JACC. Asia最新文献

{"title":"Initial Real-World Experience of Tricuspid Transcatheter Edge-to-Edge Repair in Asia.","authors":"Kent Chak-Yu So, Krissada Meemook, Jianqiang Xu, Chun-Chin Chang, Tawai Ngernsritrakul, Surakiat Leelasithorn, Ching-Wei Lee, Angel Lai, Kevin Ka-Ho Kam, Bryan P Yan, Alex Pui-Wai Lee, Adam S H Sung, Yat-Yin Lam","doi":"10.1016/j.jacasi.2025.07.024","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.07.024","url":null,"abstract":"<p><strong>Background: </strong>Tricuspid regurgitation (TR) causes significant morbidity. Transcatheter edge-to-edge repair (TEER) has been proven effective in relieving TR symptoms. Access to tricuspid TEER and the associated experience are limited in Asia.</p><p><strong>Objectives: </strong>This study aimed to summarize the initial experience with the tricuspid TEER system (Abbott) in Asia.</p><p><strong>Methods: </strong>Patients undergoing tricuspid TEER (Abbott) from 2017 to 2024 were enrolled from 4 centers in Asia. The primary endpoint was device success (TR ≤moderate) at 30 days. Secondary endpoints included inpatient complications, 30-day NYHA functional class, and 30-day major adverse events. Risk factors for 30-day device success were identified.</p><p><strong>Results: </strong>A total of 106 patients were included, with a mean age of 76.1 ± 10 years, and 88.7% (n = 94 of 106) had atrial fibrillation. Most TR cases treated were functional (88.7% [n = 94 of 106]), with over half classified as massive or torrential (56.6% [n = 60 of 106]). Tricuspid TEER was performed using off-label MitraClip in 22.6% (n = 24), while the remaining 77.4% (n = 82) utilized TriClip. Combined procedures (with mitral TEER and others) were common (47.2% [n = 50 of 106]). At 30 days, 74.0% (n = 77 of 104) achieved device success (TR ≤moderate), and 95.2% (n = 99 of 104) experienced at least a 1-grade TR reduction. Additionally, 96.2% (n = 100 of 104) were NYHA functional class I/II, and major adverse events were 1.9% (n = 2 of 106) at 30 days. Baseline nontorrential TR and increased clinical experience (second half of cases) were associated with 30-day device success (P = 0.010 and P = 0.044, respectively).</p><p><strong>Conclusions: </strong>The early experience with tricuspid TEER in Asia is promising, demonstrating a reasonable device success rate and a high safety profile. Clinical experience is associated with improved device success.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYP2C19 Genotype-Guided Antiplatelet Therapy in Precision Medicine for Stroke.","authors":"Qingling Zhang, Tong Liu","doi":"10.1016/j.jacasi.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.08.002","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke Mortality in Kazakhstan: Comparison of National Health Records to Global Burden of Disease Study.","authors":"Ruslan Akhmedullin, Temirgali Aimyshev, Gulnur Zhakhina, Iliyar Arupzhanov, Antonio Sarria-Santamera, Altynay Beyembetova, Ayana Ablayeva, Aigerim Biniyazova, Temirlan Seyil, Diyora Abdukhakimova, Yuliya Semenova, Abduzhappar Gaipov","doi":"10.1016/j.jacasi.2025.07.023","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.07.023","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a major public health concern requiring valid estimates for planning and evaluating health interventions. The GBD (Global Burden of Disease) studies have become a major source of information; however, data sources have historically been a limitation.</p><p><strong>Objectives: </strong>We sought to compare stroke mortality estimates in Kazakhstan with those reported by the GBD study.</p><p><strong>Methods: </strong>Mortality data were extracted from the Unified Electronic Healthcare System of Kazakhstan (UNEHS). We used the autoregressive integrated moving average (ARIMA), Bayesian structural time-series (BSTS), and Extreme Gradient Boosting (XGBoost) to model data from the UNEHS and forecast its trends until 2030. The accuracy metrics were mean absolute error, root mean square error, and mean absolute percentage error. We calculated the standardized difference in mortality estimates between the databases for the observed and forecasted estimates.