Fereshteh Farshidi, G. Abedi, M. Moosazadeh, M. Afshari
{"title":"Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis","authors":"Fereshteh Farshidi, G. Abedi, M. Moosazadeh, M. Afshari","doi":"10.17795/IJCP-3704","DOIUrl":"https://doi.org/10.17795/IJCP-3704","url":null,"abstract":"Background: Seroprevalence of Cytomegalovirus infection varies between 40% and 100% worldwide. Different studies carried out in Iran indicate this variation in this country. It is important to estimate the total infection prevalence using a reliable method such as meta- analysis in order to be applied by policymakers. This study aims to estimate the IgG and IgM seroprevalences of CMV infection among Iranian women and neonates. Method: We selected eligible articles for final meta- analysis by searching the national and international databases, excluding duplicates and irrelevant papers from primarily identified studies after abstract/full text review, implementing exclusion/inclusion criteria and quality assessment. Standard error of the prevalence was calculated according to binomial distribution formula. Based on the degree of heterogeneity, fixed or random effects models were applied for estimating the pooled prevalences. Results: In this study, 16 papers providing 20 evidences of CMV prevalence in Iran entered in the meta- analysis. CMV IgG and IgM seroprevalences as well as primary infection rate (95% confidence interval) among pregnant women were 92.8% (90.6 - 94.9), 6.4% (2.8 - 9.9) and 1.1% (0.7 - 1.5) respectively. CMV IgM seroprevalence among neonates were 0.6% (0.09 - 1.2), while CMV IgG and CMV IgM seroprevalences among non-pregnant women were 78.4% (70 - 86.8) and 4.6% (1.5 - 7.6) respectively. Conclusions: This meta- analysis showed that the prevalence of CMV infection among studied population is relatively high. Therefore, mortality, complications, anomalies and injuries among fetuses, neonates and immunocompromized patients can be partially related to the CMV infection.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68177922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Moghaddasifar, K. Lankarani, M. Moosazadeh, M. Afshari, Mina Malary
{"title":"Prevalence of Hepatitis B Virus infection among Pregnant Women in Iran: A Systematic Review and Meta-analysis","authors":"I. Moghaddasifar, K. Lankarani, M. Moosazadeh, M. Afshari, Mina Malary","doi":"10.17795/IJCP-3703","DOIUrl":"https://doi.org/10.17795/IJCP-3703","url":null,"abstract":"Background: Hepatitis B infection can be transmitted both vertically and horizontally. Although the universal neonatal vaccination and catch up vaccination of teenagers along with targeted vaccination of at risk population have decreased the prevalence of HBV infection in Iran dramatically, there is still risk of vertical transmission with subsequent chronic liver disease and hepatocellular carcinoma. This study aims to estimate the prevalence of latent HBV infection among Iranian pregnant women using meta- analysis method. Data Sources: Papers written in Persian or English were identified during a comprehensive search within five national and four international main databases. Study Eligibility Criteria and Participants: Studies reported the HBV infection prevalence among Iranian pregnant women and provided enough quality scores were selected for this meta-analysis. Methods: After a systematic review of national and international databases, duplicated and irrelevant studies were excluded. Standard error of the infection prevalence was calculated based on the binomial distribution. Because of the significant heterogeneity observed among the results, random effects model was applied to combine the results of the primary studies. Moreover, sensitivity analysis and meta-regression models were used to detect the sources of this heterogeneity. Results: At final step of the systematic search, 18 papers entered into the meta-analysis investigating 24853 pregnant women. Prevalence of HBV infection among Iranian pregnant women was estimated as 1.2% (95% confidence interval: 0.9 - 1.6). Among different risk factors assessed, only familial history in four studies out of five relevant evidences was statistically significant. Conclusions: HBV infection prevalence among Iranian pregnant women is low and familial history is its major determinant.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68176854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arezoo Chouhdari, P. Yavari, M. Pourhoseingholi, M. Zali
