JACC. Asia最新文献

{"title":"Nationwide Epidemiology and Management Time Trends for Atrial Fibrillation: Insights From the Korean AF Factsheet.","authors":"So-Ryoung Lee, Daehoon Kim, Yun Gi Kim, Pil-Sung Yang, Ki Hong Lee, Jaemin Shim, Bong-Seong Kim, Kyung-Do Han, Eue-Keun Choi","doi":"10.1016/j.jacasi.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.012","url":null,"abstract":"<p><p>Atrial fibrillation (AF) represents the most prevalent cardiac arrhythmia in clinical practice, with its incidence rising globally. Korea's comprehensive national health insurance system facilitates the meticulous collection and management of health care utilization data for its entire population. This robust data infrastructure has enabled numerous recent studies on AF in Korea, encompassing its prevalence, incidence, anticoagulation treatment rates, health care burden, and associated complications. A comprehensive understanding of AF epidemiology and patient characteristics is essential for enhancing both primary and secondary prevention strategies and improving clinical outcomes. This review presents an up-to-date analysis of AF epidemiology, patient demographics, and treatment modalities in Korea, drawing from the extensive Korea National Health Insurance Service database.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Modifiable Lifestyle Factors and Incident Cardiac Conduction Disease.","authors":"Jiwen Zhong, Rui Tang, Liuxin Li, Wei Zheng, Shuohua Chen, Jun Feng, Jingli Qu, Xi Wang, Yu Yin, Yu Yuan, Shouling Wu","doi":"10.1016/j.jacasi.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.009","url":null,"abstract":"<p><strong>Background: </strong>The associations between modifiable lifestyles and cardiac conduction disease (CCD) are poorly studied.</p><p><strong>Objectives: </strong>The study aimed to prospectively assess the association between modifiable lifestyle factors and incident CCD.</p><p><strong>Methods: </strong>A total of 89,377 participants (aged 18-90 years) free of CCD at baseline were enrolled in the Kailuan cohort. Lifestyle factors, including smoking, alcohol consumption, physical activity, sedentary behavior, and nighttime sleep duration, were collected to test the relations of both baseline and long-term lifestyle factors with incident CCD.</p><p><strong>Results: </strong>During 1,226,634.1 person-years of follow-up (median: 14.1 years; Q1-Q3: 13.8-14.2 years), 3,723 CCD cases (3.04 per 1,000 person-years; 95% CI: 2.94-3.13 person-years) were identified. Compared with the participants who had healthy lifestyles at baseline, the adjusted HRs for participants who consumed alcohol ≥5 drinks per day, had sedentary behavior ≥4 hours per day, and had night sleep ≥9 hours per day were 1.16 (95% CI: 1.04-1.32), 1.12 (95% CI: 1.03-1.22), and 1.32 (95% CI: 1.02-1.68), respectively. Furthermore, compared with the participants adhered to long-term healthy lifestyles, the adjusted HRs for participants who chronically consumed alcohol ≥5 drinks per day, had sedentary behavior ≥4 hours per day, and had night sleep ≥9 hours per day were 2.16 (95% CI: 1.68-2.79), 1.77 (95% CI: 1.50-2.09), and 1.67 (95% CI: 1.25-2.24), respectively.</p><p><strong>Conclusions: </strong>The study revealed excessive alcohol consumption, high sedentary behavior, and longer sleep duration were associated with higher risks of CCD in adults. The findings supported the beneficial impact of a low-risk lifestyle on the primary prevention of CCD.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Heterogeneity in the Risk of Thrombosis and Bleeding in Patients With Peripheral Artery Disease.","authors":"Shinya Goto, Daisuke Yamasawa, Shinichi Goto","doi":"10.1016/j.jacasi.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.007","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implication of the Dose of Mineralocorticoid Receptor Antagonist Following Transcatheter Edge-To-Edge Mitral Valve Repair.","authors":"Teruhiko Imamura, Shuhei Tanaka, Nobuyuki Fukuda, Hiroshi Ueno, Koichiro Kinugawa, Shunsuke Kubo, Masanori Yamamoto, Yuki Izumi, Mike Saji, Masahiko Asami, Yusuke Enta, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Toru Naganuma, Hiroki Bota, Yohei Ohno, Daisuke Hachinohe, Masahiro Yamawaki, Kazuki Mizutani, Toshiaki Otsuka, Kentaro Hayashida","doi":"10.1016/j.jacasi.