Infectious microbes & diseases最新文献_第7页

A Retrospective Study of the Epidemiologic and Clinical Characteristics of COVID-19 Among Hospitalized Patients in Quanzhou, China. 泉州市住院患者新冠肺炎流行病学及临床特征的回顾性研究

Infectious microbes & diseases Pub Date : 2021-01-15 eCollection Date: 2021-03-01 DOI: 10.1097/IM9.0000000000000048

Wenhuang Chen, Yijian Lin, Hongbo Huang, Maosheng Cai, Dongheng Lin, Milong Su, Zhijun Su, Xibin Zhuang, Xueping Yu

{"title":"A Retrospective Study of the Epidemiologic and Clinical Characteristics of COVID-19 Among Hospitalized Patients in Quanzhou, China.","authors":"Wenhuang Chen, Yijian Lin, Hongbo Huang, Maosheng Cai, Dongheng Lin, Milong Su, Zhijun Su, Xibin Zhuang, Xueping Yu","doi":"10.1097/IM9.0000000000000048","DOIUrl":"10.1097/IM9.0000000000000048","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) has spread throughout China. However, information about COVID-19 in cities and regions outside Wuhan is limited and the indicators that predict the length of hospital stay for patients with COVID-19 are unclear. Therefore, we collected clinical data from 47 patients with COVID-19 in Quanzhou City. The median age was 38 years [interquartile range (IQR): 31-50 years], and 24 (51%) were male. There were 8 mild, 36 moderate, and 3 severe/critical cases. The median interval from exposure to disease onset was 13 days (IQR: 8-18 days). The incidence of severe/critical cases was 33% (3/10) in patients with hypertension. Common symptoms included fever (83%), cough (77%), fatigue (40%), a sore, dry throat (28%), and diarrhea (21%). One patient (2%) developed respiratory distress syndrome on day 13 of inpatient treatment. Six patients had leukopenia, 17 had elevated C-reactive protein (CRP), and 8 had lymphocytopenia and elevated lactate dehydrogenase (LDH). The median length of hospitalization was 22 days (IQR: 16-30 days). Dynamic monitoring of LDH, CRP, and neutrophil-lymphocyte ratio predicted whether length of hospitalization would exceed 21 days. Most patients presented with mild and moderate disease. Patients with hypertension were more likely to become severe or critical. Dynamic monitoring of LDH, CRP, and neutrophil-lymphocyte ratio levels can help predict delayed discharge from the hospital.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"3 1","pages":"32-40"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47062366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Pterostilbene Inhibited Colonic Inflammation in Dextran-Sodium-Sulfate-Treated Mice: A Perspective of Gut Microbiota 膳食紫檀芪抑制右旋糖酐-硫酸钠处理小鼠的结肠炎症:肠道微生物群的观点

Infectious microbes & diseases Pub Date : 2021-01-08 DOI: 10.1097/IM9.0000000000000047

Fang Li, Qi Wang, Yanhui Han, Mingyue Song, Xiaokun Cai, Timothy R. Goulette, Hang Xiao

{"title":"Dietary Pterostilbene Inhibited Colonic Inflammation in Dextran-Sodium-Sulfate-Treated Mice: A Perspective of Gut Microbiota","authors":"Fang Li, Qi Wang, Yanhui Han, Mingyue Song, Xiaokun Cai, Timothy R. Goulette, Hang Xiao","doi":"10.1097/IM9.0000000000000047","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000047","url":null,"abstract":"Abstract Dietary interventions based on the use of bioactive nutraceuticals might offer an effective adjuvant therapeutic and preventive method for inflammatory bowel disease by reshaping colitis-associated bacterial dysbiosis. The current study aimed to determine the anti-inflammatory effect of pterostilbene (PTE, a methylated derivative of resveratrol) and its potential modulatory roles in gut microbiota in a dextran sodium sulfate (DSS)-induced colitis mouse model. Our results supported our hypothesis that dietary PTE exerted protective effects against colonic inflammation; evidenced by the reduced colonic tissue damage, decreased disease activity index, and lowered production of pro-inflammatory cytokines such as interferon gamma, interleukin (IL)-2, IL-4, and IL-6 in the colon of DSS-treated mice. Moreover, α-diversity analysis indicated that dietary PTE significantly improved gut microbial evenness and diversity. Noteworthy, PTE modified gut microbiota composition toward a healthier profile by boosting the richness of Bifidobacterium and decreasing the distribution of pathogenic Bilophila and Rc4-4. Pearson correlation analysis also revealed strong associations between the shifting of gut microbiota and expression of inflammatory cytokines in the colon. Overall, our study demonstrated that dietary PTE alleviated the severity of colitis in DSS-treated mice and gut microbiota may play an indispensable role in this process mechanistically.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"3 1","pages":"22 - 29"},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45731558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Probiotics and Their Metabolites Ameliorate Inflammatory Bowel Disease: A Critical Review 益生菌及其代谢产物改善炎症性肠病的研究进展