{"title":"Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer","authors":"Arezoo Chouhdari, P. Yavari, M. Pourhoseingholi, M. Zali","doi":"10.17795/IJCP-4808","DOIUrl":"https://doi.org/10.17795/IJCP-4808","url":null,"abstract":"Background: First-degreerelatives(FDRs)of peoplediagnosedwithcolorectalcancer(CRC)haveatwo-tothree-foldincreasedriskof developingdisease. Colonoscopy screeningtestcanbeeffectiveinpreventionandearlytreatment. Objectives: Thepurposeof thisstudywastodeterminetherateof participationincolonoscopyscreeningtestandrelatedfactorsinfirstdegreerelatives. Methods: 200FDRsof CRCcaseswereinterviewedbytheresearchers.Areliableandvalidquestionnaireaboutundergoingcolonoscopyscreeningtestandbarrierswas filledviaphone. Toreportqualitativedataresults,weusedpercentandproportion. Full(bytotalvariables)andfinal(ForwardLR)multiplelogisticregressionanalysis wereusedtomakeamodelwhichwasexecutedusingspss19. Results: Intotal,59% FDRshadundergonecolonoscopyscreeningtesttothetimeofinterview.Majorreasonsfornotparticipatingwerefearofpain(23%),concernsabout complicationsandtestpositiveresult(21.5%),lackofhealthinsurance(21.5%),notbelievinginthetesteffectiveness(17%),noneedbecauseofhealthyfeeling(13%),embar-rassment(12%)anddistrusttoserviceproviderskills(10%).Resultsofmultiplelogisticregressionanalysisindicatedthereisstatisticalsignificancebetweenparticipatingcolonoscopyscreeningandvariables“notaffectedwithhypertension(95%CI:0.4-2.04,OR=3.7),believeintesteffectivenessinFDRs(95%CI:1.8-16.9,OR=5.6),alsoageofdiagnosis 50inCRCcases(95%CI:1.7-2.3,OR=2)”.Finally,agebelow50(95%CI:1.1-5.1,OR=2.4),notbeingalivepersonaffectedbyCRC(95%CI:1.2-5.8,OR=3.3),monthly familyincome 10millionRials(95%CI:1.08-4.7,OR=2.2)andbelief ineffectivenessof thetest(95%CI:2.61-12.55,OR=5.7)werepredictorfactorstoparticipate. Conclusion: FutureInterventionsshouldfocusonfosteringpositiveattitudes,overcomingbarriers,enhancingsocialandhealthinsurancesupportandfollowingmed- icalrecommendationconsecutivetoperformingcolonoscopyscreeningtest.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Soheylizad, S. Khazaei, S. Khazaei, S. Rezaeian
{"title":"Relation Between Lung Cancer Incidence and Mortality Rates with Human Development Index and Its Components: A Global Ecological Study","authors":"M. Soheylizad, S. Khazaei, S. Khazaei, S. Rezaeian","doi":"10.17795/IJCP-5310","DOIUrl":"https://doi.org/10.17795/IJCP-5310","url":null,"abstract":": This study aimed to identify the role of HDI in the incidence and mortality rates of lung cancer (LC) worldwide. Data about the incidence and mortality rate of LC for the year 2012 was obtained from the global cancer project for 172 countries. Data about the HDI and other indices were obtained for 169 countries from the United Nations development programme database. In 2012, LC was estimated to have affected a total of 1,824,701 individuals (crude rate: 25.9 per 100,000 individuals), and caused 1,589,925 deaths worldwide (crude rate: 22.5 per 100,000 individuals). LC accounts for 13% of total cancers incidence. There was a positive correlation between the HDI and LC incidence (R = 0.79, P < 0.05), and also with LC mortality rate (R = 0.77, P < 0.05) in the world in 2012. Linear regression model showed that increasing of HDI, mean of life expectancy at birth, mean years of schooling, GNI per capita, percent of urbanization, and age standardized obesity had a positive effect on increase in both incidence and mortality rates of LC. Our study showed that the burden of LC is enormous in high and very high HDI regions. Such actions include primary prevention strategies to effective control of the lifestyle behaviours prevalence including tobacco avoidance and cessation of smoking, a reduction in alcohol consumption and obesity, and the promotion of increased levels of physical activity, as well as the implementation of early detection programs. Moreover, further reductions in mortality could be brought about by increasing access to curative treatment for patients with LC.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Seyedfatemi, M. M. Hamooleh, L. Borimnejad, M. Tahmasebi
{"title":"Palliative Care as the Driving Force for Providing Psychological Comfort to Patients with Cancer: A Hermeneutic Study","authors":"N. Seyedfatemi, M. M. Hamooleh, L. Borimnejad, M. Tahmasebi","doi":"10.17795/IJCP-4516","DOIUrl":"https://doi.org/10.17795/IJCP-4516","url":null,"abstract":"Background: Palliative care is an important part of eective cancer care Objectives: The purpose of our study was to explore the lived experiences of nurses providing psychological palliative care for cancer patients in Iran. Methods: A hermeneutic phenomenological study was performed. We interviewed 11 oncology nurses to understand their lived experiences in cancer wards about psychological palliative care. We employed a seven-stage process of data analysis. Results: One constitutive pattern 'palliative care as the driving force for providing psychological comfort to patients with cancer' and three associated themes, namely 'stress management', 'empathetic behavior', and 'all-embracing outlook', were identified. Conclusions: The findings present better understanding of the lived experiences of oncology nurses in Iran regarding the phenomena under study.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kermani, R. Vakili, Samaneh Dadkhah, A. Jafarian, R. Bagheri
