International journal of statistics in medical research最新文献

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Role of Predictive Modeling in Healthcare Research: A Scoping Review 预测建模在医疗保健研究中的作用:范围界定综述
International journal of statistics in medical research Pub Date : 2022-09-19 DOI: 10.6000/1929-6029.2022.11.09
N. Panda, Jitendra Kumar Pati, Ruchi Bhuyan
{"title":"Role of Predictive Modeling in Healthcare Research: A Scoping Review","authors":"N. Panda, Jitendra Kumar Pati, Ruchi Bhuyan","doi":"10.6000/1929-6029.2022.11.09","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.09","url":null,"abstract":"The huge preponderance of inferences drawn in empirical medical research follows from model-based relations (e.g. regression). Here, we described the role of predictive modeling as a complement to this approach. Predictive models are usually probabilistic model which gives a good quality fit to our data. In medical research, it’s very common to use regression models for predictive purposes. Here in this article, we described the types of predictive modeling (Linear and Non-linear) used in medical research and how effectively the researchers take decisions based on predictive modeling, and what precautions, we have to take while building a predictive model. Finally, we consider a working example to illustrate the effectiveness of the predictive model in healthcare.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43945723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Mobile Applications in the Doctor’s Working Time Management System 移动应用在医生工作时间管理系统中的作用
International journal of statistics in medical research Pub Date : 2022-09-19 DOI: 10.6000/1929-6029.2022.11.08
Tetiana Sviatenko, Inna V. Gogunska, T. Semigina, Liliya Kasianenko, Olena Salei, M. Prokopenko
{"title":"The Role of Mobile Applications in the Doctor’s Working Time Management System","authors":"Tetiana Sviatenko, Inna V. Gogunska, T. Semigina, Liliya Kasianenko, Olena Salei, M. Prokopenko","doi":"10.6000/1929-6029.2022.11.08","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.08","url":null,"abstract":"Background: Information technologies have become a mandatory component for health care institutions, as well as for doctors. Doctors’ use of medical mobile applications to access medical information has the potential to improve the use of their working time. Primary care physicians can use mobile applications to communicate with their patients, thereby improving the health of individual patients and the population as a whole. \u0000Objectives: The aim of the study is to determine the effectiveness of the use of medical reference mobile applications by general practitioners in their medical practice. \u0000Methods: The research was conducted through a sociological survey and a questionnaire survey. Descriptive statistics were used for the analysis. \u0000Results and Conclusions: The study found that in Ukraine, medical mobile applications are mainly reference, and their use allows doctors to improve decision-making and has a positive effect on the level of health of the population and the doctor’s working time management. The assessment of the duration of the appointment using applications showed that in most cases, the time of the consultation reduced to 15 minutes, which testifies to the improvement of this type of assistance to the population. Besides, the use of applications provides a significant reduction of the time for making a clinical decision by 5 minutes. We found a relationship between the average duration of the appointment, as well as the time for making a clinical decision and the frequency of using the mobile application during the working day. The hypothesis of a direct effect of an innovative approach (use of a mobile application) on the time of outpatient appointments by family doctors with a significance level of 0.05 was tested using statistical data analysis according to the Student's test. The presented results of the analysis of a medical experiment with general practitioners allowed drawing a conclusion about the positive impact of the use of mobile applications on the working time savings of general practitioners when providing medical services.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44419243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Data Driven Study on the Variant of Covid-19 in Hong Kong 香港新冠肺炎变异的数据驱动研究
International journal of statistics in medical research Pub Date : 2022-09-05 DOI: 10.6000/1929-6029.2022.11.06
