Infectious microbes & diseases最新文献

The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens. 维甲酸对中性粒细胞与皮肤细菌病原体的先天性免疫相互作用的影响

IF 2

Infectious microbes & diseases Pub Date : 2024-06-01 Epub Date: 2024-04-29 DOI: 10.1097/im9.0000000000000145

Alexandra Stream, Ross Corriden, Simon Döhrmann, Richard L Gallo, Victor Nizet, Ericka L Anderson

{"title":"The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens.","authors":"Alexandra Stream, Ross Corriden, Simon Döhrmann, Richard L Gallo, Victor Nizet, Ericka L Anderson","doi":"10.1097/im9.0000000000000145","DOIUrl":"10.1097/im9.0000000000000145","url":null,"abstract":"Vitamin A and its biologically active derivative, retinoic acid (RA), are important for many immune processes. RA, in particular, is essential for the development of immune cells, including neutrophils, which serve as a front-line defense against infection. While vitamin A deficiency has been linked to higher susceptibility to infections, the precise role of vitamin A/RA in host-pathogen interactions remains poorly understood. Here, we provided evidence that RA boosts neutrophil killing of methicillin-resistant Staphylococcus aureus (MRSA). RA treatment stimulated primary human neutrophils to produce reactive oxygen species, neutrophil extracellular traps, and the antimicrobial peptide cathelicidin (LL-37). Because RA treatment was insufficient to reduce MRSA burden in an in vivo murine model of skin infection, we expanded our analysis to other infectious agents. RA did not affect the growth of a number of common bacterial pathogens, including MRSA, Escherichia coli K1 and Pseudomonas aeruginosa; however, RA directly inhibited the growth of group A Streptococcus (GAS). This antimicrobial effect, likely in combination with RA-mediated neutrophil boosting, resulted in substantial GAS killing in neutrophil killing assays conducted in the presence of RA. Furthermore, in a murine model of GAS skin infection, topical RA treatment showed therapeutic potential by reducing both skin lesion size and bacterial burden. These findings suggest that RA may hold promise as a therapeutic agent against GAS and perhaps other clinically significant human pathogens.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of 10 Different Pipelines for Bacterial Single-Nucleotide Variant Detection 评估用于细菌单核苷酸变异检测的 10 种不同管道

Infectious microbes & diseases Pub Date : 2023-11-22 DOI: 10.1097/IM9.0000000000000134

Zi-Hao Hu, Ying Wang, Long Yang, Qing-Yi Cao, Ming Ling, Xiao-Hua Meng, Yao Chen, Shu-Jun Ni, Zhi Chen, Cheng-Zhi Liu, Kun-Kai Su

{"title":"Evaluation of 10 Different Pipelines for Bacterial Single-Nucleotide Variant Detection","authors":"Zi-Hao Hu, Ying Wang, Long Yang, Qing-Yi Cao, Ming Ling, Xiao-Hua Meng, Yao Chen, Shu-Jun Ni, Zhi Chen, Cheng-Zhi Liu, Kun-Kai Su","doi":"10.1097/IM9.0000000000000134","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000134","url":null,"abstract":"Abstract Bacterial genome sequencing is a powerful technique for studying the genetic diversity and evolution of microbial populations. However, the detection of genomic variants from sequencing data is challenging due to the presence of contamination, sequencing errors and multiple strains within the same species. Several bioinformatics tools have been developed to address these issues, but their performance and accuracy have not been systematically evaluated. In this study, we compared 10 variant detection pipelines using 18 simulated and 17 real datasets of high-throughput sequences from a bundle of representative bacteria. We assessed the sensitivity of each pipeline under different conditions of coverage, simulation and strain diversity. We also demonstrated the application of these tools to identify consistent mutations in a 30-time repeated sequencing dataset of Staphylococcus hominis. We found that HaplotypeCaller, but not Mutect2, from the GATK tool set showed the best performance in terms of accuracy and robustness. CFSAN and Snippy performed not as well in several simulated and real sequencing datasets. Our results provided a comprehensive benchmark and guidance for choosing the optimal variant detection pipeline for high-throughput bacterial genome sequencing data.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Ten-Year Retrospective Cohort Study of Real-World Effectiveness of Sofosbuvir-Based Regimens for Hepatitis C in a Single Center in China 基于索非布韦的丙型肝炎治疗方案在中国单中心的十年回顾性队列研究

