Infectious microbes & diseases最新文献_第8页

On or Off: Life-Changing Decisions Made by Vibrio cholerae Under Stress. 开或关：霍乱弧菌在压力下做出的改变生命的决定。

Infectious microbes & diseases Pub Date : 2020-10-14 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000037

Yitian Zhou, Zachariah L Lee, Jun Zhu

引用次数: 0

Sex Bias in Sample Collections From Bats, the Culprit of SARS Coronavirus, SARS-Coronavirus-2, and Other Emerging Viruses. 蝙蝠——SARS冠状病毒、SARS冠状病毒-2和其他新出现的病毒的罪魁祸首——样本采集中的性别偏见

Infectious microbes & diseases Pub Date : 2020-10-06 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000036

Susanna K P Lau, Zirong He, Ken P K Lin, Patrick C Y Woo

引用次数: 0

Microbiological Characteristics and Antibiotic Sensitivity in Patients with Nosocomial Spontaneous Bacterial Peritonitis Caused by Escherichia coli: A Multicenter Study. 大肠杆菌引起的院内自发性细菌性腹膜炎的微生物学特征和抗生素敏感性:一项多中心研究

Infectious microbes & diseases Pub Date : 2020-08-07 eCollection Date: 2020-12-01 DOI: 10.1097/IM9.0000000000000035

Bo Tu, Yuening Zhang, Jingfeng Bi, Zhe Xu, Lei Shi, Xin Zhang, Peng Zhao, Dawei Zhang, Guang Yang, Enqiang Qin

{"title":"Microbiological Characteristics and Antibiotic Sensitivity in Patients with Nosocomial Spontaneous Bacterial Peritonitis Caused by Escherichia coli: A Multicenter Study.","authors":"Bo Tu, Yuening Zhang, Jingfeng Bi, Zhe Xu, Lei Shi, Xin Zhang, Peng Zhao, Dawei Zhang, Guang Yang, Enqiang Qin","doi":"10.1097/IM9.0000000000000035","DOIUrl":"10.1097/IM9.0000000000000035","url":null,"abstract":"Escherichia coli is a prevalent causative pathogen of spontaneous bacterial peritonitis (SBP). In this retrospective study, we investigated the microbiological characteristics and antibiotic susceptibility of E. coli clinical isolates obtained from liver cirrhosis patients suffering from nosocomial SBP. Our results showed that extended-spectrum β-lactamase (ESBL)-producing E. coli accounted for 47% of the cases, while 62% of the isolates were multi-drug resistant (MDR) pathogens. ESBL-producing and MDR isolates showed high incidences of resistance to third-generation cephalosporins, but they displayed susceptibility to carbapenems, β-lactamase inhibitors, and aminoglycosides. Importantly, liver cirrhosis patients with MDR E. coli SBP showed a significantly higher death rate than patients with non-MDR infections (P = 0.021). The 30-day mortality of nosocomial SBP was independently correlated with female gender [odds ratio (OR) = 5.200, 95% confidence interval (CI) = 1.194-22.642], liver failure (OR = 9.609, 95% CI = 1.914-48.225), hepatocellular carcinoma (OR = 8.176, 95% CI = 2.065-32.364), hepatic encephalopathy (OR = 8.176, 95% CI = 2.065-32.364), model of end-stage liver disease score (OR = 1.191, 95% CI = 1.053-1.346), white blood cell count (OR = 0.847, 95% CI = 0.737-0.973), and ascites polymorphonuclear (OR = 95.903, 95% CI = 3.410-2697.356). In conclusion, third-generation cephalosporins may be inappropriate for empiric treatment of nosocomial SBP caused by E. coli, due to the widespread presence of ESBLs and high incidence of MDR pathogens.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"2 1","pages":"167-172"},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48720831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Will the Overuse of Antibiotics During the Coronavirus Pandemic Accelerate Antimicrobial Resistance of Bacteria? 冠状病毒大流行期间抗生素的过度使用会加速细菌的抗菌素耐药性吗?

Infectious microbes & diseases Pub Date : 2020-07-21 eCollection Date: 2020-09-01 DOI: 10.1097/IM9.0000000000000034

Prasanth Manohar, Belinda Loh, Sebastian Leptihn

引用次数: 0

Potential Therapeutic Options for COVID-19. COVID-19的潜在治疗方案

IF 2

Infectious microbes & diseases Pub Date : 2020-07-16 eCollection Date: 2020-09-01 DOI: 10.1097/IM9.0000000000000033

Xiaoqin Zheng, Lanjuan Li

引用次数: 0

Molecular Mechanisms of Gut Microbiota-Associated Colorectal Carcinogenesis 肠道微生物群与结直肠癌发生的分子机制

Infectious microbes & diseases Pub Date : 2020-06-24 DOI: 10.1097/IM9.0000000000000030

Yichang Shao, Xun Zeng

引用次数: 1

Impact of Population Mask Wearing on Covid-19 Post Lockdown. 人口戴口罩对封锁后新冠肺炎的影响

IF 2

Infectious microbes & diseases Pub Date : 2020-06-05 DOI: 10.1097/IM9.0000000000000029

