文献

{"title":"Identifying Frailty in Thermal/Spa Clinical Setting: A Cross-Sectional Study.","authors":"C Jeandel,&nbsp;T Hanh","doi":"10.14283/jarlife.2022.5","DOIUrl":"https://doi.org/10.14283/jarlife.2022.5","url":null,"abstract":"<p><strong>Background: </strong>No investigation has assessed frailty in the clinical setting of thermal/spa facilities, which often receive older patients with osteo-articular and musculoskeletal conditions.</p><p><strong>Objective: </strong>To examine the prevalence of frailty in older adults receiving thermal/spa treatment and to gather preliminary evidence about the feasibility of integrating geriatric assessments, including frailty, in the routine clinical consultations in spa facilities.</p><p><strong>Methods: </strong>Mixed design, with a quantitative cross-sectional investigation performed among 197 volunteer patients (mean age 73.2 ± 6.4 years-old; 82.2% women) of seven French thermal/spa facilities and a qualitative investigation (semi-structured interviews) with the nine physicians working in the participating facilities. Frailty was defined according to a modified Fried frailty phenotype based on six self-reported criteria (including mobility impairment, nutritional status, and fatigue): individuals meeting ≥3 criteria were considered frail; 1-2 criteria, pre-frail; no criterion, robust. Interviews with the participating physicians on the feasibility of integrating geriatric assessments in routine clinical consultations at spa facilities were recorded and their content, analyzed.</p><p><strong>Results: </strong>Frailty was detected in 112 individuals (56.9%), 26 (13.2%) were considered prefrail, and 59 (29.9%), robust. Regarding the interviews, three physicians indicated the geriatric assessments could be integrated in the routine spa consultations; two, in the consultations of specific/targeted patients, but not in routine; two, only in the context of health education; two, in the context of research protocols. The content of interviews highlighted geriatric assessments provided a better overview of the health/clinical status of the patients.</p><p><strong>Conclusion: </strong>Frailty is very prevalent in older patients of spa facilities. Such facilities may constitute an interesting clinical setting for screening for frailty through the implementation of geriatric assessments.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"11 ","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002897/pdf/jarlife-11-026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Well-Being, Psychological Factors, and Chronic Conditions Among Older Adults.","authors":"J Min,&nbsp;Y-C Yeh,&nbsp;I S Harvey","doi":"10.14283/jarlife.2022.3","DOIUrl":"https://doi.org/10.14283/jarlife.2022.3","url":null,"abstract":"Background Aging is characterized by the decline in physical health, functional status, and loss of social roles and relationships that can challenge the quality of life. Social well-being may help explain how aging individuals experience declining physical health and social relationships. Despite the high prevalence of chronic conditions among older adults, research exploring the relationship between social well-being and chronic disease is sparse. Objectives The study aims were to investigate the relationship between social well-being and psychological factors (e.g., perceived control, life satisfaction, self-esteem, active coping, optimism, and religious coping) by chronic condition in older adults. Design Cross-sectional study. Participants The current study comprises older adults (N = 1,251, aged ≥ 65 y) who participated in the third wave of the National Survey of Midlife in the United States (i.e., MIDUS). Setting MIDUS was conducted on a random-digit-dial sample of community-dwelling, English-speaking adults. Measurements Six instruments representing psychological resources (life satisfaction, perceived control, self-esteem, optimism, active coping, and religious coping) and five dimensions of social well-being (social actualization, social coherence, social acceptance, social contribution, social integration) were measured. An index of chronic disease comprised of self-reported data whether they had received a physician's diagnosis for any chronic conditions over the past year. Results The findings indicated that the individuals without chronic conditions had significantly higher social integration, social acceptance, and social contribution scores than the individuals with chronic conditions (t = 2.26, p < 0.05, t = 2.85, p < 0.01, and t = 2.23, p < 0.05, respectively). For individuals diagnosed with more than one chronic condition, perceived control, self-esteem, and optimism were positively related to their social well-being (β = .33, p < .001, β = .17, p < .001, and β = .33, p < .001, respectively). Conclusion Findings suggested that older adults with multiple chronic conditions have a decrease in social well-being. Chronic disease management programs may help increase social well-being among individuals with multiple chronic conditions.","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"11 ","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002881/pdf/jarlife-11-014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Controlled Whole-body Vibration Training on Balance and Fall Outcomes Among Healthy Older Adults: A 6-Week Pilot Study.","authors":"F Saucedo,&nbsp;E A Chavez,&nbsp;H R Vanderhoof,&nbsp;V N Pradeep Ambati,&nbsp;J D Eggleston","doi":"10.14283/jarlife.2022.6","DOIUrl":"https://doi.org/10.14283/jarlife.2022.6","url":null,"abstract":"<p><strong>Background: </strong>Falling is the second leading cause of injury-related death worldwide and is a leading cause of injury among older adults. Whole-body vibration has been used to improve balance and reduce fall risk in older adults. No study has assessed if vibration benefits can be retained over time.</p><p><strong>Objectives: </strong>The aims of this study were to examine if six-weeks of whole-body vibration could improve balance and fall outcomes, and to assess if benefits associated with the training program could be sustained two months following the final training session.</p><p><strong>Design and setting: </strong>Repeated measures randomized controlled design.</p><p><strong>Participants: </strong>Twenty-four independent living older adults were recruited and were randomly assigned to the whole-body vibration or control group.</p><p><strong>Intervention: </strong>Participants performed three sessions of whole-body vibration training per week with a vibration frequency of 20 Hz or with only an audio recording of the vibration noise. An assessment of balance and fall outcomes was performed prior to, immediately following, and two-months after the completion of the training program.</p><p><strong>Main outcome measures: </strong>Composite balance scores from the Berg Balance Scale and treadmill fall rates were assessed pre-training, post-training, and two-months post-training.</p><p><strong>Results: </strong>Seventeen participants completed the study. No between groups differences were found (p<0.05) in the measures of balance or fall rates.</p><p><strong>Conclusions: </strong>Findings revealed that six weeks of whole-body vibration was not effective in improving balance scores or fall rates.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"11 ","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9491476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Polygenic Risk Scoring to Predict Cognitive Impairment as Measured by Preclinical Alzheimer Cognitive Composite Score.","authors":"Q Gao,&nbsp;P Daunt,&nbsp;A M Gibson,&nbsp;R J Pither","doi":"10.14283/jarlife.2022.1","DOIUrl":"https://doi.org/10.14283/jarlife.2022.1","url":null,"abstract":"<p><strong>Background: </strong>The utility of Polygenic Risk Scores (PRS) is gaining increasing attention for generating an individual genetic risk profile to predict subsequent likelihood of future onset of Alzheimer's disease (AD), especially those carry two copies of the APOE E3 allele, currently considered at neutral risk in all populations studied.</p><p><strong>Objectives: </strong>To access the performance of PRS in predicting individuals whilst pre-symptomatic or with mild cognitive impairment who are at greatest risk of progression of cognitive impairment due to Alzheimer's Disease from the Alzheimer's Disease Neuroimaging Initiative (ADNI) as measured by the Preclinical Alzheimer Cognitive Composite (PACC) score profile. Design: A longitudinal analysis of data from the ADNI study conducted across over 50 sites in the US and Canada.</p><p><strong>Setting: </strong>Multi-centre genetics study.</p><p><strong>Participants: </strong>594 subjects either APOE E3 homozygotes or APOE E3/E4 heterozygotes who upon entry to the study were diagnosed as cognitively normal or with mild cognitive impairment.</p><p><strong>Measurements: </strong>Use of genotyping and/or whole genome sequencing data to calculate polygenic risk scores and assess its ability to predict subsequent cognitive decline as measured by PACC over 5 years. Results: Assessing both cognitively normal and mild cognitive impaired subjects using a PRS threshold of greater than 0.6, the high genetic risk participant group declined more than the low risk group over 5 years as measured by PACC score (PACC score reduced by time).