JACC. Asia最新文献

{"title":"Echocardiography in Cardiac Amyloidosis","authors":"Shichu Liang MD , He Huang MD , Yucheng Chen MD","doi":"10.1016/j.jacasi.2025.03.002","DOIUrl":"10.1016/j.jacasi.2025.03.002","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 647-649"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Benchmark for Modern Management of Valvular Heart Disease","authors":"Yuqiang Wang MD ,&nbsp;Tingqian Cao MS ,&nbsp;Xiang Liu MS ,&nbsp;Siyu He MD ,&nbsp;Zechao Ran MD ,&nbsp;Chunlin Du MS ,&nbsp;Beiyao Lu MS ,&nbsp;Yahui Liu MS ,&nbsp;Jun Shi MD ,&nbsp;Lulu Liu MD ,&nbsp;Yongzhao Zhou MD ,&nbsp;Yingqiang Guo MD, PhD","doi":"10.1016/j.jacasi.2025.01.017","DOIUrl":"10.1016/j.jacasi.2025.01.017","url":null,"abstract":"<div><div>Valvular heart disease (VHD) is rapidly increasing in prevalence worldwide, affecting millions and significantly impacting global health care systems. Despite notable advancements in understanding VHD progression, perioperative management, imaging techniques, and transcatheter therapies over the past 2 decades, the condition has not received the attention it deserves from the public and policymakers. Many patients with VHD in low- and middle-income countries continue to experience low detection, intervention, and follow-up rates. Systematic care for elderly patients and those with severe comorbidities, as well as postoperative patients, remains insufficient, leading to higher mortality and morbidity rates. This review focuses on the deficiencies in VHD treatment within the Chinese health care system and discusses the modern management program, known as the whole-life cycle management system, that has been implemented to enhance the survival prognosis of VHD patients.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 609-632"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic Features of Wild-Type Transthyretin Cardiac Amyloidosis From J-Case","authors":"Shuichi Kitada MD, PhD ,&nbsp;Yu Kawada MD, PhD ,&nbsp;Yasuhiro Shintani MD, PhD ,&nbsp;Junki Yamamoto MD, PhD ,&nbsp;Shohei Kikuchi MD, PhD ,&nbsp;Hiroki Usuku MD, PhD ,&nbsp;Kenichi Tsujita MD, PhD ,&nbsp;Yuri Ochi MD, PhD ,&nbsp;Toru Kubo MD, PhD ,&nbsp;Hirohiko Motoki MD, PhD ,&nbsp;Hiroyuki Iwano MD, PhD ,&nbsp;Takatomo Watanabe MD, PhD ,&nbsp;Nobuyuki Ohte MD, PhD ,&nbsp;Yoshihiro Seo MD, PhD","doi":"10.1016/j.jacasi.2025.01.016","DOIUrl":"10.1016/j.jacasi.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) occurs at a high prevalence in older patients with left ventricular (LV) hypertrophy. However, detecting ATTRwt-CA using echocardiography is challenging.</div></div><div><h3>Objectives</h3><div>This study identified echocardiographic findings characterizing ATTRwt-CA compared with monoclonal immunoglobulin light chain cardiac amyloidosis (CA) and hereditary transthyretin CA.</div></div><div><h3>Methods</h3><div>We conducted a multicenter, retrospective study on the echocardiographic findings characterizing ATTRwt-CA. J-CASE (Japan Cardiac Amyloidosis Survey of typical Echocardiographic findings) analyzed echocardiographic data in 311 patients with histologically proven amyloid deposition in the myocardium and diagnosis of transthyretin CA or monoclonal immunoglobulin light chain CA.</div></div><div><h3>Results</h3><div>Among the cohort, 172 patients (55.3%) were diagnosed with ATTRwt-CA. A multiple discriminant analysis revealed that LV hypertrophy with a more extensive LV mass index but relatively modest interventricular septum thickening and enlargement of maximal papillary muscle diameter were significant echocardiographic findings characterizing ATTRwt-CA. In addition to the patient backgrounds such as advanced age, male sex, concomitant diabetes mellitus, hyperlipidemia, carpal tunnel syndrome, and paroxysmal atrial fibrillation, the discriminant model, including these echocardiographic findings showed significant discriminant power of ATTRwt-CA from the other subtypes (83.8% accuracy with 86.0% positive predictive value and 81.4% negative predictive value, when the sensitivity and specificity are at their maximum values of the model).