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.014","url":null,"abstract":"<p><strong>Background: </strong>Mineralocorticoid receptor antagonists (MRAs) are integral components of medical therapy for patients with heart failure with reduced ejection fraction. However, implication of MRA dosing in older patients undergoing transcatheter edge-to-edge mitral valve repair (TEER) for secondary mitral regurgitation remains uncertain.</p><p><strong>Objectives: </strong>The authors aimed to investigate the prognostic impacts of MRA dosing in older patients receiving TEER for secondary mitral regurgitation.</p><p><strong>Methods: </strong>This study included patients who underwent TEER and were enrolled in the OCEAN (Optimized CathEter vAlvular iNtervention)-Mitral registry. Patients with a left ventricular ejection fraction <50% and secondary mitral regurgitation were selected. The dose-dependent effects of MRA, administered at discharge, on the 2-year composite outcome of all-cause mortality and heart failure hospitalization were evaluated.</p><p><strong>Results: </strong>A total of 2,026 patients (median age 77 years; 1,287 men) were included and followed for a median 416 days (Q1-Q3: 294-730 days). Post-TEER, the administration of MRA at a dose of ≥12.5 mg/d (ie, any doses of MRA) was independently associated with a lower 2-year cumulative incidence of the primary composite outcome, with an adjusted HR of 0.83 (95% CI: 0.69-0.99; P = 0.046). In contrast, higher doses of MRA were not significantly associated with a further reduction in the risk of the primary outcome (P = 0.97).</p><p><strong>Conclusions: </strong>In older patients who underwent TEER for secondary mitral regurgitation caused by systolic heart failure, even a low-dose MRA was associated with improved clinical outcomes compared with no MRA administration. However, further up-titration of the MRA dose did not result in additional improvements in clinical outcomes. (OCEAN-Mitral registry; UMIN000023653).</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term and Time-Dependent Association of Predictors on Mortality in Patients With Iliofemoral Artery Disease.","authors":"Yoshimitsu Soga, Mitsuyoshi Takahara, Osamu Iida, Kenji Suzuki, Shinsuke Mori, Daizo Kawasaki, Kazuki Haraguchi, Terutoshi Yamaoka, Kenji Ando","doi":"10.1016/j.jacasi.2025.03.013","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.013","url":null,"abstract":"<p><strong>Background: </strong>Although several predictors affect long-term mortality in patients with lower extremity artery disease, long-term association of predictors on mortality over time remain unclear.</p><p><strong>Objectives: </strong>The aim of this study was to explore the long-term and time-dependent association of baseline characteristics with mortality in patients with iliofemoral arterial disease.</p><p><strong>Methods: </strong>This study is a multicenter retrospective analysis of 4,086 consecutive patients (mean age 72 ± 9 years, 74% men) who underwent endovascular therapy for symptomatic de novo iliofemoral arterial disease between January 2004 and December 2011 at 16 cardiovascular centers in Japan.</p><p><strong>Results: </strong>During the median follow-up of 3.8 years (Q1-Q3: 1.4-7.4 years), 1,100 deaths, and 637 major adverse cardiovascular events (MACE) (defined as death, myocardial infarction, and stroke) were observed. Overall survival and MACE-free rates were estimated to be 56.1% and 50.6% at 10 years. Old age, chronic kidney disease stage, heart failure, the lack of renin-angiotensin-system inhibitor use, chronic limb threatening ischemia (CLTI), decreased ankle-brachial index, femoropopliteal lesion were significantly associated with an increased risk of mortality. while the prognostic impact of CLTI was significantly attenuated afterwards. Old age, chronic kidney disease stage, cerebrovascular disease, coronary artery disease, heart failure, warfarin use, the lack of statin use, and CLTI were significantly associated with an increased risk of MACE, while the prognostic impact of cerebrovascular disease and CLTI was significantly attenuated afterwards.