JAR life最新文献

{"title":"Building a brain watch: Crafting Accurate and High-Precision Personalized Plans for Optimal Brain Performance and Sustained Functionality.","authors":"Ara S Khachaturian","doi":"10.1016/j.jarlif.2025.100013","DOIUrl":"https://doi.org/10.1016/j.jarlif.2025.100013","url":null,"abstract":"","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100013"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of psychological stress and subjective cognitive decline.","authors":"Manju Ramakrishnan, Nikhila Gandrakota, Yash Kamdar, Ambar Kulshreshtha","doi":"10.1016/j.jarlif.2025.100012","DOIUrl":"https://doi.org/10.1016/j.jarlif.2025.100012","url":null,"abstract":"<p><p>Psychological stress is associated with several long-term consequences, including cognitive decline. Our study examined the relationship between psychological stress levels and subjective cognitive decline (SCD) using cross-sectional data from CDC's Behavioral Risk Factor Surveillance System (BRFSS 2020-2022) for participants aged 45 years and older. Among 881,479 participants, 7.5 % were African American, and 10.7 % reported high psychological stress, with 29 % experiencing SCD. High psychological stress had a 3-fold risk of SCD compared to low psychological stress (OR: 3.3; 95 % CI: 2.8, 4.0). A significant interaction between psychological stress and BMI was found in their association with SCD (p = 0.013). Individuals with high psychological stress and a BMI ≥ 25 had 4.3 times higher SCD risk (OR: 4.3; 95 % CI: 3.9, 4.7) compared to those with low psychological stress and a BMI < 25 (OR: 0.23, 95 % CI: 0.2, 0.3). These results highlight the importance of addressing stress to prevent cognitive decline.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100012"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living longer and lifestyle: A report on the oldest of the old in the Adventist Health Study-2.","authors":"Hildemar Dos Santos, Alaa Alabadi-Bierman, Michael Paalani, Sen Luu Padilla, Abel Alvarez, W Lawrence Beeson, Gary E Fraser","doi":"10.1016/j.jarlif.2025.100010","DOIUrl":"https://doi.org/10.1016/j.jarlif.2025.100010","url":null,"abstract":"<p><strong>Objective: </strong>This investigation aimed to evaluate and describe the health profile and dietary patterns of the oldest Adventists (individuals aged 80 years and older).</p><p><strong>Design: </strong>Cross-sectional investigation.</p><p><strong>Setting: </strong>Self-administered lifestyle questionnaire in Adventist congregations in North America.</p><p><strong>Participants: </strong>7192 individuals aged 80 years of age or older enrolled in the Adventist Health Study-2.</p><p><strong>Measurements: </strong>Dietary intakes for participants were evaluated using a self-administered quantitative food frequency questionnaire. Selected health outcomes data were assessed with the baseline self-administered medical history questionnaire.</p><p><strong>Results: </strong>Our cohort of the old adults Adventists had a predominant female participation (62 %), and the percentage of vegetarians was 52.7 %. Based on classification into respective dietary patterns, 7.8 % of the study population were vegan, 29.2 % of the participants were lacto-ovo vegetarians, 10.2 % were pesco-vegetarians, 5.5 % were semi-vegetarians, and 47.3 % were non-vegetarians. Regarding the assessment of prevalent conditions, non-vegetarians were more likely to report having hypertension than other dietary patterns. Semi-vegetarians and non-vegetarians were more likely to report high cholesterol. A large number of participants reported never smoking (78.5 %) and never drinking alcoholic beverages (57.8 %), and non-vegetarians reported the poorest health perception (20 %) compared to vegans (11.4 %).</p><p><strong>Conclusion: </strong>Our Adventist Health oldest of the old cohort shared many of the characteristics observed among the individuals that make up the long-living cohorts worldwide as well as younger aged Adventist participants. This observation indicates the importance of non-smoking, abstinence from alcohol consumption, daily engagement in regular physical activity, avoidance of disease in older ages, and following a plant-based diet concerning the potential for successful aging.