Babak Javid, Nathalie Q Balaban

引用次数: 0

Transcriptomics Curation of SARS-CoV-2 Related Host Genes in Mice With COVID-19 Comorbidity: A Pilot Study. COVID-19合并症小鼠中SARS-CoV-2相关宿主基因的转录组学调控:一项初步研究

Infectious microbes & diseases Pub Date : 2020-05-06 eCollection Date: 2020-06-01 DOI: 10.1097/IM9.0000000000000025

Kunkai Su, Xin Huang, Kaijin Xu, Weibo Du, Danhua Zhu, Meifang Yang, Wenji Yuan, Lanjuan Li

{"title":"Transcriptomics Curation of SARS-CoV-2 Related Host Genes in Mice With COVID-19 Comorbidity: A Pilot Study.","authors":"Kunkai Su, Xin Huang, Kaijin Xu, Weibo Du, Danhua Zhu, Meifang Yang, Wenji Yuan, Lanjuan Li","doi":"10.1097/IM9.0000000000000025","DOIUrl":"10.1097/IM9.0000000000000025","url":null,"abstract":"The pandemic of coronavirus disease 2019 (COVID-19), a respiratory disease caused by a novel severe acute respiratory syndrome coronavirus-2, is causing substantial morbidity and mortality. Along with the respiratory symptoms, underlying diseases in senior patients, such as diabetes, hypertension, and coronary heart disease, are the most common comorbidities, which cause more severe outcomes and even death. During cellular attachment and entry of severe acute respiratory syndrome coronavirus-2, the key protein involved is the angiotensin I converting enzyme 2 (ACE2), which is located on the membrane of host cells. Here, we aim to curate an expression profile of Ace2 and other COVID-19 related genes across the available diabetes murine strains. Based on strictly manual curation and bioinformatics analysis of the publicly deposited expression datasets, Ace2 and other potentially involved genes such as Furin, Tmprss2, Ang, and Ang2 were examined. We found that Ace2 expression is rather ubiquitous in three selected diabetes prone strains (db/db, ob/ob and diet-induced obese). With the most abundant datasets present, the liver shows a medium Ace2 expression level compared with the lungs, pancreatic islets, brain and even T cells. Age is a more critical factor for Ace2 expression in db/db compared with the other two strains. Besides Ace2, the other four host genes showed varied levels of correlation to each other. To accelerate research on the interaction between COVID-19 and underlying diseases, the Murine4Covid transcriptomics database (www.geneureka.org/Murine4Covid) will facilitate the design of research on COVID-19 and comorbidities.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":"2 1","pages":"42-47"},"PeriodicalIF":0.0,"publicationDate":"2020-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8529699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46949773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suspected Close Contacts as the Pilot Indicator of the Growth Trend of Confirmed Population During the COVID-19 Pandemic: A Simulation Approach. 疑似密切接触者作为新冠肺炎大流行期间确诊人口增长趋势的试点指标：一种模拟方法

IF 2

Infectious microbes & diseases Pub Date : 2020-05-05 DOI: 10.1097/IM9.0000000000000026

Sisi Huang, Anding Zhu, Yan Wang, Yancong Xu, Lu Li, Dexing Kong

{"title":"Suspected Close Contacts as the Pilot Indicator of the Growth Trend of Confirmed Population During the COVID-19 Pandemic: A Simulation Approach.","authors":"Sisi Huang, Anding Zhu, Yan Wang, Yancong Xu, Lu Li, Dexing Kong","doi":"10.1097/IM9.0000000000000026","DOIUrl":"10.1097/IM9.0000000000000026","url":null,"abstract":"Background: Regarding to the actual situation of the new coronavirus disease 2019 epidemic, social factors should be taken into account and the increasing growth trend of confirmed populations needs to be explained. A proper model needs to be established, not only to simulate the epidemic, but also to evaluate the future epidemic situation and find a pilot indicator for the outbreak.Methods: The original susceptible-infectious-recover model is modified into the susceptible-infectious-quarantine-confirm-recover combined with social factors (SIDCRL) model, which combines the natural transmission with social factors such as external interventions and isolation. The numerical simulation method is used to imitate the change curve of the cumulative number of the confirmed cases and the number of cured patients. Furthermore, we investigate the relationship between the suspected close contacts (SCC) and the final outcome of the growth trend of confirmed cases with a simulation approach.Results: This article selects four representative countries, that is, China, South Korea, Italy, and the United States, and gives separate numerical simulations. The simulation results of the model fit the actual situation of the epidemic development and reasonable predictions are made. In addition, it is analyzed that the increasing number of SCC contributes to the epidemic outbreak and the prediction of the United States based on the population of the SCC highlights the importance of external intervention and active prevention measures.Conclusions: The simulation of the model verifies its reliability and stresses that observable variable SCC can be taken as a pilot indicator of the coronavirus disease 2019 pandemic.","PeriodicalId":73374,"journal":{"name":"Infectious microbes & diseases","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41914273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation: Expert Consensus on the Application of Artificial Liver Blood Purification System in the Treatment of Severe and Critical COVID-19: National Clinical Research Center for Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. 翻译：人工肝血液净化系统在重症和危重症新冠肺炎治疗中的应用专家共识

IF 2

Infectious microbes & diseases Pub Date : 2020-04-17 DOI: 10.1097/IM9.0000000000000021

Lanjuan Li

引用次数: 0