</p><p><strong>Conclusions: </strong>Our findings have shown that polygenic risk score provides a promising tool to identify those with higher risk to decline over 5 years regardless of their APOE alleles according to modified PACC profile, especially its ability to identify APOE3/E3 cognitively normal individuals who are at most risk for early cognitive decline. This genotype accounts for approximately 60% of the general population and 35% of the AD population but currently would not be considered at higher risk without access to expensive or invasive biomarker testing.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"11 ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Changes in Midlife Women'S Percentage Body Fat: A 1-Year Cohort Study.","authors":"A M Nelson,&nbsp;S L Casperson,&nbsp;L Jahns,&nbsp;D G Palmer,&nbsp;J N Roemmich","doi":"10.14283/jarlife.2022.4","DOIUrl":"https://doi.org/10.14283/jarlife.2022.4","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this longitudinal, observational study was to examine whether age and seasonal changes in sedentary activity (sedAct), moderate-to-vigorous physical activity (MVPA), and energy intake (EI) predict changes in body composition among midlife women. We hypothesized that reductions in MVPA and increases in sedAct and EI in winter, along with greater baseline age would predict increases in percentage body fat (%BF) across seasons.</p><p><strong>Design: </strong>This study used a longitudinal, within-subjects design. <i>Setting:</i> This study took place in Grand Forks, North Dakota.</p><p><strong>Participants: </strong>Participants included 52 midlife women (aged 40-60 years) who were observed over the course of one year.</p><p><strong>Measurements: </strong>Percentage body fat measures were obtained via whole body Dual Energy X-ray absorptiometry. Participants were scanned once per season. We measured EI using the ASA24®. We used a GTX3 accelerometer to measure physical activity. Each season, participants wore the monitors for 7 days, 12 hours per day. All measures began in summer.</p><p><strong>Results: </strong>Results of hierarchical multiple regression (MR) analyses showed that age increases (β = 0.310, <i>p</i> = 0.021) and summer-to-fall increases in EI (β = 0.427, <i>p</i> = 0.002) predicted seasonal increases in %BF (<i>R2</i> = .36, <i>F</i>(5, 42)= 4.66, <i>p</i> = 0.02). Changes in MVPA and sedAct were not significant predictors. Repeated measures ANCOVA revealed that summer (<i>M</i> = 37.7263, 95% CI [35.8377, 39.6149]) to winter (<i>M</i> = 38.1463, 95% CI [36.1983, 40.0942]) increases in %BF are not reversed by spring (<i>M</i> = 37.8761, 95% CI [35.9365, 39.8157]).</p><p><strong>Conclusions: </strong>To minimize increases in %BF and maintain health, midlife women, particularly older women, should be encouraged to pay extra attention to their diet in the fall months.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"11 ","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9491475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling the Pan-European Economic Burden of Alzheimer's Disease.","authors":"R Martins,&nbsp;M Urbich,&nbsp;K Brännvall,&nbsp;M Gianinazzi,&nbsp;J E Ching,&nbsp;C P Khoury,&nbsp;Y H El-Hayek","doi":"10.14283/jarlife.2022.7","DOIUrl":"https://doi.org/10.14283/jarlife.2022.7","url":null,"abstract":"<p><strong>Background: </strong>Recent advances open the opportunity of altering the course of Alzheimer's disease (AD) through lifestyle-based modifications and novel therapies. Ensuring that society is investing limited budgets in the interventions that have the greatest potential to generate tangible impact will require tools to guide policymakers.</p><p><strong>Objectives: </strong>To build on previous studies to develop an economic model that estimates the societal burden of AD and evaluates the potential impact of novel interventions in six large European countries.</p><p><strong>Design: </strong>AD progression was modelled using a published Markov structure with a 40-year time horizon to estimate lifetime costs and life years in a cohort aged 65 years and above diagnosed with mild cognitive impairment due to AD (MCI-AD) in 2020. Demographic projections were utilized to estimate the prevalence of MCI-AD up to 2100, total corresponding costs and life years. The model allows a comparison of costs associated with the introduction of a hypothetical new disease-modifying therapy that slows disease progression between MCI-AD and all AD-Dementia stages as well as a 'delayed onset' scenario where disease progression is halted at the MCI-AD stage, potentially occurring, for example, through lifestyle-based modifications.