Infectious microbes & diseases最新文献

{"title":"Translation: Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7): National Health Commission, National Administration of Traditional Chinese Medicine.","authors":"Yueyue He","doi":"10.1097/IM9.0000000000000022","DOIUrl":"10.1097/IM9.0000000000000022","url":null,"abstract":"<p><p>The National Health Commission of the People's Republic of China has released the document: Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia to standardize the diagnosis and treatment of COVID-19.</p>","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41926580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation: Management of Coronavirus Disease 2019 (COVID-19): Experience in Zhejiang Province, China.","authors":"Kaijin Xu, Hongliu Cai, Yihong Shen, Qin Ni, Yu Chen, Shaohua Hu, Jianping Li, Huafen Wang, Liang Yu, He Huang, Yunqing Qiu, Guoqing Wei, Qiang Fang, Jianying Zhou, Jifang Sheng, Tingbo Liang, Lanjuan Li","doi":"10.1097/IM9.0000000000000023","DOIUrl":"10.1097/IM9.0000000000000023","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The current epidemic situation of coronavirus disease 2019 (COVID-19) still remains severe. As the National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital of the Zhejiang University School of Medicine is the primary medical care center for COVID-19 in Zhejiang Province. Based on the present expert consensus carried out by the National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on \"Four-Anti and Two-Balance\" for clinical practice. The \"Four-Anti and Two-Balance\" strategy includes antivirus, anti-shock, anti-hypoxemia, and anti-secondary infection, and maintaining of water, electrolyte and acid/base balance and microecological balance. Simultaneously, an integrated multidisciplinary personalized treatment is recommended to improve therapeutic effects. The importance of early viral detection, dynamic monitoring of inflammatory indexes, and chest radiographs has been emphasized in clinical decision-making. Sputum was observed with the highest positive rate by RT-PCR. Viral nucleic acids could be detected in 10% of the patients' blood samples at the acute phase and 50% of patients had positive RT-PCR results in their feces. We also isolated live viral strains from feces, indicating potential infectiousness of feces. Dynamic cytokine detection was necessary to timely identify cytokine storms and for the application of the artificial liver blood purification system. The \"Four-Anti and Two-Balance\" strategy effectively increased cure rates and reduced mortality. Early antiviral treatment alleviated disease severity and prevented illness progression. We found that lopinavir/ritonavir combined with abidol showed antiviral effects against COVID-19. Shock and hypoxemia were usually caused by cytokine storms. The artificial liver blood purification system was able to rapidly remove inflammatory mediators and block the cytokine storm. Moreover, it also contributed to the balance of fluids, electrolytes, and acids/bases and thus improved treatment efficacy during critical illness. For cases of severe illness, early and also short periods of moderate glucocorticoid administration was supported. Patients with an oxygenation index below 200 mm Hg were transferred to the intensive care unit. Conservative oxygen therapy was preferred and noninvasive ventilation (NIV) was not recommended. Patients with mechanical ventilation were strictly supervised with cluster ventilator-associated pneumonia prevention strategies. Antimicrobial prophylaxis was prescribed rationally and was not recommended, except for patients with a long course of disease, repeated fever, and elevated procalcitonin, similarly secondary fungal infections were of concern. Some patients with COVID-19 showed intestinal microbial dysbiosis with decreased genus such as &lt;i&gt;Lactobacillus&lt;/i&gt; and &lt;i&gt;Bifidobacterium&lt;/i&gt;. Nutritional and gastrointestinal funct","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"1 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41421902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Antimicrobial Peptides Against SARS-CoV-2: Today is the Future: Retraction.","authors":"","doi":"10.1097/IM9.0000000000000056","DOIUrl":"10.1097/IM9.0000000000000056","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1097/IM9.0000000000000050.].</p>","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"3 1","pages":"49"},"PeriodicalIF":2.0,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44234763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Obesity and Falls Among Korean Adults: A Population-Based Cross-Sectional Study.","authors":"So Young Kim, Min-Su Kim, Songyong Sim, Bumjung Park, Hyo Geun Choi","doi":"10.1097/MD.0000000000003130","DOIUrl":"10.1097/MD.0000000000003130","url":null,"abstract":"<p><p>The objective of this study was to evaluate the association between falls and obesity using Asian body mass index (BMI) classifications. Using the data from the Korean community health survey in 2011, a total of 229,226 participants ranging from 19 to 106 years old were included in this study. The BMI groups were classified as underweight (<18.5), healthy (18.5 ≤ BMI < 23), overweight (23 ≤ BMI <25), and obese (≥25) using Asian BMI classifications. The associations between BMI groups and falls (≥1 time or ≥2 times per year) were analyzed using multiple logistic regression analyses with complex sampling. A subgroup analysis was conducted according to age (19-40, 41-60, and ≥61 years) and the location of the fall (indoor and outdoor). Physical activity, household income, education level, alcohol consumption, smoking, stress level, and medical comorbidities were adjusted as confounders. In total, 16.8% and 6.1% of the participants experienced falls ≥1 time and ≥2 times per year, respectively. Compared to the healthy weight group, the other BMI groups showed a significant U-shaped relationship with falls ≥1 time (AOR underweight = 1.12, 95% CI [confidence interval] = 1.05-1.19; AOR obese = 1.06, 95% CI = 1.02-1.10, P < 0.001) and ≥2 times (AOR underweight = 1.14, 95% CI = 1.04-1.26; AOR obese = 1.04, 95% CI = 0.99-1.10, P < 0.001). Obese status was significantly associated with falls (≥1 fall per year) in all age groups, whereas being underweight was significantly associated with falls in the 19 to 40 year age group only. In conclusion, both underweight and obese statuses were significantly associated with falls in this adult Korean population. However, the relationship between BMI group and falls varied according to age and the location of the falls. </p>","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"4 1","pages":"e3130"},"PeriodicalIF":1.6,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61669319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}