JACC. Asia最新文献

{"title":"The Paradox of Aortic Valve Prolapse in Transcatheter Closure of Ventricular Septal Defects.","authors":"Ka-Chun Un, Chun-Ka Wong","doi":"10.1016/j.jacasi.2026.08.002","DOIUrl":"https://doi.org/10.1016/j.jacasi.2026.08.002","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Uric Acid and Cardiovascular Risk","authors":"Sunao Kojima MD, PhD,&nbsp;Kensuke Nishimiya MD, PhD,&nbsp;Ichiro Hisatome MD, PhD","doi":"10.1016/j.jacasi.2026.05.024","DOIUrl":"10.1016/j.jacasi.2026.05.024","url":null,"abstract":"<div><div>Urate-lowering trials have not consistently demonstrated benefits in preventing coronary events, revealing an interventional gap and challenging the causal role of uric acid in cardiovascular disease. Advances in dual-energy computed tomography have revealed monosodium urate crystal deposition within vessel walls and atherosclerotic plaques, leading to the concept of vascular gout. Persistent hyperuricemia, particularly in Asian populations characterized by urate underexcretion, may facilitate crystal deposition and innate immune pathway activation. These inflammatory processes may promote vascular inflammation, plaque instability, and cardiovascular events. Xanthine oxidase inhibition effectively lowers serum uric acid levels and reduces monosodium urate crystal burden in articular tissues. However, whether urate-lowering therapy reduces monosodium urate crystal deposition and crystal-driven inflammation within the vascular wall remains unknown. Therefore, we aimed to reframe uric acid from a metabolic marker to a mediator of urate crystal-driven vascular inflammation and discuss future therapeutic strategies targeting crystal burden and inflammation in Asian populations.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 1897-1916"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TAVR for Women","authors":"Dritan Useini MD, PhD","doi":"10.1016/j.jacasi.2026.06.036","DOIUrl":"10.1016/j.jacasi.2026.06.036","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Page 2144"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiographic Radial Wall Strain","authors":"Rui Zhang MD,&nbsp;Lei Song MD","doi":"10.1016/j.jacasi.2026.07.027","DOIUrl":"10.1016/j.jacasi.2026.07.027","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (196KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 2015-2017"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Rehabilitation for All","authors":"Andrew Maiorana BSc, MSc, PhD","doi":"10.1016/j.jacasi.2026.07.022","DOIUrl":"10.1016/j.jacasi.2026.07.022","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (205KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 2078-2079"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the Evidence Base for Tricuspid TEER","authors":"Tsz-Ho Chan MBBS,&nbsp;Kent Chak-yu So MBChB","doi":"10.1016/j.jacasi.2026.07.013","DOIUrl":"10.1016/j.jacasi.2026.07.013","url":null,"abstract":"<div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (175KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 1969-1971"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Transcatheter Edge-to-Edge Repair System for Degenerative Mitral Regurgitation","authors":"Da Zhu MD,&nbsp;Zhenfei Fang MD,&nbsp;Xianbao Liu MD,&nbsp;Nan Zhang MSc,&nbsp;Yuhao Liu MD,&nbsp;Yan Wang MD,&nbsp;Liang Ma MD,&nbsp;Jinjun Liu MD,&nbsp;Jian Yang MD,&nbsp;Yan Li MD,&nbsp;Caidong Luo MD,&nbsp;Xiaoping Peng MD,&nbsp;Wei Zhong MD,&nbsp;Liangwan Chen MD,&nbsp;Jian Xu MD,&nbsp;Fan Ouyang MD,&nbsp;Jiancheng Xiu MD,&nbsp;Jinping Liu MD,&nbsp;Ben He MD,&nbsp;Mao Chen MD,&nbsp;Xiangbin Pan MD","doi":"10.1016/j.jacasi.2026.04.013","DOIUrl":"10.1016/j.jacasi.2026.04.013","url":null,"abstract":"<div><h3>Background</h3><div>For patients with severe degenerative mitral regurgitation (DMR) at prohibitive or high surgical risk, transcatheter edge-to-edge repair (TEER) has become an effective alternative. The GeminiOne is a novel TEER device featuring a unique groove-cam mechanism.