Infectious microbes & diseases Pub Date : 2023-10-24 DOI: 10.1097/im9.0000000000000131

Qiao Yang, Fangping Xu, Yi Shen, Borui Pi, Fangfang Lv

{"title":"A Ten-Year Retrospective Cohort Study of Real-World Effectiveness of Sofosbuvir-Based Regimens for Hepatitis C in a Single Center in China","authors":"Qiao Yang, Fangping Xu, Yi Shen, Borui Pi, Fangfang Lv","doi":"10.1097/im9.0000000000000131","DOIUrl":"https://doi.org/10.1097/im9.0000000000000131","url":null,"abstract":"Abstract This study aimed to review the trends of hepatitis C virus (HCV) treatment over the past decade and to analyze the effectiveness of sofosbuvir (SOF)-based direct-acting antiviral regimens in the heterogeneous population of patients with chronic hepatitis C (CHC) in clinical practice. This retrospective cohort study included CHC patients attending the Sir Run Run Shaw Hospital between January 1, 2012 and December 31, 2022. All of the 194 patients treated with SOF-based regimens completed 12 weeks of treatment and were followed up for at least 12 weeks after completion of the therapy. Sustained virologic response (SVR) 12 weeks after the end of treatment was the primary endpoint. A total of 194 patients treated with SOF-based regimens were included, among which 121, 56, 10 and 7 patients received SOF + velpatasvir±ribavirin, SOF + daclatasvir, SOF + ledipasvir or SOF + ribavirin, respectively. With 36.1%, HCV genotype 1 predominated in CHC patients treated with SOF-based regimens, followed by genotype 2a with 17.5% and genotype 3 with 14.9%. Comorbidities among patients included hypertension (4.1%), diabetes (2.1%), depression (1.0%) and neoplastic disease (2.6%). All patients treated with SOF-based regimens achieved SVR. There was no association between SVR and factors such as HCV genotype, sex, age, presence of cirrhosis or previous treatment history. There were no reports of any serious adverse events in the study. This single-center retrospective study represented the latest 10-year treatment trends for HCV in real-world clinical practice and provided useful information on the excellent efficacy of SOF-based direct-acting antiviral regimens for treatment of CHC patients in Eastern China.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135265937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Depression in Elderly People Living with HIV: A Systematic Review and Meta-analysis 老年艾滋病毒感染者抑郁患病率:系统回顾和荟萃分析

Infectious microbes & diseases Pub Date : 2023-10-24 DOI: 10.1097/im9.0000000000000132

Gasmelseed Y. Ahmed, Chandni Saha, Eman M. Almusalami, Ali A. Rabaan, Saad Alhumaid, Abdelraheem A. Ali, AbdAllah A. Basheer, Yousra Babikir, Ziyad Fahad Aljofan, Abbas Al Mutair

{"title":"Prevalence of Depression in Elderly People Living with HIV: A Systematic Review and Meta-analysis","authors":"Gasmelseed Y. Ahmed, Chandni Saha, Eman M. Almusalami, Ali A. Rabaan, Saad Alhumaid, Abdelraheem A. Ali, AbdAllah A. Basheer, Yousra Babikir, Ziyad Fahad Aljofan, Abbas Al Mutair","doi":"10.1097/im9.0000000000000132","DOIUrl":"https://doi.org/10.1097/im9.0000000000000132","url":null,"abstract":"Abstract We conducted a systematic review and meta-analysis to determine the prevalence of depression among elderly people living with HIV. We searched electronic databases and included 12 observational studies that reported on depression among people who were 50 years of age or older and had HIV. The studies were mostly hospital-based and from Western and African countries. They included a total of 5868 older people with HIV, of whom 1667 had depression. Pooled prevalence of depression was 28% with heterogeneity of 95.2%. Prevalence ranged from 14.5% in the Netherlands to 42.4% in South Africa. Although there was asymmetry in the funnel plot, the Egger’s test showed no significant publication bias. Our meta-analysis found a high burden of depression among older people with HIV. Comprehensive health services addressing psychosocial needs and interventions to prevent and treat depression are needed, especially in community settings. Healthcare providers and policymakers should address the prevalence of depression in such communities.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135265777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erysipeloid and Erysipelothrix rhusiopathiae Bacteremia Secondary to a Crab Stab Wound: A Case Report and Literature Review 蟹刺伤致类丹毒及红唇丹毒菌血症1例报告及文献复习

