JACC. AsiaPub Date : 2025-02-01DOI: 10.1016/j.jacasi.2024.11.002
Ying-Hwa Chen MD, PhD , Howard C. Herrmann MD
{"title":"Selecting the Proper Transcatheter Aortic Valve Replacement Device in East Asians With a Small Aortic Annulus","authors":"Ying-Hwa Chen MD, PhD , Howard C. Herrmann MD","doi":"10.1016/j.jacasi.2024.11.002","DOIUrl":"10.1016/j.jacasi.2024.11.002","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 2","pages":"Pages 322-326"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Renal Impairment on Clinical Outcomes After Mitral Valve Transcatheter Edge-to-Edge Repair","authors":"Kazuki Tanaka MD , Junichi Yamaguchi MD , Masafumi Yoshikawa MD , Eiji Shibahashi MD , Hisao Otsuki MD , Takanori Kawamoto MD , Chihiro Koyanagi MD , Yusuke Inagaki MD , Tomohito Kogure MD , Masanori Yamamoto MD , Mike Saji MD , Masahiko Asami MD , Masaki Nakashima MD , Yusuke Enta MD , Shinichi Shirai MD , Masaki Izumo MD , Shingo Mizuno MD , Yusuke Watanabe MD , Makoto Amaki MD , Kazuhisa Kodama MD , Kentaro Hayashida MD","doi":"10.1016/j.jacasi.2024.10.025","DOIUrl":"10.1016/j.jacasi.2024.10.025","url":null,"abstract":"<div><h3>Background</h3><div>Renal impairment is associated with poor clinical outcomes in patients with cardiovascular diseases. Some studies have revealed the impact of renal impairment on the clinical outcomes of patients who underwent mitral valve transcatheter edge-to-edge repair (M-TEER). However, limited data are available regarding the impact of baseline renal impairment after M-TEER in Asian-Pacific patients with heart failure and severe mitral regurgitation.</div></div><div><h3>Objectives</h3><div>This study sought to examine the effect of renal impairment on clinical outcomes after M-TEER using a large-scale nationwide registry in Japan.</div></div><div><h3>Methods</h3><div>A total of 2,150 patients enrolled in the OCEAN-Mitral (Optimized Catheter Valvular Intervention) registry were divided into 3 groups according to the estimated glomerular filtration rate (eGFR) before M-TEER: normal eGFR (≥60 mL/min/1.73 m<sup>2</sup>) (n = 291), renal impairment (<60 mL/min/1.73 m<sup>2</sup>) (n = 1,746), and dialysis (n = 113). The impact of renal impairment and dialysis on major adverse cardiovascular events (MACE) (a composite of all-cause death and hospitalization for heart failure) was examined.</div></div><div><h3>Results</h3><div>Kaplan-Meier analysis revealed that the renal impairment and dialysis groups had a significantly higher incidence of MACE (survival rates at 2 years: normal eGFR, 74.2% [95% CI: 66.9%-80.1%] vs renal impairment, 63.9% [95% CI: 61.0%-66.6%] vs dialysis, 50.9% [95% CI: 38.2%-62.2%]; <em>P <</em> 0.001). Multivariate Cox regression analysis identified dialysis as the strongest independent predictor of MACE (HR: 1.95; 95% CI: 1.33-2.85; <em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Renal impairment was associated with an increased incidence of major adverse events, and dialysis was the strongest independent predictor of poor clinical outcomes after M-TEER in Asian-Pacific patients.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 2","pages":"Pages 273-282"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-02-01DOI: 10.1016/j.jacasi.2024.11.012
Anugrah Nair DM , Jenish P. Shroff DM , Lukah Q. Tuan BSc , Adriana Tokich BSc , Deep Chandh Raja DM , Abhinav Mehta BSc , Walter P. Abhayaratna MBBS, PhD , Prashanthan Sanders MBBS, PhD , Francis E. Marchlinski MD , Kalyanam Shivkumar MD, PhD , Rajeev K. Pathak MBBS, PhD
{"title":"Electrocardiographic Characteristics and Ablation Outcomes Associated With Para-Hisian Ventricular Arrhythmias","authors":"Anugrah Nair DM , Jenish P. Shroff DM , Lukah Q. Tuan BSc , Adriana Tokich BSc , Deep Chandh Raja DM , Abhinav Mehta BSc , Walter P. Abhayaratna MBBS, PhD , Prashanthan Sanders MBBS, PhD , Francis E. Marchlinski MD , Kalyanam Shivkumar MD, PhD , Rajeev K. Pathak MBBS, PhD","doi":"10.1016/j.jacasi.2024.11.012","DOIUrl":"10.1016/j.jacasi.2024.11.012","url":null,"abstract":"<div><h3>Background</h3><div>Ventricular arrhythmias (VAs) near the His-bundle comprise 9% of unexplained VAs and present challenges for ablation caused by the risk of atrioventricular block.</div></div><div><h3>Objectives</h3><div>The authors studied the electrocardiographic (ECG) and electrophysiological characteristics of Para-Hisian (PH) VAs, comparing them with septal right ventricular outflow tract VAs.</div></div><div><h3>Methods</h3><div>From 210 patients with VAs between 2018 and 2024, 31 (14.7%) with PH-VAs and 23 (10.9%) with septal right ventricular outflow tract VAs were included. ECG characteristics of both were compared, and features differentiating left and right PH and supra- and infra-Hisian VAs were identified.</div></div><div><h3>Results</h3><div>Of 31 patients, 15 had VAs from the right PH site and 16 from the left. Median follow-up was 15 months (Q1-Q3: 14-21 months) for left infra-Hisian, 16 months (Q1-Q3: 14-20 months) for left supra-Hisian, and 14 months (Q1-Q3: 14-16 months) for right infra-Hisian and right supra-Hisian VAs (Q1-Q3: 14-15 months). PH-VAs had narrower QRS complexes (134 ± 19.6 ms vs 169 ± 24 ms; <em>P</em> < 0.05), R-wave in lead aVL (100% [31 of 31] vs 4.3% [1 of 23]; <em>P</em> < 0.001), and earlier R-wave transition at or before lead V<sub>3</sub> (80.6% [25 of 31] vs 47.8% [11 of 23]; <em>P</em> < 0.05). Left PH-VAs had earlier R-wave transition at lead V<sub>2</sub> (50% [8 of 16] vs 20% [3 of 15]; <em>P =</em> 0.036). Right PH VAs had deeper S-wave relative to the preceding sinus beat in lead V<sub>1</sub> (73.3% [11 of 15] vs 37.5% [6 of 16]; <em>P =</em> 0.04) and lead aVR (80% [12 of 15] vs 56.3% [9 of 16]; <em>P =</em> 0.01). Postprocedure heart block occurred in 1 patient.</div></div><div><h3>Conclusions</h3><div>PH-VAs exhibit unique ECG features based on their origins, and can be effectively treated without affecting atrioventricular conduction.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 2","pages":"Pages 299-312"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}