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100010"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of the body mass index in the prospective association between a healthy diet and evolution of asthma symptoms in elderly women.","authors":"Wassila Ait-Hadad, Annabelle Bédard, Laurent Orsi, Sébastien Chanoine, Orianne Dumas, Nasser Laouali, Nicole Le Moual, Bénédicte Leynaert, Valérie Siroux, Marie-Christine Boutron-Ruault, Raphaëlle Varraso","doi":"10.1016/j.jarlif.2025.100011","DOIUrl":"https://doi.org/10.1016/j.jarlif.2025.100011","url":null,"abstract":"<p><strong>Objectives: </strong>Diet and obesity exhibit complex interrelationships with asthma, particularly among elderly women. We aimed to clarify the impact of healthy diet assessed by the Alternate Healthy Eating Index-2010 (AHEI-2010) on: 1) the incidence of asthma symptoms, and 2) among women with symptoms in 2011, the change in asthma symptoms, while accounting for the potential mediating role of BMI.</p><p><strong>Design: </strong>A nested case-control study on asthma with follow-up data.</p><p><strong>Setting: </strong>Within the French E3N cohort.</p><p><strong>Participants: </strong>8621 elderly women (62 years on average in 1993).</p><p><strong>Measurements: </strong>Dietary data were collected in 1993 and 2005 using semi-quantitative questionnaires. Using the validated asthma symptom score assessed in 2011 and 2018, asthma symptom incidence among women with no asthma symptom in 2011 (<i>n</i> = 5700) and change in asthma symptoms (reduced, stable, increased) among those with asthma symptoms in 2011 (<i>n</i> = 2921) were defined. BMI was calculated in 2008. Marginal structural models were used to estimate total, direct and indirect effects mediated by BMI.</p><p><strong>Results: </strong>After adjustment for potential confounders, we found a significant indirect effect of healthier diet on lower risk of asthma symptoms incidence mediated by lower BMI (OR for AHEI-2010 quintile 5 vs quintile 1 = 0.95 (0.92-0.97)), without significant total (OR=0.87 (0.66-1.10)) nor direct (OR=0.92 (0.71-1.15)) effects. Among women with asthma symptoms, we also found a significant indirect effect of healthier diet on reduced asthma symptoms mediated by lower BMI (OR for AHEI-2010 >median <i>vs</i> ≤median=1.02 (1.00-1.03)) without significant total (OR=1.12 (0.94-1.34)) nor direct effects (OR=1.10 (0.93-1.31)).</p><p><strong>Conclusion: </strong>A healthy diet was associated with reduced risk of asthma symptoms over time, partly through a lower BMI.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100011"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centenarian physical functioning evolution and COVID-19 impact: A study in Japan.","authors":"Xinyu Zhang, Jean-Marie Robine, Yasuyuki Gondo","doi":"10.1016/j.jarlif.2025.100009","DOIUrl":"10.1016/j.jarlif.2025.100009","url":null,"abstract":"<p><strong>Background: </strong>Studies show that centenarians' physical function and activities of daily living (ADL) levels improved recently. However, it is unclear whether this positive impact has been altered due to COVID-19, causing reduced ADL. This study had two objectives: 1) to investigate whether the physical function of Japanese centenarians has improved over time, and 2) to examine the impact of COVID-19 on centenarians.</p><p><strong>Method: </strong>The data were collected from research conducted in Kyotango City from 2014 to the present. Kyotango City Hall collected data, including the functional status of all centenarians who reached 100 years of age every year. In this study, we divided nine-year cohort into three periods: 2014-2016 (P1), 2017-2019 (P2), and 2020-2022 (P3). The participation rates were 89 % (<i>n</i> = 100), 78 % (<i>n</i> = 90), and 74 % (<i>n</i> = 114), respectively.</p><p><strong>Results: </strong>The centenarians' ADL declined as the cohort aged. For basic activities of daily living (BADL), independent participants and female centenarians exhibited a proportional increase from P1 to P2 and a proportional decrease from P2 to P3, whereas male centenarians did not experience this trend. Concerning mobility, only the proportion of bedridden centenarians decreased over the three periods. Statistically significant differences in the trends of female centenarians with robust mobility and those with weak mobility were obtained in the three periods.