JACC. Asia最新文献

{"title":"Triple Assessments of Atherosclerosis in Patients With Heterozygous Familial Hypercholesterolemia.","authors":"Hayato Tada, Nobuko Kojima, Kan Yamagami, Akihiro Nomura, Atsushi Nohara, Soichiro Usui, Kenji Sakata, Masa-Aki Kawashiri, Masayuki Takamura","doi":"10.1016/j.jacasi.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.04.011","url":null,"abstract":"<p><strong>Background: </strong>Data on the appropriate timing and impact of atherosclerosis assessment in patients with heterozygous familial hypercholesterolemia (HeFH) are limited.</p><p><strong>Objectives: </strong>The authors aimed to determine when atherosclerotic changes occur and the utility of triple assessments of carotid plaque, coronary plaque, and coronary artery calcium (CAC) in patients with HeFH.</p><p><strong>Methods: </strong>Data from patients with HeFH in the primary prevention setting admitted to Kanazawa University Hospital between 2000 and 2020 who underwent triple atherosclerosis assessment and were followed up were retrospectively reviewed (n = 622, male = 306, mean age = 54 ± 13 years). Risk factors for coronary heart disease events were determined using the Cox proportional hazard model. Carotid plaque, coronary plaque, and CAC scores were plotted against age.</p><p><strong>Results: </strong>We found that the age was independently associated with coronary heart disease events. Regression equations of carotid plaque, coronary plaque, and CAC scores against age were Y = 0.12X - 2.07 (β coefficient = 0.12 [95% CI: 0.09-0.15]; r² = 0.12), Y = 0.36X - 9.30 (β coefficient = 0.36 [95% CI: 0.26-0.46]; r² = 0.14), and Y = 2.48X - 77.23 (β coefficient = 0.07 [95% CI: 0.04-0.10]; r² = 0.23) in men and Y = 0.12X - 3.60 (β coefficient = 0.12 [95% CI: 0.08-0.16]; r² = 0.18), Y = 0.33X - 11.75 (β coefficient = 0.33 [95% CI: 0.29-0.37]; r² = 0.17), and Y = 2.23X - 89.47 (β coefficient = 0.09 [95% CI: 0.06-0.12]; r² = 0.34) in women, respectively. Significant differences of cardiovascular events were observed among the groups according to atherosclerotic burden.</p><p><strong>Conclusions: </strong>On average, carotid plaque, coronary plaque, and CAC may develop at ages 17, 26, and 31 years in male patients and 30, 36, and 40 years in female patients with HeFH, respectively, based on regression equations. Furthermore, triple assessments help in risk stratification.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Atrial Fibrillation in East Asia.","authors":"Shin-Huei Liu, Tze-Fan Chao","doi":"10.1016/j.jacasi.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.05.009","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Right Atrial Strain by Echocardiography for Predicting Prognosis in Hypertrophic Cardiomyopathy.","authors":"Yu Zhang, Haiming Zhuang, Kejia Lou, Channa Zhang, Lianjun Xu, Lianming Kang, Kunjing Pang, Lei Song","doi":"10.1016/j.jacasi.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.05.003","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systolic Dyssynchrony Index in Hypertrophic Cardiomyopathy: Association With Ventricular Arrhythmias and Risk Prediction.","authors":"Rong Wang, Haiming Zhuang, Nan Xu, Li Zhang, Jiayi Xing, Tingting Zhang, Lianming Kang, Lei Song, Kunjing Pang","doi":"10.1016/j.jacasi.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.05.002","url":null,"abstract":"<p><strong>Background: </strong>Mechanical dispersion (MD) has been demonstrated to be associated with nonsustained ventricular tachycardia (NSVT) and could potentially predict sudden cardiac death in hypertrophic cardiomyopathy (HCM) patients.</p><p><strong>Objectives: </strong>The authors sought to evaluate the systolic dyssynchrony index (SDI) measured with 3-dimensional echocardiography and explore its predictive value for risk assessment in HCM patients.</p><p><strong>Methods: </strong>A total of 610 HCM patients were prospectively enrolled, and we measured the MD and SDI. Their associations with NSVT and guideline-based implantable cardioverter-defibrillator class of recommendation (ICD-COR) were analyzed.