Iranian journal of cancer prevention最新文献

{"title":"Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran","authors":"K. Anvari, Mehdi Seilanian Toussi, S. Shahidsales, F. Motlagh, Mohammad Reza Ehsaee, Farzaneh Afshari","doi":"10.17795/ijcp-4099","DOIUrl":"https://doi.org/10.17795/ijcp-4099","url":null,"abstract":"Background Astrocytomas are the most common primary adult brain tumors. Objectives In this study, we investigated the impact of some potential prognostic factors on survival in patients with low and high grade astrocytomas. Patients and Methods This retrospective cohort study was performed on patients with brain astrocytoma who were referred to oncology departments, Omid and Ghaem hospitals, Mashhad University of Medical Sciences (2000 - 2011). Results 415 patients with a median age of 43 and a male to female ratio of 252:163 (1.54) were recorded. Grade I to IV astrocytoma were found in 40 (9.6%), 88 (21.2%), 71 (17.1%) and 216 (52%) patients. With a median follow up time of 37 months for low grade and 13 months for high grade astrocytoma, the 5-year survival in grades I to IV was 92.1%, 69.1%, 49.2% and 9.6% respectively. In low grade astrocytomas, patients with grade I tumors, being ambulatory (5-year survival: 88% vs. 60.3%, P < 0.001) and performing optimal surgery (5-year survival 86% vs. 59.3%, P < 0.001) were associated with more favorable survival. In high grade astrocytomas, patients with grade III tumors, age < 50 (5-year survival 29.6% vs. 14.6%, P < 0.001), being ambulatory (5-year survival 39.4% vs. 10.5, P < 0.001), performing optimal surgery (5-year survival 46.1% vs. 4.3%, P < 0.001) and receiving chemotherapy (5-year survival 23.7% vs. 18.7%, P = 0.02) were associated with significantly higher overall survival. Conclusions Performing optimal surgery and good performance status were associated with more favorable survival in both low and high grade astrocytomas. In high grade a strocytomas, patients younger than 43 and those who received chemotherapy had better overall survival.","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68179740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Histologic Subtype Influence the Post-Operative Outcome in Spinal Meningioma?","authors":"Hanieh Zham,&nbsp;Afshin Moradi,&nbsp;Azadeh Rakhshan,&nbsp;Alireza Zali,&nbsp;Ali Rahbari,&nbsp;Mohammadreza Raee,&nbsp;Farzad Ashrafi,&nbsp;Mahsa Ahadi,&nbsp;Leila Larijani,&nbsp;Masoud Baikpour,&nbsp;Maryam Khayamzadeh","doi":"10.17795/ijcp-3838","DOIUrl":"https://doi.org/10.17795/ijcp-3838","url":null,"abstract":"<p><strong>Background: </strong>Postoperative outcome of spinal meningiomas is an important issue in surgery decision-making. There are limited and conflicting data in the literature about the prognostic factors influencing recovery, especially about the histopathologic subtypes.</p><p><strong>Objectives: </strong>This study was carried out to evaluate the effect of some of these factors on postoperative outcome.</p><p><strong>Patients and methods: </strong>This study was performed on 39 patients operated for spinal meningioma between October 1998 and January 2012; their histopathologic subtype was determined according to WHO criteria. The follow up period ranged between 8 - 120 months. The influence of histopathologic subtype, grade, age, sex, surgical approach, local adhesion and anatomical location was assessed according to Frankel classification of neurologic deficit.</p><p><strong>Results: </strong>From a total number of 39 spinal meningiomas, 34 cases were WHO grade I, from which 15 cases were psammomatous, 7 cases were meningothelial, 9 cases were transitional and 3 cases were fibroblastic. Five cases were grade II, 3 of which had clear cell appearance and the remaining 2 had chordoid appearance. The mean age was 51.6 (22 to 76) years; 25 cases were female and 14 cases were male. This study revealed that grade II meningioma cases had poor prognosis in all 5 cases and psammomatous subtype had poor postoperative outcome in 40% of cases while the other subtypes had good outcome in all cases (P = 0.026). Cervical location of the tumor was also related with poor outcome in 37.5% of the cases, while 22.5% had poor outcome in other locations (P = 0.029). Age below and above 45 years and sex had no significant influence on the outcome.</p><p><strong>Conclusions: </strong>Spinal meningiomas of psammomatous type and grade II spinal meningiomas are associated with less favorable postoperative neurologic outcome. Cervical location has also a negative correlation with a good outcome.