膀胱移行细胞癌中表皮生长因子受体的表达及其与其他预后因素的关系。

Iranian journal of cancer prevention Pub Date : 2016-02-23 eCollection Date: 2016-02-01 DOI:10.17795/ijcp-4022
Mahmoud Parvin, Parto Sabet-Rasekh, Parastoo Hajian, Peyman Mohammadi Torbati, Parisa Sabet-Rasekh, Hamidreza Mirzaei
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引用次数: 10

摘要

背景:泌尿系统最常见的恶性肿瘤是膀胱癌,最主要的组织学亚型是移行细胞癌(TCC)。分子危险因素较多,与预后不良有关。其中一个因素是表皮生长因子受体(EGFR)的表达。目的:探讨膀胱移行细胞癌中表皮生长因子受体的表达及其与预后的关系。患者和方法:本分析性描述性研究纳入了2007年至2010年间在伊朗德黑兰Labbafinejad医院住院的61例根治性膀胱切除术后膀胱TCC患者。我们使用卡方检验和t检验来分析我们的数据样本。结果:对61例患者的病历进行了研究。EGFR阳性53例(86.9%)。这53个样本中有50个属于男性,另外3个属于女性样本(P = 0.46)。EGFR表达组60岁以下25例(47.2%),60岁以上28例(52.8%)(P = 0.023),侵及固有层16例(30.2%),侵及较深层16例(P = 0.56)。对于大多数患者,我们无法确定肿瘤细胞是否侵入淋巴结(Nx) (P = 0.067)。34例(64.2%)未见淋巴血管侵犯(P = 0.44), 43例(81.1%)未见周围神经侵犯(P = 0.23)。36例(67.9%)为3级(P = 0.27)。结论:在本研究中,我们得出结论,大多数患者EGFR阳性表达。此外,除年龄外,EGFR的表达与其他预后因素如性别、肿瘤浸润层、累及淋巴结、淋巴血管或神经周围浸润、分级等均无显著关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the Prevalence of the Epidermal Growth Factor Receptor in Transitional Cell Carcinoma of Bladder and its Relationship With Other Prognostic Factors.

Background: The most common malignancy in the urinary system has been bladder cancer and the most predominant histologic subtype has been transitional cell carcinoma (TCC). There were many molecular risk factors, related with poor prognosis. One of these factors was expression of epidermal growth factor receptor (EGFR).

Objectives: The aim of this study was to evaluate the prevalence of the epidermal growth factor receptor in transitional cell carcinoma of bladder and its relationship with other prognostic factors.

Patients and methods: This analytic descriptive study has performed with 61 patients with TCC of bladder after radical cystectomy whom have been hospitalized in Labbafinejad hospital in Tehran, Iran between 2007 and 2010. We have used Chi-square and t-test to analyze our data samples.

Results: Records of 61 patients have studied. Fifty three of the total samples were positive for EGFR expression (86.9%). Fifty samples of these fifty-three belonged to men and three others were women's samples (P = 0.46). Among the group with EGFR expression the results were as follows: 25 patients (47.2%) were 60 years old or less and 28 patients (52.8%) were older than 60 (P = 0.023), 16 patients (30.2%) had invasion to lamina properia, and the rest of them had invasion to deeper layers (P = 0.56). For most patients we could not determine the invasion of tumoral cells into the lymph nodes (Nx) (P = 0.067). Thirty four patients (64.2%) had not lymphovascular invasion (P = 0.44) and in forty three of patients (81.1%), perineural invasion have not seen (P = 0.23). Finally, 36 patients (67.9%) were grade 3 (P = 0.27).

Conclusions: In this study we have concluded that most patients had EGFR positive expression. Also, except for the age, there was not any significant relation between expression of EGFR and the other prognostic factors such as, gender, invasion of the tumor into the layers, involving the lymph nodes, lymphovascular or perineural invasion, and grading.

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