Infectious microbes & diseases Pub Date : 2023-10-24 DOI: 10.1097/im9.0000000000000133

Chaowen Deng, Xin Li, Defu Liu, Linlin Sun, Haiyan Ye, Fanfan Xing

引用次数: 0

The Quest for Understanding Cutaneous Leishmaniasis in Northern Province, Sri Lanka: An Analysis of Clinical Data from the District General Hospital, Vavuniya 了解斯里兰卡北部省皮肤利什曼病的探索:对瓦武尼亚地区总医院临床数据的分析

Infectious microbes & diseases Pub Date : 2023-09-12 DOI: 10.1097/im9.0000000000000130

Rajadurai Arulenthiran, Arumugam Murugananthan, Kanchana P. Amarasinghe, Umashankar Mathivathani

{"title":"The Quest for Understanding Cutaneous Leishmaniasis in Northern Province, Sri Lanka: An Analysis of Clinical Data from the District General Hospital, Vavuniya","authors":"Rajadurai Arulenthiran, Arumugam Murugananthan, Kanchana P. Amarasinghe, Umashankar Mathivathani","doi":"10.1097/im9.0000000000000130","DOIUrl":"https://doi.org/10.1097/im9.0000000000000130","url":null,"abstract":"Abstract The study aimed to examine the clinical and epidemiological patterns of cutaneous leishmaniasis (CL) in patients attending the Dermatology Unit, District General Hospital in Vavuniya, Sri Lanka. A total of 77 patients clinically suspected for CL were interviewed through a structured questionnaire and skin-lesion samples were obtained between January 2016 and January 2017. The definitive diagnosis of CL was made through microscopic identification of smears, histopathological examination of biopsies and kDNA PCR. Treatment modalities were chosen based on the location of the lesions on the body and complexity of the lesions. Of 77 suspected patients, 68 were confirmed for CL, with a mean age of 34.6 (±12.7) years, and included 54 males (79.4%) and 14 females (20.6%). Being a male was a significant risk factor ( P = 0.032, OR = 4.82) associated with CL. Lesions were observed mainly on the exposed areas of the body, of which the forearm (22.1%) was the most commonly affected site. Single lesions (75.0%) and ulcerated nodules with central crust (39.7%) were the prominent features among the infected group. The age-group of 21-40 years was significantly associated with healing lesions ( P = 0.028, ME = 0.55). However, a significant negative relationship was detected between ulcerated nodular lesions and lesion healing ( P = 0.0436, ME = -0.375). Males are at higher risk of CL. Early diagnosis and specific treatment, along with preventive measures such as protective clothing and sand fly repellents can limit the spread of the disease. There is a need for a comprehensive approach to prevent and control the transmission of CL.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135830564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of RT-PCR Kits Available in Sri Lanka for Diagnosis of COVID-19 斯里兰卡用于诊断COVID-19的RT-PCR试剂盒的比较评估

Infectious microbes & diseases Pub Date : 2023-08-07 DOI: 10.1097/IM9.0000000000000128

Kanchana P. Amarasinghe, A. Murugananthan, P. T. Amalraajan, Mithusha Thavaththurai, Gayathri Ravindran, K. Murugananthan, Shakila K. Gunathilake