</p><p><strong>Conclusions: </strong>This study demonstrated long-term and time-dependent association of predictors on mortality and MACE following endovascular therapy. It highlights the need for continuous management of cardiovascular risk factors in this high-risk population.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Valvular Heart Disease in Asia Pacific Region.","authors":"Kent Chak-Yu So, Jonathan Yap, Guang-Yuan Song, Karl Poon, Shih-Hsien Sung, Mann Chandavimol, Kentaro Hayashida, Duk-Woo Park, See-Hooi Ewe, Mi Chen, Vyanne Hei-Tung Chan, Juri Iwata, Tarinee Tangcharoen, Paul Tern, Han-Su Park, Mirvat Alasnag, Yohei Ohno, Jimmy Kim Fatt Hon, Rohan Bhagwandeen, Minoru Tabata, Alex Pui-Wai Lee, Hasan Jilaihawi, Dee Dee Wang, Gilbert H L Tang, D Scott Lim, Thomas Modine, Yat-Yin Lam","doi":"10.1016/j.jacasi.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.03.011","url":null,"abstract":"<p><p>Valvular heart disease poses a significant health burden in the Asia-Pacific region, with its epidemiology varying widely across countries caused by diverse socioeconomic and health care situations. Rheumatic heart disease remains prevalent, especially in low- to middle-income areas, while degenerative valvular diseases are emerging in developed regions caused by an aging population. Significant disparities in access to health care and intervention result in variable clinical outcomes. In the past decade, transcatheter interventions have revolutionized the management of patients with valvular heart disease globally. In the Asia-Pacific region, the uptake and development of transcatheter valvular interventions has been slow until recent years. Continued collaboration across the Asia-Pacific region is essential to mitigate the impact of the upcoming surge of valvular heart disease in this diverse and rapidly changing area.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"China Multi-Center Cohort Study on Risk Evaluation of Arrhythmogenic Cardiomyopathy (ChinaCORE ACM) Registry.","authors":"Yuxiao Hu, Zhongli Chen, Anteng Shi, Zemeng Li, Zixian Chen, Yingying Zheng, Xi Zhao, Shimo Dai, Yubi Lin, Yifei Li, Bing Yang, Xiaoyan Zhao, Guoliang Li, Xianliang Zhou, Shengshou Hu, Lingmin Wu, Liang Chen","doi":"10.1016/j.jacasi.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.04.005","url":null,"abstract":"<p><strong>Background: </strong>Arrhythmogenic cardiomyopathy (ACM) patients in China exhibit unique genetic and clinical characteristics. There is a lack of prognostic models specific to Chinese ACM patients.</p><p><strong>Objectives: </strong>This study aims to establish a large, national ACM patient cohort with uniformly collected, high-quality data for future risk prediction.</p><p><strong>Methods: </strong>This study includes patients with definite or borderline ACM diagnoses, along with their genotype-positive relatives. At baseline, comprehensive data collection includes medical history, electrocardiograms, imaging data, genetic testing, and laboratory evaluations. Outcome data include heart failure events and malignant ventricular arrhythmias (MVA).</p><p><strong>Results: </strong>As of September 2024, the registry has enrolled 622 participants, including 552 probands (88.7%) and 70 family members (11.3%) carrying ACM-related variants. Preliminary cohort includes 577 patients (92.8%), of whom 495 were diagnosed with definite ARVC. The median age of symptom onset was 33.0 years (IQR: 22.0-45.0), with 41.6% experiencing arrhythmia-related symptoms. Abnormal ECG findings included T-wave inversion (72.7%) and epsilon waves (24.8%) in leads V1-V3. Imaging evaluation revealed RV dilatation in 44.6% and LV dilatation in 29.8%, with a mean LVEF of 53.0 ± 14.5%. Regarding outcomes, malignant ventricular arrhythmias (MVA) occurred in 255 (40.1%) individuals, while 21.9% developed end-stage heart failure (ESHF), including 35 individuals who died from heart failure and 101 patients who underwent heart transplantation.