局部晚期非小细胞肺癌老年患者的治疗依从性和结果:来自印度的经验

S. Pathy, Soumyajit Roy, P. Malik, B. Mohanti, V. Raina
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引用次数: 4

摘要

目的:评估老年(≥65岁)局部晚期非小细胞肺癌(LA-NSCLC)患者的治疗依从性、毒性和生存率。方法:收集科室档案资料,收集2008 - 2013年LA-NSCLC老年患者(n = 96)的人口学、治疗及转归资料。采用Kaplan-Meier法评估无进展生存期(PFS)和总生存期(OS)。使用不良事件通用术语标准第4版、放射治疗组和肿瘤组晚期发病率评分系统对急性和晚期发病率进行评分。结果:Overalltreatmentcompletionratewas65%。急性≥3级血液学毒性和非血液学毒性分别占20%和17%。晚期毒性总发生率为12.5%。中位PFS和OS值分别为7.4个月和10.54个月。合并多种合并症、社会经济背景差、血清白蛋白水平< 3.5g/dL的患者生存期较差。非依从性患者的生存率较低。结论:老年LA-NSCLC患者的多模式治疗是一项具有挑战性的任务。他们易受治疗依从性差、治疗相关毒性和生存率差的影响。LA-NSCLC。该研究显示,局部晚期NSCLC老年患者(≥65岁)的治疗依从率为65%。治疗依从性水平差,因此多重不良;
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment Compliance and Outcome in Geriatric Patients with Locally Advanced Non-Small Cell Lung Cancer: Experience from India
Objectives: To evaluate treatment compliance, toxicity and survival in geriatric patients ( ≥ 65 years) with locally advanced non-small cell lung cancer (LA-NSCLC). Methods: Departmental archive was collected for the details of demographics, treatment and outcome in elderly patients with LA-NSCLC (2008 - 2013) (n = 96). Both progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier method. Acute and late morbidity were scored using common terminology criteria for adverse events version 4, radiation therapy and oncology group late morbidity scoring system. Results: Overalltreatmentcompletionratewas65%. Theratesof acutegrade ≥ 3hematologicandnon-hematologictoxicitieswere 20% and 17% respectively. Overall rate of late toxicity was 12.5%. The median PFS and OS values were 7.4 months and 10.54 months, respectively. Patients with multiple comorbidities, poor socio-economic background and serum albumin level (< 3.5g/dL) were observed to have poor survival. Survival was lower for non-compliant patients. Conclusions: Curative multi-modality therapy in elderly patients with LA-NSCLC is a challenging task. They are susceptible to poor compliance, treatment-associated toxicities and poor survival. ulation with LA-NSCLC. The study reveals a treatment adherence rate of 65% among geriatric patients ( ≥ 65 years) with locally advanced NSCLC. Poor treatment compliance levelandmulti-ple poor therefore,
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