</div></div><div><h3>Objectives</h3><div>This study reports the primary, secondary, and 1-year outcomes of the GeminiOne-DMR (Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation) trial.</div></div><div><h3>Methods</h3><div>A total of 120 patients with prohibitive surgical risk and DMR grade ≥3+ were enrolled and evaluated by an independent echocardiography core laboratory and a clinical event committee. The primary endpoint was clinical success, defined as freedom from all-cause mortality, mitral valve reintervention, and mitral regurgitation &gt;2+ at 1-year follow-up.</div></div><div><h3>Results</h3><div>At 1 year, the clinical success rate was 89.84% ± 2.78% (95% CI: 84.56%-95.46%), meeting the prespecified primary efficacy endpoint. The rates of freedom from 1-year all-cause mortality, major adverse events, mitral valve reintervention, and heart failure hospitalization were 97.48% ± 1.35%, 91.61% ± 2.54%, 98.31% ± 1.02%, and 94.00% ± 2.20%, respectively. Mitral regurgitation ≤2+ was achieved in 92.24% of patients at 1 year. Significant improvements were observed in functional and quality-of-life outcomes, with the proportion of patients classified as NYHA funcional class I/II increasing from 23.33% at baseline to 94.74% at 1 year (<em>P</em> &lt; 0.001), and Kansas City Cardiomyopathy Questionnaire scores also improving significantly from baseline to 1 year (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This trial demonstrated the initial safety and efficacy of the GeminiOne TEER system for treating significant symptomatic DMR in patients at prohibitive or high surgical risk. (Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation; <span><span>NCT05655897</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 1946-1956"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paclitaxel-Coated Balloon for Coronary In-Stent Restenosis and De Novo Disease in Chinese Patients","authors":"Tse-Min Lu MD,&nbsp;Hsu-Lung Jen MD,&nbsp;Hee Hwa Ho MD,&nbsp;Chiung Ray Lu MD,&nbsp;Cheng-Ting Tsai MD,&nbsp;Feng-Yu Kuo MD,&nbsp;Simon Cheung-Chi Lam MD,&nbsp;Ji-Hung Wang MD,&nbsp;Jack Livingston MSBE,&nbsp;Rafael Cavalcante MD, PhD,&nbsp;Hsien-Li Kao MD","doi":"10.1016/j.jacasi.2026.06.008","DOIUrl":"10.1016/j.jacasi.2026.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Drug-coated balloons provide antiproliferative therapy without permanent implants and may benefit lesion subsets where drug-eluting stent performance is suboptimal.</div></div><div><h3>Objectives</h3><div>The authors aimed to evaluate safety and effectiveness of a paclitaxel-coated balloon in a real-world cohort of ethnically Chinese patients with in-stent restenosis (ISR) or de novo coronary artery disease.</div></div><div><h3>Methods</h3><div>This was a prospective, multicenter, single-arm registry across 9 sites in Taiwan, Hong Kong, and Singapore. Patients undergoing percutaneous coronary intervention with paclitaxel-coated balloon (AGENT, Boston Scientific Corp.) for ISR or de novo coronary artery disease were included. Primary endpoint was 12-month major adverse cardiac events (MACEs; cardiac death, myocardial infarction, or target vessel revascularization). Secondary endpoints included target lesion revascularization, target lesion thrombosis, and 9-month angiographic outcomes. Events adjudicated by independent clinical events committee; angiography analyzed by independent core laboratory.