Iranian journal of cancer prevention最新文献

{"title":"A New Mutation in WT1 Gene Associated with Wilms Tumor with Reduced Penetrance in an Iranian Family","authors":"M. Fardaei, S. Tabei, S. Ghafouri-Fard, M. Miryounesi","doi":"10.5812/IJCM.7500","DOIUrl":"https://doi.org/10.5812/IJCM.7500","url":null,"abstract":"A New Mutation in WT1 Gene Associated with Wilms Tumor with Reduced Penetrance in an Iranian Family Majid Fardaei, Seyed Mohammad Bagher Tabei, Soudeh Ghafouri-Fard, and Mohammad Miryounesi Department of Medical Genetics, Shiraz University of Medical sciences, Shiraz, IR Iran Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Corresponding author: Soudeh Ghafouri-Fard, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. Tel/Fax: +98-2122439959, E-mail: s.ghafourifard@sbmu.ac.ir Corresponding author: Mohammad Miryounesi, Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. Tel/Fax: +98-2122439959, E-mail: miryounesi@gmail.com","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47547144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the Incidence of Cancer in Iran (2003 - 2009)","authors":"Seideh Zeinab Almasi, H. Salehiniya, Neda Amoori, S. Mahdavi, M. Enayatrad","doi":"10.5812/IJCP.4715","DOIUrl":"https://doi.org/10.5812/IJCP.4715","url":null,"abstract":"","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41425771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder Cancer in Iran: Geographical Distribution and Risk Factors","authors":"T. Jafari-Koshki, S. Arsang-Jang, B. Mahaki","doi":"10.5812/IJCP.5610","DOIUrl":"https://doi.org/10.5812/IJCP.5610","url":null,"abstract":"Background: To study overall and province-specific trends of bladder cancer incidence in Iran during 2004-2008 and to evaluate the association between bladder cancer incidence and some factors. Methods: Data on 17792 bladder cancer patients and risk factors available at province level were used in Bayesian ecological setting. First, the overall and province-specific trends of risk were estimated. Then the effects of cigarette smoking, being overweight, fruits and vegetables consumption, and low levels of physical activity on trend were examined. The province-specific effects of significant factors were also assessed. The data were analyzed using R-INLA package. Results: The risk of developing bladder cancer was decreasing in Iran, 2004 - 2008 (RR = 0.95). Guilan and Semnan had the highest 5-year incidence (RR > 1.5). However, the risk increase compared to country Risk was the highest in East Azerbaijan and Tehran (DT > 0.1). Also direct and reverse association between smoking and fruit consumption and bladder cancer risk were established. Guilan, Semnan, Sistan and Baluchestan, and Ilam were the provinces affected the most by these factors. Conclusions: This study confirms previous findings and provides further evidence on protective effects of fruit consumption in bladder cancer. The results would be of value for governors to prioritize the province-specific demands on research, education, and improvements with respect to the identified risk factors.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45170962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Peritoneal Cytology as a Predictor of Prognosis in Early Stage of Endometrioid Adenocarcinoma","authors":"S. Akhavan, Z. Kazemi, A. Alibakhshi, M. Modaresgilani, A. Mousavi, A. Ahmadzadeh, Khadije Rezaie Kahkhayi","doi":"10.5812/IJCP.5285","DOIUrl":"https://doi.org/10.5812/IJCP.5285","url":null,"abstract":"Background: Peritoneal cytology has been reported to be an independent risk factor for poor survival, but it is not included in the current international federation of gynecology and obstetrics (FIGO) staging system for risk stratification. Objectives: We aimed to investigate the prognostic significance of positive peritoneal cytology (PPC) in patients with early stage endometrioid adenocarcinoma. Methods: Medical profiles of patients with uterine carcinoma referring to Imam Khomeini hospital and Mirza Koochak Khan hospital between September, 2005 and December, 2011 have been reviewed. Patients had a complete staging procedure and peritoneal cytology evaluation. Results: Among 220 patients with mean age of 56.3 ± 9.1 years, 204 were Negative for peritoneal cytology (NPC) and 16 showed PPC. In the group of patients with endometrioid adenocarcinoma, 125 were in stage I and 32 were in stage