Iranian journal of cancer prevention最新文献_第4页

Quality Assessment of the National Cancer Registry in Iran: Completeness and Validity 伊朗国家癌症登记的质量评估:完整性和有效性

Iranian journal of cancer prevention Pub Date : 2016-12-10 DOI: 10.17795/IJCP-8479

G. Mohammadi, M. Akbari, Y. Mehrabi, A. Motlagh

{"title":"Quality Assessment of the National Cancer Registry in Iran: Completeness and Validity","authors":"G. Mohammadi, M. Akbari, Y. Mehrabi, A. Motlagh","doi":"10.17795/IJCP-8479","DOIUrl":"https://doi.org/10.17795/IJCP-8479","url":null,"abstract":"Introduction: Cancer Registry is one of the important components of health information systems in developing countries. Continuous monitoring of data quality can have a crucial role in controlling cancers. This study aimed to assess the quality of cancer registry data in terms of completeness of coverage and validity. Methods: Data were collected from three main sources, including Pathology registry, Hospital and national death registries in five provinces in Iran during March 2008-March 2011. We used two source capture-recapture method for estimate of cancer registry coverage and measures of validity were percentage of death certificate only (DCO%), histological verified cases (MV%); cancer incidence in childhood based on sex and age group, percentage of cancer in the elderly (80 years or above) and mortality-to-incidence ratio (M:I).We compared them to international standards. Results: The overall completeness was estimated at 54.2% and 32.4% under reporting for stomach cancer in a period of three years (2008 - 2010). MV% and percentage of unknown primary site of the tumor were 68.7%, and 5% respectively. The mortality-to-incidence ratio for men and women was 37.6% and 28.2%, and percentage of cancer in the elderly was 10.9% in 2010 year. The age-specific rate in girls and boys in age groups of 5 - 9 and 10 - 14 years was lower than minimum of the recommended international standards. Conclusions: The results of this study showed data quality of cancer registry is relatively low in terms of the completeness and validity. Cancer registries should pay great attention to the quality of their data. In addition to technical measures in data processing, continuous evaluation of their quality in order to achieve the set goals is essential.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Trends in ovarian cancer incidence in Iran 伊朗卵巢癌发病率趋势

Iranian journal of cancer prevention Pub Date : 2016-12-07 DOI: 10.17795/IJCP-5452

Y. Moradi, M. Jafari, S. Chaichian, Sorour Khateri, A. Akbarian, Bahram Moazzami, Kamyar Mansori, Y. Mahmodi, Saeed Samie

{"title":"Trends in ovarian cancer incidence in Iran","authors":"Y. Moradi, M. Jafari, S. Chaichian, Sorour Khateri, A. Akbarian, Bahram Moazzami, Kamyar Mansori, Y. Mahmodi, Saeed Samie","doi":"10.17795/IJCP-5452","DOIUrl":"https://doi.org/10.17795/IJCP-5452","url":null,"abstract":"Background: Cancer is amajorcause of morbidityandmortality,amongwhichovarian cancer has a high incidenceandcase fatality. Gaining insight into the epidemiology and trends of ovarian cancer can be very influential in cancer screening and treatments programming. This study aimed to investigate the trends in the incidence of ovarian cancer in Iran, because this issue has been neglected so far. Methods: This study is a re-analysis of existing data from the cancer data recording system in Iran during the years 2003 to 2009. The incidence rates reported were standardized according to the world health organization (WHO) and the trend in the incidence of this disease was determined by STATA software and the significance of the morbidity trend diagram was also derived via WINPEPI software. Results: The statistics of cancer registry center shows an increasing trend of ovarian cancer from 2003 to 2008, while it decreased from 2008 to 2009. During this period, 6078 cases of ovarian cancer were registered in Iran, increasing from 591 cases in 2003 to 1077 in 2009, which shows an approximately 2-fold increase in the incidence of registered cases. During these seven years, the highest incidence rate was seen in Markazi province with 6.33 per 100,000 persons and the least in Kohkiloye-va-Boyerahmad province with zero incidence. Almost all provinces, except a few, had increasing incidence of ovarian cancer. Conclusions: According to the results of the study, the incidence of ovarian cancer is increasing in Iran, especially in the central and northwestern regions of the country. This increase may be due to changing the patterns of risk factors for this disease, such as changes in lifestyle in the population, which will lead to changes in the incidence of the disease. Hence, due to the increase in incidence of this cancer, it is recommended to implement screening and early detection programs in high risk areas and populations. Â© 2016, Iranian Journal of Cancer Prevention.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Ductal Carcinoma in Situ within a Benign Phyllodes Tumor of Breast: Report of a Case 乳腺良性叶状瘤内导管原位癌1例报告