{"title":"Comparative Evaluation of RT-PCR Kits Available in Sri Lanka for Diagnosis of COVID-19","authors":"Kanchana P. Amarasinghe, A. Murugananthan, P. T. Amalraajan, Mithusha Thavaththurai, Gayathri Ravindran, K. Murugananthan, Shakila K. Gunathilake","doi":"10.1097/IM9.0000000000000128","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000128","url":null,"abstract":"Abstract Identification of gene targets by real-time reverse transcriptase PCR (rRT-PCR) is considered as the gold standard for diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Although many commercial rRT-PCR kits are currently used in Sri Lanka, analytical performance of these kits have not been investigated adequately. Therefore, the objective of the present study was to evaluate the analytical performance of rRT-PCR kits used in the laboratory of the Faculty of Medicine, University of Jaffna (five kits). Performance of the five rRT-PCR kits selected for this study was compared with the CDC 2019-Novel Coronavirus (2019-nCoV) RT-PCR Diagnostic Panel as reference standard. The sensitivity, specificity, positive predictive value, negative predictive value and Cohen’s κ coefficient of the five different commercial kits were analyzed. SARS-CoV-2 positive (62) and negative (32) respiratory samples collected respectively from symptomatic individuals and asymptomatic healthy individuals were used in this study. Comparison of the cycle threshold (Ct) values of the five commercial kits revealed heterogeneity. Among them, the TaqPathTM kit showed the highest sensitivity (98.4%) and interrater reliability (0.976). The HBRT-COVID-19 kit showed the lowest sensitivity (91.9%), specificity (93.7%) and interrater reliability (0.838). Although the five RT-PCR kits exhibited varying sensitivity, specificity and Ct values, all of them are suitable for the routine diagnosis of SARS-CoV-2 infections as all values were higher than 90%.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47940461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAK1 Deficiency in Macrophages Increases Host Susceptibility to Leishmania Infection 巨噬细胞TAK1缺失增加宿主对利什曼原虫感染的易感性

Infectious microbes & diseases Pub Date : 2023-07-24 DOI: 10.1097/IM9.0000000000000127

Xiankai Cao, K. Kokou, Shi Yu, Mengdan Chen, Junling Niu, H. Lecoeur, É. Prina, G. Späth, Guangxun Meng

{"title":"TAK1 Deficiency in Macrophages Increases Host Susceptibility to Leishmania Infection","authors":"Xiankai Cao, K. Kokou, Shi Yu, Mengdan Chen, Junling Niu, H. Lecoeur, É. Prina, G. Späth, Guangxun Meng","doi":"10.1097/IM9.0000000000000127","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000127","url":null,"abstract":"Abstract Leishmania parasites mainly infect macrophages and may cause severe immunopathologies in their host, which are called leishmaniases. In the current work, we infected human and mouse macrophages in vitro with Leishmania major, an etiological agent of cutaneous leishmaniasis, and found that inhibition or deletion of the transforming growth factor β–activated kinase 1 (TAK1) gene resulted in increased parasite loads. In vivo, following a challenge with L. major, mice with a macrophage-specific deletion of TAK1 showed increased clinical signs and higher parasite loads compared with wild-type controls. TAK1 deficiency in mouse macrophages led to biased Th2 cell responses during the acute stage of infection, characterized by a decrease in interferon-γ expression, and increased expression of IL-4, IL-5 and IL-10. Finally, we found that, in the late stage of L. major infection, excessive Th2-related cytokines led to high arginase 1 expression in mouse tissues and a significant reduction of NO production both locally and systemically, resulting in compromised control of Leishmania. These findings suggest that TAK1 plays a vital role in host resistance to Leishmania infection.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45975731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious microbes & diseases Pub Date : 2023-07-24 DOI: 10.1097/IM9.0000000000000126

Feiyang Liu, Zi-Bei Dong, Min Zhao, Yanfei Gao, Xiang Li, Ya-Nan Jiang, Yi-Ming Li, Yu-Xin Zheng, Zhen Wang, Yansheng C. Feng, Ya-Li Liu