Yongmei Ding, Lingxiao Xiang
{"title":"A Data Driven Study on the Variant of Covid-19 in Hong Kong","authors":"Yongmei Ding, Lingxiao Xiang","doi":"10.6000/1929-6029.2022.11.06","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.06","url":null,"abstract":"The new wave of COVID-19 in Hong Kong, China was overwhelming again by “dynamic zero” strategy and non-pharmaceutical interventions (DZ-NPIs), which makes a time challenge to control the variant of this epidemic. We describe the variant of Covid-19 in Kong Hong to the infected proportion of the population, cumulative confirmed cases, cumulative deaths and current hospitalizations by age group via statistical measure firstly, then establish time series model for fitting the accumulative confirmed cases, further to predict the trend for searching out possible turning time-points. Non-linear regression model is created to feature the deaths series, then we figure out the parameters and educe the controlling condition for this epidemic. We expect our data-driven modeling process providing some insights to the controlling strategy for the new wave of the Covid-19 variant in Hong Kong, even in the mainland of China.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46569773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Statistical Knowledge of Peruvian Medical Students: A Cross-Sectional Analytical Study Based on a Survey 秘鲁医科学生统计知识分析:基于调查的横断面分析研究
International journal of statistics in medical research Pub Date : 2022-09-05 DOI: 10.6000/1929-6029.2022.11.07
V. Vera-Ponce, J. R. Torres-Malca, Jhony A. De La Cruz-Vargas, Fiorella Elvira Zuzunaga Montoya, Paola Huaccha Chavez, Jesus Enrique Talavera-Ramirez, L. Cruz-Ausejo
{"title":"Analysis of Statistical Knowledge of Peruvian Medical Students: A Cross-Sectional Analytical Study Based on a Survey","authors":"V. Vera-Ponce, J. R. Torres-Malca, Jhony A. De La Cruz-Vargas, Fiorella Elvira Zuzunaga Montoya, Paola Huaccha Chavez, Jesus Enrique Talavera-Ramirez, L. Cruz-Ausejo","doi":"10.6000/1929-6029.2022.11.07","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.07","url":null,"abstract":"Introduction: Despite the growing awareness of the importance of knowledge in biostatistics, many investigations worldwide have found that medical students have a poor understanding of it. \u0000Objective: To determine the percentage of Peruvian medical students with sufficient biostatistics knowledge and the associated factors. \u0000Methods: Cross-sectional analytical study. Application of a virtual survey to medical students from different faculties in Peru. \u0000Results: 56.46% of medical students have insufficient knowledge of biostatistics. A statistically significant association was found for those who were 25 years of age or older (aPR: 1.195; 95% CI 1.045 - 1.366; p=0.009); being between the 9th and 12th semester (aPR: 1.177; 95% CI 1.001 - 1.378; p=0.037) and medical internship (aPR: 1.373; 95% CI 1.104 - 1.707; p=0.004); take an external course in biostatistics, epidemiology or research (aPR: 4.016; 95% CI 3.438 - 4.693; p<0.001); having read more than 12 articles per year (aPR: 1.590; 95% CI 1.313 - 1.967; p<0.001); and publish at least one scientific article (aPR: 1.549; 95% CI 1.321 - 1.816; p<0.001) or more than one (PR: 2.312; 95% CI 1.832 - 2.919; p<0.001). \u0000Conclusions: There is insufficient knowledge of biostatistics in medical students. The factors associated with a good understanding of this were age, academic semester, the number of articles read and published, and having taken an external course.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45358311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Particulars of Applying Odontoprotectors at Different Stages of Therapeutic Process of Periodontal Diseases (A Scoping Review) 牙周病不同治疗阶段应用护齿剂的特点(综述)
International journal of statistics in medical research Pub Date : 2022-05-12 DOI: 10.6000/1929-6029.2022.11.05
O. Hlazunov, Alla Hruzdeva, Viktor Fesenko, O. Korniichuk, K. Penskyi