</div></div><div><h3>Conclusions</h3><div>In the J-CASE data set, LV hypertrophy with a more extensive LV mass index but relatively modest interventricular septum thickening and enlargement of papillary muscle diameter significantly characterized ATTRwt-CA. These findings may lead to more accurate screening echocardiography for diagnosing ATTRwt-CA and motivate the subsequent comprehensive clinical diagnostic process, including multimodality imaging.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 633-646"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Cumulative Low-Density Lipoprotein Cholesterol Exposure on Endothelial Function in Subjects Receiving Lipid-Lowering Drugs","authors":"Takayuki Yamaji MD, PhD ,&nbsp;Farina Mohamad Yusoff MBBS, PhD ,&nbsp;Shinji Kishimoto MD, PhD ,&nbsp;Masato Kajikawa MD, PhD ,&nbsp;Takahiro Harada MD, PhD ,&nbsp;Aya Mizobuchi MS ,&nbsp;Shunsuke Tanigawa MS ,&nbsp;Tatsuya Maruhashi MD, PhD ,&nbsp;Ayumu Nakashima MD, PhD ,&nbsp;Yukihito Higashi MD, PhD","doi":"10.1016/j.jacasi.2025.02.015","DOIUrl":"10.1016/j.jacasi.2025.02.015","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 691-694"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of SCAI Classification in Postcardiotomy Cardiogenic Shock Risk Stratification","authors":"Kitae Kim MD,&nbsp;Joon Bum Kim MD, PhD","doi":"10.1016/j.jacasi.2025.02.002","DOIUrl":"10.1016/j.jacasi.2025.02.002","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 677-678"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Modalities on Coronary Perforation in Complex Coronary Intervention","authors":"Kenji Sadamatsu MD, PhD ,&nbsp;Yoshihiro Fukumoto MD, PhD","doi":"10.1016/j.jacasi.2025.02.012","DOIUrl":"10.1016/j.jacasi.2025.02.012","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Page 699"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2772-3747(25)00214-5","DOIUrl":"10.1016/S2772-3747(25)00214-5","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages I-XCVI"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Problems of Rheumatic Heart Disease in Indonesia: The Ina-RHD Multicenter Study.","authors":"Amiliana Mardiani Soesanto, Prima Almazini, Rina Ariani, Estu Rudiktyo, Tengku Winda Ardini, Hasanah Mumpuni, Achmad Lefi, Aussie Fitriani Ghaznawie, Ni Made Ayu Wulan Sari, Mefri Yanni, Niniek Purwaningtyas, Rille Puspitoadhi Harjoko, Melawati Hasan, Siti Elkana Nauli, Fitranti Suciati Laitupa, Novita Muchtar, Wella Karolina, Indah Puspita, Gratiani Eben Haezer Reppi, Dyna Evalina Syahlul, Nia Dyah Rahmianti, Rinelia Minaswary, Yasmina Hanifah, Ario Soeryo Kuncoro","doi":"10.1016/j.jacasi.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.010","url":null,"abstract":"<p><strong>Background: </strong>Rheumatic heart disease (RHD) presents a significant public health challenge. Unfortunately, there is a lack of national data regarding the incidence and prevalence of RHD in Indonesia.</p><p><strong>Objectives: </strong>The purpose of this study was to evaluate the characteristics, burdens, and problems of RHD in Indonesia.</p><p><strong>Methods: </strong>We collected medical reports of RHD patients over 18 years of age from 21 hospitals. Secondary data about clinical and echocardiography was collected to describe the characteristics, disease conditions, and complications of the disease.</p><p><strong>Results: </strong>We recruited 3,431 patients, average age was 44 years, and 64.4% (2,209 of 3,431) were women. Dyspnea was found in 85.7% (2,939 of 3,431), and 25% (862 of 3,431) of patients with NYHA functional class III to IV. Isolated mitral stenosis was the most prevalent valve lesion in 1,357 of 3,431 patients (39.6%). A total of 62.5 % (2,146 of 3,431) of patients had atrial fibrillation (AF), with the highest prevalence being in MV lesions. Vitamin K antagonist was prescribed in 2,411 of 3,431 (70.3%) of patients. A history of stroke was reported in 227 of 3,431 (6.6%) of patients and most frequently happened in isolated mitral stenosis patients 128 of 1,357 (9.4%). Finally, secondary prophylaxis was only administered in 1,279 of 3,431 (37.3%) of patients, and only 23.2% (796 of 3,431) had it regularly.</p><p><strong>Conclusions: </strong>Our patients were predominantly women and had isolated mitral stenosis. Many patients came at a later stage of the disease, with older average age, a high prevalence of AF, pulmonary hypertension, and right heart involvement. The challenges were suboptimal use of anticoagulation despite the high prevalence of AF and underused secondary prophylaxis.