</p><p><strong>Results: </strong>The 2022 present value of total lifetime costs for this cohort moving through all disease stages is ~€1.2T. Approximately 80% of the present value of lifetime costs in our model are driven by informal care and non-medical direct costs. Our model suggests that a 25% and 50% reduction in disease progression compared to natural history could translate into a present value of cost savings of €33.7B and €72.7B. Halting MCI-AD progression for 3 years with no therapeutic effect thereafter resulted in a present value cost savings of €84.7B in savings.</p><p><strong>Conclusions: </strong>Our data further suggest that early intervention via disease-modifying therapies or lifestyle-based modifications in AD could result in cost savings for society. Additionally, our findings reinforce the importance of accounting for the full value of innovative interventions, management and care paradigms, including their potential impact on direct, indirect and intangible costs impacting patients, their care partners and health and social care systems.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"11 ","pages":"38-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002890/pdf/jarlife-11-038.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9491477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Analysis of APOE Gene Polymorphism and the Risk of Cognitive Impairments in the Alzheimer's Disease Neuroimaging Initiative Study.","authors":"G Wang, D E Vance, W Li","doi":"10.14283/jarlife.2021.5","DOIUrl":"10.14283/jarlife.2021.5","url":null,"abstract":"<p><strong>Background: </strong>It is inconclusive on how apolipoprotein epsilon (APOE) gene polymorphism is associated with the risk of having mild cognitive impairment (MCI) or Alzheimer's disease (AD).</p><p><strong>Objectives: </strong>To investigate how APOE genotype is associated with the risk of MCI or AD using the data collected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) participants.</p><p><strong>Methods: </strong>A cross-sectional design was used to analyze the baseline data collected from the 1,720 ADNI participants. APOE gene polymorphism was analyzed on how they are related to the risk of cognitive impairments of either MCI or AD using a percent yield (PY) method. Then cognitive functions were compared among six different APOE genotypes using a two-way ANCOVA by controlling possible confounding factors.</p><p><strong>Results: </strong>The prevalence of six APOE genotypes in 1,720 participants is as following: e2/e2 (0.3%), e2/e3 (7.4%), e3/e3 (45.4%), e2/e4 (2%), e3/e4 (35%) and e4/e4 (9.9%). The e2/e2 and e4/e4 genotypes were associated with the lowest and the highest risk respectively for cognitive impairments of either MCI or AD. Further, a worse cognitive diagnosis was associated with an increasing number of APOE e4 allele in a dose dependent manner. Participants with genotype e3/e3 had a better memory measure than those with the genotype of e3/e4.</p><p><strong>Conclusions: </strong>APOE gene polymorphism is associated with different level of risks for cognitive impairments. The heterozygous genotype e3/e4 is associated with a worse memory function compared to the genotype of e3/e3. Further investigations are needed to intervene the cognitive deteriorations in those with at risk APOE genotypes.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"10 ","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2021-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002875/pdf/jarlife-10-026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9120365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicomponent Interventions Against Frailty.","authors":"D Azzolino, M Cesari","doi":"10.14283/jarlife.2021.3","DOIUrl":"10.14283/jarlife.2021.3","url":null,"abstract":"","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"10 ","pages":"17-18"},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002870/pdf/jarlife-10-017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9120368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Non-Controlled Study of a Multi-Factorial Exercise and Nutritional Intervention to Improve Functional Performance and Prevent Frailty Progression in Community-Dwelling Pre-Frail Older Adults.","authors":"W L Low, R Sultana, A B Huda Mukhlis, J C Y Ho, A Latib, E L Tay, S M Mah, H N Chan, Y S Ng, L Tay","doi":"10.14283/jarlife.2021.1","DOIUrl":"10.14283/jarlife.2021.1","url":null,"abstract":"<p><strong>Background: </strong>Preventing frailty is important to avoid adverse health outcomes. Intervention studies have largely focused on frail elderly, although the intermediate pre-frail state may be more amenable to improvement.</p><p><strong>Objectives: </strong>This study aims to assess how physical performance may change among pre-frail elderly enrolled in a pragmatic non-controlled exercise and nutritional intervention programme.