Iranian journal of cancer prevention Pub Date : 2016-12-07 DOI: 10.17795/IJCP-5376

R. Salek, N. S. Sistani, M. Forghani, Mahboobeh Sadeghi Ivari

引用次数: 0

Environmental Monitoring of Occupational Exposure to Cyclophosphamide Drug in Two Iranian Hospitals 伊朗两家医院职业性环磷酰胺药物暴露环境监测

Iranian journal of cancer prevention Pub Date : 2016-12-07 DOI: 10.17795/IJCP-7229

M. Azari, Davod Panahi, M. Akbari, H. Mirzaei, H. Rezvani, R. Zendehdel, Y. Mehrabi, M. Bayatian

{"title":"Environmental Monitoring of Occupational Exposure to Cyclophosphamide Drug in Two Iranian Hospitals","authors":"M. Azari, Davod Panahi, M. Akbari, H. Mirzaei, H. Rezvani, R. Zendehdel, Y. Mehrabi, M. Bayatian","doi":"10.17795/IJCP-7229","DOIUrl":"https://doi.org/10.17795/IJCP-7229","url":null,"abstract":"Background: Most cytotoxic drugs are unable to discriminate normal cells from cancer cells and they interfere with cell division and could lead to harmful effects such as carcinogenicity, genetic mutation, and teratogenicity. In order to assess dermal occupational exposure to cytotoxic drugs, surface sampling was used to determine the residual drugs on the working surfaces, as well as the effectiveness of the procedures for cleaning the treatment area. Objectives: This study was designed with the aim to investigate the contamination of surfaces and hand skin of the oncology staff with cyclophosphamide drug. Methods: Environmental and personal monitoring were performed by collecting wipe and dermal samples over the span of a month at two different times of handling of cytotoxic drugs or other work like cleaning and patient admission. Samples were taken from exposed oncology staff after administering cyclophosphamide to patient. Results: The method of sampling and analysis of cyclophosphamide over a linear range surface density of 30 - 180 ng/cm2 was validated. Cyclophosphamide was detected on some wipe samples at two hospitals. Results of this study demonstrated that some staff had dermal exposure to cyclophosphamide and it was also revealed that working surfaces were also contaminated with this drug. Conclusions: Health workers with present work practice are at risk with cytotoxic drugs. Therefore, adequate training and control measures are justified.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India 局部晚期非小细胞肺癌老年患者的治疗依从性和结果:来自印度的经验

Iranian journal of cancer prevention Pub Date : 2016-12-07 DOI: 10.17795/IJCP-5481

S. Pathy, Soumyajit Roy, P. Malik, B. Mohanti, V. Raina

{"title":"Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India","authors":"S. Pathy, Soumyajit Roy, P. Malik, B. Mohanti, V. Raina","doi":"10.17795/IJCP-5481","DOIUrl":"https://doi.org/10.17795/IJCP-5481","url":null,"abstract":"Objectives: To evaluate treatment compliance, toxicity and survival in geriatric patients ( ≥ 65 years) with locally advanced non-small cell lung cancer (LA-NSCLC). Methods: Departmental archive was collected for the details of demographics, treatment and outcome in elderly patients with LA-NSCLC (2008 - 2013) (n = 96). Both progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier method. Acute and late morbidity were scored using common terminology criteria for adverse events version 4, radiation therapy and oncology group late morbidity scoring system. Results: Overalltreatmentcompletionratewas65%. Theratesof acutegrade ≥ 3hematologicandnon-hematologictoxicitieswere 20% and 17% respectively. Overall rate of late toxicity was 12.5%. The median PFS and OS values were 7.4 months and 10.54 months, respectively. Patients with multiple comorbidities, poor socio-economic background and serum albumin level (< 3.5g/dL) were observed to have poor survival. Survival was lower for non-compliant patients. Conclusions: Curative multi-modality therapy in elderly patients with LA-NSCLC is a challenging task. They are susceptible to poor compliance, treatment-associated toxicities and poor survival. ulation with LA-NSCLC. The study reveals a treatment adherence rate of 65% among geriatric patients ( ≥ 65 years) with locally advanced NSCLC. Poor treatment compliance levelandmulti-ple poor therefore,","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Fine-Needle Aspirations in Atypia of Unknown Significance/Follicular Lesion Undetermined Significance (AUS/FLUS): Usefulness of Repeated FNA of Thyroid Nodules 意义不明的异型性/意义不明的滤泡性病变(AUS/FLUS)的细针穿刺:甲状腺结节重复FNA的有效性