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Landscape of Translational Medicine of Calcific Aortic Valve Disease","authors":"Xingyu Qian MD ,&nbsp;Li Xu MD ,&nbsp;Bingchuan Geng PhD,&nbsp;Fei Li MD,&nbsp;Nianguo Dong MD, PhD","doi":"10.1016/j.jacasi.2025.01.014","DOIUrl":"10.1016/j.jacasi.2025.01.014","url":null,"abstract":"<div><div>Calcific aortic valve disease (CAVD) is a prevalent condition characterized by pathological thickening and calcification of the aortic valve, leading to increased pressure overload and cardiac remodeling, particularly in individuals aged 65 and older. This review synthesizes recent advances in understanding the pathogenesis of CAVD, focusing on key mechanisms including hemodynamic alterations, endothelial dysfunction, lipid deposition, inflammation, and fibrotic calcification. We evaluate emerging therapeutic targets based on pivotal basic research and clinical trials, highlighting the potential for mechanism-oriented interventions. Furthermore, we explore the implications of lipid-lowering therapies, anti-inflammatory strategies, and antifibrocalcific agents, as well as novel bioprosthetic designs aimed at enhancing patient outcomes. Additionally, we discuss the inherent genetic and molecular backgrounds influencing individual susceptibility to CAVD, emphasizing the promise of personalized therapy. By bridging the gap between basic science and clinical application, this review aims to guide future research efforts toward more effective prevention and treatment strategies for CAVD.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 503-515"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-Year Outcomes of PT-Valve for Pulmonary Regurgitation in Native Outflow Tract","authors":"ChangYu Qin MD ,&nbsp;ChangDong Zhang MD ,&nbsp;Mei Liu PhD ,&nbsp;XiaoKe Shang PhD ,&nbsp;NianGuo Dong PhD","doi":"10.1016/j.jacasi.2024.12.014","DOIUrl":"10.1016/j.jacasi.2024.12.014","url":null,"abstract":"<div><h3>Background</h3><div>Severe pulmonary regurgitation (PR) in patients with postoperative congenital heart disease is often accompanied by extensive variability of right ventricular outflow tract (RVOT) anatomy, which limited the wide application of existing transcatheter pulmonary valves device.</div></div><div><h3>Objectives</h3><div>This study sought to evaluate 1-year safety and efficacy of the PT-Valve in the treatment of PR patients presenting with native RVOT from a multicenter, single-arm clinical trial.</div></div><div><h3>Methods</h3><div>We enrolled 130 patients of moderate or greater PR. One-year clinical outcomes are reported.</div></div><div><h3>Results</h3><div>Within the cohort (mean age 30 ± 16 years; 52% men), 124 (95%) were diagnosed with tetralogy of Fallot. The procedure success rate was 98.5%. Early explants occurred to 2 device malpositions and 1 pulmonary branch obstruction. At 1 year, there were no procedure- or device-related mortality. Device-related adverse events included 2 arrhythmias, 1 pulmonary thromboembolism, 2 endocarditis, and 1 vascular access complication. Echocardiography examinations showed that 125 (99%) patients had none/trace and mild PR, and no greater than mild paravalvular leak at 1-year visit. The mean peak pulmonary gradient was 20.0 ± 17.4 mm Hg and 16.0 ± 7.8 mm Hg at baseline and 1 year after implantation, respectively. The right ventricular end-diastolic volume index was reduced from 176.3 ± 28.4 mL/m² at baseline to 121.1 ± 20.7 mL/m² at 1 year (<em>P &lt;</em> 0.001).</div></div><div><h3>Conclusions</h3><div>The PT-Valve demonstrated a high success rate of implantation and favorable safety and efficacy in the treatment of PR through 1 year. This device is anatomically suitable for more than 90% of PR patients with native RVOT. (Prospective, Single Arm, Multi-Center Clinical Study on the Safety And Efficacy of the Sterile Transcatheter Pulmonary Valve and Delivery System; <span><span>ChiCTR2100043367</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 568-581"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}