Infectious microbes & diseases Pub Date : 2020-12-30 DOI: 10.1097/IM9.0000000000000046

Y. Liang, Manman Liu, J. Pu, Zichun Zhu, Zining Gao, Qingqing Zhou, Q. Gu, Ping Li

{"title":"Probiotics and Their Metabolites Ameliorate Inflammatory Bowel Disease: A Critical Review","authors":"Y. Liang, Manman Liu, J. Pu, Zichun Zhu, Zining Gao, Qingqing Zhou, Q. Gu, Ping Li","doi":"10.1097/IM9.0000000000000046","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000046","url":null,"abstract":"Abstract Crohn disease and ulcerative colitis are the two main manifestations of inflammatory bowel disease (IBD), and both are highly morbid. However, the precise etiology of IBD is still unknown and effective therapeutics are yet to be discovered. It is becoming increasingly clear that a combination of factors, including genetic background, host immune response, and microbial reduced diversity status are related to IBD. The cardinal symptom of IBD patients is the imbalance of the intestinal microflora. According to previous studies, both probiotics and symbiotic microbiota can play a protective role through intestinal micro-ecosystem regulation, epithelial barrier integrity enhancement, and inflammation reduction. Therefore, probiotics can provide an alternative or auxiliary method to traditional IBD treatment. Here, we reviewed the possible pathogenesis of IBD, summarized the possible mechanisms of probiotics modulation of IBD, and emphasized the prevention and treatment targets of probiotics-mediated IBD, with the aim to provide theoretical support for the treatment of IBD patients by probiotics in clinical trials.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"3 1","pages":"4 - 13"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43145400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Impact of SARS-CoV-2 on the Human Immune System and Microbiome. 严重急性呼吸系统综合征冠状病毒2型对人体免疫系统和微生物组的影响

Infectious microbes & diseases Pub Date : 2020-12-23 eCollection Date: 2021-03-01 DOI: 10.1097/IM9.0000000000000045

Chuxi Wang, Xin Zhou, Meng Wang, Xin Chen

{"title":"The Impact of SARS-CoV-2 on the Human Immune System and Microbiome.","authors":"Chuxi Wang, Xin Zhou, Meng Wang, Xin Chen","doi":"10.1097/IM9.0000000000000045","DOIUrl":"10.1097/IM9.0000000000000045","url":null,"abstract":"A recent outbreak of coronavirus disease 2019 (COVID-19) caused by the single-stranded enveloped RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into a global pandemic, after it was first reported in Wuhan in December 2019. SARS-CoV-2 is an emerging virus, and little is known about the basic characteristics of this pathogen, the underlying mechanism of infection, and the potential treatments. The immune system has been known to be actively involved in viral infections. To facilitate the development of COVID-19 treatments, the understanding of immune regulation by this viral infection is urgently needed. This review describes the mechanisms of immune system involvement in viral infections and provides an overview of the dysregulation of immune responses in COVID-19 patients in recent studies. Furthermore, we emphasize the role of gut microbiota in regulating immunity and summarized the impact of SARS-CoV-2 infection on the composition of the microbiome. Overall, this review provides insights for understanding and developing preventive and therapeutic strategies by regulating the immune system and microbiota.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"3 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42226093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiota, Viral Infection, and the Relationship to Human Diseases: An Area of Increasing Interest in the SARS-CoV-2 Pandemic. 微生物群、病毒感染及其与人类疾病的关系：严重急性呼吸系统综合征冠状病毒2型大流行日益引起关注的领域