{"title":"The Particulars of Applying Odontoprotectors at Different Stages of Therapeutic Process of Periodontal Diseases (A Scoping Review)","authors":"O. Hlazunov, Alla Hruzdeva, Viktor Fesenko, O. Korniichuk, K. Penskyi","doi":"10.6000/1929-6029.2022.11.05","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.05","url":null,"abstract":"Rational use of drugs underlies the development of a treatment strategy. In particular, it is important in dental practice to properly select odontoprotectors for the prevention, treatment and maintenance therapy of periodontal diseases. A methodological approach based on the Arskey & O’Malley’s framework was applied to analyse the state of knowledge and previous studies on the use of odontoprotector drug group at different stages of the therapeutic process of periodontal disease. Of the 6 initial scientific databases, the research was conducted in 3 databases that best met the specified search conditions: Google (Google Scholar); PubMed; Wiley InterScience (The Cochrane Library). The literature was selected for the last 5 years (2016-2021). A total of 492 scientific papers were analysed. It is established that the available scientific information is divided into 4 main areas: the use of herbal remedies and folk remedies; antibiotic therapy in dental practice; prospects for the use of nanotechnology in dentistry; results of experimental researches and review articles on a particular active pharmaceutical ingredient.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48315653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asthma Control Level and Relating Socio-Demographic Factors in Hospital Admissions 住院患者哮喘控制水平及相关社会人口学因素
International journal of statistics in medical research Pub Date : 2022-04-07 DOI: 10.6000/1929-6029.2022.11.03
Gönül Yalçınkaya, M. Kılıç
{"title":"Asthma Control Level and Relating Socio-Demographic Factors in Hospital Admissions","authors":"Gönül Yalçınkaya, M. Kılıç","doi":"10.6000/1929-6029.2022.11.03","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.03","url":null,"abstract":"Purpose: Asthma is one of the serious public health problems that we face today and the rate of complete control is very low. This study aims to determine the level of asthma control and its relationship with socio-demographic factors in asthma patients. \u0000Methods: This cross-sectional study was conducted between November 2020-April 2021 among people aged 18-64 who applied to the hospital and were not diagnosed with asthma. The data of the research were made with the personal information form, ACT (asthma control test). ACT is a questionnaire consisting of 5 questions. Patients rate each question between one and five points. The total score of the five questions forms the test result. If the total score is 25, it is considered as full control, 24-20 as partial control, and ≤19 as not under control. In the research, 206 people participated. \u0000Results: Of the participants, 60.7% were female, 60.2% had a family history of asthma, 94.2% of them used asthma medication, and the average age was 45.7±13.85. In the last 12 years, 50.5% of asthma patients stated that they applied to the emergency department due to respiratory problems, and 23.3% were hospitalized due to these problems. It was determined that 78.6% of asthma patients were not under control, 21.4% were under partial control, and there was no patient under full control. The mean age (48.8) and body mass index (BMI) (29.4) of those whose asthma was not under control were higher than those with partial control (32.2 and 24.7, respectively) (p<0.001). It has been determined that the probability of asthma not being controlled increases as age and BMI increase, and life satisfaction decreases, and it is higher in quit smokers than in current smokers (p<0.05). \u0000Conclusion: Asthma is largely uncontrolled. The rate of uncontrolled asthma increases with increasing age and BMI. Patients with high BMI should be supported to lose weight and should be directed to exercise.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43751065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Relating to the Expectations and Perceptions of Post-Stroke Outpatients’ in the Rehabilitation Services of Bangladesh 孟加拉国卒中后门诊患者对康复服务的期望与认知的相关因素
International journal of statistics in medical research Pub Date : 2022-04-07 DOI: 10.6000/1929-6029.2022.11.04
M. Hasan, Kantabhat Anusaksathien, Kanida Narattharaksa, Nahar Afrin