</p><p><strong>Results: </strong>A total of 81 (13.28%) patients were diagnosed with NSVT by the 24-hour Holter monitoring. The SDI of HCM patients with NSVT was significantly higher than that of HCM patients without NSVT (8.60% (7.00%-10.80%) vs. 6.00% (4.70%-7.15%). P = 0.000). The SDI was independently associated with the presence of NSVT (OR: 1.57; P = 0.000). The SDI identified NSVT in HCM patients with an area under the curve of 0.79 at a cutoff value of 7.58%, which was significantly higher than MD, with an area under the curve of 0.70 (P = 0.025). The percentages for class IIa ICD-COR in HCM patients with SDI ≥7.58% were significantly higher than those in HCM patients with SDI <7.58% according the current guidelines.</p><p><strong>Conclusions: </strong>The SDI was more capable of assessing mechanical dyssynchrony and detecting NSVT in HCM patients compared with MD. The SDI might serve to identify HCM patients eligible for class IIa ICD-COR according to current guidelines.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization.","authors":"Wulamiding Kaisaier, Min Ye, Zexuan Wu, Chen Liu, Jiangui He, Gregory Y H Lip, Yili Chen, Wengen Zhu","doi":"10.1016/j.jacasi.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.04.008","url":null,"abstract":"<p><strong>Background: </strong>Lower socioeconomic status, intelligence, and cognition are linked to a higher likelihood of atrial fibrillation (AF). However, whether these factors directly cause AF or whether others mediate this relationship is unclear.</p><p><strong>Objectives: </strong>Our study aimed to determine the causal link between lower socioeconomic status, intelligence, cognition, and AF, and identify mediators.</p><p><strong>Methods: </strong>We conducted a 2-sample Mendelian randomization analysis with data from European ancestry genome-wide association studies. Genetic instruments for education, intelligence, cognition, income, and occupation (n = 248,847-1,131,881) evaluated their relationship with AF (FinnGen study: 50,743 cases and 210,652 control subjects; 6 European studies: 60,620 and 970,216).</p><p><strong>Results: </strong>The pooled results from meta-analysis combining data from 2 studies indicated that education, intelligence, and cognition were causally associated with AF (P < 0.05). Genetically predicted, each 1-SD increase in educational attainment was associated with a 19% decreased risk of AF (OR: 0.81; 95% CI: 0.71-0.92), independent of intelligence and cognition. Among 44 candidate mediators, 8 factors were identified to mediate the education-AF association, including heart failure (mediation proportion: 95.35%), body fat mass (44.05%), waist circumference (42.93%), coronary heart disease (30.1%), body mass index (29.0%), myocardial infarction (28.8%), diastolic blood pressure (21.7%), and waist-to-hip ratio (14.3%).</p><p><strong>Conclusions: </strong>Our study suggests that education exerts a causal and protective effect against AF, independent of intelligence and cognition. Heart failure, obesity, and ischemic heart disease serve as mediating factors in the pathway from education to AF, underscoring the importance of considering these conditions in preventing AF associated with education inequality.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Versus Echocardiographic Aortic Valve Gradients Pre and Post Balloon-Expandable TAV-in-TAV for Failed TAVR Prosthesis","authors":"Luai Madanat MD ,&nbsp;Ivan D. Hanson MD ,&nbsp;Ahmad Jabri MD ,&nbsp;Brian Renard MD ,&nbsp;Amr E. Abbas MD","doi":"10.1016/j.jacasi.2025.02.016","DOIUrl":"10.1016/j.jacasi.2025.02.016","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 6","pages":"Pages 814-816"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2772-3747(25)00251-0","DOIUrl":"10.1016/S2772-3747(25)00251-0","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 6","pages":"Pages I-CXXIII"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Body Mass Index in Patients With Cardiogenic Shock Requiring Microaxial Flow Pump","authors":"Yuki Katagiri MD, PhD ,&nbsp;Yutaro Kasai MD ,&nbsp;Mamoru Miyazaki MD ,&nbsp;Ken Kuroda MD ,&nbsp;Yuichiro Hosoi MD ,&nbsp;Kohei Ishikawa MD ,&nbsp;Hiroki Bota MD ,&nbsp;Yuki Ikeda MD, PhD ,&nbsp;Yohei Sotomi MD, PhD ,&nbsp;Kenichi Matsutani MD, PhD ,&nbsp;Kazumasa Yamasaki MD ,&nbsp;Tomoyuki Tani MD ,&nbsp;Takashi Ueda MD, PhD ,&nbsp;Seiji Yamazaki MD ,&nbsp;Shigeru Saito MD ,&nbsp;J-PVAD Investigators","doi":"10.1016/j.jacasi.2025.03.003","DOIUrl":"10.1016/j.jacasi.