</p><p><strong>Conclusions: </strong>China multi-center cohort study on risk evaluation of ACM (ChinaCORE ACM) registry is a national, longitudinal, observational cohort study. This study contributes to expanding the understanding of the disease spectrum of Chinese ACM patients and improving prognostic predictions.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Significance of Time Between Balloon and Peak CK-MB in AMI Patients Undergoing Primary PCI","authors":"Eiji Shibahashi MD, PhD ,&nbsp;Ryoko Kawakami PhD ,&nbsp;Noritoshi Fukushima MD, PhD ,&nbsp;Issei Ishida MD ,&nbsp;Hisao Otsuki MD, PhD ,&nbsp;Takehiro Hata MD ,&nbsp;Kazuho Kamishima MD, PhD ,&nbsp;Kensuke Shimazaki MD ,&nbsp;Takahiro Yamada MD ,&nbsp;Natsuko Shiozaki MD ,&nbsp;Shohei Kataoka MD, PhD ,&nbsp;Yuta Morioka MD ,&nbsp;Toshiaki Oka MD, PhD ,&nbsp;Yutaka Terajima MD, PhD ,&nbsp;Yoshimi Ota MD ,&nbsp;Katsumi Saito MD, PhD ,&nbsp;Atsushi Honda MD, PhD ,&nbsp;Hiroyuki Tanaka MD, PhD ,&nbsp;Junichi Yamaguchi MD, PhD ,&nbsp;Kentaro Jujo MD, PhD","doi":"10.1016/j.jacasi.2024.12.013","DOIUrl":"10.1016/j.jacasi.2024.12.013","url":null,"abstract":"<div><h3>Background</h3><div>Peak creatine kinase-MB (CK-MB) level is an established predictor of clinical outcomes following acute myocardial infarction (AMI). However, the significance of the duration between balloon inflation and peak CK-MB level (BP time) after primary percutaneous coronary intervention (PCI) remains underexplored in terms of prognostic impact.</div></div><div><h3>Objectives</h3><div>This study aimed to elucidate the relationship between BP time and prognostic outcomes in patients with AMI.</div></div><div><h3>Methods</h3><div>In this multicenter observational study, 935 AMI patients who underwent primary PCI and achieved TIMI flow grade 3 on final angiography were included. CK-MB levels were measured systematically at admission and at 3-hour intervals post-PCI. Based on a BP time threshold of 553 minutes, patients were categorized into 2 groups: the long BP-time group (n = 183) and the short BP-time group (n = 752).</div></div><div><h3>Results</h3><div>The mean age of the patients was 67 years, with a median BP time of 334 minutes (Q1-Q3: 248-491 minutes). The long BP-time group exhibited a higher prevalence of male patients and a history of prior PCI. Cardiovascular mortality was significantly greater in the long BP-time group (log-rank test: <em>P =</em> 0.002). Multivariable Cox regression analysis indicated that a prolonged BP time was independently associated with increased cardiovascular mortality (HR: 2.63; 95% CI: 1.19-5.78).</div></div><div><h3>Conclusions</h3><div>Our findings reveal a significant association between BP time and 1-year cardiovascular mortality in patients with AMI. As a readily assessable parameter, BP time can be a valuable tool for early mortality risk stratification in patients post-primary PCI. (Prognostic Implications of Time between Balloon to Peak Creatinine Kinase-MB in patients with Acute Myocardial Infarction Undergoing Primary PCI: Multicenter Cohort Study; <span><span>UMIN000049942</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 650-659"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CK-MB Kinetics as a Superior Prognostic Indicator in Primary PCI","authors":"Abhishek Goyal MBBS, MD, DM","doi":"10.1016/j.jacasi.2025.02.004","DOIUrl":"10.1016/j.jacasi.2025.02.004","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 660-662"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of Thrombi in Left Atrial Appendage With Edoxaban","authors":"Jongmin Hwang MD ,&nbsp;Seongwook Han MD ,&nbsp;Hyoung-Seob Park MD ,&nbsp;Tae-Wan Chung MD ,&nbsp;Min-Su Jung MD ,&nbsp;Seung Yong Shin MD ,&nbsp;Eue-Keun Choi MD ,&nbsp;Young Keun On MD ,&nbsp;Gi-Byoung Nam MD ,&nbsp;Young Soo Lee MD ,&nbsp;Dong Gu Shin MD ,&nbsp;Ki Hong Lee MD ,&nbsp;Jong-Il Choi MD ,&nbsp;Ji Hyun Lee MD","doi":"10.1016/j.jacasi.2025.01.011","DOIUrl":"10.1016/j.jacasi.2025.01.011","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 5","pages":"Pages 695-698"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}