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/85/ijcp-09-02-3838.PMC4951769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34626952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Lymphangioma as a Rare Pancreatic Mass: A Case Report.","authors":"Abdolhasan Talaiezadeh,&nbsp;Nastaran Ranjbari,&nbsp;Mohammad Bakhtiari","doi":"10.17795/ijcp-3505","DOIUrl":"https://doi.org/10.17795/ijcp-3505","url":null,"abstract":"<p><strong>Introduction: </strong>Cystic lymphangiomas of abdomen has mostly involved mesentery and retro peritoneum that should be considered as a differential diagnosis of abdominal masses. Pancreatic lymphangiomas were extremely rare that should be differentiated from neoplastic pancreatic cysts. Patients have commonly presented with epigastric pain and a relevant palpable epigastric mass.</p><p><strong>Case presentation: </strong>A 65-year-old lady who has presented with epigastric pain, then during investigations, a cystic tumor which located in the tail of pancreas, has found. Whereas definite diagnosis of tumor with routine procedures was impossible, the tumor has completely resected by distal pancreatectomy and splenectomy. Pathology and IHC was suggestive of benign lymphangioma.</p><p><strong>Conclusions: </strong>According to this presentation diagnosis of cystic lymphangioma of the tail of pancreas should be considered as a differential diagnosis of pancreatic cystic lesions and complete excision has been the treatment of choice.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/72/ijcp-09-01-3505.PMC4922201.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34691402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Two Common Promoter Polymorphisms of Transforming Growth Factor-β1 on Breast Cancer Risks in Ahvaz, West South of Iran.","authors":"Somayeh Parvizi,&nbsp;Ghorban Mohammadzadeh,&nbsp;Maryam Karimi,&nbsp;Mozhgan Noorbehbahani,&nbsp;Alireza Jafary","doi":"10.17795/ijcp-5266","DOIUrl":"https://doi.org/10.17795/ijcp-5266","url":null,"abstract":"<p><strong>Background: </strong>Transforming growth factor-β1 (TGF-β1) has a critical role in breast cancer initiation and progression.</p><p><strong>Objectives: </strong>We have investigated the possible differences in two promoter polymorphisms (-509C/T and -800G/A) of TGF-β1 gene between breast cancer cases and controls.</p><p><strong>Patients and methods: </strong>A total of 100 patients with confirmed breast cancer and 100 subjects without breast cancer was selected. Two promoter polymorphisms (-509C/T and -800G/A) of TGF-β1 gene were genotyped using PCR-based restriction fragment length polymorphism (RFLP) method.</p><p><strong>Results: </strong>The allele frequencies were 63% for C allele and 37% for T allele of SNP -509C/T and 66% for G allele and 34% for A allele of SNP -800G/A. Although no significant difference has observed between two groups, according to the genotype distribution, However, the TT genotype of -509 and AA genotype of -800 was significantly associated with breast cancer risk [odds ratio (OR) = 2.409; 95% confidence interval (CI) = 1.087 - 5.337, P = 0.030; and OR = 2.383; CI = 1.039 - 5.40, P = 0.040, respectively]. In addition, a multinomial logistic regression model shown, homozygous of -800 G/A (OR = 0.570; 95% CI = 0.362 - 0.896, P = 0.015); and HDL-C (OR = 0.935; 95% CI = 0.906 - 0.965, P < 0.001) were the selected variables associated with the presence of breast cancer. Haplotype analysis has shown no significant association between TGF-β1 haplotypes and breast cancer risk.</p><p><strong>Conclusions: </strong>Our results indicated that among two promoter polymorphisms of the TGF-β1gene, -800G/A compared to -509C/T is more associated with breast cancer.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/8d/ijcp-09-01-5266.PMC4922207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34628212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XRCC1 and OGG1 Gene Polymorphisms and Breast Cancer: A Systematic Review of Literature.","authors":"Ali Sanjari Moghaddam,&nbsp;Milad Nazarzadeh,&nbsp;Rezvan Noroozi,&nbsp;Hossein Darvish,&nbsp;Alireza Mosavi Jarrahi","doi":"10.17795/ijcp-3467","DOIUrl":"https://doi.org/10.17795/ijcp-3467","url":null,"abstract":"<p><strong>Context: </strong>Known polymorphisms of DNA repair genes can be associated with the risk of many types of cancer. There is no consensus regarding association between XRCC1 and OGG1 with breast cancer (BC).