Infectious microbes & diseases Pub Date : 2020-11-04 eCollection Date: 2021-03-01 DOI: 10.1097/IM9.0000000000000043

Matthew D Moore, Cassandra Suther, Yanjiao Zhou

引用次数: 0

The Correlation Between Heart Failure and Gut Microbiome Metabolites. 心力衰竭与肠道微生物代谢物的相关性

IF 2

Infectious microbes & diseases Pub Date : 2020-11-04 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000042

Lina Chen, Senhao Li, Lanmu Ai, Jun Zhou, Junlin Huang, Feng Xu, Xiangyuan Zeng, Jia Han, Fangxue Yin, Yixin Zhu, Yifang Xie

引用次数: 0

Will Technology Rather Than Vaccination Be the Way to Control Pandemics? 控制流行病的方法是技术而不是疫苗吗?

Infectious microbes & diseases Pub Date : 2020-10-23 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000041

Sebastian Leptihn, Susan C Welburn

引用次数: 0

Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019. 2011 年至 2019 年在日本分离到的化脓性链球菌 emm89 菌株的遗传特征。

Infectious microbes & diseases Pub Date : 2020-10-21 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000038

Yujiro Hirose, Masaya Yamaguchi, Norihiko Takemoto, Tohru Miyoshi-Akiyama, Tomoko Sumitomo, Masanobu Nakata, Tadayoshi Ikebe, Tomoki Hanada, Takahiro Yamaguchi, Ryuji Kawahara, Rumi Okuno, Hitoshi Otsuka, Yuko Matsumoto, Yuji Terashima, Yu Kazawa, Noriko Nakanishi, Kaoru Uchida, Yumi Akiyama, Kaori Iwabuchi, Chikara Nakagawa, Kazunari Yamamoto, Victor Nizet, Shigetada Kawabata

{"title":"Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019.","authors":"Yujiro Hirose, Masaya Yamaguchi, Norihiko Takemoto, Tohru Miyoshi-Akiyama, Tomoko Sumitomo, Masanobu Nakata, Tadayoshi Ikebe, Tomoki Hanada, Takahiro Yamaguchi, Ryuji Kawahara, Rumi Okuno, Hitoshi Otsuka, Yuko Matsumoto, Yuji Terashima, Yu Kazawa, Noriko Nakanishi, Kaoru Uchida, Yumi Akiyama, Kaori Iwabuchi, Chikara Nakagawa, Kazunari Yamamoto, Victor Nizet, Shigetada Kawabata","doi":"10.1097/IM9.0000000000000038","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000038","url":null,"abstract":"Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains, designated clade 3. In Japan, the features of emm89 S. pyogenes strains, such as clade classification, remains unknown. In this study, we collected emm89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among emm89 strains, including mutations of control of virulence sensor, and absence of the hylP1 gene encoding hyaluronidase. These findings provide new insights into genetic features of emm89 strains.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"2 4","pages":"160-166"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Liver Functions in Patients With COVID-19 and Construction of a Prognostic Evaluation Decision Model Based on Liver Functions. 新冠肺炎患者肝功能特点及基于肝功能的预后评估决策模型的构建

Infectious microbes & diseases Pub Date : 2020-10-20 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000039

Tongtong Pan, Dazhi Chen, Chenwei Pan, Yi Kang, Junping Liu, Feifei Su, Liang Hong, Huili Li, Hui Zhao, Zhuo Lin, Xiaodong Wang, Hongwei Lin, Qianjing Du, Chao Cai, Yongping Chen