</div></div><div><h3>Results</h3><div>A total of 500 patients (mean age 65.6 ± 11.2) were enrolled. At 365 days (IQR: 354-379) after the index procedure, 13.9% (68 of 489) of patients experienced MACE. MACE rates were 16.3% (48 of 294) and 10.5% (20 of 191), in ISR and de novo patients, respectively. Cardiac death and myocardial infarction rates were 1.6% (8 of 489) and 2.0% (10 of 489), respectively; target vessel revascularization occurred in 11.7% (57 of 489). Angiographic follow-up was performed in 35% (175 of 500) of patients. The 12-month MACE was significantly higher in patients undergoing surveillance angiography compared to without (26.9% [47 of 175] vs 4.9% [15 of 305], <em>P</em> &lt; 0.001), driven by increased target lesion revascularization.</div></div><div><h3>Conclusions</h3><div>Paclitaxel-coated balloon was safe and effective in ethnically Chinese patients. Surveillance imaging significantly influenced revascularization rates, underscoring its impact on clinical decision-making. (An \"All-Comers\" Study of the AgentTM MONORAILTM Paclitaxel-Coated PTCA Balloon Catheter Used in Real-World Clinical Practice in Chinese Patients; <span><span>NCT04085445</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 2018-2029"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Rehabilitation Improves Outcomes After Thoracic Aortic Aneurysm Repair","authors":"Chiemi Yamazaki MD,&nbsp;Atsuko Nakayama MD, PhD,&nbsp;Junko Sakamoto PT,&nbsp;Noriko Ishii RN, MSN,&nbsp;Kentaro Hori PT,&nbsp;Tomohiro Iwakura MD, PhD,&nbsp;Mamoru Nanasato MD, PhD,&nbsp;Mitsuaki Isobe MD, PhD","doi":"10.1016/j.jacasi.2026.04.018","DOIUrl":"10.1016/j.jacasi.2026.04.018","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac rehabilitation (CR) improves prognosis in patients with ischemic heart disease and heart failure. However, its effectiveness in aortic diseases, such as thoracic aortic aneurysms (TAA), remains unclear.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the effects of outpatient CR on major adverse cardiovascular events (MACEs) and all-cause mortality after open repair surgery for TAA.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 1,710 patients who underwent open TAA repair between 2003 and 2015. Patients were divided into a CR group (n = 419) and a non-CR group (n = 1,193). Follow-up duration was 1,603 (734-2,301) days in the CR group and 1,169 (610-1,991) days in the non-CR group. Propensity score matching was used to balance the baseline characteristics. Primary outcomes were MACE and all-cause mortality.</div></div><div><h3>Results</h3><div>After matching, the CR group exhibited a significantly lower incidence of MACEs (HR: 0.58; 95% CI: 0.34-0.97; <em>P</em> = 0.039) and all-cause mortality (HR: 0.59; 95% CI: 0.37-0.94; <em>P</em> = 0.026). The 5-year estimated all-cause mortality rate was 7.5% (95% CI: 4.9%-11.3%) and 12.3% (95% CI: 8.7%-17.3%), respectively. Cardiovascular deaths were 1.7% (7 of 419) and 2.9% (35 of 1,193) in the CR and non-CR groups, respectively (<em>P</em> = 0.17). Former smoking was independently associated with higher all-cause mortality (HR: 2.69; 95% CI: 1.62-4.45; <em>P</em> = 0.001). In former smokers, CR was associated with lower all-cause mortality (log-rank <em>P</em> = 0.008).</div></div><div><h3>Conclusions</h3><div>Outpatient CR following TAA surgery was associated with reduced risks of MACE and all-cause mortality, even in the patients with former smoking.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 2066-2077"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valve Deterioration After Supra-Annular Transcatheter Aortic Valve Replacement","authors":"Ying-Hwa Chen MD, PhD,&nbsp;Hsiao-Huang Chang MD, PhD,&nbsp;Wei-Ting Wang MD,&nbsp;Hsin-Bang Leu MD,&nbsp;I-Ming Chen MD, PhD,&nbsp;Su-Man Lin MD","doi":"10.1016/j.jacasi.2026.05.022","DOIUrl":"10.1016/j.jacasi.2026.05.022","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"6 9","pages":"Pages 2126-2129"},"PeriodicalIF":6.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}