JACC. Asia最新文献

{"title":"Trends in Characteristics and Treatment of Patients With Chronic Limb-Threatening Ischemia Undergoing Endovascular Therapy","authors":"Yosuke Hata MD ,&nbsp;Osamu Iida MD, PhD ,&nbsp;Sho Nakao MD ,&nbsp;Taku Toyoshima MD ,&nbsp;Motoki Yasunaga MD ,&nbsp;Hiroaki Nohara MD ,&nbsp;Akito Kawamura MD ,&nbsp;Haruya Yamane MD ,&nbsp;Kuniyasu Ikeoka MD, PhD ,&nbsp;Yohei Sotomi MD, PhD ,&nbsp;Toshiaki Mano MD, PhD ,&nbsp;Yasushi Sakata MD, PhD","doi":"10.1016/j.jacasi.2025.06.019","DOIUrl":"10.1016/j.jacasi.2025.06.019","url":null,"abstract":"<div><h3>Background</h3><div>Due to an aging population and the growing prevalence of diabetes, patients with chronic limb-threatening ischemia (CLTI) represent a growing burden on health care and social services.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the trends in characteristics and treatment of patients with CLTI.</div></div><div><h3>Methods</h3><div>This multicenter retrospective study included 2,085 patients with CLTI who underwent endovascular therapy between April 2010 and March 2023. Clinical characteristics and outcomes were compared among 4 groups based on treatment period quartiles (Q1-Q4). The clinical characteristics of the patients, limbs, and anatomical severity were assessed according to the global vascular guidelines. The outcome measures were mortality or major amputation rate, and reintervention rate.</div></div><div><h3>Results</h3><div>The median follow-up period was 14.9 months (IQR: 3.9-36.5 months). In the later periods, patient risk was higher, wound severity was lower, and anatomical severity was higher in inframalleolar lesions (each <em>P</em> &lt; 0.05). The mortality or major amputation rate at 1 year did not significantly differ across Q1-Q4 (24.2% [95% CI: 20.5%-28.5%], 22.7% [95% CI: 19.0%-27.0%], 25.6% [95% CI: 21.8%-30.0%], and 28.9% [95% CI: 24.7%-33.5%] in Q1-Q4, respectively; <em>P</em> for trend = 0.18). The reintervention rate at 1 year was significantly lower in the later periods (43.2% [95% CI: 38.5%-48.3%], 45.2% [95% CI: 40.4%-50.4%], 37.8% [95% CI: 33.2%-42.8%], and 32.5% [95% CI: 27.9%-37.6%] in Q1-Q4, respectively; <em>P</em> for trend = 0.002).</div></div><div><h3>Conclusions</h3><div>The characteristics of patients with CLTI were significantly different across the treatment period. The mortality or major amputation rates did not significantly different, whereas the reintervention rate was significantly lower in the later periods.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1317-1326"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolving Landscape of CLTI","authors":"Taku Kato MD, PhD","doi":"10.1016/j.jacasi.2025.09.001","DOIUrl":"10.1016/j.jacasi.2025.09.001","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1327-1328"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valve-in-Valve Transcatheter Aortic Valve Replacement (ViV-TAVR)","authors":"Ho-On Alston Conrad Chiu MBBS ,&nbsp;Simon Cheung-Chi Lam MBBS ,&nbsp;Gilbert H.L. Tang MD, MSc, MBA","doi":"10.1016/j.jacasi.2025.08.003","DOIUrl":"10.1016/j.jacasi.2025.08.003","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1298-1301"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of High-Sensitivity CRP in the East Asian Population","authors":"Emma L. Aspinall MB, ChB ,&nbsp;Anirudh Rao PhD ,&nbsp;Garry McDowell PhD","doi":"10.1016/j.jacasi.2025.08.005","DOIUrl":"10.1016/j.jacasi.2025.08.005","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1313-1316"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Withdrawal From Continuous Intravenous Infusion and Delirium in Heart Failure","authors":"Hiroyuki Sowa MD, PhD ,&nbsp;Tetsuhiko Tange MD ,&nbsp;Yusuke Nakano MD, PhD ,&nbsp;Yoriyasu Suzuki MD ,&nbsp;Yugo Nara MD ,&nbsp;Tadayuki Kadohira MD, PhD ,&nbsp;Mitsunobu Kaneko MD ,&nbsp;Tomoko Terai MD, PhD ,&nbsp;Masahiro Simoda MD, PhD ,&nbsp;Hikari Seki MD, PhD ,&nbsp;Masashi Fukuyama MD, PhD ,&nbsp;Hiroki Yoshida MD, PhD ,&nbsp;Takamasa Kogure PhD ,&nbsp;Koki Nakanishi MD, PhD ,&nbsp;Masashi Kasao MD, PhD ,&nbsp;Norihiko Takeda MD, PhD ,&nbsp;Hiroyuki Morita MD, PhD ,&nbsp;Kazutaka Ueda