</p><p><strong>Objectives: </strong>The aim of this study is to collect relevant published studies systematically.</p><p><strong>Data sources: </strong>Sixty-two publications were identified through searching PubMed, PubMed Central, ISI web of knowledge, and reference list of related articles.</p><p><strong>Study selection: </strong>We performed a systematic review according MOOSE guideline criteria. All longitudinal cohort and case-control studies investigating association of any type and grade of breast cancer with XRCC1 and OGG1 gene and their polymorphisms were eligible for initial inclusion.</p><p><strong>Data extraction: </strong>Two authors screened titles and abstracts and extracted all needed information from eligible studies. Four research methodological components causing bias for the association between gene polymorphisms and breast cancer risk, including source of controls sampling, population ethnicity, sample size of studies and menopausal status of cases and controls was used for assessment of quality of studies.</p><p><strong>Results: </strong>A total of 14,793 breast cancer cases and 15,409 controls were included in assessment of XRCC1 Arg194Trp. Four studies showed significant association and one study showed protective effect of XRCC1 Arg194Trp and BC. A total of 7,716 cases and 7,370 controls were included for XRCC1 Arg280His. Only one study showed significant association of XRCC1 Arg280His and breast cancer (OR = 1.82 (1.06 - 3.15). A total of 27,167 cases and 31,998 controls were included to estimate association between XRCC1 Arg399Gln polymorphism and breast cancer. Seven studies showed significant association and one showed protective effect of XRCC1 Arg399Gln and BC. A total of 9,417 cases and 11,087 controls were included for OGG1 Ser326Cys. Among studies focused on OGG1 Ser326Cys, none showed significant association with breast cancer.</p><p><strong>Conclusions: </strong>Systematic search of major databases identify many studies addressing the relationship between BC and susceptible alleles in the base excision repair genes and the fact that there are many variations in the magnitude of association depending on inheritance model and the population of the study.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ed/50/ijcp-09-01-3467.PMC4922200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34691401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr Virus Infection and Opisthorchiasis: A Story of Cholangiocarcinoma in the Highly Endemic Area.","authors":"Viroj Wiwanitkit","doi":"10.17795/ijcp-3647","DOIUrl":"https://doi.org/10.17795/ijcp-3647","url":null,"abstract":"Dear Editor, \u0000 \u0000Cholangiocarcinoma is an important hepatobiliary cancer. It is considered a deadly cancer. This cancer is very common in Indochina area and there are several deaths due to this cancer every year. This cancer is usually late detected. The patients usually present with severe obstructive jaundice. The advanced cancer is usually seen at first diagnosis and it is usually a non resectable mass. Hence, only palliative care is usually provided to the patients with cholangiocarcinoma. \u0000 \u0000The main endemic countries of cholangiocarcinoma are Laos People’s Democratic Republic and Thailand (1). Hundreds of new cases of cholangiocarcinoma are registered in the endemic area (1). The prevention of the cholangiocarcinoma becomes the regional public health policy. It is accepted that chronic opisthorchiasis is the main risk factor of cholangiocarcinoma in this region (1). Of interest, opisthorchiasis is a fluke infestation. The infestation is usually a result of intake of contaminated fresh water fish that is not well cooked. Of interest, raw fish dish is a common local dish in the endemic area, Indochina. In the endemic area, there is a campaign to promote cancer prevention by avoidance of raw fish intake (2). However, there are many additional factors that can promote the cholangiocarcinogenesis including exposure to nitrosamine contamination in local food (3, 4) and exposure to contaminated pesticide in local food (3, 4). An important possible risk is the concurrent infection. Indeed, there are many tropical infections in the endemic area and some might be considered as risk for promoting cholangiocarcinogenesis. For example, concurrent hepatitis