</p><p><strong>Conclusion: </strong>The proportion of independent female centenarians declined with cohort aged in both BADL and Mobility. The opposite is true for male centenarians. This phenomenon was not affected by COVID-19.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100009"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting participation in web-based Alzheimer's questionnaire surveys: Lessons from the Japanese trial-ready cohort.","authors":"Saki Nakashima, Kenichiro Sato, Yoshiki Niimi, Tatsushi Toda, Takeshi Iwatsubo","doi":"10.1016/j.jarlif.2025.100008","DOIUrl":"10.1016/j.jarlif.2025.100008","url":null,"abstract":"<p><strong>Background: </strong>Web-based approach is considered helpful for the research focused on screening and early detection of individuals with preclinical Alzheimer's disease (AD); obtaining sufficient responses is critical to the success of such online study.</p><p><strong>Objectives: </strong>This study examined factors influencing response rates to an online survey about disease-modifying drugs for AD among participants in the Japanese Trial-Ready Cohort (J-TRC) webstudy.</p><p><strong>Design: </strong>This was a retrospective observational study.</p><p><strong>Settings: </strong>Online survey in Japan using Google Forms.</p><p><strong>Participants: </strong>We enrolled the eligible J-TRC webstudy participants who had registered before September 2023. We sent them an invitation e-mail including a questionnaire web address on November-December 2023, in order to conduct an online survey regarding their perceptions of disease-modifying therapy drug that was approved in July 2023, Japan.</p><p><strong>Measurements: </strong>We analyzed the impact of mailed day of the week (DOW), participant gender, age, employment status, and educational background with/without response to the invitation, quantified by the odds ratio of response.</p><p><strong>Results: </strong>Among approximately 10,400 J-TRC web study participants who sent invitation emails, the overall response rate was approximately 20 %, without significant influence depending on the DOW when the survey invitation was sent. Individuals who were older (50s-70s), retired, or had higher education levels were significantly more likely to respond, regardless of the DOW. Differences in response rates by sex/gender were observed, but were largely influenced by the employment status.</p><p><strong>Conclusions: </strong>In order to improve response rates and enhance data quality, these findings provide valuable insights for optimizing the design of future online studies/surveys in the field of AD and dementia, particularly for targeting cognitively unimpaired middle-aged and older populations.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100008"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is late-life vulnerability to cardiovascular disease risk associated with longitudinal tau accumulation in older adults with mild cognitive impairment?","authors":"M A Dratva, J M Diaz, M L Thomas, Q Shen, A A Tsiknia, K A Rostowsky, E E Sundermann, S J Banks","doi":"10.1016/j.jarlif.2025.100001","DOIUrl":"10.1016/j.jarlif.2025.100001","url":null,"abstract":"<p><strong>Background: </strong>Older females have higher Alzheimer's Disease (AD) risk and tau burden, especially in early disease stages, compared to males. Overlapping cardiovascular disease (CVD) and dementia risk factors, like the apolipoprotein (APOE)-ε4 allele, show mixed sex-specific results. We previously found that late-life CVD risk related more strongly to tau at a single timepoint in cognitively normal, older female APOE-ε4 carriers than in males.</p><p><strong>Objectives: </strong>Do composite and component CVD risk factors explain sex differences in tau accumulation in older adults with mild cognitive impairment (MCI) and underlying amyloid-beta (Aβ) pathology?</p><p><strong>Design: </strong>Longitudinal analysis in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.</p><p><strong>Setting: </strong>ADNI is a multi-site longitudinal study across the United States and Canada.