MD, PhD","doi":"10.1016/j.jacasi.2025.08.006","DOIUrl":"10.1016/j.jacasi.2025.08.006","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1392-1395"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transjugular Transcatheter Tricuspid Valve Replacement in Patients With Cardiac Implantable Electronic Devices","authors":"Kent Chak-yu So MD ,&nbsp;Lukas Stolz MD ,&nbsp;Neil Fam MD ,&nbsp;Geraldine Ong MD ,&nbsp;Anson Cheung MD ,&nbsp;Robert Boone MD ,&nbsp;Pedro Villablanca MD ,&nbsp;Ahmad Jabri MD ,&nbsp;Yat-yin Lam MD ,&nbsp;Didier Tchétché MD ,&nbsp;Omar Oliva MD ,&nbsp;Ole De Backer MD ,&nbsp;Jacob Eifer Mølller MD ,&nbsp;Azeem Latib MD ,&nbsp;Andrea Scotti MD ,&nbsp;Augustin Coisne MD ,&nbsp;Arnaud Sudre MD ,&nbsp;Julien Dreyfus MD ,&nbsp;Mohammed Nejjari MD ,&nbsp;Paul-Emile Favre MD ,&nbsp;Jörg Hausleiter MD","doi":"10.1016/j.jacasi.2025.07.009","DOIUrl":"10.1016/j.jacasi.2025.07.009","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac implantable electronic device (CIED)-related tricuspid regurgitation (TR) is common. Transcatheter tricuspid valve replacement (TTVR) is feasible with CIEDs in the right ventricle; however, data in this population are limited.</div></div><div><h3>Objectives</h3><div>This study retrospectively analyzed patients undergoing compassionate-use transjugular TTVR with the LuX-Valve Plus for symptomatic TR with CIEDs from January 2022 to August 2024 at 17 international centers.</div></div><div><h3>Methods</h3><div>The primary endpoint was procedural TR reduction. Secondary endpoints included TR reduction, survival at 30 days, NYHA functional class changes, and CIED function at follow-up. Non-CIED group was used for comparison.</div></div><div><h3>Results</h3><div>Of 99 patients, 36 (36.4%) had CIEDs. Baseline characteristics were similar, though the CIED group had a higher EuroSCORE (European System for Cardiac Operative Risk Evaluation) II score and more comorbidities. Procedural success (CIED vs non-CIED: 91.7% vs 95.2%; <em>P</em> = 0.781), 30-day mortality (5.6% vs 4.8%; <em>P</em> &gt; 0.999), TR reduction (≤1+: 83.8% vs 84.9%; <em>P</em> &gt; 0.999), and NYHA functional class I/II (80.8% vs 83.7%; <em>P</em> = 0.89) were comparable. The CIED cohort exhibited a higher numerical incidence of conversion to surgery (8.3% vs 1.6%) and tricuspid reintervention (11.5% vs 3.3%) within 6 months; however, these differences did not reach statistical significance (<em>P</em> = 0.267 and <em>P</em> = 0.160, respectively). Of the 22 patients with postoperative interrogation (median of 3.3 months), 9.1% of CIED patients exhibited worsening device parameters, with no need for lead replacement or extraction.</div></div><div><h3>Conclusions</h3><div>Transjugular TTVR is safe and effective for managing TR and heart failure in patients with CIEDs. Due to the small sample size, these findings highlight the need for larger, prospective studies to validate these outcomes.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1260-1269"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Income Inequality and Sleep Duration With Cardiovascular Outcomes in China and the UK","authors":"Cong Li MD, PhD ,&nbsp;Guangyao Hua MD ,&nbsp;Yan Wang MD ,&nbsp;Xue He MD ,&nbsp;Jinghua Jiao MD, PhD ,&nbsp;Xiaohong Yang MD ,&nbsp;Honghua Yu MD, PhD ,&nbsp;Lei Liu MD, PhD","doi":"10.1016/j.jacasi.2025.06.013","DOIUrl":"10.1016/j.jacasi.2025.06.013","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular diseases (CVDs) are a major global health issue, influenced by income level and sleep duration.</div></div><div><h3>Objectives</h3><div>This study sought to assess the impact of income inequality and sleep duration on CVD outcomes in China and the United Kingdom.</div></div><div><h3>Methods</h3><div>We analyzed data from the China Kadoorie Biobank (CKB) (n = 486,131) and UK Biobank (UKB) (n = 403,858). Income level was categorized into low, medium, and high based on the annual household income, and sleep duration into short (&lt;7 hours), optimal (7-9 hours), and long (&gt;9 hours). Cox models estimated HRs for income level, sleep duration, and CVD outcomes.