卡介苗(BCG)疫苗在疾病预防、诊断和免疫治疗中的适用范围扩大

IF 2 Q3 INFECTIOUS DISEASES
Infectious microbes & diseases Pub Date : 2020-10-20 eCollection Date: 2020-12-01 DOI:10.1097/IM9.0000000000000040
Oluwafolajimi A Adesanya, Christabel I Uche-Orji, Yeshua A Adedeji, John I Joshua, Adeniyi A Adesola, Chibuike J Chukwudike
{"title":"卡介苗(BCG)疫苗在疾病预防、诊断和免疫治疗中的适用范围扩大","authors":"Oluwafolajimi A Adesanya, Christabel I Uche-Orji, Yeshua A Adedeji, John I Joshua, Adeniyi A Adesola, Chibuike J Chukwudike","doi":"10.1097/IM9.0000000000000040","DOIUrl":null,"url":null,"abstract":"<p><p>Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy against <i>Mycobacterium tuberculosis</i> was soon established, with several countries adopting universal BCG vaccination schemes for their populations. Soon, however, studies aimed to further establish the efficacy of the vaccine in different populations discovered that the vaccine has a larger effect in reducing mortality rate than could be explained by its effect on tuberculosis alone, which sparked suggestions that the BCG vaccine could have effects on other unrelated or non-mycobacterial pathogens causing diseases in humans. These effects were termed heterologous, non-specific or off-target effects and have been shown to be due to both innate and adaptive immune system responses. Experiments carried out in a bid to further understand these effects led to many more discoveries about the applicability of the BCG vaccine for the prevention, diagnosis, and treatment of certain disease conditions. As we approach the second century since the discovery of the vaccine, we believe it is timely to review these interesting applications of the BCG vaccine, such as in the prevention of diabetes, atherosclerosis, and leukemia; the diagnosis of Kawasaki disease; and the treatment of multiple sclerosis, non-muscle invading bladder cancer, and stage III melanoma. Furthermore, complications associated with the administration of the BCG vaccine to certain groups of patients, including those with severe combined immunodeficiency and HIV, have been well described in literature, and we conclude by describing the mechanisms behind these complications and discuss their implications on vaccination strategies, especially in low-resource settings.</p>","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769055/pdf/","citationCount":"0","resultStr":"{\"title\":\"Expanded Scope of Bacillus Calmette-Guerin (BCG) Vaccine Applicability in Disease Prophylaxis, Diagnostics, and Immunotherapeutics.\",\"authors\":\"Oluwafolajimi A Adesanya, Christabel I Uche-Orji, Yeshua A Adedeji, John I Joshua, Adeniyi A Adesola, Chibuike J Chukwudike\",\"doi\":\"10.1097/IM9.0000000000000040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy against <i>Mycobacterium tuberculosis</i> was soon established, with several countries adopting universal BCG vaccination schemes for their populations. Soon, however, studies aimed to further establish the efficacy of the vaccine in different populations discovered that the vaccine has a larger effect in reducing mortality rate than could be explained by its effect on tuberculosis alone, which sparked suggestions that the BCG vaccine could have effects on other unrelated or non-mycobacterial pathogens causing diseases in humans. These effects were termed heterologous, non-specific or off-target effects and have been shown to be due to both innate and adaptive immune system responses. Experiments carried out in a bid to further understand these effects led to many more discoveries about the applicability of the BCG vaccine for the prevention, diagnosis, and treatment of certain disease conditions. As we approach the second century since the discovery of the vaccine, we believe it is timely to review these interesting applications of the BCG vaccine, such as in the prevention of diabetes, atherosclerosis, and leukemia; the diagnosis of Kawasaki disease; and the treatment of multiple sclerosis, non-muscle invading bladder cancer, and stage III melanoma. Furthermore, complications associated with the administration of the BCG vaccine to certain groups of patients, including those with severe combined immunodeficiency and HIV, have been well described in literature, and we conclude by describing the mechanisms behind these complications and discuss their implications on vaccination strategies, especially in low-resource settings.</p>\",\"PeriodicalId\":73374,\"journal\":{\"name\":\"Infectious microbes & diseases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2020-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769055/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infectious microbes & diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/IM9.0000000000000040\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious microbes & diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/IM9.0000000000000040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/12/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

随着卡介苗(Bacillus calmetter - guerin, BCG)疫苗的发现,其抗结核分枝杆菌的有效性很快得到了证实,一些国家在其人口中普遍采用了卡介苗接种方案。然而,不久,旨在进一步确定疫苗在不同人群中的功效的研究发现,该疫苗在降低死亡率方面的作用比仅对结核病的作用更大,这引发了人们的建议,即卡介苗可能对引起人类疾病的其他不相关或非分枝杆菌病原体也有影响。这些效应被称为异源、非特异性或脱靶效应,并已被证明是由于先天和适应性免疫系统反应。为了进一步了解这些影响而进行的实验导致了更多关于卡介苗在预防、诊断和治疗某些疾病条件方面适用性的发现。在我们接近卡介苗发现的第二个世纪之际,我们认为是时候回顾一下卡介苗在预防糖尿病、动脉粥样硬化和白血病等方面的有趣应用;川崎病的诊断;以及多发性硬化症、非肌肉侵袭性膀胱癌和III期黑色素瘤的治疗。此外,与某些患者群体(包括严重联合免疫缺陷和HIV患者)接种卡介苗相关的并发症已经在文献中得到了很好的描述,我们通过描述这些并发症背后的机制并讨论它们对疫苗接种策略的影响,特别是在资源匮乏的环境中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expanded Scope of Bacillus Calmette-Guerin (BCG) Vaccine Applicability in Disease Prophylaxis, Diagnostics, and Immunotherapeutics.

Following the discovery of the Bacillus Calmette-Guerin (BCG) vaccine, its efficacy against Mycobacterium tuberculosis was soon established, with several countries adopting universal BCG vaccination schemes for their populations. Soon, however, studies aimed to further establish the efficacy of the vaccine in different populations discovered that the vaccine has a larger effect in reducing mortality rate than could be explained by its effect on tuberculosis alone, which sparked suggestions that the BCG vaccine could have effects on other unrelated or non-mycobacterial pathogens causing diseases in humans. These effects were termed heterologous, non-specific or off-target effects and have been shown to be due to both innate and adaptive immune system responses. Experiments carried out in a bid to further understand these effects led to many more discoveries about the applicability of the BCG vaccine for the prevention, diagnosis, and treatment of certain disease conditions. As we approach the second century since the discovery of the vaccine, we believe it is timely to review these interesting applications of the BCG vaccine, such as in the prevention of diabetes, atherosclerosis, and leukemia; the diagnosis of Kawasaki disease; and the treatment of multiple sclerosis, non-muscle invading bladder cancer, and stage III melanoma. Furthermore, complications associated with the administration of the BCG vaccine to certain groups of patients, including those with severe combined immunodeficiency and HIV, have been well described in literature, and we conclude by describing the mechanisms behind these complications and discuss their implications on vaccination strategies, especially in low-resource settings.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信