{"title":"COVID-19–Related Insomnia Populations Research and Management Strategies: A Review","authors":"Feiyang Liu, Zi-Bei Dong, Min Zhao, Yanfei Gao, Xiang Li, Ya-Nan Jiang, Yi-Ming Li, Yu-Xin Zheng, Zhen Wang, Yansheng C. Feng, Ya-Li Liu","doi":"10.1097/IM9.0000000000000126","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000126","url":null,"abstract":"Abstract Coronavirus disease 2019 (COVID-19) has affected the quality of sleep for various populations, causing anxiety and depression worldwide. COVID-19–related insomnia (COVIDRI) appears to be more common in certain populations, including females, urban residents and other individuals who reside in high-risk COVID-19–related areas, lack higher socioeconomic and educational levels, have a history of underlying mental illness, have no access to social support and work, or have been mandated for isolation. Among vulnerable populations, pregnant women, adolescents and children are more likely to suffer from anxiety and depression, which leads to irregular sleep-wake cycles and significantly poor sleep quality. Insomnia in COVID-19 patients is associated with decreased immune levels, excessive psychological stress and severe anxiety. The COVIDRI incidence and severity among frontline healthcare workers is high, especially among females and those working in isolation wards and intensive care units. The factors related to COVIDRI for college students during home study are stress from upcoming graduation, disharmonious family relationships and inadaptability to online education. For military personnel, anxiety and depression are the main causes of poor sleep quality. Based on the characteristics of different populations, active Chinese and Western medications, non-drug therapy, psychological counseling and suitable sleep management are vital measures to strengthen immunity, alleviate insomnia and limit recurrence.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45247619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlates of Sexual Lifestyles Among Older Adults Living With HIV in China: Findings From the Sexual Well-being (SWELL) Study 中国老年HIV感染者性生活方式的相关性研究

Infectious microbes & diseases Pub Date : 2023-07-24 DOI: 10.1097/IM9.0000000000000125

Bingyi Wang, Xin Peng, Leiwen Fu, Xinyi Li, Tong-xin Shi, B. Liang, Tian Tian, Thomas Fitzpatrick, Zhen Lu, Weijie Zhang, Junye Bian, Xin Xiao, Ying Wang, Yunlong Ao, Ouyang Lin, Yong Cai, M. Yu, Guohui Wu, Linghua Li, X. Meng, H. Zou

{"title":"Correlates of Sexual Lifestyles Among Older Adults Living With HIV in China: Findings From the Sexual Well-being (SWELL) Study","authors":"Bingyi Wang, Xin Peng, Leiwen Fu, Xinyi Li, Tong-xin Shi, B. Liang, Tian Tian, Thomas Fitzpatrick, Zhen Lu, Weijie Zhang, Junye Bian, Xin Xiao, Ying Wang, Yunlong Ao, Ouyang Lin, Yong Cai, M. Yu, Guohui Wu, Linghua Li, X. Meng, H. Zou","doi":"10.1097/IM9.0000000000000125","DOIUrl":"https://doi.org/10.1097/IM9.0000000000000125","url":null,"abstract":"Abstract Sexual lifestyles are closely related to overall human health and well-being. Few studies have focused on sexual lifestyles among older adults living with HIV (OALHIV), especially in low- and middle-income countries. This study is a part of the sexual well-being among older adults in China (SWELL) study, which is a multicenter cross-sectional study focused on sexual health among older adults aged 50 years and older. Participants were 680 OALHIV (≥50 years old) from the SWELL study conducted from June 2020 to December 2022. Data were collected through one-on-one interviews. We used logistic regression to assess the correlates of sexual activity and sexual satisfaction. Among all participants, 37.1% were sexually active. Being older, male, in a steady relationship and employed were associated with being sexually active. The prevalence of sexual satisfaction was 69.8% among sexually active OALHIV. Being homosexual and reporting a better general health status were associated with sexual satisfaction. The OALHIV who have depressive symptoms were less likely to report sexual satisfaction. To support holistic healthy aging among OALHIV, it is important for healthcare providers to be educated about the importance of enquiring about sexual activity, satisfaction and problems and addressing concerns while conveying sex-positive attitudes during clinical reviews, as these are still critical aspects of their health and well-being.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46551245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2