伊朗东北部成人星形细胞瘤的治疗结果和预后因素

K. Anvari, Mehdi Seilanian Toussi, S. Shahidsales, F. Motlagh, Mohammad Reza Ehsaee, Farzaneh Afshari
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引用次数: 3

摘要

星形细胞瘤是最常见的成人原发性脑肿瘤。目的在本研究中,我们探讨了一些潜在的预后因素对低级别和高级别星形细胞瘤患者生存的影响。患者和方法本回顾性队列研究是对2000 - 2011年在马什哈德医科大学Omid和Ghaem医院肿瘤科转诊的脑星形细胞瘤患者进行的。结果415例患者中位年龄43岁,男女比例为252:163(1.54)。I ~ IV级星形细胞瘤40例(9.6%),88例(21.2%),71例(17.1%),216例(52%)。低级别星形细胞瘤的中位随访时间为37个月,高级别星形细胞瘤的中位随访时间为13个月,I至IV级星形细胞瘤的5年生存率分别为92.1%、69.1%、49.2%和9.6%。在低级别星形细胞瘤中,I级肿瘤患者,门诊(5年生存率:88%对60.3%,P < 0.001)和最佳手术(5年生存率:86%对59.3%,P < 0.001)与更有利的生存率相关。在高级别星形细胞瘤中,III级肿瘤患者,年龄< 50岁(5年生存率29.6% vs. 14.6%, P < 0.001),门诊(5年生存率39.4% vs. 10.5, P < 0.001),进行最佳手术(5年生存率46.1% vs. 4.3%, P < 0.001)和接受化疗(5年生存率23.7% vs. 18.7%, P = 0.02)与总生存率显著提高相关。结论在低级别和高级别星形细胞瘤患者中,采用最佳的手术方式和良好的运动状态均可提高生存率。在高级别间质细胞瘤中,年龄小于43岁的患者和接受化疗的患者有更好的总生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran
Background Astrocytomas are the most common primary adult brain tumors. Objectives In this study, we investigated the impact of some potential prognostic factors on survival in patients with low and high grade astrocytomas. Patients and Methods This retrospective cohort study was performed on patients with brain astrocytoma who were referred to oncology departments, Omid and Ghaem hospitals, Mashhad University of Medical Sciences (2000 - 2011). Results 415 patients with a median age of 43 and a male to female ratio of 252:163 (1.54) were recorded. Grade I to IV astrocytoma were found in 40 (9.6%), 88 (21.2%), 71 (17.1%) and 216 (52%) patients. With a median follow up time of 37 months for low grade and 13 months for high grade astrocytoma, the 5-year survival in grades I to IV was 92.1%, 69.1%, 49.2% and 9.6% respectively. In low grade astrocytomas, patients with grade I tumors, being ambulatory (5-year survival: 88% vs. 60.3%, P < 0.001) and performing optimal surgery (5-year survival 86% vs. 59.3%, P < 0.001) were associated with more favorable survival. In high grade astrocytomas, patients with grade III tumors, age < 50 (5-year survival 29.6% vs. 14.6%, P < 0.001), being ambulatory (5-year survival 39.4% vs. 10.5, P < 0.001), performing optimal surgery (5-year survival 46.1% vs. 4.3%, P < 0.001) and receiving chemotherapy (5-year survival 23.7% vs. 18.7%, P = 0.02) were associated with significantly higher overall survival. Conclusions Performing optimal surgery and good performance status were associated with more favorable survival in both low and high grade astrocytomas. In high grade a strocytomas, patients younger than 43 and those who received chemotherapy had better overall survival.
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