</p><p><strong>Results: </strong>The BSTS, ARIMA, and XGBoost models revealed slight variations in accuracy metrics, which depended on forecasting horizons and mostly favored XGBoost. During 2014-2030, the absolute difference in death counts was 207,108 between the GBD and UNEHS. The GBD estimates were twice as many across both the observed and predicted periods, with a moderate standardized difference (0.73) when considering their average. This study showed a systematic difference between GBD and national data.</p><p><strong>Conclusions: </strong>We found that UNEHS estimates were not comparable despite our efforts to replicate the GBD methods. Further studies are needed to explore the discrepancies between the national or regional data and GBD. Current limitations related to primary data and reproducibility require caution when interpreting GBD findings.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Statement-Concordant Implantable Cardioverter-Defibrillator Programming on Therapy Reduction in an Asian Cohort.","authors":"Jiro Koya, Taro Temma, Kei Kawakami, Masahiro Kawasaki, Kintaro Shimano, Shota Saito, Daishiro Tatsuta, Kotaro Nishino, Takahide Kadosaka, Taro Koya, Motoki Nakao, Masaya Watanabe, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai","doi":"10.1016/j.jacasi.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.08.009","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shielding Interventional Echocardiographers From Radiation Hazards.","authors":"Soo-Young Lee, Si-Hyuck Kang, Tae-Jin Youn","doi":"10.1016/j.jacasi.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.08.004","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Patterns and Frailty: Joint Impact on Major Adverse Cardiac Events.","authors":"Zhi-Teng Chen, Da-Chuan Guo, Jing-Wei Gao, Wen-Hao Liu, Yan-Ren Peng, Wan-Bing He, Qing-Yuan Gao, Mao-Xiong Wu, Pin-Ming Liu, Jing-Feng Wang, Hai-Feng Zhang, Yang-Xin Chen","doi":"10.1016/j.jacasi.2025.07.019","DOIUrl":"https://doi.org/10.1016/j.jacasi.2025.07.019","url":null,"abstract":"<p><strong>Background: </strong>Sleep patterns and frailty phenotypes are becoming increasingly important metrics for assessing cardiovascular disease (CVD) risk; however, research investigating their synergistic effects on major adverse cardiac events (MACE) remains scarce.</p><p><strong>Objectives: </strong>This study aimed to investigate how sleep patterns and frailty phenotypes jointly influence MACE.</p><p><strong>Methods: </strong>A total of 380,105 participants from the UK Biobank were included for the analysis. Frailty phenotypes and sleep patterns were defined based on the frailty scores and sleep scores, respectively. Cox proportional hazards models were used to evaluate the associations between combinations of frailty phenotypes and sleep patterns and MACE, including nonfatal myocardial infarction, stroke, or CVD-related death.</p><p><strong>Results: </strong>After a median follow-up period of 12.94 years (Q1-Q3: 12.23-13.64 years), 18,074 participants experienced incident MACE, with an incidence rate of 3.73 per 1,000 person-years (95% CI: 3.68-3.79). Compared with participants with frailty and poor sleep patterns, nonfrail participants with healthy sleep patterns have the lowest risk of MACE (HR: 0.560; 95% CI: 0.445-0.704; P < 0.001) and other secondary outcomes. Maintaining a healthy sleep pattern was associated with a reduced risk of MACE among the pre-frail participants (HR: 0.815; 95% CI: 0.732-0.853; P < 0.001). These findings remained robust across a series of sensitivity analyses and various subgroups.</p><p><strong>Conclusions: </strong>Maintaining a healthy sleep pattern and a nonfrail status were jointly associated with a significantly decreased risk of MACE. These results emphasize the importance of promoting sleep health to mitigate CVD risk in prefrail participants.