Temporal muscle thickness predicts change in nutritional markers in individuals at risk of dementia: Insights from a 24-week longitudinal study.

JAR life Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI:10.1016/j.jarlif.2025.100023

Salomón Salazar-Londoño, Valeria Pérez-Foucrier, Jonathan Patricio Baldera, Markus Aarsland, Luis Carlos Venegas-Sanabria, Miguel German Borda

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Abstract

Objectives: To investigate whether temporal muscle thickness (TMT) can serve as a predictor of change in nutritional widely used biomarkers in patients at risk of dementia.

Design: Longitudinal observational study.

Setting: Secondary analysis from a 24-week study conducted across three centers in Norway between 2018 and 2020.

Participants: Patients with mild cognitive impairment (MCI) or with two cardiometabolic disorders were included (n = 165).

Measurements: Baseline and longitudinal statistical analysis were carried out to establish the association for outcomes (albumin, weight, C-Reactive Protein and Episodic Memory Quality) with TMT.

Results: At baseline, there was a positive association between TMT and weight (Estimate=1.5157, p = 0.009). At follow-up, positive associations were observed between TMT and albumin levels (Estimate=0.3031, P = 0.048), as well as TMT and weight (Estimate=1.8954, P = 0.001).

Conclusion: TMT is a possible accessible tool in clinical practice for monitoring health variables beyond cognitive decline in patients at risk of dementia.

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颞肌厚度预测痴呆风险个体营养指标的变化：来自24周纵向研究的见解。

目的：研究颞肌厚度（TMT）是否可以作为痴呆风险患者营养广泛使用的生物标志物变化的预测因子。设计：纵向观察研究。环境：2018年至2020年期间在挪威三个中心进行的为期24周的研究的二次分析。参与者：包括轻度认知障碍（MCI）或两种心脏代谢障碍的患者（n = 165）。测量方法：进行基线和纵向统计分析，以确定结果（白蛋白、体重、c反应蛋白和情景记忆质量）与TMT的关联。结果：在基线时，TMT与体重呈正相关（估计值=1.5157,p = 0.009）。随访时，TMT与白蛋白水平呈正相关（估计值=0.3031,P = 0.048）， TMT与体重呈正相关（估计值=1.8954,P = 0.001）。结论：TMT在临床实践中可能是一种可获得的工具，用于监测痴呆风险患者认知能力下降以外的健康变量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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JAR life

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