II. Univariate analysis on patients with endometrioid adenocacinoma revealed that stage II (OR = 7.12, 95% CI = 2.95-22.10, P value < 0.001), stage III (OR = 8.04, 95% CI = 2.14 - 30.09, P value < 0.001), stage IV (OR = 58.09, 95% CI = 13.74 - 245.66, P value < 0.001), recurrence of either intra (OR = 32.65, 95% CI = 12.2 - 86.7, P value < 0.001) or extra pelvic (OR = 14.54, 95% CI = 4.4 - 47.7, P value < 0.001), and the number of lymph nodes involvement (OR = 5.59, 95% CI = 2.5 - 12.51, P value < 0.001) were significantly associated with survival. Also, patients with PPC had significantly poorer survival compared to those with negative peritoneal cytology; 38% Vs 88% were alive after 5 years (P value < 0.0001). Mean 5-year survival in PPC and NPC patients were 3.31 years and 4.74 years, respectively. Conclusions: Our study demonstrated that positive peritoneal cytology is an independent prognostic factor in patients with early stage endometrioid adenocarcinoma. We propound that peritoneal cytology adds back into the future FIGO staging criteria revision. Until then, peritoneal washings should still be considered as an important part for accurate risk-stratification.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46157873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intact Expression of Hypoxia-Inducible Factor 1α (HIF-1α) Gene in HeLa Cell Line Following Treatment with Lactobacilli Supernatants","authors":"A. Esfandiary, A. Abedin-Do, Z. Taherian-Esfahani, S. Ghafouri-Fard, E. Motevaseli","doi":"10.5812/IJCP.4774","DOIUrl":"https://doi.org/10.5812/IJCP.4774","url":null,"abstract":"","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49293617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Acceptance and Commitment Therapy on Breast Cancer Female Patients’ Hope","authors":"A. Montazer, F. Nemati, F. Dehghani, Tahereh Fallah","doi":"10.5812/IJCP.5526","DOIUrl":"https://doi.org/10.5812/IJCP.5526","url":null,"abstract":"Background: Breast cancer is one of the most serious diseases that can endanger physical, psychological, and social health of women suffering from this disease. Objectives: The aim of this study was to evaluate the effectiveness of commitment and acceptance (ACT) on breast cancer patients’ hope. Methods: This quasi-experimental study included all patients with breast cancer who were inhibited in Yazd, Iran. Using convenience sampling, 34 patients were selected and randomly divided into two groups: the treatment group and the control group. Both groups completed Miller’s questionnaire on hope. Treatment group received psychological therapy of ACT for 12 weeks, 3 hours per week. Miller’s questionnaire was redistributed and completed again by both groups after completion of the treatment. The collected data were analyzed by SPSS software and running analysis of covariance. Results: The results of the current study revealed significant differences between control and treatment groups in terms of pre-test and post-test scores (P = 0.05). Conclusions: According to the results of the present study, psychological therapy of ACT can be useful in promoting the breast cancer patients’ hope.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45091506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitization of Radio-Resistant Lung Cancer Cells with a B Subunit of Bacterial Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans","authors":"H. Yaghoobi, B. Kazemi, M. Bandehpour","doi":"10.5812/IJCP.5792","DOIUrl":"https://doi.org/10.5812/IJCP.5792","url":null,"abstract":"Background: Combination cancer therapy is a promising strategy which employs multiple therapeutic agents with different mechanisms of action along with minimal intolerable side effects. For example, a combination of radiotherapy with gene therapy can overcome the development of resistance to therapeutic doses of irradiation (IR) and normal tissue damages caused by high-dose radiation. Recent studies have revealed radio-resistance in non-small cell lung cancer (NSCLC) cells. In this study, for the first time, subunit B of cytolethal distending toxin (cdtB)-expressing plasmid was introduced as a sensitizer of the cells to IR with a high efficacy. Methods: A vector expressing cdtB suicide gene of human periodontal bacterium Aggregatibacter actinomycetemcomitans was constructed and then transfected into A549 cell line. In the next step, cells transfected