B infection is proved to be a risk (5, 6). It is noted that there is a very high rate of hepatitis B seropositive among patients with cholangiocarcinoma (5, 6). Indeed, the concurrent viral infection should be specially focused on since many viruses are proved to have the cytopathogenic effect. In fact, the virus infection is proved for induction of carcinogenesis in many cancers such as uterine cervix cancer, nasopharyngeal cancer and hepatocellular cancer. Hence, it is no doubt that the virus infection might have possible role in carcinogenesis of cholangiocarcinoma. Of several viruses, the Epstein-Barr virus should be mentioned. In oncology, Epstein-Barr virus infection is proved for relationship to carcinogenesis of nasopharyngeal cancer. Focusing on cholangiocarcinoma, there are many reports indicating that Epstein-Barr virus infection might cause cellular aberration and this can superimpose the pathology due to chronic opisthorchiasis resulting in increased chance of cholangiocarcinoma development (7). It should be hereby noted that Epstein-Barr virus infection does not directly induce the carcinogenesis of biliary tract but its cytopathogenic effect superimpose the problem (7, 8). Focusing on Epstein-Barr virus infection, the seroprevalence of this infection is also extremely high in the Indochi","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/ca/ijcp-09-02-3647.PMC4951762.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34614736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Manpower Development (HMD) Corner Stone of Improving National Health System.","authors":"Mohammad Esmaeil Akbari","doi":"10.17795/ijcp-5625","DOIUrl":"https://doi.org/10.17795/ijcp-5625","url":null,"abstract":"","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/20/ijcp-09-01-5625.PMC4922209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34628214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Effects of the Ethanol Bane Skin Extract in Human Prostate Cancer Pc3 Cells.","authors":"Maryam Amiri,&nbsp;Faranak Kazerouni,&nbsp;Saeed Namaki,&nbsp;Hassan Darbandi Tamijani,&nbsp;Hooman Rahimipour,&nbsp;Nasrin Boroumand,&nbsp;Siyamak Barghi,&nbsp;Nazanin Ebrahimi,&nbsp;Seyed Mohammad Gheibi Hayat","doi":"10.17795/ijcp-4755","DOIUrl":"https://doi.org/10.17795/ijcp-4755","url":null,"abstract":"<p><strong>Background: </strong>It is extensively supposed that vegetarian diet could affect cancer progress and increase the influence of formal chemotherapy.</p><p><strong>Objectives: </strong>The present study was designed to determine the effect of the ethanol Bane skin extract against chemo resistant prostate cancer PC3 cells.</p><p><strong>Materials and methods: </strong>PC3 and L929 cells were cultivated and then incubated in the ethanol Bane skin extract with various concentrations of 0.78, 1.5, 3.13, 6.25, 12.5 mg/mL in 3 times 24, 48, 72 hours. Cytotoxic effect of the ethanol Bane skin extract on PC3 and L929 cells was examined by MTT assay after 24, 48, and 72 hours. Morphology of PC3 cells was evaluated by Gimsa staining.</p><p><strong>Results: </strong>The ethanol Bane skin extract inhibited proliferation and caused cell death with IC50 values of 2.8 mg/mL on PC3 cells and the IC50 was 6.1 mg/mL on l929 cells. Morphological changes and apoptotic bodies were observed in PC3 cells faced with the ethanol Bane skin extract by staining with Gimsa.</p><p><strong>Conclusions: </strong>The ethanol Bane skin extract could repress the growth of PC3 cell line. This inhibitory effect of the Bane extract depended on the dose and the time on PC3. The result of this study shows that the ethanol Bane skin extract includes photochemical and inhibitory function against proliferation and inducer of apoptosis in human prostate cancer PC3 cells and also has less cytotoxic effect on l929 than PC3 cells. The ethanol Bane skin extract might be a good candidate for the new herbal anticancer drug.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/a7/ijcp-09-02-4755.PMC4951764.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34626959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Prevalence of the Epidermal Growth Factor Receptor in Transitional Cell Carcinoma of Bladder and its Relationship With Other Prognostic Factors.","authors":"Mahmoud Parvin,&nbsp;Parto Sabet-Rasekh,&nbsp;Parastoo Hajian,&nbsp;Peyman Mohammadi Torbati,&nbsp;Parisa Sabet-Rasekh,&nbsp;Hamidreza Mirzaei","doi":"10.17795/ijcp-4022","DOIUrl":"https://doi.org/10.17795/ijcp-4022","url":null,"abstract":"<p><strong>Background: </strong>The most common malignancy in the urinary system has been bladder cancer and the most predominant histologic subtype has been transitional cell carcinoma (TCC). There were many molecular risk factors, related with poor prognosis. One of these factors was expression of epidermal growth factor receptor (EGFR).