{"title":"HER-2/neu Overxpression in Esophageal Squamous Cell Carcinoma (ESCC) and Its Correlation with Patient’s Clinicopathological Features","authors":"A. Kermani, R. Vakili, Samaneh Dadkhah, A. Jafarian, R. Bagheri","doi":"10.17795/IJCP-5007","DOIUrl":"https://doi.org/10.17795/IJCP-5007","url":null,"abstract":"Background: HER-2/neu overexpression has been reported in various human cancers and identified as a significant predictor of poor survival. In this studyHER-2/neu overexpression and its associations with clinicopathological characteristics were evaluated in patients with esophageal squamous cell carcinoma (ESCC). Methods: This cross-sectional study was performed on 64 patients with histological diagnosis of primary ESCC who underwent surgery for curative treatment. Immunohistochemistry (IHC) was used to assess expression of HER-2/neu receptor in formalin-fixed paran-embedded tissue blocks. Results: The mean age of patients was 60.1 1.28 years. The overall HER2 expression was observed in 51.5% of ESCC patients without considering IHC scores. HER2/neu overexpression (6%) was significantly associated with the tumor dierentiation (P < 0.001). 20.3% of cases were stage I, 67.2% stage II, and 12.5% stage III. 17 patients (26.2%) had vascular invasion, 12 patients (18.8%) had neuronal invasion and 7 patients (10.9%) had invasion to margins. Nine of 12 patients withHER-2/neu over expression had thoracic tumors and only three of them had an abdominal ESCC. Conclusions: No significant correlations were found between HER2/neu overexpression and gender, age, tumor invasion, location of tumor, TNM stages and stage of tumor in patients with ESCC.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Social Capital Enhancement on Quality of Life, Treatment Compliance and Pain in Patients with Breast Cancer","authors":"S. M. Hosseini, M. Mousavi, H. Rafiee, S. Karimi","doi":"10.17795/IJCP-4618","DOIUrl":"https://doi.org/10.17795/IJCP-4618","url":null,"abstract":"Background: Nowadays, research about quality of life in breast cancer patients is so important, because of progress in treatment procedure in health science. Brest cancer influences quality of life aspects and disrupts social relationships. This creates recluse lifestyle and speeds up disease trend. Objectives: The aim of this study was to investigate the eect(s) of social capital on quality of life, treatment compliance, and pain in patients with breast cancer. Materials and Methods: In a clinical trial, 29 patients with breast cancer (who referred to Kashany hospital in Shahrekord during 2010 - 2012) through non-probability (available) sampling were selected and randomly divided into two groups. The intervention group received some inter- ventions to promote social capital and the non-intervention group took routine treatment. Results: Before the intervention, both groups were similar in terms of the study variables. But after the intervention, in the intervention group social capital, Qol and treatment compliance increased and in the non-intervention group, these variables decreased. Pain in both groups was reduced, but this reduction was more noticeable in the intervention group. Conclusions: Increasing the social capital results in promoting Qol, health behaviors, treatment compliance and pain relief. Then methods of promoting social capital can be used as a way to improve Qol and treatment compliance and relieve pain.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Pourali, A. Taghizadeh, Mohammad Akhoundi, F. Varshoei, A. Zarifian, M. Andalibi
{"title":"Frequency of Chemotherapy Induced Anemia in Breast Cancer Patients","authors":"L. Pourali, A. Taghizadeh, Mohammad Akhoundi, F. Varshoei, A. Zarifian, M. Andalibi","doi":"10.17795/IJCP-4672","DOIUrl":"https://doi.org/10.17795/IJCP-4672","url":null,"abstract":"Background: Breast cancer is the second most common malignancy in women, worldwide. Several etiologic factors may cause anemia in a patient with breast cancer. Anemia is a prevalent complication in patients with breast cancer who undergo chemotherapy which affects the health status and quality of life in these patients. The aim of this study was to evaluate the prevalence of anemia in patients with non-metastatic breast cancer who underwent adjuvant chemotherapy. Methods: In this cross-sectional study, 144 women with non-metastatic breast cancer who referred to radiotherapy and oncology department of Imam Reza hospital and met inclusion criteria were included. Data were obtained from patients’ archived documents and were analyzed by SPSS software (version16). Results: In this study, 41% of patients were anemic before the chemotherapy and 43.1% of patients became anemic during and after treatment. The prevalence of post-chemotherapy anemia was significantly higher in advanced stages of cancer (P = 0.01). The chance of developing anemia were more in patients who underwent 8 cycles and AC + paclitaxel regimen, compared to the ones with 6 cycles and other regimens. There was no significant relationship between the prevalence of anemia and type of chemotherapy regimen, number of chemotherapy cycles, positive lymph nodes, co-morbidities, menstrual status, and body mass index (BMI). Conclusions: Due to the high prevalence of chemotherapy-induced anemia and its effects on quality of life, even mild degrees of anemia should be detected and evaluated before treatment. Considering early interventions is of cardinal importance, especially in the elderly.