{"title":"Factors Relating to the Expectations and Perceptions of Post-Stroke Outpatients’ in the Rehabilitation Services of Bangladesh","authors":"M. Hasan, Kantabhat Anusaksathien, Kanida Narattharaksa, Nahar Afrin","doi":"10.6000/1929-6029.2022.11.04","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.04","url":null,"abstract":"Purpose: For enhancing patients’ participation, this study aims to identify the patient-related factors that relate to the expectations and perceptions of post-stroke outpatients’ in the rehabilitation services of Bangladesh. \u0000Methods: A questionnaire survey was administered to 342 outpatients from the stroke rehabilitation department. Descriptive statistical analysis was applied to measure patients’ perceptions and expectations. Eta statistic from ANOVA was applied to examine the relationship between patient-related factors and the patients’ expectations and perceptions of the rehabilitation services. \u0000Findings: Patients’ expectations rated higher than the perceptions in all the dimensions of rehabilitation services. Factors such as; (i) patients' education (0.222, p=0.005) and post-stroke disability (0.447, p<0.001) indicated a significant relationship with patients' expectations. (ii) Patients' education (0.210, p=0.010), occupation (0.226, p=0.003), family status (0.180, p=0.048) and daily activities before the stroke (0.169, p=0.044), post-stroke disability (0.195, p=0.004) and distance from home to the hospital (0.190, p=0.006) indicated a significant relationship with their perceptions in the rehabilitation services. \u0000Conclusion: The findings of this study concluded that the rehabilitation manager needs to work on these factors and recommended developing a continuing education program to minimize these factors of poor perceptions in the rehabilitation services.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47840041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inclusive Physical Activity to Promote the Participation of People with Disabilities: A Preliminary Study 促进残疾人参与的包容性体育活动:一项初步研究
International journal of statistics in medical research Pub Date : 2022-03-09 DOI: 10.6000/1929-6029.2022.11.02
Felice Di Domenico, T. D’Isanto, G. Altavilla, F. D’Elia, G. Raiola
{"title":"Inclusive Physical Activity to Promote the Participation of People with Disabilities: A Preliminary Study","authors":"Felice Di Domenico, T. D’Isanto, G. Altavilla, F. D’Elia, G. Raiola","doi":"10.6000/1929-6029.2022.11.02","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.02","url":null,"abstract":"Background: Physical activity brings improvements in the quality of life in all individuals, disabled and non-disabled. There is little evidence in the literature of inclusive physical activity in which disabled and non-disabled people participate at the same level. \u0000Objectives: The study aimed to demonstrate the effectiveness of an inclusive training program, structured in such a way as to encourage physical activity for all participants with and without disabilities, in improving body composition, explosive strength, and endurance. \u0000Methods: A sample of twenty-four subjects (mean age: 24.09±3.92 years), 12 disabled and 12 non-disabled, was selected. Quantitative input and output data were recruited at 16-week intervals using a battery of tests: anthropometric measurements, Vertec Squat Jump test, and Yoyo Endurance Test. During the 16 weeks, all participants followed an appropriately structured training program in four mesocycle without any differences. Input and output data were compared employing the t-test for dependent samples. \u0000Results and conclusions: The results showed statistically meaningful improvements at an alpha level set at 0.05 for the three parameters tested. These results confirmed the effectiveness of the proposed inclusive training protocol on the improvement of the tested parameters in all participants. These strategies didn't jeopardise the achievement of the overall objectives set; on the contrary, improvements in BMI, explosive strength, and endurance strength of 4.8%, 4.3%, and 56.2% respectively were observed.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44527116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Imputation of Missing Race and Ethnicity in CDC COVID-19 Case-Level Surveillance Data. CDC COVID-19病例级监测数据中缺失种族和民族的多重代入
International journal of statistics in medical research Pub Date : 2022-01-28 DOI: 10.6000/1929-6029.2022.11.01
Guangyu Zhang, Charles E Rose, Yujia Zhang, Rui Li, Florence C Lee, Greta Massetti, Laura E Adams