with pcDNA3.1/cdtB were irradiated and its growth inhibitory effect was evaluated in NSCLC cancer in vitro by MTT (3-(4, 5-methylthiazol-2-yl) -2, 5-diphenyl-tetrazolium bromide) assay. Terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were carried out in order to examine the apoptosis induction by a combination of IR with cdtB. Results: Our data indicated significant cell death in NSCLC cells in comparison with controls with an increase from 5% in response to IR up to 73.27% for combination of IR with cdtB. Moreover, the result of TUNEL assay showed significant differences in the number of apoptotic cells among the different affected groups. Conclusions: Our results confirmed that cdtB-expressing plasmid sensitizes NSCLC cells to IR and significantly increases the efficacy of radiotherapy and therefore, combining toxin with IR has a synergistic effect on NSCLC.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49101459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Occurrence of B-Cell Lymphocytic Leukemia and Acute Myeloid Leukemia in an Elderly Female Patient","authors":"A. Allahyari, N. Esfandiari, F. Nazemian, M. Sadeghi","doi":"10.5812/IJCP.4930","DOIUrl":"https://doi.org/10.5812/IJCP.4930","url":null,"abstract":"Introduction: The coexistence of B-cell chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) in the same patient is rare. The aim of this study is to report of simultaneous occurrence of CLL and AML M5 in an old female patient for the first time. Case Presentation: A 72-year-old woman referred to hematology clinic for evaluation of leukocytosis, anemia, and thrombocytopenia. She had no known history of chronic illness or exposure to radiation or myelotoxic drugs. Physical examination showed the existence of generalized lymphadenopathy and splenomegaly. Section of the biopsy core disclosed a diffuse infiltration of lymphoid cells with hyperchromic irregular nuclei and scant cytoplasm in the background. Immunohistochemical staining for CD20 in lymphoid cells and CD68 in blastic cells were positive but it was negative for terminal deoxynucleotidyl transferase (TdT). The flow cytometric immunophenotyping analysis was performed in the presence of CD5 positive B-cell population (CD19; CD20 dim; CD23 and CD5/CD19) with small cell size that comprised 76% of cells with abnormal phenotype was revealed. Simultaneous occurrence of CLL and AML M5 was confirmed in the patients. Conclusions: We report a case of previously untreated CLL and AML M5 with rapidly progressive course to death in less than one month from diagnosis. To the best of our knowledge, the development of AML M5 in patient with CLL has not been reported before.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48767268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral Respiratory Infections in Patients with Cancer","authors":"Yaser Arjeyni, H. Goudarzi, G. Eslami, E. Faghihloo","doi":"10.5812/IJCP.8084","DOIUrl":"https://doi.org/10.5812/IJCP.8084","url":null,"abstract":"Context: Cancers are among the gravest causes of the intensive immunodeficiency and provide favorable conditions for severe respiratory tract infections. Evidence Acquisition: Using various keywords related to the subject matter, articles were analyzed in PubMed and appropriately selected for review. Results: Inpatientswithcancer,someviralrespiratoryinfectionssuchasHRSV,Influenzavirus,HCMV,HMPVandHPIVareprevalent. Conclusions: Viral respiratory infections in cancer patients are common and can worsen the patients’ condition and disrupt the treatment process. Therefore, prevention and treatment of respiratory viral infections in cancer patients is important. rhesus monkey (RMK), MRC-5 antibody (DFA) testing, viral culture and real time RT-PCR. Twenty-four influenza infected pediatric cancer patients (20 influenza A and 4 influenza B cases) 27 clinical","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46462340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between NAT2 Polymorphisms and Prostate Cancer","authors":"M. Hasanzad, S. Ziaei, V. Montazeri, M. Afshari, S. Jamaldini, M. Imani, M. Sattari, Leila Hashemian, Seyed Rouhollah Kalantar Moaetamed, Mohammad Samzadeh","doi":"10.5812/IJCP.5716","DOIUrl":"https://doi.org/10.5812/IJCP.5716","url":null,"abstract":"","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47775220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}