</p><p><strong>Methods: </strong>This is a non-controlled study involving a 4-month exercise and nutritional intervention for community dwelling pre-frail older adults. Pre-frailty was defined as the presence of 1 or 2 positive responses on the FRAIL questionnaire, or evidence of weak grip strength (<26kg for males; <18kg for females) or slow gait speed (<0.8m/s) amongst participants who were asymptomatic on FRAIL. Physical performance in flexibility, grip and lower limb strength, endurance, balance, and Short Physical Performance Battery were measured at 3 time-points: baseline, 3-month from recruitment (without intervention), and immediate post-intervention. Repeated measures mixed model analysis was performed to compare physical performance measures across the 3 time-points.</p><p><strong>Results: </strong>94 pre-frail participants were eligible for intervention, of whom 59 (mean age = 70.9±7.2 years) were ready for the post-intervention review. 21 (35.6%) transitioned to robust phenotype while 32 (54.2%) remained as pre-frail. Significant improvement post-intervention was observed in lower limb strength and power, evident on reduction in time taken for 5 sit-to-stand repetitions (0.46±0.20s, p=0.03). There was no significant change to the other physical performance measures examined.</p><p><strong>Conclusion: </strong>We observed reversibility of pre-frailty, and the benefit of multi-component intervention in improving physical performance of pre-frail older adults. The findings in this non-controlled study will need to be corroborated with future controlled trials.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"10 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002973/pdf/jarlife-10-001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9120370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Assessment in Patients with Early-Onset Autosomal Dominant Alzheimer's Disease Due to PSEN1- E280A Genetic Variant: A Cross-Sectional Study.","authors":"M Gómez-Vega,&nbsp;E Garcia-Cifuentes,&nbsp;D Aguillon,&nbsp;J E Velez,&nbsp;A Jaramillo-Jimenez,&nbsp;D Vasquez,&nbsp;C Gómez-Henck,&nbsp;C Andrés Tobon,&nbsp;G C Deossa Restrepo,&nbsp;F Lopera","doi":"10.14283/jarlife.2021.6","DOIUrl":"https://doi.org/10.14283/jarlife.2021.6","url":null,"abstract":"<p><strong>Background: </strong>Weight loss and malnutrition are frequent findings in late-onset and sporadic presentations of Alzheimer's Disease (AD). However, less is known about nutritional status in Early-Onset Autosomal Dominant AD (EO-ADAD).</p><p><strong>Objective: </strong>To analyze the association between nutritional status and other clinical and sociodemographic characteristics in individuals with a genetic form of EO-ADAD.</p><p><strong>Design settings and participants: </strong>Cross-sectional study with 75 non-institutionalized participants from a cohort of Autosomal Dominant AD (13 with mild cognitive impairment and 61 with dementia, ages from 38 to 67 years) underwent a structured clinical assessment with emphasis on nutritional status.</p><p><strong>Measurements: </strong>Primary outcome was nutritional status and it was measured using the Mini Nutritional Assessment (MNA). Patients were categorized according to MNA total score, as undernourished (MNA ≤23.5) and well-nourished (MNA ≥ 24). Sociodemographic and clinical variables identified as potential predictors or confounders of nutritional status were also collected.</p><p><strong>Results: </strong>Undernourishment by MNA was present in 57.3% of the sample. Forty-two percent of participants had abnormal BMI values considered lower than 18.5 or higher than 24.9 kg/m2. Total BMI values were similar in well and undernourished patients (median 24.2 IQR 3.59 and median 23.9 IQR 4.42, respectively, p=0.476). When comparing well and undernourished groups, we found statistically significant differences for variables: severity of dementia (p=0.034), frailty (p=0.001), multimorbidity (p=0.035) and, polymedication (p=0.045). Neither adjusted logistic regression nor the Poisson regression showed that any clinical or sociodemographic variables explained undernourishment.</p><p><strong>Conclusions: </strong>Undernourishment was a frequent finding in our sample of EO-ADAD, especially in later stages of the disease. Patients with polymedication, multimorbidity, frailty and severe dementia show differences in their nutritional status with a tendency to be more frequently undernourished. Further studies with larger sample sizes are needed to establish this association.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"10 ","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002882/pdf/jarlife-10-032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9120367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}