</p><p><strong>Participants: </strong><i>n</i> = 52 older adults (aged 60-90), designated as both Aβ-positive and MCI.</p><p><strong>Measurements: </strong>CVD risk was measured by body mass index (BMI) and FRS, which includes age, systolic blood pressure (BP), high-density lipoprotein (HDL), total cholesterol, hypertension treatment, smoking, and diabetes. Regional standardized uptake value ratios (SUVRs) were extracted at each tau-PET timepoint. Composite SUVRs for Braak34 and Braak56 were calculated. Statistical models examined the separate and interactive effects of sex and APOE-ε4 on tau accumulation, and moderating effects of FRS, its components, or BMI, on tau accumulation.</p><p><strong>Results: </strong>Females accumulated more tau than males in bilateral Braak34 and right Braak56, while APOE-ε4 carriers trended toward more tau accumulation in left Braak56. FRS and its components did not relate to tau accumulation, nor influence sex effects, although they attenuated APOE-ε4 effects. In left Braak56, higher baseline BMI in males showed a trend toward greater tau accumulation.</p><p><strong>Conclusions: </strong>In MCI and Aβ-positive older adults, females accumulated more tau than males, and late-life vascular risk did not explain this relationship. Higher BMI related to more tau accumulation in males only, suggesting sex-specific vulnerability to BMI on brain health. Although replication in larger and more representative cohorts is needed, these findings corroborate accelerated tau progression in older females, independent of CVD risk, and suggest that vascular health has limited influence on tau progression once AD pathology is established in the brain.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100001"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of body composition changes and nutritional status after surgery between older Japanese patients with upper and lower gastrointestinal cancer.","authors":"Eiko Takano, Tsukasa Aritake, Kakeru Hashimoto, Yumi Suzuki, Yuichi Kitagawa, Ken Fujishiro, Yasuji Kawabata, Shinichirou Kobayashi, Izumi Kondo","doi":"10.1016/j.jarlif.2025.100006","DOIUrl":"10.1016/j.jarlif.2025.100006","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative changes in body composition and nutritional challenges are significant concerns for older patients undergoing gastrointestinal (GI) cancer surgery. This study compared body composition changes and nutritional outcomes between patients with upper gastrointestinal (UGI) and lower gastrointestinal (LGI) cancers over 12 months to identify tailored postoperative care needs.</p><p><strong>Methods: </strong>This retrospective study included 55 Japanese patients (≥65 years) who underwent curative GI cancer surgery at the National Center for Geriatrics and Gerontology between 2018 and 2022. Patients were categorized as UGI (<i>n</i> = 17) or LGI (<i>n</i> = 38). Body composition parameters, including body mass index (BMI), fat-free mass (FFM), and body fat mass (BFM), were measured preoperatively and at 1, 3, 6, and 12 months postoperatively using bioelectrical impedance analysis. Two-way repeated-measures ANOVA was conducted, adjusting for age, sex, surgical method, operation time, blood loss, infection rates, and MMSE scores to minimize bias.</p><p><strong>Results: </strong>UGI patients showed significant reductions in weight, BMI, FFM, and BFM postoperatively, indicating a higher risk of malnutrition and muscle loss. In contrast, LGI patients exhibited stable or increasing trends in these parameters. Significant time and interaction effects were observed for FFM and BFM (p<0.05), underscoring differential recovery patterns between groups.</p><p><strong>Conclusions: </strong>UGI patients face a higher risk of postoperative malnutrition and muscle loss compared to LGI patients, who showed more favorable recovery trajectories. Early, intensive nutritional interventions and personalized rehabilitation strategies are essential for mitigating muscle wasting and improving outcomes in UGI patients.