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current Status of the Fetography: Preventing of the Future Radiation Induced Cancer","authors":"M. Zabihzadeh, V. Karami","doi":"10.17795/IJCP-5209","DOIUrl":"https://doi.org/10.17795/IJCP-5209","url":null,"abstract":"Background: Fetography has named the radiography of the fetus in utero. Due to the potential risk of radiation-induced cancers and other malignant effects, this procedure has avoided and has completely replaced by ultrasonography. However it has observed that this invasive procedure has still followed in some clinical departments. Objectives: The aim of this study was to assess the current status of the fetography and its prevalence as an un-recommended diagnostic procedure in teaching hospitals of Ahvaz, Iran. Methods: The radiology and ultrasonography reception systems of two teaching hospitals of Ahvaz have investigated to identify pregnant patients who has undergone fetal presentation imaging (cephalic or breech) between 21 March 2013 and 21 March 2015. Results: In general 3741 pregnant women who have undergone fetal-presentation imaging during two past years have identified. There was significant statistically differences between X-ray and ultrasonography examinations (2528 vs. 1213; P value < 0.05), as those have accounted for 67.5% and 32.5% of the performed examinations, respectively. Women younger than 30 years, who were more sensitive to radiation, accounted for 51.2% of the X-ray examinations. The number of fetographies has increased as much as 2.2 fold during 2013 to 2015. Discussion: Women of the investigated hospital have received avoidable fetal irradiation due to fetography then it was a reason for concern. Ultrasonography should be the first-line imaging modality for pregnant women, especially in the case of fetal-presentation.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Mezginejad, F. Haghighi, Mahmoodreza Behravan, B. Bijari
{"title":"Cancer Types in Pathological Samples Referred to Educational Hospitals in Birjand During the Past Three Years (2011 - 2013)","authors":"F. Mezginejad, F. Haghighi, Mahmoodreza Behravan, B. Bijari","doi":"10.17795/IJCP-4075","DOIUrl":"https://doi.org/10.17795/IJCP-4075","url":null,"abstract":"Introduction: Cancer is ranked as the third leading cause of death in Iran. Today, more than 20 million people worldwide suffer from this disease. By the year 2030, this number is predicted to reach 75 million. Regarding the importance of cancer and its outbreak and different age patterns for cancer outbreak and also the occurrence of cancer in different geographic regions, the current study aimed at studying the occurrence of this disease during 3 past years in order to determine the epidemiologic characteristics of the cases among patients visiting educational hospitals in Birjand, Iran. Methods: In this cross-sectional study, patients visiting educational hospitals affiliated to Birjand University of Medical Sciences (BUMS) from December 22, 2011 to December 22, 2013 were assessed. The required data was collected from medical records of patients. Demographic data such as age, gender, types of cancer, and the total number of pathological cases were collected and recorded. The obtained data was analyzed by means of SPSS (V;15. using χ2 and ANOVA test). Results: The results show that 458 out of 2631 of biopsy samples referred to the pathology wards in the educational hospitals of BUMS suffered from cancer, among whom 257 (56.1%) were male and 201 (43.9%) were female. The most common cancers were those of the brain and the spinal cord (15.1%), skin (14.8%), and the breast (14%). The mean age of the patients was 60.35 ± 17.15 years. The most common cancer in men was stomach cancer (17.1%), and the most common cancer in women was breast cancer (31.8%). There could be found a significant relation between the type of cancer and gender (P = 0.001). Conclusions: Considering the importance of cancer and the possibility of prevention and treatment in the early stages of most cancers, and carrying out research projects to find risk factors related to common cancers in the area, one can use mass media for further awareness of the public and their education; and also help patients who pass away as a result of lack of awareness.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68179467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}