{"title":"Multiple Imputation of Missing Race and Ethnicity in CDC COVID-19 Case-Level Surveillance Data.","authors":"Guangyu Zhang,&nbsp;Charles E Rose,&nbsp;Yujia Zhang,&nbsp;Rui Li,&nbsp;Florence C Lee,&nbsp;Greta Massetti,&nbsp;Laura E Adams","doi":"10.6000/1929-6029.2022.11.01","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.01","url":null,"abstract":"<p><p>The COVID-19 pandemic has resulted in a disproportionate burden on racial and ethnic minority groups, but incompleteness in surveillance data limits understanding of disparities. CDC's case-based surveillance system contains case-level information on most COVID-19 cases in the United States. Data analyzed in this paper contain COVID-19 cases with case-level information through September 25, 2020, which represent 70.9% of all COVID-19 cases reported to CDC during the period. Case-level surveillance data are used to investigate COVID-19 disparities by race/ethnicity, sex, and age. However, demographic information on race and ethnicity is missing for a substantial percentage of COVID-19 cases (e.g., 35.8% and 47.2% of cases analyzed were missing race and ethnicity information, respectively). Our goal in this study was to impute missing race and ethnicity to derive more accurate incidence and incidence rate ratio (IRR) estimates for different racial and ethnic groups, and evaluate the results from imputation compared to complete case analysis, which involves removing cases with missing race/ethnicity information from the analysis. Two multiple imputation (MI) models were developed. Model 1 imputes race using six binary race variables, and Model 2 imputes race as a composite multinomial variable. Our evaluation found that compared with complete case analysis, MI reduced biases and improved coverage on incidence and IRR estimates for all race/ethnicity groups, except for the Non-Hispanic Multiple/other group. Our research highlights the importance of supplementing complete case analysis with additional methods of analysis to better describe racial and ethnic disparities. When race and ethnicity data are missing, multiple imputation may provide more accurate incidence and IRR estimates to monitor these disparities in tandem with efforts to improve the collection of race and ethnicity information for pandemic surveillance.</p>","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":"11 ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10626657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The Use of Putative Dialysis Initiation Time in Comparative Outcomes of Patients with Advanced Chronic Kidney Disease: Methodological Aspects. 使用假定的透析起始时间在晚期慢性肾病患者的比较结果:方法学方面。
International journal of statistics in medical research Pub Date : 2022-01-01 DOI: 10.6000/1929-6029.2022.11.16
Danh V Nguyen, Esra Kurum, Damla Senturk
{"title":"The Use of Putative Dialysis Initiation Time in Comparative Outcomes of Patients with Advanced Chronic Kidney Disease: Methodological Aspects.","authors":"Danh V Nguyen,&nbsp;Esra Kurum,&nbsp;Damla Senturk","doi":"10.6000/1929-6029.2022.11.16","DOIUrl":"https://doi.org/10.6000/1929-6029.2022.11.16","url":null,"abstract":"<p><p>The latest data from the United States Renal Data Systems show over 134,000 individuals with end-stage kidney disease (ESKD) starting dialysis in the year 2019. ESKD patients on dialysis, the default treatment strategy, have high mortality and hospitalization, especially in the first year of dialysis. An alternative treatment strategy is (non-dialysis) conservative management (CM). The relative effectiveness of CM with respect to various patient outcomes, including survival, hospitalization, and health-related quality of life among others, especially in elderly ESKD or advanced chronic kidney disease patients with serious comorbidities, is an active area of research. A technical challenge inherent in comparing patient outcomes between CM and dialysis patient groups is that the start of follow-up time is \"not defined\" for patients on CM because they do not initiate dialysis. One solution is the use of putative dialysis initiation (PDI) time. In this work, we examine the validity of the use of PDI time to determine the start of follow-up for longitudinal retrospective and prospective cohort studies involving CM. We propose and assess the efficacy of estimating PDI time using linear mixed effects model of kidney function decline over time via simulation studies. We also illustrate how the estimated PDI time can be used to effectively estimate the survival distribution.</p>","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":"11 ","pages":"128-135"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9619760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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