{"title":"Characteristics of Liver Functions in Patients With COVID-19 and Construction of a Prognostic Evaluation Decision Model Based on Liver Functions.","authors":"Tongtong Pan, Dazhi Chen, Chenwei Pan, Yi Kang, Junping Liu, Feifei Su, Liang Hong, Huili Li, Hui Zhao, Zhuo Lin, Xiaodong Wang, Hongwei Lin, Qianjing Du, Chao Cai, Yongping Chen","doi":"10.1097/IM9.0000000000000039","DOIUrl":"10.1097/IM9.0000000000000039","url":null,"abstract":"A number of studies have suggested that coronavirus disease 2019 (COVID-19) can cause liver damage. However, clinical features and outcome of COVID-19 in patients with liver injury remain to be further investigated. In this study, the clinical data of 265 COVID-19 patients admitted to seven tertiary hospitals were collected. Based on a threshold for transaminase or total bilirubin levels at two times the normal upper limit, patients were divided into mild or moderate/severe liver injury groups. Among the 265 patients, 183 patients showed liver injury within 48 hours of admission. Aspartate aminotransferase levels were predominantly elevated in the liver injury group, but albumin levels were reduced. Moreover, fibrinogen and D-dimer were significantly increased. Furthermore, 68% of the patients with moderate/severe liver injury had one or more underlying diseases. Almost half of these patients developed acute respiratory distress syndrome (44%) and secondary infections (46%). These patients showed increased interleukin-6 and interleukin-10 levels and a decrease in PaO2 and the oxygenation index. In addition, levels of alanine aminotransferase, aspartate aminotransferase, and albumin were correlated with the oxygenation index, D-dimer and lymphocyte counts. Furthermore, a novel prognostic assessment model based on liver function was established, which accuracy reached 88% and was able to accurately assess the prognosis of COVID-19 patients.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"2 1","pages":"151-159"},"PeriodicalIF":0.0,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45196164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanded Scope of Bacillus Calmette-Guerin (BCG) Vaccine Applicability in Disease Prophylaxis, Diagnostics, and Immunotherapeutics. 卡介苗（BCG）疫苗在疾病预防、诊断和免疫治疗中的适用范围扩大

Infectious microbes & diseases Pub Date : 2020-10-20 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000040

Oluwafolajimi A Adesanya, Christabel I Uche-Orji, Yeshua A Adedeji, John I Joshua, Adeniyi A Adesola, Chibuike J Chukwudike

{"title":"Expanded Scope of Bacillus Calmette-Guerin (BCG) Vaccine Applicability in Disease Prophylaxis, Diagnostics, and Immunotherapeutics.","authors":"Oluwafolajimi A Adesanya, Christabel I Uche-Orji, Yeshua A Adedeji, John I Joshua, Adeniyi A Adesola, Chibuike J Chukwudike","doi":"10.1097/IM9.0000000000000040","DOIUrl":"10.1097/IM9.0000000000000040","url":null,"abstract":"Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy against Mycobacterium tuberculosis was soon established, with several countries adopting universal BCG vaccination schemes for their populations. Soon, however, studies aimed to further establish the efficacy of the vaccine in different populations discovered that the vaccine has a larger effect in reducing mortality rate than could be explained by its effect on tuberculosis alone, which sparked suggestions that the BCG vaccine could have effects on other unrelated or non-mycobacterial pathogens causing diseases in humans. These effects were termed heterologous, non-specific or off-target effects and have been shown to be due to both innate and adaptive immune system responses. Experiments carried out in a bid to further understand these effects led to many more discoveries about the applicability of the BCG vaccine for the prevention, diagnosis, and treatment of certain disease conditions. As we approach the second century since the discovery of the vaccine, we believe it is timely to review these interesting applications of the BCG vaccine, such as in the prevention of diabetes, atherosclerosis, and leukemia; the diagnosis of Kawasaki disease; and the treatment of multiple sclerosis, non-muscle invading bladder cancer, and stage III melanoma. Furthermore, complications associated with the administration of the BCG vaccine to certain groups of patients, including those with severe combined immunodeficiency and HIV, have been well described in literature, and we conclude by describing the mechanisms behind these complications and discuss their implications on vaccination strategies, especially in low-resource settings.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"2 1","pages":"144-150"},"PeriodicalIF":0.0,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48247643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0