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>The impact of obesity on mortality in patients with cardiogenic shock (CS) requiring microaxial flow pumps (mAFP) remains undetermined.</div></div><div><h3>Objectives</h3><div>This study investigated the effect of body mass index (BMI) on mortality in CS patients treated with mAFP.</div></div><div><h3>Methods</h3><div>Data from 3,636 consecutive CS patients treated with Impella mAFP in the J-PVAD (Japanese Registry for Percutaneous Ventricular Assist Device) nationwide prospective registry in Japan between February 2020 and December 2022 were analyzed. Patients were stratified into 5 BMI categories: underweight (&lt;18.5 kg/m²), normal weight (18.5-22.9 kg/m²), overweight (23.0-24.9 kg/m²), obesity (25.0-29.9 kg/m²), and severe obesity (≥30.0 kg/m²). Multivariate Cox regression analysis assessed the relationship between BMI and 30-day mortality.</div></div><div><h3>Results</h3><div>Crude 30-day mortality increased incrementally with higher BMI categories. Adjusted HRs for 30-day mortality (normal weight as reference) were 0.71 (95% CI [CI]: 0.56-0.90; <em>P =</em> 0.005) for underweight, 1.03 (95% CI: 0.88-1.21; <em>P =</em> 0.681) for overweight, 1.37 (95% CI: 1.19-1.57; <em>P &lt;</em> 0.001) for obesity, and 2.00 (95% CI: 1.66-2.41; <em>P &lt;</em> 0.001) for severe obesity. Patients in the underweight and severe obesity groups experienced a higher incidence of bleeding after percutaneous coronary intervention under mAFP, whereas hemolysis increased with higher BMI categories. Bleeding and hemolysis were associated with mortality only in patients who were underweight.</div></div><div><h3>Conclusions</h3><div>Higher BMI was associated with increased mortality in CS patients treated with mAFP. Although patients who were underweight demonstrated overall favorable survival outcomes, bleeding and hemolysis contributed to mortality in this group. Further research is needed to explore whether a BMI-based approach can improve clinical outcomes. (Japanese registry for Percutaneous Ventricular Assist Device; <span><span>UMIN000033603</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 6","pages":"Pages 771-783"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Coated Balloons-Based Intervention for Coronary Artery Disease","authors":"Ae-Young Her MD, PhD ,&nbsp;Wan Azman Wan Ahmad MD, PhD ,&nbsp;Liew Houng Bang MD ,&nbsp;Ong Tiong Kiam MD ,&nbsp;Amin Ariff Nuruddin MD ,&nbsp;I-Chang Hsieh MD ,&nbsp;Ho Hee Hwa MD ,&nbsp;Shaiful Azmi Yahaya MD ,&nbsp;Qiang Tang MD ,&nbsp;Jung-Cheng Hsu MD ,&nbsp;ChunGuang Qiu MD ,&nbsp;Jie Qian MD ,&nbsp;Rosli Mohd Ali MD ,&nbsp;Eun-Seok Shin MD, PhD","doi":"10.1016/j.jacasi.2025.02.017","DOIUrl":"10.1016/j.jacasi.2025.02.017","url":null,"abstract":"<div><div>Drug-coated balloons (DCBs) provide a stent-free alternative, reducing risks like stent thrombosis and in-stent restenosis and the need for prolonged dual antiplatelet therapy. Recent studies show that DCBs can be effective and safe across various coronary artery diseases (CADs) when lesions are adequately prepared. Specifically, all coronary lesions are treated using the provisional approach, where active lesion preparation is followed by DCB or drug-eluting stent treatment, depending on the results. This approach means DCB is considered the default device before initiating intervention, with efforts focused on obtaining adequate lesion preparation. Depending on the result, DCB or drug-eluting stent is selected, which is termed DCB-based percutaneous coronary intervention. Therefore, this second report of the Asia-Pacific Consensus Group provides practical guidelines (DCB-based percutaneous coronary intervention) based on the latest evidence for DCB treatment in CAD and aims to expand its application across various CADs, facilitating its effective use in real-world clinical practice.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 6","pages":"Pages 701-717"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the BMI-Outcome Relationship in Cardiogenic Shock","authors":"Kentaro Ejiri MD, PhD ,&nbsp;Shun Kohsaka MD, PhD","doi":"10.1016/j.jacasi.2025.04.006","DOIUrl":"10.1016/j.jacasi.2025.04.006","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 6","pages":"Pages 784-785"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}