Iranian journal of cancer prevention Pub Date : 2016-12-07 DOI: 10.17795/IJCP-7879

M. Nazem, Behrouz Kaleydari, M. Kolahdouzan, Valiollah Kashi, M. Amini

{"title":"Fine-Needle Aspirations in Atypia of Unknown Significance/Follicular Lesion Undetermined Significance (AUS/FLUS): Usefulness of Repeated FNA of Thyroid Nodules","authors":"M. Nazem, Behrouz Kaleydari, M. Kolahdouzan, Valiollah Kashi, M. Amini","doi":"10.17795/IJCP-7879","DOIUrl":"https://doi.org/10.17795/IJCP-7879","url":null,"abstract":"Background: One of the first steps to determine the thyroid nodules nature is fine needle aspiration. Almost 15% of the nodules are reported as atypia of unknown significance/follicular lesion of unknown significance (AUS/FLUS), with no clear nature of benign or malignant cells. Objectives: This study aimed to evaluate the diagnostic value of repeated FNA in patients with AUS/FLUS undergoing thyroidectomy. Methods: This trial was conducted on 50 patients candidate for thyroid surgery due to both FNA report (AUS/FLUS) and clinical/ ultrasound findings from 2013 - 2014 in a referral surgery centre. First, a new FNA sample was taken from the lesion during surgery and was sent for cytopatholgy. Then, permanent pathology results (as gold standard method of diagnosis) and repeated FNA reports were analyzed and compared. The data were analyzed using SPSS Ver. 17, with P values less than 0.05 being considered significant. Results: The obtained results revealed that repeated FNA had sensitivity of 61.9%, specificity of 100%. It had 0% false positive and 38.1% false negative results. In our study the malignancy rate in repeated FNA was 26%. Also, according to the results, the positive and negative predictive values were 100% and 46.7% respectively, and the accuracy was reported as 71.4%. Conclusions: Repeated FNA for AUS/FLUS has low sensitivity and negative predictive value despite 100% specificity and positive predictive value. Also, the prevalence of “undetermined” reports in repeated FNA for such lesions is high. It is recommended that repeating FNA for AUS/FLUS may have a limited role in decision making for managing patients with this type of thyroid nodules.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-Testis Antigens: A Novel Group of Tumor Biomarkers in Ovarian Cancers 癌睾丸抗原:卵巢癌中一组新的肿瘤生物标志物

Iranian journal of cancer prevention Pub Date : 2016-12-06 DOI: 10.17795/IJCP-4993

Z. Taherian-Esfahani, A. Abedin-Do, Elahe Nikpayam, Behnoosh Tasharofi, Akram Ghahghaei Nezamabadi, S. Ghafouri-Fard

{"title":"Cancer-Testis Antigens: A Novel Group of Tumor Biomarkers in Ovarian Cancers","authors":"Z. Taherian-Esfahani, A. Abedin-Do, Elahe Nikpayam, Behnoosh Tasharofi, Akram Ghahghaei Nezamabadi, S. Ghafouri-Fard","doi":"10.17795/IJCP-4993","DOIUrl":"https://doi.org/10.17795/IJCP-4993","url":null,"abstract":"Context: Ovarian cancer is the most fatal gynecological malignancy with no eﬀective screening strategy for early detection. As mostcasesarebeingdetectedinadvancestages,conventionaltherapiesarenotbeneﬁcialforthemajorityof patients. Cancer-testis antigens (CTAs) are a group of tumor associated antigens with speciﬁc expression pattern in cancers which potentiate them for application as cancer biomarkers and targets for immunotherapy. Evidence Acquisition: We performed a computerized search of the MEDLINE/PUBMED databases with key words: ovarian cancer, cancer-testis antigen, biomarker and immunotherapy. Results: Thirty ﬁve CTAs have been shown to be expressed in ovarian cancer. At least 13 of them have been shown to elicit immune responses in diﬀerent studies. The pattern of expression for some of them may facilitate molecular classiﬁcation of diﬀerent histo-logicclassesof ovariancancer. Inaddition,someCTAssuchasNY-ESO-1andMAGEhavebeenusedastargetsforimmunotherapeutic approaches with promising results. Conclusions: The expression pattern of CTAs in ovarian cancer and the preliminary results of clinical trials indicate that CTAs can be used as targets for immunotherapy of ovarian cancer patients.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Human Development Index (HDI) in Iran 伊朗人类发展指数(HDI