</p>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Bleeding Risks and Survival in Patients Undergoing Percutaneous Coronary Intervention on Antiplatelet Therapy","authors":"Chun-Chin Chang MD, PhD ,&nbsp;Andrew Kei-Yan Ng MD ,&nbsp;Norihiro Kogame MD, PhD ,&nbsp;Po-Hsun Huang MD, PhD ,&nbsp;Byeong-Keuk Kim MD, PhD ,&nbsp;Robert-Jan M. van Geuns MD, PhD","doi":"10.1016/j.jacasi.2025.05.017","DOIUrl":"10.1016/j.jacasi.2025.05.017","url":null,"abstract":"<div><div>This comprehensive review focuses on bleeding risk and outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI) with antiplatelet therapy. Bleeding prevalence varies widely, ranging from 1% to 10% in clinical trials and 2.8% to 11% in real-world studies, with a significant impact on mortality. The Academic Research Consortium for High Bleeding Risk criteria are well-validated, classifying approximately 50% of patients as high bleeding risk, who subsequently experience higher post-PCI bleeding rates. Key risk factors include advanced age, chronic kidney disease, and multiple comorbidities. This review also explores bleeding event definitions, risk stratification methods, and the clinical consequences of bleeding. The strong association between bleeding and mortality after PCI underscores the importance of vigilant monitoring and tailored management strategies.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 9","pages":"Pages 1083-1094"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2772-3747(25)00420-X","DOIUrl":"10.1016/S2772-3747(25)00420-X","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 9","pages":"Pages I-CXLVI"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Mass Index in TAVR","authors":"Hassaan Bin Arshad MD,&nbsp;Peter Bittenbender MD","doi":"10.1016/j.jacasi.2025.07.003","DOIUrl":"10.1016/j.jacasi.2025.07.003","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 9","pages":"Pages 1134-1136"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Introduction to ASIAN-HF Registry","authors":"Tiew-Hwa Katherine Teng MPH, PhD ,&nbsp;Carolyn S.P. Lam MBBS, PhD","doi":"10.1016/j.jacasi.2025.05.020","DOIUrl":"10.1016/j.jacasi.2025.05.020","url":null,"abstract":"<div><div><strong>Study Type: A Prospective Observational Study</strong></div><div><strong>Study Period: 2012-09 to 2020-03</strong></div><div><strong>Study Data Overview</strong><ul><li><span>•</span><span><div><strong>Data Provenance:</strong> Consecutive patients prospectively enrolled using a common protocol from 44 sites across 11 Asian regions (China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Philippines, Singapore, Taiwan, and Thailand).</div></span></li><li><span>•</span><span><div><strong>Data Custodianship:</strong> Data accessible upon request and approval by the ASIAN-HF executive committees.</div></span></li><li><span>•</span><span><div><strong>Analysis Responsibility:</strong> Conducted by the data management/analytics team at the National Heart Centre Singapore.</div></span></li><li><span>•</span><span><div><strong>Preprocessing of Data:</strong> Deidentification of data performed using standard protocols.</div></span></li><li><span>•</span><span><div><strong>Population Overview:</strong> Adult patients (aged ≥18 years), with a diagnosis of heart failure with symptomatic decompensation within the prior 6 months including heart failure with reduced ejection fraction (EF) with left ventricular EF ≤40% (n = 5,276) and heart failure with preserved EF with left ventricular EF ≥50% (n = 1,204); all prospectively followed for clinical outcomes.</div></span></li><li><span>•</span><span><div><strong>Data Merging:</strong> Single data set.</div></span></li><li><span>•</span><span><div><strong>Data Quality:</strong> 9.3% missing outcome data (lost to follow-up).</div></span></li><li><span>•</span><span><div><strong>Data Availability:</strong> Proprietary; not publicly available.</div></span></li></ul></div><div>(ASIAN HF Registry, A Prospective Observational Study [ASIANHF]; <span><span>NCT01633398</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 9","pages":"Pages 1206-1216"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}