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100006"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-surgical memory impairment is associated with risk of postoperative cognitive dysfunction in a large geriatric cohort.","authors":"Kiri T Granger, Claudia Spies, Sheryl Caswell, Daniel Hadzidiakos, Saya Speidel, Arjen Jc Slooter, Ilse Kant, Sophie K Piper, Simone Jt van Montfort, Jennifer H Barnett, Paula M Moran, Friedrich Borchers","doi":"10.1016/j.jarlif.2025.100002","DOIUrl":"10.1016/j.jarlif.2025.100002","url":null,"abstract":"<p><p>Some patients undergoing surgical procedures display long-term post-surgery cognitive impairment (post-operative cognitive dysfunction; POCD), which may precipitate progression to dementia. We investigated whether preoperative cognitive impairment defined using specific cognitive tests (Paired-Associates Learning and Spatial-Span from the Cambridge Neuropsychological Test Automated Battery, (CANTAB) was associated with increased risk of POCD. N = 590 patients >65years and a matched control group n=114 comprised the final sample. Patients were classified as impaired if a composite memory-score derived from two tests from the CANTAB test battery (spatial working memory and paired-associate learning) scored 1 SD below norms derived from a normative database. Risk of developing POCD 3 months post-surgery was higher [odds ratio 2.048 (95% CI 1.027 - 4.087)] for those with pre-surgical cognitive impairment compared to those with no impairment. This suggests that impairment on hippocampus-based tasks spatial-span memory and paired-associates learning is associated with increased risk for POCD in older surgical patients.</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia.","authors":"Taiki Sugimoto, Kazuaki Uchida, Yoko Yokoyama, Ayaka Onoyama, Kosuke Fujita, Yujiro Kuroda, Keigo Hinakura, Susumu Ogawa, Hiroyuki Suzuki, Yoshinori Fujiwara, Paul K Crane, Hidenori Arai, Takashi Sakurai","doi":"10.1016/j.jarlif.2025.100003","DOIUrl":"10.1016/j.jarlif.2025.100003","url":null,"abstract":"<p><strong>Background: </strong>Intervention adherence is crucial to ensure cognitive benefits in trials designed to prevent cognitive decline. During the coronavirus disease 2019 (COVID-19) pandemic, the Japan-Multimodal Intervention Trial for the Prevention of Dementia offered live online exercise sessions to older adults with mild cognitive impairment (MCI).</p><p><strong>Objectives: </strong>To assess adherence and aerobic exercise intensity through live online exercise sessions in older adults with MCI.</p><p><strong>Design: </strong>Posthoc analysis of the 18-month, multi-center, randomized controlled trial.</p><p><strong>Setting: </strong>The study was conducted across five institutions in Japan.</p><p><strong>Participants: </strong>Older adults aged 65-85 years who were assigned to the intervention group and completed the intervention. Participants were stratified by region (Aichi and Tokyo), where the state of emergency duration due to COVID-19 varied.</p><p><strong>Interventions: </strong>The intervention group participated in multidomain interventions, including 90-minute group-based physical exercise sessions held weekly for 78 sessions. During the state of emergency, live online sessions were conducted via video conferencing.</p><p><strong>Measurements: </strong>Attendance rates and aerobic exercise intensity (based on heart rates) during online and onsite sessions were compared using the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>A total of 207 participants were analyzed. Over 18 months, 78 exercise sessions were conducted, including live online sessions. In the Aichi region, 2 online sessions were held, while in the Tokyo region, 24 online sessions were conducted. In the Tokyo region, adherence was higher in online sessions compared to onsite sessions (92 % vs. 86 %, <i>p</i> = 0.046), while exercise intensity showed no significant difference (49 % vs. 52 %, <i>p</i> = 0.279). No adverse events were reported.</p><p><strong>Conclusions: </strong>Live online exercise sessions were safe, feasible, and demonstrated adherence and intensity comparable to onsite sessions.</p><p><strong>Trial registration: </strong>The trial was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) on November 24, 2019 (UMIN000038671) (https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000044075).</p>","PeriodicalId":73537,"journal":{"name":"JAR life","volume":"14 ","pages":"100003"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}