Iranian journal of cancer prevention Pub Date : 2016-10-29 DOI: 10.17795/IJCP-9408

M. Akbari

引用次数: 54

Potential anticarcinogenic effects of lactic acid bacteria and probiotics in detoxification of process-induced food toxicants 乳酸菌和益生菌在解毒过程中诱发食品毒物的潜在抗癌作用

Iranian journal of cancer prevention Pub Date : 2016-10-18 DOI: 10.17795/IJCP-7920

Nasim Khorshidian, M. Y. Asli, H. Hosseini, Mahdi Shadnoush, A. Mortazavian

{"title":"Potential anticarcinogenic effects of lactic acid bacteria and probiotics in detoxification of process-induced food toxicants","authors":"Nasim Khorshidian, M. Y. Asli, H. Hosseini, Mahdi Shadnoush, A. Mortazavian","doi":"10.17795/IJCP-7920","DOIUrl":"https://doi.org/10.17795/IJCP-7920","url":null,"abstract":"Context: Nowadays, it has been proved that there is a relation between dietary habits and incidence of different types of cancers. Consumption of processed foods exposes human to a wide range of toxicants such as heterocyclic aromatic amines, polycyclic aromatic hydrocarbons, acrylamide and nitrosamines that have mutagenic and carcinogenic effects on body and especially induce colon cancer. Under such circumstances, search for antimutagenic agents and helpful strategies have gained interest. \u0000Evidence Acquisition: We performed a computerized search of Scopus, Pubmed and google scholar databases with keywords: cancer, food toxicants, lactic acid bacteria, and probiotics. \u0000Results: Natural dietary compounds like lactic acid bacteria and probiotics can be beneficial in decline of detrimental effects associated with toxicants formed during food processing. It has been stated that binding ability of lactic acid bacteria and probiotics via their cell wall have prominent roles in detoxifying these toxicants. Also, this capability is influenced by various factors. \u0000Conclusions: It can be concluded that probiotics can play a vital role in prevention of colon cancer that is induced by food toxicants and their incorporation into food can be helpful in this respect. \u0000Keywords: Anticarcinogenic; Cancer; Food Toxicants; Lactic Acid Bacteria; Probiotics","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68182577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Hypoxia Response Elements Can Cause the Overexpression of the BAX mRNA Under Hypoxic Condition 缺氧反应元件可引起缺氧条件下BAX mRNA的过表达

Iranian journal of cancer prevention Pub Date : 2016-10-05 DOI: 10.17795/IJCP-4554

Ali Ghanbariasad, M. Bandehpour, B. Kazemi

{"title":"Hypoxia Response Elements Can Cause the Overexpression of the BAX mRNA Under Hypoxic Condition","authors":"Ali Ghanbariasad, M. Bandehpour, B. Kazemi","doi":"10.17795/IJCP-4554","DOIUrl":"https://doi.org/10.17795/IJCP-4554","url":null,"abstract":"Background: Suicide gene therapy is one of the modern methods of cancer treatment. However, transmission for tumor cells is one of the main challenges to overcome. Hypoxia is a common phenomenon in solid tumors that lead to changes in tumors microenvironment. Hypoxia-responsive element sequences are regulatory sequences that lead to activation of their upstream and downstream genes in hypoxic time. Bax is a strong proapoptotic gene that causes apoptosis in the time of over expression in cells. Objectives: The aim of this study is to use this sequence in order to specify suicide gene therapy by the help of a gene producing Bax protein under control of CMV promoter. Methods: The gene of BAX, BAX3HRE and 3HRE were cloned into interested vectors. In the next step, the function of HRE sequence on over expression of upstream gene under hypoxic condition was evaluated through western blot, MTT assay and real time PCR. Results: The results of this study indicate that cells transected by pcDNA3.1/BAX 3HRE. The rate of apoptosis in them significantly increased in comparison with pcDNA3.1/BAX in hypoxic conditions. Conclusions: Regarding the role of HREs in increasing the expression of its upstream genes, it can be used to specify suicide gene therapy in treatment of solid tumors.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68181217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1