</div></div><div><h3>Results</h3><div>A total of 134,227 incident CVD cases and 16,852 deaths were identified. Low income was associated with higher CVD incidence and mortality in both cohorts (<em>P</em> &lt; 0.001). Short and long sleep durations increased CVD incidence in both cohorts (<em>P</em> &lt; 0.05), except for long sleep and ischemic heart disease in the CKB. Long sleep duration was associated with higher CVD mortality in both cohorts, whereas short sleep duration increased ischemic heart disease risk in the UKB. Compared with individuals of high income and optimal sleep duration, low income was associated with higher CVD risk across all sleep categories. Medium income raised CVD incidence risk in all sleep categories, with mortality associations varying by sleep duration between the CKB and the UKB.</div></div><div><h3>Conclusions</h3><div>Income level and sleep duration independently and jointly affect CVD incidence and mortality. Low income and suboptimal sleep duration are detrimental to cardiovascular health, highlighting the need for public health strategies to address income disparities and promote optimal sleep for CVD prevention.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1373-1385"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing on a Wire","authors":"Yuchao Guo MD,&nbsp;Yuxin He MD,&nbsp;Jian’an Wang MD, PhD","doi":"10.1016/j.jacasi.2025.07.022","DOIUrl":"10.1016/j.jacasi.2025.07.022","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1270-1272"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of hsCRP in CVD/CKD Among East Asian Population","authors":"Xiangyi Kong MD ,&nbsp;Ling Du MD ,&nbsp;Wenyan Liu MM ,&nbsp;Yan Qiao MD ,&nbsp;Changsheng Ma MD","doi":"10.1016/j.jacasi.2025.06.021","DOIUrl":"10.1016/j.jacasi.2025.06.021","url":null,"abstract":"<div><h3>Background</h3><div>Systemic inflammation marked by high-sensitivity C-reactive protein (hsCRP) significantly influences cardiovascular disease (CVD) and chronic kidney disease (CKD) progression, yet its prognostic value in the East Asian population remains unclear.</div></div><div><h3>Objectives</h3><div>This scoping review evaluates the prognostic value of hsCRP for CVD and CKD within these populations.</div></div><div><h3>Methods</h3><div>We conducted electronic searches in PubMed, Embase, and the Cochrane Library. English studies published before January 9, 2024, related to hsCRP and CVD/CKD in East Asian population were included (Protocol pre-registration number: <span><span>INPLASY202490133</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>A total of 117 studies compared hsCRP levels between CVD/CKD patients and population without CVD/CKD; 30 studies explored the relationship between hsCRP level and CVD/CKD incident, and 125 studies focused on the association between hsCRP level and major adverse cardiac events (MACE) in CVD/CKD patients. Overall, 92.7% (n = 102 of 110) of studies indicated that hsCRP levels in CVD patients were significantly higher than those in population without CVD, with all studies on CKD patients reporting elevated hsCRP levels. Additionally, 75% (n = 21 of 28) of studies found an association between elevated hsCRP level and increased risk of CVD, as did both studies focusing on CKD. Regarding prognosis, 73.3% (n = 77 of 105) of studies linked higher hsCRP to MACE in atherosclerotic CVD patients, 68.8% (n = 11 of 16) in heart failure patients, and 62.5% (n = 5 of 8) in CKD patients. Notably, hsCRP cutoff values were highly heterogeneous, but mainly ranged from 1 to 3 mg/L.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that elevated hsCRP levels are associated with increased risk of CVD/CKD and MACE. Well-designed, large-scale prospective studies and subsequent meta-analyses are warranted to further validate these associations.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1302-1312"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Therapy Following Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation","authors":"Qifeng Zhu MD,&nbsp;Xianbao Liu MD, PhD","doi":"10.1016/j.jacasi.2025.06.005","DOIUrl":"10.1016/j.jacasi.2025.06.005","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 10","pages":"Pages 1396-1397"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}