</p><p><strong>Objectives: </strong>The aim of this study was to evaluate the prevalence of the epidermal growth factor receptor in transitional cell carcinoma of bladder and its relationship with other prognostic factors.</p><p><strong>Patients and methods: </strong>This analytic descriptive study has performed with 61 patients with TCC of bladder after radical cystectomy whom have been hospitalized in Labbafinejad hospital in Tehran, Iran between 2007 and 2010. We have used Chi-square and t-test to analyze our data samples.</p><p><strong>Results: </strong>Records of 61 patients have studied. Fifty three of the total samples were positive for EGFR expression (86.9%). Fifty samples of these fifty-three belonged to men and three others were women's samples (P = 0.46). Among the group with EGFR expression the results were as follows: 25 patients (47.2%) were 60 years old or less and 28 patients (52.8%) were older than 60 (P = 0.023), 16 patients (30.2%) had invasion to lamina properia, and the rest of them had invasion to deeper layers (P = 0.56). For most patients we could not determine the invasion of tumoral cells into the lymph nodes (Nx) (P = 0.067). Thirty four patients (64.2%) had not lymphovascular invasion (P = 0.44) and in forty three of patients (81.1%), perineural invasion have not seen (P = 0.23). Finally, 36 patients (67.9%) were grade 3 (P = 0.27).</p><p><strong>Conclusions: </strong>In this study we have concluded that most patients had EGFR positive expression. Also, except for the age, there was not any significant relation between expression of EGFR and the other prognostic factors such as, gender, invasion of the tumor into the layers, involving the lymph nodes, lymphovascular or perineural invasion, and grading.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/98/ijcp-09-01-4022.PMC4922206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34628211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Three Rounds of Mammography Breast Cancer Screening in Iranian Women.","authors":"Shahpar Haghighat, Mohammad Esmaeil Akbari, Parvin Yavari, Mehdi Javanbakht, Shahram Ghaffari","doi":"10.17795/ijcp-5443","DOIUrl":"10.17795/ijcp-5443","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most common cancer in Iranian women as is worldwide. Mammography screening has been introduced as a beneficial method for reducing mortality and morbidity of this disease.</p><p><strong>Objectives: </strong>We developed an analytical model to assess the cost effectiveness of an organized mammography screening program in Iran for early detection of the breast cancer.</p><p><strong>Patients and methods: </strong>This study is an economic evaluation of mammography screening program among Iranian woman aged 40 - 70 years. A decision tree and Markov model were applied to estimate total quality adjusted life years (QALY) and lifetime costs.</p><p><strong>Results: </strong>The results revealed that the incremental cost effectiveness ratio (ICER) of mammography screening in Iranian women in the first round was Int. $ 37,350 per QALY gained. The model showed that the ICER in the second and third rounds of screening program were Int. $ 141,641 and Int. $ 389,148 respectively.</p><p><strong>Conclusions: </strong>Study results identified that mammography screening program was cost-effective in 53% of the cases, but incremental cost per QALY in the second and third rounds of screening are much higher than the accepted payment threshold of Iranian health system. Thus, evaluation of other screening strategies would be useful to identify more cost-effective program. Future studies with new national data can improve the accuracy of our finding and provide better information for health policy makers for decision making.</p>","PeriodicalId":73510,"journal":{"name":"Iranian journal of cancer prevention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/5b/ijcp-09-01-5443.PMC4922208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34628213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}